Archives of Osteoporosis最新文献

{"title":"Effects of denosumab and zoledronic acid on postmenopausal osteoporosis, bone density, and fat-free mass","authors":"Jeonghoon Ha,&nbsp;Jinyoung Kim,&nbsp;Chaiho Jeong,&nbsp;Jeongmin Lee,&nbsp;Yejee Lim,&nbsp;Ki-Hyun Baek","doi":"10.1007/s11657-024-01475-3","DOIUrl":"10.1007/s11657-024-01475-3","url":null,"abstract":"<div><h3>Summary</h3><p>This study compared denosumab and zoledronic acid for treating osteoporosis in drug-naïve postmenopausal Korean women. Over 3 years, both drugs significantly increased bone mineral density. However, denosumab also improved fat-free mass, suggesting it may be a better initial treatment for osteoporosis with low muscle mass, assuming all other conditions remain constant.</p><h3>Background</h3><p>Denosumab (DMAB) and zoledronic acid (ZOL), which are strong antiresorptive agents, are used to treat osteoporosis in postmenopause. Nonetheless, the data on their comparative efficacy in drug-naïve patients remain limited. Our research compared the therapeutic efficacy of DMAB and ZOL in drug-naïve postmenopausal Korean women with osteoporosis.</p><h3>Methods</h3><p>In total, 120 women were enrolled and equally divided to the DMAB and ZOL groups. The bone density and biochemical parameters of the patients were monitored over 3 years. Furthermore, the changes in fat-free mass (FFM), which comprises muscle mass, were assessed by bioelectric impedance analysis. Baseline characteristics, including age, BMI, and the prevalence of fractures, were similar between the groups at the onset of the study. Serum 25(OH), calcium and, phosphorus levels and baseline bone mineral density (BMD) were also comparable between the groups.</p><h3>Results</h3><p>Following 3 years of treatment, both groups exhibited a significant increase in BMD versus the baseline value. In particular, BMD increased by 9.7% and 5.1% at the lumber spine and total hip, respectively, in the DMAB group, versus increases of 7.1% and 4.4%, respectively, in the ZOL group. The increase in FFM was greater in the DMAB group. BMI-adjusted FFM decreased by 1.3% in the ZOL group, versus an increase of 3.6% in the DMAB group.</p><h3>Conclusions</h3><p>Conclusively, both DMAB and ZOL are effective antiresorptive agents that improved BMD over 3 years in drug-naïve individuals. Moreover, DMAB might represent a more reliable initial option for patients with osteoporosis accompanied by low muscle mass.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing healthcare disparities and improving osteoporosis management in rural communities: a cluster randomized control trial","authors":"Shau-Huai Fu,&nbsp;Wei-Jhen Lai,&nbsp;Hung-Kuan Yen,&nbsp;Shikha Kukreti,&nbsp;Chung-Yi Li,&nbsp;Chih-Chien Hung,&nbsp;Chen-Yu Wang","doi":"10.1007/s11657-025-01498-4","DOIUrl":"10.1007/s11657-025-01498-4","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Rural communities face healthcare challenges. This study assessed a multicomponent intervention to improve hospital visits and anti-osteoporosis medication (AOM) treatment rates. A total of 567 patients were randomized into three groups. Results showed significant improvements in hospital attendance and AOM treatment in intervention groups compared to usual care group.</p><h3>Purpose</h3><p>Rural communities face limited healthcare access, financial constraints, and transportation barriers leading to health disparities. This study examined interventions that reduced health disparities in increasing the outpatient attendance and treatment rate of anti-osteoporosis medication (AOM), while identifying factors contributing to therapy refusal in rural communities.</p><h3>Methods</h3><p>A total of 567 patients were randomized at the community level into three groups: multicomponent integrated care (MIC), osteoporosis care only (OC), and usual care (UC). Fracture Risk Assessment Tool and dual-energy X-ray absorptiometry scans were used to evaluate the osteoporosis and osteoporotic fracture risk. High- and moderate-risk patients were advised to pursue further hospital-based assessments and treatment. Both the MIC and OC groups received five interventions to address rural barriers, including specialist access, disease education, overcoming transportation barriers, peer support, and dedicated case managers. However, UC excluded transportation assistance, peer support, and case management. Outcomes measured included outpatient attendance, AOM treatment rates, and factors affecting hospital assessment refusal, analyzed via multivariable logistic modeling.