Archives of Osteoporosis最新文献

{"title":"Epidemiological (secular) trends of pelvic and acetabular fractures (2006–2022) in South Korea using a nationwide cohort data over ages 50: is it osteoporosis related?","authors":"Byung-Ho Yoon,&nbsp;Tae-Young Kim,&nbsp;HoeJeong Chung,&nbsp;Jaiyong Kim,&nbsp;Jihye Kim,&nbsp;Hoyeon Jang,&nbsp;Young-Kyun Lee","doi":"10.1007/s11657-025-01549-w","DOIUrl":"10.1007/s11657-025-01549-w","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Osteoporotic pelvic and acetabular fractures (PAFs) rose significantly from 2006 to 2022, especially among those aged 80–89. Despite increased cases, one-year mortality rates declined from 7.29 to 4.59%. Findings highlight the need for early osteoporosis detection and targeted interventions to address aging demographics and evolving fracture trends.</p><h3>Purposes</h3><p>Osteoporotic fractures present a growing health challenge, especially in the context aging population. The purpose of our epidemiologic study was to determine the current trend in the number and incidence of pelvic and acetabular fractures (PAFs) providing an in-depth analysis of prevalence, demographic patterns, and related mortality.</p><h3>Methods</h3><p>This retrospective cohort study analyzed data from the National Health Insurance Review and Assessment claims database. Men and women who had pelvic and acetabular fractures, aged ≥ 50 years, between January 1 2006, and December 31 2022, were included. After proper identification using International Classification of Diseases, 10th revision (ICD-10) codes, we calculated absolute number and age-gender specific incidence rates for PAFs and one-year mortality rate following index fracture by sex and age groups.</p><h3>Results</h3><p>The total number of PAFs increased considerably during the study period, from 11,607 in 2006 to 35,691 in 2022, 207.5% per 16 years, an average increase of 12.9% a year. When analyzed by age groups, the total number of PAFs increased in all age groups, but showed the highest increase in 80–89. While the crude incidence of PAFs showed a consistency in 50–59, 60–69, and 70–79, a steady increase was noted in 80–89. The annual total mortality rates of PAFs within 1 year showed a decreasing trend from 7.29% in 2006 to 4.59% in 2022. When analyzed by age groups, the highest mortality rates were observed in the 80–89 age group, followed by 70–79, 60–69, and 50–59, with a consistent trend in the latter two age groups but a decreasing trend in the 80–89 age group.</p><h3>Conclusion</h3><p>The secular trend of PAFs reflects features typical of osteoporotic fractures, characterized by age- and gender-dependent pattern, while mortality rates are declining. With the increasing aggressive surgical interventions for PAFs, it is essential to detect osteoporosis early and implement targeted interventions for treatment and prevention in elderly patients.\u0000</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total radius BMD correlates with the hip and lumbar spine BMD among post-menopausal patients with fragility wrist fracture in a machine learning model","authors":"Tapio Ruotsalainen,&nbsp;Egor Panfilov,&nbsp;Jerome Thevenot,&nbsp;Aleksei Tiulpin,&nbsp;Simo Saarakkala,&nbsp;Jaakko Niinimäki,&nbsp;Petri Lehenkari,&nbsp;Maarit Valkealahti","doi":"10.1007/s11657-025-01542-3","DOIUrl":"10.1007/s11657-025-01542-3","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Osteoporosis screening should be systematic in the group of over 50-year-old females with a radius fracture. We tested a phantom combined with machine learning model and studied osteoporosis-related variables. This machine learning model for screening osteoporosis using plain radiographs requires further investigation in larger cohorts to assess its potential as a replacement for DXA measurements in settings where DXA is not available.</p><h3>Purpose</h3><p>The main purpose of this study was to improve osteoporosis screening, especially in post-menopausal patients with fragility wrist fractures. The secondary objective was to increase understanding of the connection between osteoporosis and aging, as well as other risk factors.