Archives of Osteoporosis最新文献

{"title":"Long-term trajectories and cumulative exposure of the triglyceride–glucose–frailty index in relation to hip fracture risk: evidence from a large-scale population-based cohort","authors":"Han Su,&nbsp;Chengfeng Fu,&nbsp;Pingping Wang,&nbsp;Yingying Zhang","doi":"10.1007/s11657-026-01683-z","DOIUrl":"10.1007/s11657-026-01683-z","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Long-term trajectories and cumulative burden of the triglyceride–glucose–frailty index (TyGFI) exhibited nonlinear associations with hip fracture risk. Persistent metabolic–frailty imbalance markedly increased fracture susceptibility, identifying TyGFI as a potential risk factor for early detection and prevention of hip fracture.</p><h3>Background</h3><p>Hip fracture is a major cause of disability and mortality in older adults, yet traditional risk factors explain only part of its variability. Metabolic dysfunction and frailty may jointly contribute to skeletal fragility. The triglyceride–glucose–frailty index (TyGFI) integrates these domains, but its long-term association with hip fracture risk remains unclear.</p><h3>Methods</h3><p>A total of 6130 adults aged ≥ 45 years from the China Health and Retirement Longitudinal Study were included. TyGFI was calculated as the product of the triglyceride–glucose index and frailty index. Participants were grouped into longitudinal trajectories using <i>k</i>-means clustering, and cumulative exposure was estimated as the area under the curve between 2012 and 2015. Cox regression and spline analyses evaluated associations with hip fracture risk.</p><h3>Results</h3><p>Three distinct TyGFI trajectories were identified—low–stable, moderate–increasing, and high–increasing. Compared with the low–stable group, participants in the moderate– and high–increasing groups had higher hip fracture risks (HR = 1.97 and 3.79, both <i>P</i> &lt; 0.001). Cumulative TyGFI showed a nonlinear association with fracture risk, with a potential threshold around 4.5. Incorporating cumTyGFI significantly improved predictive performance (<i>C</i>-statistic = 0.7340; NRI = 0.4330; IDI = 0.0097; all <i>P</i> &lt; 0.001). Results were robust across subgroups and multiple sensitivity analyses.</p><h3>Conclusions</h3><p>Long-term trajectories and cumulative exposure of TyGFI were independently associated with hip fracture risk, suggesting that persistent metabolic–frailty imbalance contributes to skeletal fragility. TyGFI may serve as a practical integrative marker for early identification and prevention of high-risk individuals.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-026-01683-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trend in DXA examination rates and the prevalence of osteoporosis in patients with distal radius fractures at a trauma flagship hospital","authors":"Yusuke Kubo,&nbsp;Kazuhiko Sonoda,&nbsp;Toshihiko Hara","doi":"10.1007/s11657-026-01712-x","DOIUrl":"10.1007/s11657-026-01712-x","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Distal radius fractures may indicate underlying osteoporosis. In 856 surgical patients ≥ 50 years, DXA testing rose from 19.0 to 85.7%; 64.5% had osteoporosis and 36.3% had fracture risk. Many were previously untreated. Routine DXA screening for all DRF patients ≥ 50, including men, may enable early treatment and secondary fracture prevention.</p><h3>Purposes</h3><p>The objective was to investigate the dual-energy X-ray absorptiometry (DXA) examination rate, osteoporosis diagnosis rate, and osteoporosis severity in distal radius fracture (DRF) at a trauma flagship hospital.</p><h3>Methods</h3><p>We retrospectively examined 856 DRF patients aged 50 years or older (723 women, 133 men; mean 71.8 years) who underwent surgery between 2007 and 2025. We evaluated the presence of DXA testing, osteoporosis diagnosis (<i>T</i>-score ≤ −2.5SD), and osteoporosis with high fracture risk, including (1) L-spine <i>T</i>-score &lt; −3.3SD, (2) <i>T</i>-score ≤ −2.5SD with at least one fragility fracture, (3) two or more vertebral fractures, or (4) semiquantitative grade 3 vertebral fracture. Subgroup comparisons were according to sex, age, and mechanism of injury (low vs. high energy). The chi-square test and Cochran-Armitage test were used for statistical analysis.