Archives of Osteoporosis最新文献

{"title":"Association between bone health and cardiovascular events in a population-based cohort","authors":"Álex García Tellado,&nbsp;Mercedes de la Fuente,&nbsp;José Luis Hernández,&nbsp;Ludovic Humbert,&nbsp;Carmen García Ibarbia,&nbsp;Álvaro del Real,&nbsp;José A. Riancho,&nbsp;Carmen Valero","doi":"10.1007/s11657-026-01704-x","DOIUrl":"10.1007/s11657-026-01704-x","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p><b>Brief rationale:</b> Low bone mineral density may be linked to cardiovascular risk, but causality is unclear.</p><p><b>Main result:</b> In 1233 individuals followed for 14 years, osteoporotic fractures and trabecular vBMD independently predicted cardiovascular events, while areal BMD did not.</p><p><b>Significance of the paper:</b> Bone health could be associated with the development of cardiovascular events.</p><h3>Purpose</h3><p>In this observational cohort of a general population sample, we aimed to assess the association between bone mineral density (BMD) and osteoporotic fractures on the risk of subsequent cardiovascular events in both sexes.</p><h3>Methods</h3><p>This prospective study included 1233 individuals (mean age 62.5 ± 8.4 years; 76% women) from the Camargo cohort in Northern Spain, followed for 14.3 ± 4.0 years. Baseline clinical data, DXA-based BMD (lumbar spine, femoral neck, total hip), trabecular bone score (TBS), and volumetric BMD by 3D-DXA were analyzed. Incident cardiovascular events (myocardial infarction, stroke, peripheral artery disease) were documented. Cox regression analyses were performed adjusting for cardiovascular risk factors.</p><h3>Results</h3><p>During follow-up, 240 participants (19.5%) experienced cardiovascular events. These individuals were older and had higher rates of hypertension, diabetes, dyslipidemia, smoking, atrial fibrillation, and previous cardiovascular event. A history of osteoporotic fracture was more frequent among those with cardiovascular events (9.6% vs. 3.1%, HR 2.59). Lower trabecular vBMD and TBS were observed in the event group, while areal BMD showed no significant differences. Adjusted analyses revealed that a history of osteoporotic fracture independently increased cardiovascular risk by 125% (HR 2.25; 95% CI 1.43–3.54). Moreover, for each 1 SD increase in trabecular vBMD, the risk was slightly reduced by 14% (HR 0.86; 95% CI 0.74–0.99).</p><h3>Conclusions</h3><p>Our findings indicate that prior osteoporotic fractures and trabecular vBMD are significant predictors of cardiovascular event risk, independent of traditional risk factors.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The effect of OsteoStrong compared to dynamic multicomponent exercise on bone strength in older women: the BONEMORE non-inferiority randomized controlled trial","authors":"Peter W. S. Lindberg,&nbsp;Kristin Moystad Michelet,&nbsp;Christina Kaijser Alin,&nbsp;Eva Andersson,&nbsp;Ann-Charlotte Grahn Kronhed,&nbsp;Per Magnusson,&nbsp;Sven Nyrén,&nbsp;Hans Ranch Lundin,&nbsp;Eva Toth-Pal,&nbsp;Maria Sääf,&nbsp;Helena Salminen","doi":"10.1007/s11657-026-01700-1","DOIUrl":"10.1007/s11657-026-01700-1","url":null,"abstract":"","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-026-01700-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147737325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weak bones, strong obsessions: a controlled study on Orthorexia Nervosa, body image, and mood in postmenopausal osteoporosis","authors":"Büşra Şirin Ahısha,&nbsp;Eser Kalaoğlu,&nbsp;Tuba Uyanık Kesmez,&nbsp;Ahmet Yılmaz,&nbsp;Nurdan Paker,&nbsp;Nur Kesiktaş,&nbsp;Yiğit Can Ahısha,&nbsp;Nazlı Derya Buğdaycı","doi":"10.1007/s11657-026-01706-9","DOIUrl":"10.1007/s11657-026-01706-9","url":null,"abstract":"<div><h3>Summary</h3><p>Postmenopausal women with osteoporosis may show higher levels of orthorexic tendencies than healthy peers. These tendencies were associated with lower lumbar spine bone density but not with mood or body image measures. The findings suggest that maladaptive health-focused behaviors may be present in this population.</p><h3>Objective</h3><p>This study aimed to evaluate orthorexic tendencies in postmenopausal women with osteoporosis compared to healthy controls and to investigate the associations between orthorexic tendencies, body appreciation, and mood-related symptoms.