</p><h3>Methods</h3><p>We collected data on 83 females &gt; 50 years old with a distal radius fracture treated at Oulu University Hospital in 2019–2020. The data included basic patient information, WHO FRAX tool, blood tests, X-ray imaging of the fractured wrist, and DXA scanning of the non-fractured forearm, both hips, and the lumbar spine. Machine learning was used in combination with a custom phantom.</p><h3>Results</h3><p>Eighty-five percent of the study population had osteopenia or osteoporosis. Only 28.4% of patients had increased bone resorption activity measured by ICTP values. Total radius BMD correlated with other osteoporosis-related variables (age <i>r</i> =  − 0.494, BMI <i>r</i> = 0.273, FRAX osteoporotic fracture risk <i>r</i> =  − 0.419, FRAX hip fracture risk <i>r</i> =  − 0.433, hip BMD <i>r</i> = 0.435, and lumbar spine BMD <i>r</i> = 0.645), but the ultra distal (UD) radius BMD did not. Our custom phantom combined with a machine learning model showed potential for screening osteoporosis, with the class-wise accuracies for “Osteoporotic vs. osteopenic &amp; normal bone” of 76% and 75%, respectively.</p><h3>Conclusion</h3><p>We suggest osteoporosis screening for all females over 50 years old with wrist fractures. We found that the total radius BMD correlates with the central BMD. Due to the limited sample size in the phantom and machine learning parts of the study, further research is needed to make a clinically useful tool for screening osteoporosis.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone microarchitecture using HR-pQCT in adult patients with renal tubular acidosis presenting with rickets/osteomalacia","authors":"Durairaj Arjunan,&nbsp;Soham Mukherjee,&nbsp;Sanjay K Bhadada,&nbsp;Jayaditya Ghosh,&nbsp;Ravi Shah,&nbsp;Subin S.,&nbsp;Sadam Hussain,&nbsp;Rimesh Pal,&nbsp;GSRSNK Naidu,&nbsp;Pinaki Dutta","doi":"10.1007/s11657-025-01545-0","DOIUrl":"10.1007/s11657-025-01545-0","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Adults with renal tubular acidosis (RTA) show high bone turnover, reduced trabecular volumetric bone mineral density (vBMD), and compromised bone microarchitecture, especially in trabecular bone. HR-pQCT analysis reveals lower total vBMD, reduced trabecular number, increased separation, and cortical thinning, highlighting bone deterioration in RTA patients compared to controls.</p><h3>Background</h3><p>Renal tubular acidosis (RTA) impairs urinary acidification, leading to a normal anion gap metabolic acidosis and often hypokalemia. RTA can result in poor bone mineralization and reduced bone density in adults. This study aims to evaluate bone microarchitecture in adults with RTA using second-generation high-resolution peripheral quantitative computed tomography (HR-pQCT).</p><h3>Methods</h3><p>In this cross-sectional case–control study, 12 adult RTA patients with rickets/osteomalacia and 12 age, sex, and BMI-matched controls were enrolled. Clinical assessments, biochemical tests with calcium, phosphate, alkaline phosphatase, 25(OH)D, intact PTH, bone turnover markers, dual-energy X-ray absorptiometry (DXA), and HR-pQCT scans were conducted.</p><h3>Results</h3><p>Patients with RTA had increased bone turnover compared to the controls. RTA patients had significantly lower total hip areal bone mineral density (aBMD) [g/cm²] (median, 0.792 vs. 0.943; <i>p</i> = 0.014) and lower distal radius aBMD [g/cm²] (median, 0.469 vs. 0.694, <i>p</i> 0.000), compared to controls. HR-pQCT findings suggest lower total and trabecular volumetric BMD (v.BMD), at both the radius (median total vBMD [mg HA/cm³]: 236 vs. 380.1, <i>p</i> = 0.001; median trabecular vBMD [mg HA/cm³]; 83.4 vs. 170.1, <i>p</i> = 0.000) and tibia (median total vBMD [mg HA/cm³]: 222.1 vs. 317.4, <i>p</i> = 0.000; median trabecular vBMD [mg HA/cm³]: 69.0 vs. 160.9, <i>p</i> = 0.000) in RTA patients compared to controls. Cortical vBMD was comparable between groups. Microarchitecture analysis revealed reduced trabecular number, increased trabecular separation, increased trabecular bone inhomogeneity, and reduced cortical thickness in RTA patients, both at radius and tibia.