</p><h3>Results</h3><p>In the MIC group, 73.3% of patients attended the outpatient clinic and 58.6% received AOM. In the OC group, 81% patients attended and 69.3% received AOM. Conversely, in the UC group, only 4.1% attended and received AOM. Significant differences in attendance and AOM rates were found between the MIC and UC groups and between the OC and UC groups (<i>p</i> &lt; .001 for both). Common barriers included beliefs that treatment was unnecessary and lack of hospital access. Risk factors hindering outpatient attendance include male sex, low education, low budget, multiple disabilities, and osteopenia diagnosis.</p><h3>Conclusion</h3><p>Addressing transportation barriers and implementing dedicated case management are crucial for improving healthcare access among rural patients.</p><h3>Trial registration</h3><p>ClinicalTrials.gov NCT05104034.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing loss and risk of major osteoporotic fracture: a population-based cohort study in the United Kingdom","authors":"Sara Khalid,&nbsp;Daniel Prieto Alhambra,&nbsp;Seyed Alireza Hasheminasab,&nbsp;Yana Vinogradova,&nbsp;Nadeem Qureshi,&nbsp;Michaela Ratzinger,&nbsp;Vanessa Brunetti,&nbsp;Adrian Salas,&nbsp;Laura Canals","doi":"10.1007/s11657-024-01484-2","DOIUrl":"10.1007/s11657-024-01484-2","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Using the UK Clinical Practice Research Datalink, our cohort study matched 237,297 individuals with hearing loss (HL) to 829,431 without HL. The study found an 8–10% higher risk of major osteoporotic fracture in individuals with HL compared to those without. Additionally, within the HL cohort, we identified risk factors for potential inclusion in fracture risk models.</p><h3>Purpose</h3><p>Assess association between hearing loss (HL) and major osteoporotic fracture (MOF; spine, wrist/forearm, shoulder/proximal humerus, hip) in individuals aged ≥ 60 years, and risk factors for MOF in individuals with HL.</p><h3>Methods</h3><p>From the UK Clinical Practice Research Datalink, our cohort study matched individuals aged ≥ 60 years diagnosed with HL (READ/ICD-10 codes; 01January2001–31December2021; index event), without secondary osteoporosis causes, with up to five individuals without HL (birth, index year, sex, general practice). Incidence rates and Cox proportional hazard ratios (HL vs. no HL; stratified by low/high fracture risk) were calculated for MOF and hip fracture; multivariate logistic regression assessed risk factors for MOF and hip fracture (HL cohort).</p><h3>Results</h3><p>A total of 237,297 individuals with HL matched to 829,431 without HL, with a median age of 74 and 72 years, respectively. Compared with those without HL, individuals with HL had greater frailty (severe electronic frailty index, 5.9% vs. 2.7%), higher incidence of prior falls (14.1% vs. 10.6%), longer mean follow-up with higher incidence of MOF and hip fractures (5.1 vs. 4.4 years, 20.1 and 5.32 vs. 16.58 and 4.54 per 1000 person-years, respectively) and higher risk of MOF and hip fracture (adjusted HR, 1.10 and 1.08, respectively). Significant risk factors for MOF and hip fracture included age ≥ 70 years, fracture history, falls, osteoporosis diagnosis, chronic obstructive pulmonary disorder and cardiovascular disease (HL cohort).</p><h3>Conclusion</h3><p>In individuals with HL, we observed an 8–10% higher risk of MOF and hip fracture versus individuals without HL and identified risk factors for potential inclusion in fracture risk models.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging academia and public interest: the impact of Altmetrics on osteoporosis treatment research","authors":"Özge Özpolat Bulut,&nbsp;Bülent Alyanak,&nbsp;Burak Tayyip Dede,&nbsp;Mustafa Hüseyin Temel,&nbsp;Mustafa Turgut Yıldızgören,&nbsp;Fatih Bağcıer","doi":"10.1007/s11657-025-01500-z","DOIUrl":"10.1007/s11657-025-01500-z","url":null,"abstract":"","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of low-sodium salt intervention with osteoporosis: A cross-sectional study based on the SSaSS study","authors":"Xilei Li,&nbsp;Xin Wang,&nbsp;Yuyi Peng,&nbsp;Qiu Xia,&nbsp;Yue Lu,&nbsp;Hao Sun,&nbsp;Bo Zhou","doi":"10.1007/s11657-024-01495-z","DOIUrl":"10.1007/s11657-024-01495-z","url":null,"abstract":"<div><h3>Mini abstract</h3><p>Low-sodium salt has a protective effect on BMD and also reduces the risk of osteopenia due to elevated blood glucose. This provides a direct and effective way to improve bone health in patients with hyperglycemia.</p><h3>Objective</h3><p>There is no consensus on the relationship between salt type and bone mineral density (BMD). This study examined the factors affecting osteoporosis and the relationship between low-sodium salt consumption with osteoporosis based on the Substitute Salt and Stroke Study (SSaSS).