Archives of Osteoporosis最新文献

{"title":"The association between prealbumin concentration at admission and mortality in elderly patients with hip fractures: a cohort study","authors":"Shao-Hua Chen, Bin-Fei Zhang, Yu-Min Zhang","doi":"10.1007/s11657-024-01384-5","DOIUrl":"https://doi.org/10.1007/s11657-024-01384-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">\u0000<i>Summary</i>\u0000</h3><p>Malnutrition is associated with complications and mortality in patients of hip fracture. Prealbumin may be more suitable than albumin to accurately predict the prognosis of hip fracture in elderly patients. We found that prealbumin concentration was nonlinearly associated with mortality in elderly patients with hip fracture, and an inflection point effect was observed.</p><h3 data-test=\"abstract-sub-heading\">Objective</h3><p>To evaluate the association between prealbumin concentration at admission and mortality in elderly patients with hip fractures.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Elderly patients with hip fractures were screened between Jan 2015 and Sep 2019. Demographic and clinical characteristics of the patients were collected. Linear and nonlinear multivariate Cox regression models were used to identify the association between prealbumin concentration at admission and mortality. All analyses were performed using EmpowerStats and the R software.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>This cohort study included 2387 patients who met the study criteria. The mean follow-up was 37.64 months. The prealbumin concentration was 162.67 ± 43.2 mg/L. Multivariate Cox regression showed that prealbumin concentration was associated with mortality in geriatric patients with hip fracture (hazard ratio [HR] = 0.95, 95% confidence intervals [CI]: 0.93–0.97, <i>P</i> &lt; 0.0001). In addition, an inflection point effect was observed in the nonlinear association. The inflection point was 162.2 mg/L. If it is less than this inflection point, then every 10 mg/L increase in prealbumin was associated with a 7% reduction in the risk of death (HR = 0.93, 95%CI: 0.90–0.96, <i>P</i> &lt; 0.0001). When greater than the inflection point, there was no difference in the risk of death (HR = 0.99, 95%CI: 0.95–1.03, <i>P</i> = 0.5127).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The prealbumin concentrations at admission were nonlinearly associated with long-term mortality in geriatric hip fractures, and 162.2 mg/L could be considered a prognostic factor of mortality risk.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"8 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decrease in incidence of distal radius fractures in Oslo, Norway","authors":"I. Oftebro, S. A. Skjaker, H. L. Fridheim, F. Frihagen, H. E. Meyer, L. Nordsletten, L. B. Solberg","doi":"10.1007/s11657-024-01383-6","DOIUrl":"https://doi.org/10.1007/s11657-024-01383-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">\u0000<i>Summary</i>\u0000</h3><p>This study reported the incidence of validated adult distal radius fractures in Oslo, Norway, in 2019. The incidence has been reduced over the last 20 years. However, it is still high compared to other regions in Norway and some of the other Nordic countries.</p><h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>We aimed to report the incidence of distal radius fractures in Oslo in 2019 and compare it to the incidence rates in 1998/1999.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Patients aged ≥ 20 years resident in Oslo sustaining a distal radius fracture in 2019 were identified by electronic diagnosis registers, patient protocols, and/or radiology registers. The diagnosis was verified using medical records and/or radiology descriptions. We used the same method as the previous study from Oslo, making the comparison over time more accurate. The age-adjusted incidence rates and the age-standardized incidence rate ratio (IRR) were calculated.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The absolute number of fractures decreased from 1490 in 1998/1999 to 1395 in 2019. The IRR for women and men in the age group ≥ 20 years in 2019 compared to 1998/1999 was 0.77 (95% CI 0.71–0.84) and 0.77 (95% CI 0.66–0.90), respectively. The IRR for women and men in the age group ≥ 50 years in 2019 compared to 1998/1999 was 0.78 (95% CI 0.71–0.86) and 0.78 (95% CI 0.63–0.97), respectively. For the population in Oslo with Asian background compared to Norwegian background in the age group ≥ 50 years, the IRR in 2019 was 0.57 (95% CI 0.40–0.80) for women and 0.77 (95% CI 0.44–1.37) for men.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>The incidence of distal radius fractures in Oslo has decreased over the last 20 years. It is still, however, higher than in other areas of Norway and in some of the other Nordic countries.