</p><h3>Conclusion</h3><p>Adults with RTA exhibit high bone turnover, reduced trabecular vBMD, and compromised bone microarchitecture, particularly in trabecular bone.\u0000</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary care follow-up of patients after attending a fracture liaison service: an integrative review","authors":"Michael J. Bennett,&nbsp;Jacqueline R. Center,&nbsp;Lin Perry","doi":"10.1007/s11657-025-01521-8","DOIUrl":"10.1007/s11657-025-01521-8","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Summary&lt;/h3&gt;&lt;p&gt;Based on a small number of predominantly low-to-moderate quality studies with moderate-to-high risk of bias, the FLS-to-primary care transition is portrayed as a challenging time for patients, GPs, and FLS clinicians, who experience numerous barriers to care continuation and coordination at this care juncture.&lt;/p&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;p&gt;Continuity and coordination of care between fracture liaison services (FLS) and primary care is required for optimal long-term osteoporosis care. This study aims to explore (1) how patients and healthcare providers (HCPs) experience the FLS to primary care transition, (2) the barriers and facilitators to primary care follow-up after FLS, and (3) interventions that enhance integration of FLS with primary care.&lt;/p&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;An integrative review was performed and reported in accordance with the Preferred Reporting Items for Systematic Review and Meta Analysis (PRISMA) Statement 2020. Online bibliographic databases were searched using the terms “osteoporosis”, “primary care”, and “fracture liaison services” and related terms for original English-language studies conducted between January 1, 2003 and December 29, 2023. Manuscripts were assessed for relevance using pre-defined criteria, and for quality and bias using validated instruments. Thematic analysis was used to extract key themes relevant to each research question.&lt;/p&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Overall, 14 relevant manuscripts were identified. Among the four studies that addressed patient and HCP experience of the FLS-to-primary care transition, five key themes emerged: (1) time and workload pressures, (2) limited confidence in primary care follow-up, (3) GP knowledge gaps, (4) siloed or disconnected care, and (5) communication issues. Twelve studies addressed barriers and facilitators to primary care follow-up after FLS, which fell into five themes: (1) patient knowledge and understanding (2) miscommunication and misinformation, (3) understanding roles and responsibilities, (4) GP engagement, and (5) GP-patient relationship. Additionally, single studies suggested healthcare policies and funding, accessing primary care from residential facilities, and GP gender influenced primary care follow-up. Five studies detailed interventions to enhance FLS-to-primary care integration. GP education and patient reminders, delivered as part of a multifaceted intervention, appeared to improve integration of acute and primary post-fracture care; however, the contribution of these individual interventions to outcomes remains unclear. While telephone coaching and bone marker monitoring were identified as potential interventions, there was insufficient evidence to conclude they are effective.