</p><h3>Methods</h3><p>This study was a cross-sectional study and compares the prevalence and characteristics of osteoporosis and osteopenia. Multiple linear regression and restricted spline models were used to analyze the factors affecting BMD and its dose–response relationship with osteoporosis and to compare the effects of different salts.</p><h3>Results</h3><p>The rates of osteoporosis and osteopenia were lower in those consuming low-sodium salt (31.11% and 38.52%) than in those consuming normal salt (38.65% and 41.10%). BMD was higher in the population consuming low-sodium salt than in that using normal salt (= 0.64, 95%CI: 0.25, 0.97). Age, gender, and blood glucose level interacted with low-sodium salt and together affected BMD. Analysis of the dose–response relationship revealed a positive linear association between elevated blood glucose and the risk of osteopenia (<i>P</i> for overall &lt; 0.05, <i>P</i> for nonlinear = 0.77), but intake of low-sodium salt significantly reduced this risk. The risk of OP increased with age (<i>P</i> for overall &lt; 0.05, <i>P</i> for nonlinear = 0.72); low-sodium salt intake reduced this risk, with the effect being more pronounced among individuals &lt; 70 years old.</p><h3>Conclusion</h3><p>Low-sodium salt has a positive effect on maintaining BMD. Elevated blood glucose and age &lt; 70 years increase the risk of osteoporosis, but use of low-sodium salt mitigates this risk.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary acidity and bone mass in minority children and adolescents: a cross-sectional analysis from the MetA-Bone trial","authors":"Ashley Petrie,&nbsp;Maria Angélica Trak-Fellermeier,&nbsp;Jacqueline Hernandez,&nbsp;Alison Macchi,&nbsp;Preciosa Martinez-Motta,&nbsp;Rodolfo Galván,&nbsp;Yolangel Hernandez,&nbsp;Rebeca Martinez,&nbsp;Cristina Palacios","doi":"10.1007/s11657-025-01497-5","DOIUrl":"10.1007/s11657-025-01497-5","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Dietary acid load could be associated with bone mass, but there are limited and conflicting results. This secondary cross-sectional analysis evaluated these associations among 123 children/adolescents, mostly Hispanics. Dietary acid load seems to be associated with bone mass in boys, but these results should be confirmed through long-term studies.</p><h3>Background</h3><p>Childhood/adolescence is key for developing strong bones. With the continuing rise in osteoporosis rates in Western societies, attention has turned to the possible impact of diets that create high levels of acid in the body. Some studies have shown an association between dietary acid load and bone mass, but there are limited studies in children/adolescents and none in Hispanics.</p><h3>Objective</h3><p>This study aimed to evaluate the associations between dietary acid load (assessed as dietary potential renal acid load, PRAL, and protein to potassium ratio) and whole-body bone mineral content (BMC) and density (BMD) in a sample of 123 children and adolescents of predominantly Hispanic ethnicity.</p><h3>Design</h3><p>This study is a secondary cross-sectional analysis.</p><h3>Results</h3><p>Dietary PRAL was positively associated with BMC and BMD overall (<i>p</i> &lt; 0.05) and with BMC in boys (<i>p</i> &lt; 0.05) when adjusted for energy misreporting only. The vegetable protein to potassium ratio was inversely associated with BMC (<i>p</i> = 0.004) in boys only, after adjusting for important factors.</p><h3>Conclusions</h3><p>Dietary acid load seems to be associated with BMC in boys in this sample of primarily Hispanic children. Long-term studies are needed to confirm these results and to understand the importance of protein intake in relation to other key nutrients in bone mass acquisition among Hispanic boys.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lee’s TRIAD—osteoporosis, fragility fracture, and bone health optimization","authors":"Joon-Kiong Lee","doi":"10.1007/s11657-024-01482-4","DOIUrl":"10.1007/s11657-024-01482-4","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Osteoporosis, fragility fractures, and bone health optimization share the same pathophysiology, diagnostic tools, risk assessment, and treatments. Grouping them into “Lee’s TRIAD” allows surgeons and physicians to collaborate more efficiently, using unified principles and strategies for managing these conditions.