</p><h3>Methods</h3><p>This cross-sectional study included 128 participants (64 postmenopausal women with osteoporosis and 64 healthy controls). Femoral neck and L1–L4 T-scores and bone mineral density (BMD) values were obtained from dual-energy X-ray absorptiometry (DXA) measurements performed within the previous six months. Orthorexic tendencies were assessed using the Orthorexia Nervosa Scale–11 (ORTO-11), symptoms related to depression and anxiety were evaluated using the Hospital Anxiety and Depression Scale (HADS), and body satisfaction was assessed using the Body Appreciation Scale (BAS).</p><h3>Results</h3><p>ORTO-11 scores were significantly lower in the osteoporotic group compared to healthy controls (<i>p</i> = 0.041), indicating more pronounced orthorexic tendencies. Although the prevalence of clinically significant orthorexic tendencies (ORTO-11 ≤ 27) was higher in the osteoporotic group (68.8%) than in controls (54.7%), this difference did not reach statistical significance. ORTO-11 scores showed positive correlations with lumbar spine T-scores (r = 0.202, <i>p</i> = 0.022) and BMD values (r = 0.210, <i>p</i> = 0.017), whereas no association was observed with femoral neck measurements. Orthorexic tendencies were not correlated with anxiety, depression, or body appreciation scores. In contrast, depressive and anxiety symptoms were negatively correlated with body appreciation.</p><h3>Conclusion</h3><p>Orthorexic tendencies may be more common in postmenopausal women with osteoporosis. These findings suggest that maladaptive healthy eating behaviors may be present in this population.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between femoral cortical thickness index and hip fracture in older persons","authors":"Alperen Kaan Yaman,&nbsp;Doğaç Karagüven,&nbsp;Burak Akan,&nbsp;Berk Güçlü,&nbsp;Hakan Ömeroğlu","doi":"10.1007/s11657-026-01699-5","DOIUrl":"10.1007/s11657-026-01699-5","url":null,"abstract":"<div><h3>Purpose</h3><p>This study aimed to reevaluate a simple radiographic measurement, the cortical thickness index (CTI), using standard plain radiographs to investigate its association with the presence of hip fracture in older persons. </p><h3>Methods</h3><p>The study group (SG) consisted of 46 patients (35 females, 11 males) aged 65 years and older who presented to the emergency department with hip fractures. Two control groups were formed: One comprising 46 older persons aged 65 years and older (CG-G) and another of young adults aged 20–30 (CG-YA), both referred to the outpatient clinic and had available plain hip radiographs. CTI was measured for all participants by the first author. Additionally, two observers independently measured CTI to assess intraobserver and interobserver agreement.</p><h3>Results</h3><p>Intraobserver and interobserver agreement was almost perfect based on Cohen’s kappa classification (<span>(kappa)</span> &gt; 0.8). The mean CTI for the SG was 0.389 ± 0.05, while the mean CTI for the CG-G was 0.571 ± 0.048, and for the CG-YA was 0.585 ± 0.048. A statistically significant difference was found between the SG and both CG-G and CG-YA groups (<i>p</i> &lt; 0.001). No significant difference was observed between CG-G and CG-YA (<i>p</i> &gt; 0.05). A CTI threshold of 0.485 demonstrated high discriminative ability for distinguishing older persons with hip fracture from those without fracture, yielding a sensitivity of 97.83% and a specificity of 95.65%.</p><h3>Conclusion</h3><p>CTI is significantly reduced in older persons with hip fracture. As a quick and accessible measurement on standard radiographs, CTI may assist clinicians in distinguishing individuals with hip fracture from those without fracture in outpatient settings.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Osteoporosis in Elderly Men: Large Real-World Data Addressing the Current Screening Evidence Gap","authors":"Vanessa Rouach,&nbsp;Ziv Versano,&nbsp;Meital Sasson,&nbsp;Yona Greenman,&nbsp;Arnon Makori,&nbsp;Gabriel Chodick,&nbsp;Inbal Goldshtein","doi":"10.1007/s11657-026-01701-0","DOIUrl":"10.1007/s11657-026-01701-0","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Evidence supporting osteoporosis screening in older men remains limited. In a large real-world cohort of 29,906 men aged ≥ 70 undergoing DXA screening, osteoporosis was identified in 16.5% and osteopenia in 51.3%, with prevalence increasing with age. These findings indicate that a substantial proportion of older men have low bone mass and are therefore at increased risk of fracture.</p><h3>Purpose</h3><p>Evidence supporting routine osteoporosis screening in older men remains limited. We aimed to evaluate the prevalence and skeletal distribution of low bone mineral density (BMD) in elderly men within a large healthcare system where an age-based DXA screening recommendation has been implemented.