&lt;/p&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;Available evidence was generally low-to-moderate quality with moderate-to-high risk of bias. Integration of the available evidence portrays the FLS-to-primary care transition as a challenging time for patients, GPs, and FLS clinicians, who experie","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01521-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world characteristics & disease history of patients with X-linked hypophosphatemia before treatment with burosumab","authors":"Kathryn M. Dahir,&nbsp;Zhiyi Li,&nbsp;Heather M. Heerssen,&nbsp;Ahmed Noman,&nbsp;Jeremy Kim,&nbsp;Yang Zhao,&nbsp;Erik A. Imel","doi":"10.1007/s11657-025-01544-1","DOIUrl":"10.1007/s11657-025-01544-1","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>In a United States claims database, 1,358 persons with familial hypophosphatemia who began treatment with burosumab were identified. Prior to treatment, high rates of several morbidities were coded including osteoarthritis, fractures, enthesopathy, spinal stenosis, hypertension, depression and opioid use, which generally increased with age, emphasizing disease burden throughout the lifespan.</p><h3>Purpose</h3><p>To examine the characteristics and disease history of real-world patients with X-linked hypophosphatemia (XLH) in the United States, prior to initiating burosumab.</p><h3>Methods</h3><p>This retrospective cohort study used Komodo Health’s Healthcare Map™, a de-identified patient-level claims database. Included patients had ≥ 1 claim for familial hypophosphatemia between 01-Jan-2015 and 30-Jun-2022 (the study period) and ≥ 1 claim for burosumab between 01-Apr-2018 and 30-Jun-2022. The index date was the date of first burosumab claim. Patient demographics were measured at index; disease history was measured over the pre-index period and stratified by age. All variables were evaluated descriptively.</p><h3>Results</h3><p>1,358 patients were included (mean age 23.5 ± 19.1 years, 847 [62%] female); 720 patients (53%) were aged &lt; 18 years. Prior to index, patients had high levels of XLH-related morbidities. Most XLH-related morbidities appeared in the youngest age groups, and the prevalence was generally greater among the older age groups. For example, arthralgia was found in 57 patients (12%) aged ≤ 11 years and 123 patients (69%) aged ≥ 50 years. Opioid use increased with age (173 patients [24%] aged &lt; 18 years; 328 [51%] ≥ 18 years). Physical therapy use was observed across age groups (126 patients [18%] aged &lt; 18 years; 253 [40%] ≥ 18 years).</p><h3>Conclusions</h3><p>At initiation of burosumab, over half of patients with XLH were &lt; 18 years of age. Claims indicated a high prevalence of XLH-related morbidities, which began at a young age and increased over time.\u0000</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01544-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric nutritional risk index (GNRI) as a predictor of fragility fracture risk in older adults living with HIV: a 10-year retrospective longitudinal cohort study from China","authors":"Bo Liu,&nbsp;Qiang Zhang","doi":"10.1007/s11657-025-01543-2","DOIUrl":"10.1007/s11657-025-01543-2","url":null,"abstract":"<div><h3>Summary</h3><p>This study reveals that the Geriatric Nutritional Risk Index (GNRI) is a strong predictor of fragility fracture risk in older adults living with HIV in China. Regular nutritional assessment using GNRI could identify high-risk individuals, potentially guiding interventions to reduce fracture risk in this vulnerable population.</p><h3>Background</h3><p>In China, a significant proportion of the PLWH are older adults, which differs from other regions. Malnutrition and fragility fractures are major concerns in this population. This study aimed to investigate the utility of the Geriatric Nutritional Risk Index (GNRI) as a predictor of fragility fracture risk in older adults living with HIV in China.</p><h3>Methods</h3><p>This retrospective longitudinal cohort study included older adults living with HIV (aged ≥ 50 years) from the Department of Orthopedics at Ditan Hospital in Beijing, China, between January 2010 and September 2023. Baseline GNRI scores were calculated using serum albumin, height, and weight, and patients were followed up for the occurrence of fragility fractures. Cox proportional hazards models were used to evaluate the association between GNRI and fragility fracture risk, adjusting for potential confounders.