</p><h3>Purpose</h3><p>The primary goal of osteoporosis management is to prevent fragility fractures, which occur from falls from standing height or less in individuals over fifty. However, the management of bone health optimization is often neglected in patients undergoing elective surgeries, such as arthroplasty and spinal surgeries. The objective of this article is to link all these three conditions into a TRIAD so that surgeons and physicians can collaborate more effectively, utilizing similar principles and strategies for better management.</p><h3>Methodology</h3><p>Clinical approaches based on country-specific guidelines are commonly used to manage osteoporosis. However, skeletal assessments are rarely conducted before or after elective procedures, leading to overlooked conditions such as osteoporosis, osteopenia, and fragility fracture risk factors. These three conditions are illustrated from the patient case study shown, to highlight the importance of not neglecting bone health optimization in high risk individuals undergoing elective surgery, with underlying osteopenia and multiple risk factors who sustained fragility fracture intraoperatively.</p><h3>Result</h3><p>Patients undergoing elective surgeries often have their bone health neglected, leading to a higher incidence of complications such as aseptic loosening and peri-prosthetic fractures due to poor bone quality and density. Bone health assessment and optimization therefore is essential in patients with osteoporosis, osteopenia with clinical risk factors, and patients with history of fragility fracture, to ensure implants sit on bone with good density and quality to minimize the complications.</p><h3>Conclusion</h3><p>By combining osteoporosis, fragility fractures, and bone health optimization into a TRIAD, “Lee’s TRIAD,” surgeons and physicians can collaborate more effectively, utilizing similar principles and strategies for better management.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of using grip strength and hand muscle cross-sectional area to predict secondary fractures post distal radius fracture","authors":"Matthew Tsz Kin Kong,&nbsp;Christian Fang,&nbsp;Colin Shing Yat Yung,&nbsp;Theresa Kwok,&nbsp;Keith Leung,&nbsp;Frankie Leung","doi":"10.1007/s11657-024-01465-5","DOIUrl":"10.1007/s11657-024-01465-5","url":null,"abstract":"<div><h3>Summary</h3><p>Grip strength measurement, as a surrogate of sarcopenia diagnosis, effectively predicts secondary fracture risk in distal radius fracture patients. This simple tool enhances clinical practice by identifying high-risk patients for targeted interventions, potentially preventing or reversing functional decline and recurrent fractures.</p><h3>Purpose</h3><p>To evaluate grip strength and hand muscle cross-sectional area as predictors of secondary fracture risk in patients with a history of distal radius fracture (DRF), serving as surrogates of the diagnosis of sarcopenia.</p><h3>Methods</h3><p>A retrospective cohort study of 745 DRF patients was analyzed with their grip strength data using Cox proportional hazards regression, receiver operating characteristic analysis, and Kaplan–Meier analysis to predict secondary fracture risk over an average of 12 years. Hand muscle cross-sectional area was similarly analyzed.</p><h3>Results</h3><p>Patients with a history of DRF were predicted to have a 4.1% higher likelihood of experiencing a secondary fracture per kilogram reduction in their grip strength (<i>p</i> &lt; 0.008), independent of age and sex. Patients were categorized as high-risk (≤ 16 kg), moderate-risk (17–24 kg), or low–risk (≥ 25 kg) (<i>p</i> &lt; 0.001). High-risk patients showed a 2.2-fold (95% CI = 1.55–3.17) higher recurrent fracture risk compared to low-risk patients. Cumulative secondary fracture probabilities of the high-risk group patients at 5, 10, and 15 years were estimated to be 16%, 30%, and 54%, respectively.</p><h3>Conclusions</h3><p>Grip strength measurement, as a surrogate of sarcopenia diagnosis, effectively predicts secondary fracture risk in patients with DRF. This simple tool could improve clinical practice by identifying high-risk patients for targeted interventions to prevent recurrent fractures or even reverse functional decline.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-024-01465-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient perceptions of osteoporosis management: a qualitative pilot study by a patient advisory group","authors":"R. M. Javier,&nbsp;F. Debiais,&nbsp;F. Alliot-Launois,&nbsp;D. Poivret,&nbsp;P. Bosgiraud,&nbsp;F. Barbe,&nbsp;M. Bouyssié,&nbsp;M. Devert,&nbsp;F. Roux,&nbsp;M. P. Sacchi,&nbsp;S. Sirot,&nbsp;P. Halbout,&nbsp;T. Chevalley,&nbsp;J. Y. Reginster,&nbsp;B. Cortet","doi":"10.1007/s11657-024-01486-0","DOIUrl":"10.1007/s11657-024-01486-0","url":null,"abstract":"<div><h3>Summary</h3><p>The management of osteoporosis even after a fracture is declining. Our pilot study in patients with osteoporosis confirms a large ignorance of the disease and major fears and uncertainties about the treatments. Complete and sustained medical information seems essential to counteract the contradictory information, which are exclusively negative.