</p><h3>Results</h3><p>DXA implementation rate was 31.0% and increased significantly from 19.0% in 2007 to 85.7% in 2025. This rate was significantly higher in women (34.2%) than men (13.5%). Of those tested, 64.5% were diagnosed with osteoporosis (women 65.2%, men 55.6%). Osteoporosis was observed in over half of patients even in 50 s (57.1%) and with high-energy injuries (56.5%). Among osteoporosis patients, 81.9% had not received prior treatment for osteoporosis, and 90% of untreated cases subsequently initiated treatment. Fracture risk was estimated in 36.3% of osteoporosis cases.</p><h3>Conclusion</h3><p>These results revealed a high prevalence of latent osteoporosis, regardless of age, sex, or injury mechanism. DXA testing should be recommended to prevent secondary fragility fractures for all DRF patients aged 50 and older, including males.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of metformin on bone turnover markers: a systematic review and meta-analysis of clinical trials","authors":"Mohammadreza Heidari,&nbsp;Niloofar Mirdamadi,&nbsp;Pouria Khashayar,&nbsp;Ozra Tabatabaei-Malazy,&nbsp;Marzieh Golabchi,&nbsp;Patricia khashayar","doi":"10.1007/s11657-026-01713-w","DOIUrl":"10.1007/s11657-026-01713-w","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Metformin is widely used for diabetes, but its effects on bone health are uncertain. This meta-analysis study found that it reduces markers of both bone loss and bone formation. It is still unclear whether this benefits or harms bones long term, highlighting the need for larger, longer clinical studies.</p><h3>Purpose</h3><p>Metformin is a widely used antidiabetic drug that has shown potential effects on bone metabolism. However, its impact on bone turnover markers remains unclear. This systematic review and meta-analysis aimed to assess this effect.</p><h3>Methods</h3><p>A comprehensive search was conducted across PubMed, Scopus, Embase, Web of Science, and Cochrane Library databases, identifying clinical trials published up to February 04, 2026, that evaluated the effects of metformin on validated bone turnover markers. The quality and risk of bias were assessed using the Modified Jadad Scale, and Cochrane Collaboration’s risk of bias tool, respectively. A random-effects meta-analysis was performed to estimate the standardized mean difference (SMD) with a 95% confidence interval.</p><h3>Results</h3><p>Fourteen studies met the inclusion criteria, involving diabetic and non-diabetic populations. Metformin significantly reduced both bone resorption, bone formation markers (SMD: −1.28 [95% CI: −2.03, −0.52], <i>I</i>² = 99.33%), and (−0.18 [−0.28, −0.08], <i>I</i>² = 67.78%), respectively. These findings suggest a pattern consistent with reduced bone turnover rather than selective modulation of either bone resorption or bone formation. However, substantial statistical heterogeneity was observed across studies, especially for bone resorption markers, limiting the precision and generalizability of pooled estimates.</p><h3>Conclusion</h3><p>Metformin appears to lower overall bone turnover, reducing both bone resorption and bone formation markers. However, given the high heterogeneity across studies and the reliance on surrogate biochemical endpoints rather than fracture or bone mineral density outcomes, the clinical significance of these findings remains uncertain. Larger, long-term trials are needed to determine whether metformin provides real benefits or risks for osteoporosis.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moroccan national guidelines for the management of postmenopausal osteoporosis","authors":"Mirieme Ghazi,&nbsp;Anass Kherrab,&nbsp;Ilyass Chergaoui,&nbsp;Hamza Toufik,&nbsp;Hamza El Jadi,&nbsp;Mohamed Amine Benhima,&nbsp;Radouane Niamane,&nbsp;Abdellah El Maghraoui","doi":"10.1007/s11657-026-01705-w","DOIUrl":"10.1007/s11657-026-01705-w","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This updated Moroccan guideline provides 17 expert recommendations for managing postmenopausal osteoporosis. Developed through a national consensus process, it aligns with international standards and includes a practical algorithm to support clinical decisions. It aims to improve diagnosis, fracture risk assessment, and treatment outcomes for women in routine care.