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"55 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone evaluation study-2: update on the epidemiology of osteoporosis in Germany","authors":"Hadji Peyman, Esterberg Elizabeth, Obermüller Dominik, Bartsch Robert","doi":"10.1007/s11657-024-01380-9","DOIUrl":"https://doi.org/10.1007/s11657-024-01380-9","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Summary</h3><p>Osteoporosis is the most common bone disorder. Our data gives an estimate of around 5.87 million cases of osteoporosis in the general German population in 2018. Only 30% of insured individuals who suffered an osteoporotic fracture and/or had a confirmed diagnosis of osteoporosis, received an appropriate prescription.</p><h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Osteoporosis is the most common bone disorder. It particularly affects elderly people and increases the risk of atraumatic fractures. The aim of this study was to estimate the prevalence of osteoporosis in the general German population aged ≥ 50 years and to collect data on the frequency of prescription of osteoporosis-specific medication in order to assess the treatment gap.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Retrospective analysis of anonymized data of individuals aged ≥ 50 years insured under statutory healthcare schemes from the database of the Institute for Applied Health Research Berlin (InGef) for 2018 (study population). Insured individuals with osteoporosis were identified based on osteoporosis diagnoses, osteoporosis-specific prescriptions, or osteoporotic fractures. Thus, we estimated the prevalence of osteoporosis in the general German population aged ≥ 50 years. The prevalence of diagnoses, fractures, and prescriptions was determined for the study population and stratified by age and gender.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Within the study population of 1,599,299 insured individuals, a prevalence of osteoporosis of 15.9% was determined. This estimated approximately 5.87 million cases of osteoporosis for the general German population. 81.6% of the cases were women. Osteoporosis-specific prescriptions were received by 30.0% of the insured individuals in the study population who had been diagnosed with osteoporosis and/or suffered an osteoporotic fracture.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Germany has a high prevalence of osteoporosis. Only a small portion of individuals who may require osteoporosis-specific treatment actually receive it.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"63 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low plasma 25-hydroxyvitamin D levels are not associated with a high risk of recurrent falls in community-dwelling Japanese adults: the Murakami cohort study","authors":"Toshi Nishikura, Kaori Kitamura, Yumi Watanabe, Keiko Kabasawa, Toshiko Saito, Akemi Takahashi, Ribeka Takachi, Ryosaku Kobayashi, Rieko Oshiki, Shoichiro Tsugane, Kei Watanabe, Kazutoshi Nakamura","doi":"10.1007/s11657-024-01381-8","DOIUrl":"https://doi.org/10.1007/s11657-024-01381-8","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Mini-abstract</h3><p>Reports on the association between vitamin D levels and fall risk have been mixed, and long-term follow-up studies are lacking. This 5-year cohort study of 5,343 community-dwelling Japanese people aged 40–74 years found that low vitamin D levels are not associated with a high risk of recurrent falls.</p><h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Findings of cohort studies on the association between plasma 25-hydoxyvitamin D (25[OH]D) levels and fall risk have been mixed, and long-term follow-up studies are lacking. The present study investigated whether low plasma 25(OH)D levels are longitudinally associated with a high risk of recurrent falls in adults.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This 5-year cohort study included 5,343 community-dwelling Japanese people aged 40–74 years. Baseline blood collection and a questionnaire survey were conducted in 2011–2013. Plasma 25(OH)D levels were determined and divided into quintiles after stratification by season, sex, and age group. Information on recurrent falls occurring in the year before the survey 5 years later was obtained, and participants with two or more falls were considered to have experienced recurrent falls. Covariates were sex, age, marital status, education, occupation, BMI, total physical activity levels, calcium intake, vitamin K intake, smoking, drinking, and disease history.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Mean age and 25(OH)D levels were 60.9 years and 50.9 nmol/L, respectively. In the follow-up survey, 209 recurrent falls were reported. Plasma 25(OH)D levels were not significantly associated with the occurrence of recurrent falls in men, women, or men/women-combined (adjusted P for trend = 0.1198, 0.8383, and 0.2355, respectively). In men and men/women-combined, adjusted ORs for recurrent falls in the lowest quintile were significantly lower (adjusted OR = 0.42 and 0.59, respectively) than the middle quintile (reference).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Low plasma 25(OH)D levels are not associated with a high risk of recurrent falls in middle-aged and older people. Further longitudinal studies will be needed to confirm our findings in other populations.