</p><h3>Purpose</h3><p>The management of osteoporosis (OP) even after a fracture has declined over recent years despite the actions of the medical societies concerned with this disease. The objective of this pilot study was to investigate patients’ perceptions of OP, their treatment pathways, and how information is obtained.</p><h3>Methods</h3><p>The Association Française de Lutte Anti-Rhumatismale (AFLAR) constituted an advisory group of 7 French patients (mean age 63.7 years [54–74 years]), with various stages of OP and duration of disease. A qualitative, anonymized study was conducted with an open-ended semi-structured questionnaire, with a contribution of the International Osteoporosis Foundation (IOF) and the “Groupe de Recherche et Informations sur les Ostéoporoses” (GRIO).</p><h3>Results</h3><p>The onset of OP was often sudden, with the fracture occurring in a context of deep misunderstanding of OP by both the public and physicians. The patients have confidence in the physician, mostly a rheumatologist, who informs about OP and initiates the treatment. The main cause of non-adherence being major fears and uncertainties about efficacy and safety of treatments. Medical information is considered as insufficient, or poorly understood. Negative information has the highest impact, even if the sources seem unreliable, such as media. There is no trust in pharmaceutical companies and the ethics of physicians are in question.</p><h3>Conclusion</h3><p>This IOF/GRIO/AFLAR Patient Advisory Group pilot study illustrates the numerous barriers to effective OP management. Complete and sustained medical information, especially at the time of diagnosis and initiation of treatment, seems essential to counteract the contradictory information, which are exclusively negative.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-024-01486-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The development and implementation of a digital platform in a fracture liaison service","authors":"Bernadette Conlon,&nbsp;Helen O’Brien,&nbsp;Vanessa Clarke","doi":"10.1007/s11657-024-01491-3","DOIUrl":"10.1007/s11657-024-01491-3","url":null,"abstract":"<div><h3>Summary</h3><p>The fracture liaison service in the study hospital developed and successfully implemented a digital platform to support the identification of patients while concurrently optimizing participation in the National Fracture Liaison Database. This initiative provides additional evidence of the capacity of digital health to support fracture liaison services.</p><h3>Purpose</h3><p>Resourced fracture liaison services (FLSs) are accepted internationally as the preeminent means of reducing the risk of future fragility fractures. The FLS in the study hospital sought to develop and implement a digital platform to support the identification of patients and concurrently effectively participate in the National Fracture Liaison Service Database (FLS-DB) established to monitor key performance indicators (KPIs).</p><h3>Method</h3><p>Through linkage with the already established hospital’s eTrauma digital system and Inpatient Management System, a bespoke fracture liaison digital platform was developed and introduced. Platform functionality supports automated patient identification and interoperability with the National Fracture Liaison Service Database enabling the anonymized safe transfer of key performance indicator data.</p><h3>Results</h3><p>Through automated identification of patients who require fracture liaison services, rates of identification have improved from 10% in 2021 to 87%. Time previously spent manually identifying patients is now available for clinical care. Key performance indicator data are recorded as part of the assessment and treatment process and successfully anonymized and transferred to the national database.</p><h3>Conclusion</h3><p>This initiative provides additional evidence of the capacity of digital health to support fracture liaison services. In comparable settings nationally and internationally where there are coexisting digital systems to support patient management and a national digital database for FLS key performance indicators, there is potential for the successful introduction of similar FLS digital platforms.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142938849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}