</p><p>These new recommendations update those published in 2007, in accordance with the most recent international guidelines. The initial framework and key thematic areas were defined by a national steering committee. The recommendations were subsequently elaborated, discussed, and validated by a multidisciplinary panel of experts. An independent reading group was also consulted to review and approve the final document. A structured consensus process using the Delphi method (four iterative rounds) was conducted to formulate 17 recommendations; they incorporate recent advances in the diagnosis, fracture risk stratification, and therapeutic management of osteoporosis. Major updates include the integration of fracture risk assessment tools, the revision of intervention thresholds, clarification of the respective roles of antiresorptive and anabolic therapies, and the updating of prevention and follow-up strategies. A practical algorithm is proposed to guide the management of postmenopausal osteoporosis in routine clinical practice.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-COL1A1/2 genetic burden and osteoporosis-overlap in patients referred with osteogenesis imperfecta phenotype","authors":"Fatma Nihal Ozturk,&nbsp;Ece Keskin","doi":"10.1007/s11657-026-01702-z","DOIUrl":"10.1007/s11657-026-01702-z","url":null,"abstract":"<div><h3>Purpose</h3><p>Patients referred with an osteogenesis imperfecta (OI) phenotype exhibit marked genetic heterogeneity, and a substantial proportion may harbor variants associated with early-onset osteoporosis (EOO) or OI-mimicking disorders rather than classical collagenopathies. This study aimed to define the genetic spectrum and non-<i>COL1A1/2</i> variant burden in a cohort clinically diagnosed with OI.</p><h3>Methods</h3><p>Ninety-eight unrelated patients referred with a clinical diagnosis of OI were analyzed using a targeted NGS panel on the DNBSEQ-400 platform and, when indicated, whole-exome sequencing. Variants were classified according to ACMG/AMP guidelines, and copy-number variants were assessed by microarray (Affymetrix CytoScan Optima, Thermo Fisher Scientific). Genes were categorized as <i>COL1A1/COL1A2</i>-related or non-collagen bone fragility genes.</p><h3>Results</h3><p>Seventy-two variants affecting 60 distinct loci were identified. While most pathogenic variants involved <i>COL1A1</i> and <i>COL1A2</i>, a substantial proportion of patients (approximately one-quarter) carried variants in non-collagen genes including <i>FKBP10, WNT1, P3H1, PLS3,</i> and <i>SERPINF1</i>, which are known to be associated with early-onset osteoporosis and OI-overlap phenotypes. Several of these variants were detected in the heterozygous state and were incompatible with classical autosomal-recessive OI, supporting an osteoporosis-predominant or modifier-based disease model.</p><h3>Conclusions</h3><p>A significant proportion of patients referred with an OI phenotype genetically represent early-onset osteoporosis or OI-overlap disorders rather than true collagenopathies. Comprehensive NGS-based testing, including copy-number analysis and non-<i>COL1A1/2</i> genes, enables accurate classification across the bone fragility spectrum and improves diagnostic yield.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone health in young adults with inflammatory arthritis: assessment of associated factors of low bone mineral density","authors":"Myroslava Kulyk,&nbsp;Rene Westhovens,&nbsp;Kurt De Vlam,&nbsp;Rik Lories,&nbsp;Marta Dzhus","doi":"10.1007/s11657-026-01710-z","DOIUrl":"10.1007/s11657-026-01710-z","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Rationale: To evaluate bone mineral density (BMD) in young adults with inflammatory arthritis.</p><p>Main result: Low BMD was detected in 42% of patients, associated with male sex, lower BMI, slower gait speed, higher ESR, and prolonged glucocorticoids.</p><p>Significance: This population requires early, comprehensive bone health screening to prevent long-term complications.</p><h3>Introduction</h3><p>Bone loss and consequent fractures significantly reduce quality of life, causing disability and premature mortality. These issues, common in elderly patients, are also linked to inflammatory arthritis (IA). The impact of IA on bone health in young adults (20–40 years) is poorly documented. This study investigated the prevalence of low bone mineral density (BMD) and potential risk factors in young adults with IA in Ukraine.