</p><h3>Methods</h3><p>We conducted a retrospective cohort study of DXA examinations performed between 2014 and 2024 at Assuta Medical Centers within Maccabi Health Services (MHS). MHS implemented a computerized clinical recommendation within the electronic medical record supporting DXA screening in men aged ≥ 70 years approximately a decade ago. To approximate primary age-based screening conditions, individuals with prior DXA examinations before age 70, oncologic disease, prior fracture, chemotherapy or radiotherapy exposure, and other causes of secondary osteoporosis were excluded. Additional exclusions for inflammatory disease, chronic glucocorticoid therapy, and endocrine disorders were applied using structured diagnostic fields and referral free-text data. Participants were required to have at least two valid skeletal site-groups available for analysis.</p><h3>Results</h3><p>Among a total of 29,906 eligible individuals who underwent DXA, osteoporosis prevalence was 15.0% at the femoral neck, 6.1% at the total hip, and 3.8% at the lumbar spine. Using the lowest T-score definition, overall osteoporosis prevalence was 16.5% and 51.3% of participants demonstrated osteopenia. Femoral neck osteoporosis increased from 12.4% in men aged 70–74 years to 26.1% in men aged ≥ 80 years.</p><h3>Conclusion</h3><p>In a large real-world cohort approximating systematic screening conditions, nearly one in six older men met diagnostic criteria for osteoporosis. These data help address the current evidence gap regarding osteoporosis screening in men.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a gender score and its association with treatment outcomes in fragility fracture patients screened through Ontario’s Fracture Screening and Prevention Program","authors":"Anum Ali,&nbsp;Ella Huszti,&nbsp;Shahryar Noordin,&nbsp;Earl Bogoch,&nbsp;Alan Yang,&nbsp;Joanna E. M. Sale","doi":"10.1007/s11657-026-01668-y","DOIUrl":"10.1007/s11657-026-01668-y","url":null,"abstract":"<div><h3>Summary</h3><p>We developed and validated a gender score using data from Ontario’s Fracture Screening and Prevention Program and assessed its association with treatment outcomes. Individuals with higher scores exhibited female-like characteristics and were more likely to receive medication prescriptions in the program. Tailored interventions addressing both sex and gender are needed to improve post-fracture care outcomes within the program.</p><h3>Purpose</h3><p>To develop and validate a gender score using data from Ontario’s Fracture Screening and Prevention Program (FSPP) and to evaluate its association with treatment outcomes, including medication prescription and initiation, in patients at high risk for future fractures.</p><h3>Methods</h3><p>A retrospective cohort study was conducted to examine the association between gender score and treatment outcomes in high risk patients who were screened through the FSPP between July 1, 2017, and June 30, 2023. A gender score was constructed using a propensity scoring method, with sex serving as the dependent variable in a multivariable logistic regression model. The gender-related variables were identified from the FSPP dataset. The study also evaluated the face and construct validity of the derived gender score. Multivariable logistic regression was conducted to examine the association between the derived gender score and treatment outcomes.</p><h3>Results</h3><p>Among the 45,135 patients screened through the FSPP, 19,278 patients had complete data for gender-related variables included in the derivation of a gender score. Seven out of eight gender-related variables were found to have associations with sex. The derived gender score demonstrated moderate predictive accuracy, with higher scores indicating higher feminine characteristics. Patients with higher feminine characteristics were significantly more likely to receive a medication prescription within the program.</p><h3>Conclusion</h3><p>We applied and validated a method to create a gender score using FSPP data and validated the score by demonstrating both face and construct validity. The findings of this study highlight the importance of considering gender-related variables in healthcare delivery, particularly within secondary fracture prevention programs. By examining the influence of gender on treatment outcomes, this study provides valuable insights for developing tailored interventions that address the diverse needs of patients and improve overall care and long-term outcomes.