Archives of Osteoporosis最新文献

{"title":"Recommendations for the prevention of fragility fractures: a consensus from international experts and Ibero-American scientific societies.","authors":"Pilar Sáez-López, César Aldecoa Álvarez-Santullano, Rosa Arboiro-Pinel, José Luis Baquero Úbeda, José Carlos Bastida Calvo, Francisco Baixaulí García, Concepción Cassinello Ogea, Patricia Ysabel Condorhuamán Alvarado, María Cortés Berdonces, Leonor Cuadra Llopart, Nuria Fernández Martínez, Mercé Giner García, Rafael Manuel Micó Pérez, Blanca Mur Molina, Antonio Naranjo Hernández, José Luis Neyro Bilbao, Cristina Ojeda-Thies, Santiago Palacios Gil Antuñano, Manuel Santiñá Vila, José Soto Bonel, Francisco José Tarazona-Santabalbina","doi":"10.1007/s11657-025-01551-2","DOIUrl":"10.1007/s11657-025-01551-2","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a multidisciplinary consensus outlining key recommendations to prevent fragility fractures and improve care through coordinated efforts across healthcare sectors.</p><p><strong>Methods: </strong>An international group of experts, coordinated by the Spanish National Hip Fracture Registry (RNFC), engaged over 300 professionals and 31 scientific societies. Using a nominal group technique, the committee reviewed scientific evidence and collaboratively developed ten core recommendations. The consensus was refined through multiple telematic reviews and finalized at the 7th RNFC Annual Meeting in March 2024.</p><p><strong>Results: </strong>The consensus presents ten actionable recommendations: (1) inclusion of osteoporosis and fragility fractures in health policies, (2) early detection and management of frailty and falls, (3) implementation of clinical practice guidelines, (4) promotion of fracture registries and audits, (5) support for Orthogeriatric Units and Fracture Liaison Services (FLS), (6) adoption of a \"Fragility Fracture Code,\" (7) empowerment of Primary Care in fracture prevention, (8) increased patient association involvement, (9) public awareness campaigns, and (10) promotion of research including patient-reported outcomes.</p><p><strong>Conclusions: </strong>Fragility fractures are a major public health issue with rising incidence, disability, and healthcare costs. This consensus offers unified, evidence-based guidance for policy makers, healthcare professionals, and patient organizations. Broad dissemination and implementation of these recommendations aim to reduce fracture rates and enhance patient outcomes through coordinated, multidisciplinary care.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"76"},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the BHOF FLS TeleECHO program: a review of role and outcomes.","authors":"Ami R Patel, Nora Laberee, Andrea P Medeiros","doi":"10.1007/s11657-025-01557-w","DOIUrl":"10.1007/s11657-025-01557-w","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis-related fractures represent a major public health issue, impacting approximately 2 million Americans each year. Notably, 25-30% of these individuals suffer a subsequent fracture within 5 years. The concept of imminent fracture risk, which highlights the elevated risk of fracture within 1-2 years following an initial event, emphasizes the urgency of secondary prevention strategies. Fracture Liaison Service (FLS) programs have been shown to reduce the risk of subsequent fractures by up to 50%.</p><p><strong>Methods: </strong>This review evaluates the Bone Health and Osteoporosis Foundation (BHOF) FLS ECHO program, which employs a telementoring model to guide and support healthcare providers in establishing and enhancing FLS programs. Data were collected from participant surveys to assess satisfaction and the application of knowledge gained through the program.</p><p><strong>Results: </strong>Survey responses indicated high levels of participant satisfaction with the FLS ECHO program. Respondents reported a strong commitment to implementing the strategies learned during the sessions to improve secondary fracture prevention within their practices.</p><p><strong>Conclusion: </strong>The BHOF FLS ECHO program shows promise in addressing the burden of osteoporotic fractures by increasing the adoption and effectiveness of FLS models. Through targeted education and virtual mentorship, the program can expand access to secondary fracture prevention strategies, ultimately improving patient outcomes.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"75"},"PeriodicalIF":3.