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"65 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey of awareness and attitudes to the management of fragility fractures among the membership of the Asia Pacific Orthopaedic Association","authors":"Joon Kiong Lee, Paul James Mitchell, Seng Bin Ang, Leilani Basa Mercado-Asis, Reynaldo Rey-Matias, Jianan Li, Leon Flicker, Edward Leung, David Choon, Sankara Kumar Chandrasekaran, Jacqueline Clare Therese Close, Hannah Seymour, Cyrus Cooper, Philippe Halbout, Robert Daniel Blank, Yanling Zhao, Rajesh Malhotra, Aasis Unnanuntana, Yew Lok Woo, Zairin Noor, Rong-Sen Yang, Irewin Tabu, Syed Shahidul Islam, Muhammad Amin Chinoy, Sonali Pande, Buland Thapa, Ronald Man Yeung Wong, Ketan Pande, Ding-Cheng (Derrick) Chan","doi":"10.1007/s11657-024-01375-6","DOIUrl":"https://doi.org/10.1007/s11657-024-01375-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">\u0000<i>Summary</i>\u0000</h3><p>A survey of awareness and attitudes to the management of fragility fractures among the membership of the Asia Pacific Orthopaedic Association conducted in 2022 found considerable variation in care across the region. A Call to Action is proposed to improve acute care, rehabilitation and secondary fracture prevention across Asia Pacific.</p><h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Fragility fractures impose a substantial burden on older people and their families, healthcare systems and national economies. The current incidence of hip and other fragility fractures across the Asia Pacific region is enormous and set to escalate rapidly in the coming decades. This publication describes findings of a survey of awareness and attitudes to the management of fragility fractures among the membership of the Asia Pacific Orthopaedic Association (APOA) conducted in 2022.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>The survey was developed as a collaboration between the Asia Pacific Osteoporosis and Fragility Fracture Society and the Asia Pacific Fragility Fracture Alliance, and included questions relating to aspects of care upon presentation, during surgery and mobilisation, secondary fracture prevention, and access to specific services.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>In total, 521 APOA members completed the survey and marked variation in delivery of care was evident. Notable findings included:</p><ul>\u0000<li>\u0000<p>Fifty-nine percent of respondents indicated that analgesia was routinely initiated in transit (by paramedics) or within 30 minutes of arrival in the Emergency Department.</p>\u0000</li>\u0000<li>\u0000<p>One-quarter of respondents stated that more than 80% of their patients underwent surgery within 48 hours of admission.</p>\u0000</li>\u0000<li>\u0000<p>One-third of respondents considered non-hip, non-vertebral fractures to merit assessment of future fracture risk.</p>\u0000</li>\u0000<li>\u0000<p>One-third of respondents reported the presence of an Orthogeriatric Service in their hospital, and less than a quarter reported the presence of a Fracture Liaison Service.</p>\u0000</li>\u0000</ul><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>A Call to Action for all National Orthopaedic Associations affiliated with APOA is proposed to improve the care of fragility fracture patients across the region.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"1 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporotic quality of life, self-efficacy, and fracture protection behaviors in postmenopausal women.","authors":"Gamze Ünver, Aysun Özlü, Ahmet Erdoğan, Muhammed Fatih Özdemir, Sema Üstündağ","doi":"10.1007/s11657-024-01377-4","DOIUrl":"10.1007/s11657-024-01377-4","url":null,"abstract":"<p><p>It is important for postmenopausal women to acquire bone health protective behaviors to protect them from fractures. For this reason, it is necessary to evaluate bone health during menopause and to inform women.</p><p><strong>Purpose: </strong>This study was conducted to examine osteoporotic fracture protection behaviors, quality of life, and self-efficacy in postmenopausal women.</p><p><strong>Methods: </strong>In the study, the data were evaluated with the socio-demographic data form, Osteoporotic Fracture Protection Scale, Osteoporosis Self-Efficacy-Efficacy Scale, European Osteoporosis Foundation Quality of Life Questionnaire-41, which includes introductory information on socio-demographic characteristics.</p><p><strong>Results: </strong>It was determined that the postmenopausal women included in our study were between the ages of 45-92; more than half of them had chronic diseases; their average BMI was 29; and their DEXA score was - 3.00 ± 0.41. Among the people included in our study, those with a history of fractures had lower self-efficacy scores. It was determined that the fracture prevention scale scores of the participants were above the average, and the average of the osteoporosis-related quality of life score was high. In addition, it was determined that there was a strong positive correlation between self-efficacy and fracture prevention scale.