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147642839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor, regarding “The association between hyperkyphosis and physical function in geriatric outpatients with frailty”","authors":"Marije C. Koelé,&nbsp;Hanna C. Willems,&nbsp;Nathalie van der Velde","doi":"10.1007/s11657-026-01671-3","DOIUrl":"10.1007/s11657-026-01671-3","url":null,"abstract":"","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147642942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical study on the effects of teriparatide and denosumab on bone metabolism and gut microbiota in osteoporotic fracture patients","authors":"Jie Deng,&nbsp;Shan Su,&nbsp;Limin Tian","doi":"10.1007/s11657-026-01697-7","DOIUrl":"10.1007/s11657-026-01697-7","url":null,"abstract":"<div><h3>Summary</h3><p>This study compared teriparatide and denosumab in patients with osteoporotic fractures. Both treatments improved bone mineral density but showed different patterns of bone metabolism and gut microbiota changes. Variations in gut microbial profiles were associated with bone-related indicators, highlighting a potential link between gut microbiota and treatment-related skeletal responses.</p><h3>Objective</h3><p>To investigate the effects of teriparatide and denosumab on bone mineral density (BMD), bone turnover markers, and gut microbiota in patients with osteoporotic fractures.</p><h3>Methods</h3><p>This non-randomized, open-label, head-to-head comparative clinical study enrolled patients with osteoporotic fractures who received either subcutaneous teriparatide (20 μg daily) or subcutaneous denosumab (60 mg every six months). All participants received concomitant calcium and vitamin D supplementation. BMD and bone turnover markers were assessed at baseline and after a six-month treatment period. Fecal samples were collected for 16S rDNA sequencing to evaluate alterations in gut microbiota composition.</p><h3>Results</h3><p>The study was completed by 108 participants (mean age, 64.8 ± 8.4 years), including 68 in the teriparatide group and 40 in the denosumab group. The statistical analysis revealed significant increases in lumbar spine and hip BMD in the teriparatide and denosumab groups after treatment compared to baseline. OC levels increased significantly more in the teriparatide group than in the denosumab group (<i>P</i> &lt; 0.001), whereas β‑CTX levels decreased more markedly in the denosumab group compared with the teriparatide group (<i>P</i> &lt; 0.001). Both groups showed shifts mainly involving SCFA‑producing gut microbiota. Teriparatide significantly enriched the abundance of <i>Dubosiella</i> and <i>Butyrivibrio</i>, which were positively correlated with L4, hip BMD, and L2 BMD, respectively. In contrast, the denosumab group exhibited an increased abundance of <i>Lacticaseibacillus</i> and a decreased abundance of <i>Holdemanella</i>. Specifically, the abundance of <i>Lacticaseibacillus</i> was negatively correlated with parathyroid hormone (PTH), while the abundance of <i>Holdemanella</i> was positively correlated with osteocalcin (OC), alkaline phosphatase (ALP), and β-CTX and negatively correlated with lumbar spine bone density.</p><h3>Conclusion</h3><p>Although teriparatide and denosumab increased BMD, they exerted opposite effects on bone turnover. These changes were accompanied by distinct shifts in gut microbiota related to SCFA metabolism, suggesting that the gut–bone axis may be involved in their mechanisms of action.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-pandemic acceleration in osteoporotic hip fracture burden in Ecuador: a joinpoint analysis of Global Burden of Disease data, 2010–2023","authors":"Enrique Lopez Gavilanez,&nbsp;Manuel Navarro Chávez,&nbsp;Mario Hernández Bonilla,&nbsp;Noemi Bautista Litardo,&nbsp;Roberto Cedeño German,&nbsp;Abigail Segura Mestanza,&nbsp;Luis Imaicela Naula,&nbsp;Mario Navarro Grijalva","doi":"10.1007/s11657-026-01698-6","DOIUrl":"10.1007/s11657-026-01698-6","url":null,"abstract":"<div><h3>Summary</h3><p>Hip fracture burden in Ecuador is poorly characterized. Using Global Burden of Disease estimates (2010–2023), we show increasing incidence and prevalence with a sex-specific divergence in disability: women experienced rising YLDs, whereas male disability remained stable. These findings highlight unmet needs for targeted fracture prevention and post-fracture care.</p><h3>Background</h3><p>In aging populations, hip fractures are major factors in disability and healthcare costs. However, evidence from Latin America remains limited, especially regarding long-term trends and gender-specific patterns.