</p><h3>Methods</h3><p>Patients aged 18–40 with IA (juvenile idiopathic arthritis (JIA), spondyloarthritis (SpA), rheumatoid arthritis (RA)) and disease duration &gt; 2 years, observed between November 2020 and December 2022, were included in this mono-centric study. Exclusion criteria are as follows: diabetes mellitus, endoprosthesis, systemic JIA, and pregnancy. BMD was measured using dual-energy X-ray absorptiometry. Low BMD was defined as a Z-score ≤ –2.0 at the lumbar spine, total hip, or femoral neck<i>.</i> Multivariable logistic regression, adjusted for sex, body mass index (BMI), erythrocyte sedimentation rate (ESR), gait speed, and duration of glucocorticoid use, was performed to evaluate associated factors, calculating odds ratios (OR) with confidence intervals.</p><h3>Results</h3><p>Among 144 patients (81 females, 63 males; median age 29 years), the prevalence of low BMD was 42% (61/144): 42% in JIA, 31% in SpA, and 26% in RA. In the adjusted multivariable model, low BMD was associated with male sex (OR = 11.5, <i>p</i> &lt; 0.001), lower BMI (OR = 0.74, <i>p</i> &lt; 0.001), higher ESR (OR = 1.10, <i>p</i> &lt; 0.001), slower gait speed (OR = 0.02, <i>p</i> &lt; 0.001), and longer duration of glucocorticoid use (OR = 1.03, <i>p</i> = 0.003).</p><h3>Conclusions</h3><p>Our study revealed a high prevalence of low BMD among young patients with IA in Ukraine, closely linked to disease-related factors. This condition is multifactorial and associated with a specific clinical profile, including male sex, lower BMI, reduced physical performance, higher inflammation, and prolonged glucocorticoid use, highlighting the need for comprehensive screening and care.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of socioeconomic status on functional status and health-related quality of life in hip fracture patients","authors":"Khai Cheong Wong,&nbsp;Daran Huang,&nbsp;Evan Tan,&nbsp;Joyce Suang Bee Koh,&nbsp;Tet Sen Howe,&nbsp;Mann Hong Tan,&nbsp;Xian Khing Kenny Tay","doi":"10.1007/s11657-026-01708-7","DOIUrl":"10.1007/s11657-026-01708-7","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p><b>What is known?</b> Hip fractures are debilitating osteoporotic fractures that are increasingly pervasive in our aging population. SES has an overarching influence on health outcomes and well-being, having already been proven in other morbid diseases. <b>What is new?</b> Overall, this study demonstrates that hip fracture patients experience poorer perioperative quality of life at different time points based on SES, though both groups recuperate to attain comparable outcomes by 1 year. <b>What is the impact?</b> Our findings suggest that hip fracture prevention should be emphasised across all socioeconomic strata. Health policies and coverage should be re-examined in the aging population, especially the need for mental health support during immediate recovery.</p><h3>Introduction</h3><p>Hip fractures are increasingly prevalent in our fast-aging population, but effects of socioeconomic status (SES) on these patients’ perioperative wellbeing are not well understood. This study aims to investigate the effect of SES, represented by hospital ward class, on perioperative function and health-related quality of life (HRQoL) in hip fracture patients.</p><h3>Study design and methods</h3><p>Four hundred forty-five hip fracture patients were prospectively followed up and categorised into private (PTE) and government-subsidised (SUB) ward classes as a surrogate for SES. Patients were evaluated using Parker Mobility Score (PMS), EuroQol-5 Dimensions (EQ-5D) and Short Form-36 (SF-36; including Physical Function [PF] and Mental Health [MH]) scores premorbidly, and postoperatively at 3 months, 6 months and 1 year.</p><h3>Results</h3><p>Group PTE scored significantly higher in PMS across all time points and in PF at 6 months (42.5 ± 27.3 vs 35.0 ± 29.1, <i>p</i> = 0.033) postoperatively. Group PTE also had superior EQ-5D scores at 3 (0.620 ± 0.282 vs 0.497 ± 0.325, <i>p</i> = 0.002) and 6 months (0.715 ± 0.268 vs 0.576 ± 0.334, <i>p</i> = 0.001) postoperatively. Group PTE had higher MH scores at 3 months (85.9 ± 15.0 vs 80.9 ± 18.1, <i>p</i> = 0.014) postoperatively, though its scores continued to decline by 6 months. Changes over time in EQ-5D scores favoured Group PTE (<i>p</i> = 0.016). Both groups had an overall decline at 3 months before gradually returning towards baseline at 1 year.