</p><p><strong>Conclusion: </strong>It is important to determine behaviors to prevent osteoporotic fractures in postmenopausal women, to raise the necessary awareness and to inform patients about the precautions to be taken. It is thought that it will increase patients' quality of life by increasing their disease-related self-efficacy. Therefore, there is a need for research on providing education to op patients and examining the results.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":"22"},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10984879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140334540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena.","authors":"J P van den Bergh, P Geusens, N M Appelman-Dijkstra, H J G van den Broek, P J M Elders, G de Klerk, M van Oostwaard, H C Willems, M C Zillikens, W F Lems","doi":"10.1007/s11657-024-01378-3","DOIUrl":"10.1007/s11657-024-01378-3","url":null,"abstract":"<p><strong>Background: </strong>In 2018, a grant was provided for an evidence-based guideline on osteoporosis and fracture prevention based on 10 clinically relevant questions.</p><p><strong>Methods: </strong>A multidisciplinary working group was formed with delegates from Dutch scientific and professional societies, including representatives from the patient's organization and the Dutch Institute for Medical Knowledge. The purpose was to obtain a broad consensus among all participating societies to facilitate the implementation of the updated guideline.</p><p><strong>Results: </strong>Novel recommendations in our guideline are as follows: - In patients with an indication for DXA of the lumbar spine and hips, there is also an indication for VFA. - Directly starting with anabolic drugs (teriparatide or romosozumab) in patients with a very high fracture risk; - Directly starting with zoledronic acid in patients 75 years and over with a hip fracture (independent of DXA); - Directly starting with parenteral drugs (denosumab, teriparatide, zoledronic acid) in glucocorticoid-induced osteoporosis with very high fracture risk; - A lifelong fracture risk management, including lifestyle, is indicated from the start of the first treatment.</p><p><strong>Conclusion: </strong>In our new multidisciplinary guideline osteoporosis and fracture prevention, we developed 5 \"relatively new statements\" that are all a crucial step forward in the optimization of diagnosis and treatment for fracture prevention. We also developed 5 flowcharts, and we suppose that this may be helpful for individual doctors and their patients in daily practice and may facilitate implementation.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":"23"},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10987374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140334541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between alcohol intake and bone mineral density: results from the NHANES 2005-2020 and two-sample Mendelian randomization.","authors":"Bowen Lai, Heng Jiang, Rui Gao, Xuhui Zhou","doi":"10.1007/s11657-024-01382-7","DOIUrl":"10.1007/s11657-024-01382-7","url":null,"abstract":"<p><p>We used the data from the NHANES cross-sectional study among 14,113 participants and indicated a positive correlation between alcohol intake frequency and bone mineral density in different body sites. Mendelian randomization was conducted, and no causal relationship is significant between these two variables. The study can provide some suggestions on the daily consumption of alcohol for osteoporosis patients.</p><p><strong>Purpose: </strong>The effect of alcohol intake on bone mineral density (BMD) remains unclear. This study explored the association and causality between alcohol intake and BMD.</p><p><strong>Methods: </strong>Based on the 2005-2020 National Health and Nutrition Examination Survey including 14,113 participants, we conducted co-variate-adjusted multilinear regression analyses to explore the association between alcohol intake levels and spine or femur BMD. To evaluate the causal association between alcohol intake frequency and bone mineral density, the inverse variance weighted approach of two-sample Mendelian randomization (MR) was used with genetic data from the Medical Research Council Integrative Epidemiology Unit (462,346 cases) for alcohol intake frequency and the Genetic Factors for Osteoporosis Consortium (28,496 cases) for lumbar spine and femur neck BMD (32,735 cases).</p><p><strong>Results: </strong>Compared with non-drinkers, total femur BMDs but not total spine BMD increased with daily alcohol intake in males (β = 3.63*10^-2 for mild drinkers, β = 4.21*10^-2 for moderate drinkers, and β = 4.26*10^-2 for heavy drinkers). By contrast, the higher total spine BMD in females was related to higher alcohol intake levels (β = 2.15*10^-2 for mild drinkers, β = 2.59*10^-2 for moderate drinkers, and β = 3.88*10^-2 for heavy drinkers). Regarding the two-sample MR results, no causal relationship was observed between alcohol intake frequency and lumbar spine BMD (odds ratio [OR] = 1.016, P = 0.789) or femur neck BMD (OR = 1.048, P = 0.333).</p><p><strong>Conclusion: </strong>This study suggests a positive association between alcohol intake frequency and BMD, although the causal relationship was not significant.