</p><h3>Methods</h3><p>Between 2010 and 2023 we used estimates from the Global Burden of Disease (GBD) 2021 study to conduct a population-based analysis of the incidence, prevalence, and years of disability due to hip fracture (YLDs) in Ecuador. Age-standardized rates (ASRs) per 100,000 population were calculated for adults aged ≥ 50 years. Joinpoint regression was used to assess temporal trends in order to estimate the annual percentage change (APC) and average annual percentage change (AAPC), overall and by sex.</p><h3>Results</h3><p>Age-standardized incidence and prevalence rates of hip fractures increased steadily in Ecuador between 2010 and 2023, while YLDs rates remained relatively stable overall. The incidence increased from 111.8 to 138.1 per 100,000 in both sexes, while YLDs changed marginally (32.6–33.2). Marked differences were observed between the sexes: women showed substantial increases in incidence, prevalence, and YLDs, while the incidence increased modestly and YLDs decreased in men. Between 2020 and 2023, incidence accelerated in both sexes (APC 2%, p &lt; 0.05), exceeding the annual percent change observed in the preceding period.</p><h3>Conclusions</h3><p>There is an increasing burden of hip fractures in Ecuador, driven mainly by women, with a clear disconnect between incidence and disability. These findings contrast with the declining trends reported in several high-income countries. They also highlight unmet needs in osteoporosis prevention and postfracture care in Ecuador.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147606345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends in osteoprotective treatment after hip fracture in Spain: data from the Spanish National Hip Fracture Registry (2017–2024)","authors":"Leonor Cuadra-Llopart,&nbsp;Cristina González-Villaumbrosia,&nbsp;Jose Manuel Cancio-Trujillo,&nbsp;Teresa Casanova-Querol,&nbsp;Patricia Ysabel Condorhuamán-Alvarado,&nbsp;Teresa Pareja-Sierra,&nbsp;Eugenia Sopena-Bert,&nbsp;Pilar Sáez-López,&nbsp;on behalf of the SNHFR Study Group","doi":"10.1007/s11657-026-01694-w","DOIUrl":"10.1007/s11657-026-01694-w","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Post-hip fracture osteoprotective prescriptions in Spain rose significantly (40 to 58.5% at 1 month post-fracture, 2017–2024), mainly due to antiresorptives. Osteoanabolics remained underused, and treatment was disproportionately directed to healthier, younger patients. These findings highlight progress but reveal significant inequities, stressing the need for comprehensive, personalized strategies in secondary fracture prevention.</p><h3>Background</h3><p>Hip fractures in older adults are a major public health concern, associated with increased morbidity and mortality. Although osteoprotective prescriptions have risen in recent years, treatment rates remain below recommendations for secondary fracture prevention.</p><h3>Objective</h3><p>To examine temporal trends in osteoprotective treatment after hip fracture in Spain and to characterize patients receiving antiresorptive or osteoanabolic therapy.</p><h3>Methods</h3><p>We conducted a retrospective cohort study using data from the Spanish National Hip Fracture Registry (SNHFR) from 2017 to 2024. Patients aged ≥ 75 years were included. Osteoprotective treatment initiated within 1 month post-fracture was analyzed over time. Patient characteristics were compared according to treatment type.</p><h3>Results</h3><p>Of 73,016 patients identified, 58,987 met inclusion criteria. Osteoprotective treatment at 1 month increased from 40% in 2017 to 58.5% in 2024 (<i>p</i> &lt; 0.001), primarily due to increased antiresorptive use (37.3 to 54.3%). In contrast, osteoanabolic and dual therapies remained underused (&lt; 5% and ~ 1%, respectively). Treated patients were generally younger, more often female, functionally independent, cognitively intact, and had prior osteoprotective treatment. Among treated patients, those prescribed osteoanabolic were younger and more independent.</p><h3>Conclusion</h3><p>Osteoprotective prescription in SNHFR hospitals increased significantly between 2017 and 2024, by more than 46%. Despite this progress, osteoanabolic use remains limited, and treatment is disproportionately directed to healthier patients, diverging from guidelines that recommend therapy across all high-risk profiles. Strategies to ensure equitable and personalized secondary fracture prevention, particularly in frailer populations, are urgently needed.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}