</p><h3>Conclusion</h3><p>This study highlights SES-based disparities in hip fracture patients perioperatively, though both groups converge to comparable outcomes by 1 year. Health policies should consider MH support during recovery for all, regardless of SES.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone microarchitectural degradation in hypertensive patients: a population-based study","authors":"Fabio Bioletto,&nbsp;Martina Bollati,&nbsp;Marco Barale,&nbsp;Chiara Lopez,&nbsp;Alessia Pusterla,&nbsp;Emanuela Arvat,&nbsp;Ezio Ghigo,&nbsp;Mauro Maccario,&nbsp;Massimo Procopio,&nbsp;Mirko Parasiliti-Caprino","doi":"10.1007/s11657-026-01703-y","DOIUrl":"10.1007/s11657-026-01703-y","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Hypertension is associated with increased fracture risk. However, evidence on its association with BMD is conflicting. Here, we demonstrate that hypertensive patients have lower trabecular bone scores compared to normotensive subjects, despite similar BMD. This degradation of bone microarchitecture may help explain the increased skeletal fragility observed in hypertensive patients.</p><h3>Purpose</h3><p>Hypertension is associated with an increased fracture risk. However, evidence on its association with bone mineral density (BMD) is conflicting, and data on bone microarchitectural quality are scarce. The in vivo effects of anti-hypertensive medications on bone quality are poorly explored. The primary aim of this study was to evaluate whether bone microarchitecture, non-invasively assessed by trabecular bone score (TBS), is altered in hypertensive patients. The association between anti-hypertensive medications and TBS was also evaluated as a secondary endpoint.</p><h3>Methods</h3><p>We extracted individual data of 7053 subjects included in the 2005–2008 cycles of the National Health and Nutrition Examination Survey (NHANES), in which lumbar spine dual-energy X-ray absorptiometry (DXA) scans were acquired. TBS values were calculated from DXA images using dedicated software. The association between hypertension, anti-hypertensive medications, and bone outcomes was assessed by regression analyses, adjusted for relevant confounders.</p><h3>Results</h3><p>Hypertension was independently associated with lower TBS values (<i>β</i> = −0.010; 95%CI, [−0.016, −0.003]; <i>p</i> = 0.008); on the contrary, no association was observed between hypertension and BMD at any site (lumbar spine: <i>p</i> = 0.362; total hip: <i>p</i> = 0.481; femoral neck: <i>p</i> = 0.298). No class of anti-hypertensive medications was significantly associated with TBS. Thiazide diuretics and angiotensin receptor blockers were associated with higher BMD values, whereas loop diuretics and non-dihydropyridine calcium channel blockers were associated with lower BMD values.</p><h3>Conclusions</h3><p>Hypertension is associated with degraded bone microarchitecture, while no association is observed with bone mass. No significant relationships between anti-hypertensive medications and TBS were found. Associations between anti-hypertensive medications and BMD were consistent with previous reports.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends, disease burden, and cause patterns of hip fracture among older adults from 1990 to 2023 in mainland China","authors":"Xi Qi,&nbsp;Liangjie Lu,&nbsp;Haotian Li,&nbsp;Zilu Sun,&nbsp;Yao Li,&nbsp;Longbing Ren","doi":"10.1007/s11657-026-01695-9","DOIUrl":"10.1007/s11657-026-01695-9","url":null,"abstract":"<div><h3>Summary</h3><p>This study examined hip fracture trends in older Chinese adults from 1990 to 2023, finding a sharp rise in cases, especially from falls, but less disability over time. It highlights the need for better prevention, particularly for women, to ease the growing health burden as China’s population ages.</p><h3>Objective</h3><p>With China’s rapidly aging population, hip fractures have become a leading cause of disability and healthcare burden among older adults. This study examined the incidence and disability burden of hip fractures among adults aged 60 years and above from 1990 to 2023 in mainland China and described sex-specific patterns and changes over time.</p><h3>Methods</h3><p>Data were obtained from the Global Burden of Disease (GBD) 2023 study. We extracted the number of hip fractures, crude incidence rate, and years lived with disability (YLDs) rate for adults aged 60 years and older in mainland China. Age standardization followed the 2020 China census population. Temporal changes were assessed by comparing percent differences between the 1990 and 2023 estimates, with all results reported together with their 95% uncertainty intervals.