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":"21"},"PeriodicalIF":3.1,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140317732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone mineral density T-scores comparison between obese and non-obese individuals included in a Fracture Liaison Service following a recent fragility fracture.","authors":"Gauthier Marchasson, Cécile Philippoteaux, Isabelle Legroux-Gérot, Béhal Hélène, Bernard Cortet, Julien Paccou","doi":"10.1007/s11657-024-01379-2","DOIUrl":"10.1007/s11657-024-01379-2","url":null,"abstract":"<p><p>We used data from a Fracture Liaison Service to compare the mean T-scores of obese and non-obese patients after a recent fragility fracture. After adjusting for age, sex, and diabetes mellitus, T-score values were significantly higher at all measurement sites in obese patients, with a mean difference of 1 SD.</p><p><strong>Purpose: </strong>This study aimed to compare the mean T-scores of obese and non-obese patients after recent fragility fractures.</p><p><strong>Methods: </strong>Over a period of 5 and a half years, from January 2016 to May 2021, patients from a fracture liaison service were identified and their demographic characteristics, osteoporosis risk factors, BMD T-scores, and fracture sites were compared between obese (BMI ≥ 30 kg/m²) and non-obese (19 kg/m² < BMI < 30 kg/m²) patients.</p><p><strong>Results: </strong>A total of 712 patients were included (80.1% women; mean age 73.8 ± 11.3 years). Sixteen % had type 2 diabetes mellitus and 80% had a major osteoporotic fracture (MOF). 135 patients were obese and 577 non-obese, with obese patients younger (p < 0.001) and more frequently female (p = 0.03). Obese patients presented with fewer hip fractures (10% vs. 21%, p = 0.003) and more proximal humerus fractures (16% vs. 7%, p < 0.001) than non-obese patients. After adjusting for age, sex, and diabetes mellitus, BMD T-score values were significantly higher at all measurement sites (lumbar spine, total hip, and femoral neck) in obese patients than in non-obese patients for all types of fractures, with a mean difference of 1 standard deviation (p < 0.001 for all comparisons). The same results were observed in the population limited to MOF.</p><p><strong>Conclusions: </strong>Given the crucial role of BMD T-score in determining the need for anti-osteoporotic medication following fragility fractures, it is reasonable to question the existing T-score thresholds in obese patients.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":"20"},"PeriodicalIF":3.1,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of anti-osteoporosis medications in preventing vertebral body fractures after balloon kyphoplasty.","authors":"Masaki Ueno, Yusuke Tajima, Shogo Ito, Masaki Tsuji, Emi Toriumi, Aki Yoshii, Nanaka Otake, Hisashi Tanaka","doi":"10.1007/s11657-024-01374-7","DOIUrl":"10.1007/s11657-024-01374-7","url":null,"abstract":"<p><p>This retrospective study compared the efficacy of anabolic agents (romosozumab and teriparatide) with that of alendronate in preventing subsequent vertebral body fractures (SVBFs) after balloon kyphoplasty (BKP). All anabolic agents significantly reduced SVBFs. Romosozumab was most effective in increasing bone mineral density (BMD) and completely suppressed distant vertebral body fractures.</p><p><strong>Introduction: </strong>To determine optimal anti-osteoporosis medications, we compared romosozumab and teriparatide to alendronate as a control from perioperative BKP to the 1st postoperative year for treatment and secondary fracture prevention in osteoporosis.</p><p><strong>Methods: </strong>A total of 603 patients who underwent initial BKP for osteoporotic vertebral fractures were evaluated and categorized into five groups based on drug administration: romosozumab (group R, 155 patients), twice-weekly teriparatide (group TW, 48), weekly teriparatide (group W, 151), daily teriparatide (group D, 138), and alendronate (control) (group C, 111). The 1-year incidence of SVBFs, BMD change rate, and probability of requiring BKP were compared among the groups.</p><p><strong>Results: </strong>SVBF incidence was 3.9%, 6.5%, 8.3%, 6.0%, and 14.4% in groups R, D, TW, W, and C, respectively, with all other groups exhibiting significantly lower rates than group C. The groups that administered the anabolic agents had a notably lower incidence of distant fractures than group C. Compared with group C, group R showed significantly higher BMD change rates in lumbar vertebral bodies at 4, 8, and 12 months and group D at 12 months. Anabolic agent groups exhibited significantly higher improvement rates than group C after conservative treatment alone.</p><p><strong>Conclusion: </strong>The anabolic agents were found to be more effective at reducing the incidence of SVBF (especially distant vertebral fractures) than alendronate. These agents decreased the rate of repeat BKP even after the occurrence of a fracture. Overall, the use of an anabolic agent for the treatment of osteoporosis after BKP is better than the use of alendronate, even when treatment is initiated in the perioperative stage.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":"19"},"PeriodicalIF":3.1,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}