</p><h3>Results</h3><p>A total of 608 patients were included in the study (mean age: 60.3 years, 84.2% male). During the median 5-year follow-up period, 117 patients (19.2%) experienced fragility fractures. After adjusting for all potential covariates, patients with higher GNRI scores had a significantly lower risk of fragility fractures. The aHR for GNRI &lt; 92 g/L was 3.28 (95% CI: 1.35–7.97, <i>p</i> = 0.009) compared to GNRI ≥ 92. RCS analysis revealed a significant inverse relationship between GNRI and fragility fracture risk, with the non-linearity diminishing after full adjustment for covariates.</p><h3>Conclusion</h3><p>The GNRI is a valuable tool for predicting fragility fracture risk in older adults living with HIV in China. Routine assessment of nutritional status using the GNRI could help identify high-risk individuals and guide appropriate interventions to reduce fragility fracture risk in this vulnerable population.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143925625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fragility hip fractures among Nigerian older adults: a retrospective study of epidemiology, mobility and mortality outcomes at 3 and 12 months post-hospital discharge","authors":"Stephen Adesope Adesina,&nbsp;Isaac Olusayo Amole,&nbsp;Imri Goodness Adefokun,&nbsp;Adepeju Olatayo Adegoke,&nbsp;Olusola Tunde Ekunnrin,&nbsp;Akinsola Idowu Akinwumi,&nbsp;Simeon Ayorinde Ojo,&nbsp;Adewumi Ojeniyi Durodola,&nbsp;Innocent Chiedu Ikem,&nbsp;Samuel Uwale Eyesan","doi":"10.1007/s11657-025-01553-0","DOIUrl":"10.1007/s11657-025-01553-0","url":null,"abstract":"<div><h3>Summary</h3><p>Fragility hip fractures (FHFs) are a growing concern worldwide. Sub-Saharan Africa is no exception. Nigeria has limited data on FHFs. This study found that surgical treatment significantly enhances mobility and survival rates for older adults with FHFs. The findings can inform healthcare policies and practices in Nigeria and similar contexts.</p><h3>Purpose</h3><p>The global population, including that of sub-Saharan Africa, is rapidly ageing, resulting in a higher incidence of fragility fractures. This study investigates the epidemiology of fragility hip fractures (FHFs) at a Nigerian teaching hospital, focusing on the predictors of two key outcomes: (1) mobility and mortality 3 months post-discharge, and (2) mortality 12 months post-discharge.</p><h3>Methods</h3><p>A retrospective study was conducted involving 102 older adults aged ≥ 60 who received treatment for femoral neck, intertrochanteric, and subtrochanteric fractures at a mission teaching hospital in Nigeria over 6 years. Data collected included demographics, causes of fractures, comorbidities, treatment methods, time-to-surgery, length of stay, mobility, and mortality rates. Univariate analyses were performed to identify mobility and mortality outcomes predictors at 3 and 12 months post-discharge.</p><h3>Results</h3><p>The mean age was 78.0 years, with 49.0% of patients in the oldest-old category. 70.6% regained mobility 3 months post-discharge. The mortality rate was 3.9% at 3 months and 22.5% at 12 months. Predictors of better mobility and mortality outcomes included younger age, no/mild comorbidities, fractures due to community falls, femoral neck fractures, surgical treatment, and shorter time to surgery. Patients who regained mobility by 3 months had a lower 12-month mortality rate (<i>p</i> &lt; 0.001).</p><h3>Conclusion</h3><p>This study emphasizes the importance of effective surgical management for FHFs in Nigeria’s ageing population. The findings suggest that a multidisciplinary care approach, encompassing comprehensive management of comorbidities, age-friendly housing design, ongoing research, and investment in healthcare infrastructure, is essential to address the growing burden of FHFs.