</p><h3>Results</h3><p>In 2023, mainland China had an estimated 3.23 million hip fractures among adults aged 60 years and above (2.28 to 4.43 million), including 1.16 million cases among males (0.83 to 1.59 million) and 2.07 million among females (1.45 to 2.85 million). The age-standardized incidence rate reached 1065.47 per 100,000 population (685.35 to 1597.70) in 2023, increasing by 58.3% compared with 1990. The age-standardized rate was higher in females at 1312.98 per 100,000 (833.36 to 1976.11) than in males at 799.29 per 100,000 (517.93 to 1202.45). In contrast, the age-standardized YLD rate showed a modest decline from 1990 to 2023, decreasing from 222.51 (151.48 to 304.89) to 197.35 (135.20 to 277.92). Across causes, falls remained the leading contributor to hip fractures throughout the study period.</p><h3>Conclusions</h3><p>Hip fractures among older adults in mainland China continued to rise in both number and incidence rate from 1990 to 2023, with women experiencing a consistently higher burden than men. The decrease in age-standardized YLDs suggests some improvement in post-fracture management, although the growing incidence highlights the need for strengthened prevention strategies, particularly fall prevention and osteoporosis management in older adults.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistical shape modeling of the proximal femur in Mexican women: a cross-sectional morphometric and densitometric study","authors":"Griselda-Adriana Cruz-Priego,&nbsp;Fryda Medina-Rodríguez,&nbsp;Rubén Torres-González,&nbsp;Patricia Clark","doi":"10.1007/s11657-026-01682-0","DOIUrl":"10.1007/s11657-026-01682-0","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This study applied statistical shape modeling to 284 DXA hip scans from Mexican women, identifying proximal femur morphotypes characterized by long, narrow necks and valgus orientation. These shape patterns showed directionally lower regional BMD in vulnerable areas, although associations were modest. The findings describe femoral configurations that resemble those previously associated with fracture risk in international cohorts, supporting the potential role of morphometric analysis as a complementary, population-specific approach to skeletal fragility assessment.</p><h3>Purpose</h3><p>Hip fractures are a major cause of disability and mortality in older adults, particularly among women with osteoporosis. Bone mineral density (BMD) is a cornerstone of fracture risk assessment but does not fully capture biomechanical and structural vulnerability. This study is aimed at characterizing proximal femur morphology in Mexican women using statistical shape modeling and at examining its relationship with regional BMD.</p><h3>Methods</h3><p>In this exploratory cross-sectional analysis, 284 dual-energy X-ray absorptiometry (DXA) hip scans were processed with BoneFinder software to generate morphometric profiles. Active Shape Models (ASM) identified the main modes of shape variation, which were analyzed in relation to site-specific BMD.</p><h3>Results</h3><p>Seventeen femoral configurations were identified, with three representative morphotypes: long, narrow necks with valgus alignment, short and wide necks, and intermediate morphologies. Shape patterns characterized by long, narrow, valgus-oriented femoral necks showed directionally lower regional BMD in the superior neck and Ward’s triangle—sites critical for fracture initiation—although associations were modest in regression analyses. Automated morphometry identified structural traits linked to mechanical disadvantage beyond traditional cortical indices.</p><h3>Conclusion</h3><p>This is the first study to apply statistical shape modeling to Latin American women, identifying recurring femoral shape patterns that resemble morphologies previously associated with fracture risk in international cohorts. While prospective validation with fracture outcomes is needed, this exploratory study provides foundational evidence for anatomically informed, population-specific approaches to skeletal fragility assessment.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-026-01682-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}