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metacarpal cortical percentage predicts bone density and osteoporotic fracture incidence in inflammatory arthropathy patients: a retrospective cohort study","authors":"Marina A. Chimonides,&nbsp;Douglas J. Donnachie,&nbsp;David M. S. Bodansky,&nbsp;Pamela E. Leventis","doi":"10.1007/s11657-025-01552-1","DOIUrl":"10.1007/s11657-025-01552-1","url":null,"abstract":"<div><h3>Summary</h3><p>Early identification of osteoporosis promotes timely treatment. This retrospective study demonstrated that bone cortical percentage (2MCP) measured on hand X-ray in patients with inflammatory arthritis correlates significantly with bone density, fracture risk and fracture incidence. Routine hand X-ray 2MCP reporting could support identification of patients at risk of osteoporotic fractures.</p><h3>Purpose</h3><p>Effective osteoporotic screening facilitates earlier identification and treatment of patients at risk. Bone mineral density (BMD) alone has limited sensitivity and may not always be available. This study aimed to show whether radiographic second metacarpal cortical thickness percentage (2MCP) correlates with BMD and fracture incidence.</p><h3>Methods</h3><p>This retrospective cohort study measured 2MCP in 230 patients with inflammatory arthropathies who underwent both DXA and hand radiograph within 6 months. BMD, FRAX and fracture history was gathered.</p><h3>Results</h3><p>2MCP correlated with femoral neck BMD (<i>p</i> &lt; 0.001), <i>T</i>-scores (<i>p</i> &lt; 0.001), FRAX (<i>p</i> &lt; 0.001) and major and all osteoporotic fracture incidence (<i>p</i> &lt; 0.001) across all patient groups. 2MCP ≤ 55% was 88% sensitive and 51% specific in identifying patients with osteoporotic BMD (AUC 0.7893). 2MCP ≤ 65% and ≤ 73% were 100% sensitive for osteoporotic and osteopenic BMD respectively, whilst ≤ 30% and ≤ 39% were 100% specific. 2MCP ≤ 59% demonstrated 92% sensitivity for all low-impact fractures and 2MCP ≤ 56% was 87% sensitive for major osteoporotic fracture (MOF). 2MCP showed superior sensitivity and specificity to osteopenic femoral neck <i>T</i>-score for predicting MOF incidence (AUC 0.7009 and 0.6590). Combining 2MCP with <i>T</i>-score parameters enhanced sensitivity to 94.6% for MOF up to 2 years beyond the hand radiograph.</p><h3>Conclusion</h3><p>2MCP presents a fast, inexpensive adjunct to evaluate fracture risk. This technology may enhance BMD sensitivity in predicting MOF and improve global bone health assessment accessibility. 2MCP automation and routine inclusion in hand radiographs could optimise early awareness and diagnosis of patients at risk of osteoporosis and fractures.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathways linking sports participation to bone density and geometry among adolescents: ABCD growth study","authors":"Rafael Luiz de Marco,&nbsp;Pedro Henrique Narciso,&nbsp;Santiago Maillane-Vanegas,&nbsp;Yuri da Silva Faustino-da-Silva,&nbsp;Ricardo Ribeiro Agostinete,&nbsp;Rayana Loch Gomes,&nbsp;Rômulo Araújo Fernandes","doi":"10.1007/s11657-025-01550-3","DOIUrl":"10.1007/s11657-025-01550-3","url":null,"abstract":"<div><h3>Summary</h3><p>This study investigated variables linked to sports participation and its impacts on bone density and geometry among adolescents. This study shows that lean soft tissue was the main link between sports participation and bone density and geometry among adolescents of both sexes. Higher ground reaction force in sports impacts bone positively, while higher body fatness and bone resorption rate negatively, all these variables seem to assume complementary roles in this phenomenon, especially among boys.\u0000</p><h3>Introduction</h3><p>Sports participation boosts bone formation in early life, but the pathways are still unclear.</p><h3>Objective</h3><p>To investigate which variables linked to sports participation are most consistently related to bone density and geometry among adolescents.</p><h3>Methods</h3><p>A total of 86 adolescents (28 girls) aged from 11 to 17 years were classified as Control (12 adolescents) and Sport (74 adolescents). The outcomes were bone density and geometry from lower limbs measured using the bone densitometry technique. Variables linked to participation were intensity, ground reaction force, strength, lean soft tissue, and parameter of bone formation. Covariates were sex, somatic maturation, and body fatness.</p><h3>Results</h3><p>Among boys, lean soft tissue (r = 0.861) remained the main determinant of bone density along with sport ground reaction force (r = 0.211). For bone geometry, lean soft tissue remained the main determinant, while blood concentration of bone resorption markers (r = − 0.262) and body fatness (r = − 0.205) were inversely related to it. For girls, the only determinant of bone density and geometry was lean soft tissue (ranging from r = 0.461 to r = 0.759). All models explained bone density and geometry better among boys (from 73.4 to 80.9%) than girls (from 47.6 to 62.6%).</p><h3>Conclusion</h3><p>Lean soft tissue is the main link of sports participation with bone density and geometry among adolescents of both sexes. Higher ground reaction force in sports impacts bone positively, while higher body fatness and bone resorption rate negatively, all these variables seem to assume complementary roles in this phenomenon, especially among boys.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing bone and muscle health and their association in a Mongolian population aged 40 and older: a pioneering observational study","authors":"Myadagmaa Jaalkhorol,&nbsp;Fanny Buckinx,&nbsp;Amarsaikhan Dashtseren,&nbsp;Seded Baatar,&nbsp;Nansalmaa Khaidav,&nbsp;Gerelmaa Ochirdorj,&nbsp;Bolormaa Darambazar,&nbsp;Batmunkh Batsaikhan,&nbsp;Uugantamir Munkhsonguuli,&nbsp;Bayarmagnai Lkhagvasuren,&nbsp;Bulgantuya Byambaa,&nbsp;Wu Qi Zhu,&nbsp;Shiirevnyamba Avirmed,&nbsp;Olivier Bruyere","doi":"10.1007/s11657-025-01548-x","DOIUrl":"10.1007/s11657-025-01548-x","url":null,"abstract":"<div><h3>Summary</h3><p>This study in Mongolia reveals that weaker grip strength and higher sarcopenia risk are linked to greater fracture risk and lower bone density. It highlights the crucial interplay between muscle and bone health, emphasizing the need for integrated musculoskeletal assessments to prevent fractures, especially in aging populations.</p><h3>Background</h3><p>Research on the relationship between bone and muscle health in low- and middle-income countries, particularly Central Asia, remains limited.</p><h3>Objectives</h3><p>To explore the correlation between muscle and bone health and to estimate the FRAX risk for major osteoporotic fractures (MOF) and hip fractures in the Mongolian population, stratified by age and sex.</p><h3>Methods</h3><p>A cross-sectional study was conducted in Ulaanbaatar and regional Mongolia from May to August 2024. Handgrip strength, sarcopenia risk (SARC-F) and bone mineral density using peripheral DXA (BMD T-score) were assessed. Fracture risks were estimated using the FRAX model.</p><h3>Results</h3><p>Participants (<i>n</i> = 857; median age, 52 years; 53.0% women) had a median grip strength of 28 kg and a median BMD T-score of − 1.9. Most (69.5%) were at low sarcopenia risk (SARC-F &lt; 4). SARC-F was moderately correlated with FRAX scores for MOF and hip fractures (<i>r</i> ≈ 0.27, <i>p</i> &lt; 0.001) while grip strength was negatively correlated with FRAX scores(<i>r</i> =  − 0.24, <i>p</i> &lt; 0.001). Grip strength positively correlated with BMD T-scores (<i>r</i> = 0.22, <i>p</i> &lt; 0.001). Fracture risks increased with age, with women showing higher rates than men. Higher sarcopenia risk (SARC-F ≥ 4) was associated with lower BMD and increased fracture risk. Lower grip strength (&lt; 18 kg for women, &lt; 28 kg for men) was linked to higher fracture risk and lower BMD.</p><h3>Conclusions</h3><p>This study highlights the interconnected nature of muscle and bone health in the Mongolian population, demonstrating that lower grip strength and higher sarcopenia risk are significantly associated with increased fracture risk and reduced bone density. These findings underscore the importance of integrated strategies for musculoskeletal health assessment and fracture prevention, particularly in aging populations.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}