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescribing outcomes following discharge from an osteoporosis specialist-led, post-fracture clinic: a prospective cohort study in Ontario, Canada.","authors":"Kristin K Clemens, Surim Son, Yunxu Zhu, Tharsan Kanagalingam, Jenny Thain, Sarah D'Angelo, Darren Drosdowech, Tayyab Khan","doi":"10.1007/s11657-025-01559-8","DOIUrl":"https://doi.org/10.1007/s11657-025-01559-8","url":null,"abstract":"<p><p>We studied the effectiveness of an osteoporosis specialist-led post-fracture clinic on treatment and persistence with anti-osteoporosis medications in real-world patients. We found that 90% of study participants filled medications as prescribed, and 89% remained persistent with therapy. Our collaborative fracture model might be useful to other fracture centers.</p><p><strong>Purpose: </strong>Fracture liaison services (FLS) promote timely identification and treatment of osteoporosis following fragility fracture. Whether patients adhere to treatment recommendations following discharge is uncertain.</p><p><strong>Methods: </strong>We conducted a prospective cohort study of patients aged 50 and older with an upper extremity fragility fracture seen in the Post-Fracture Osteoporosis Clinic (PFOC) at St. Joseph's Health Care London between November 2018 and March 2024. As primary outcomes, we captured the percentage of patients discharged, who filled their prescribed anti-osteoporosis medication within 6-9 months, and the percentage who filled and were subsequently re-prescribed the therapy by their primary care provider (PCP) (i.e., defined as persistent). As a secondary outcome, we examined patient characteristics associated with non-persistence.</p><p><strong>Results: </strong>We included 201 participants in our cohort, of whom 101 (50.2%) had complete follow-up at the time of this study. Most were women (92.1%), and they had a mean age of 71.1 years. In those with complete follow-up information, 90.1% reported filling their anti-osteoporosis medication, and 89% remained persistent.</p><p><strong>Conclusions: </strong>Our tertiary care PFOC had good success getting high-risk patients with upper arm fracture treated for osteoporosis. Over the short term, there was excellent self-reported persistence. Longer term prescription patterns, persistence, and rates of re-fracture remain important.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"74"},"PeriodicalIF":3.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of secukinumab on skeletal microarchitecture and vertebral fractures in patients with axial spondyloarthritis using HR-pQCT.","authors":"Chloe Heiting, Don McMahon, Douglas N Mintz, Linda Russell, Dalit Ashany, Weijia Yuan, Insa Mannstadt, Emily M Stein, Susan M Goodman","doi":"10.1007/s11657-025-01565-w","DOIUrl":"10.1007/s11657-025-01565-w","url":null,"abstract":"<p><p>Participants with active AxSpA beginning secukinumab with moderate disease activity had improvements in symptoms, but no substantial change in BMD and microarchitecture. Larger, longer-term controlled studies are needed to assess the impact of IL-17 blockade on skeletal health.</p><p><strong>Background: </strong>Axial Spondyloarthritis (AxSpA) is linked to poor skeletal health, but whether IL-17 blockade, effective for symptom improvement, improves skeletal health is unknown. We investigated the impact of secukinumab on skeletal features.</p><p><strong>Methods: </strong>We prospectively enrolled AxSpA patients beginning therapy with secukinumab and followed them for 24 months. Clinical assessments, serum bone turnover markers, and cervical and lumbar spine radiographs were obtained. Areal BMD (aBMD) and trabecular bone score (TBS) measured by dual energy x-ray absorptiometry (DXA, spine, hip, forearm), volumetric BMD (vBMD), and microarchitecture measured by high-resolution peripheral quantitative computed tomography (HR-pQCT, Xtreme CT2, at the tibia and radius) were performed annually. DXA and HR-pQCT assessments were compared to reference cohorts of sex- and age-matched individuals. Changes were assessed through Wilcoxon and paired t-tests.</p><p><strong>Results: </strong>Thirty AxSpA participants were enrolled, 50% female (13% postmenopausal) and 47% HLA-B27 positive. Mean symptom duration was 12 years, with moderate activity (BASDAI mean 5 [SD = 2]). Baseline DXA and HR-pQCT Z-scores were within 1 standard deviation of sex- and age-matched controls. BASDAI (- 33%, p < 0.01) and BASMI (- 22%, p = 0.01) improved, but there was no improvement in aBMD, TBS, or microarchitecture. By HR-pQCT, vBMD decreased (- 0.6%, p = 0.04), and cortical porosity increased (8.3%, p = 0.03). New vertebral fractures were not observed.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"73"},"PeriodicalIF":3.1,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost‑effectiveness analysis of fracture liaison services in Iran.","authors":"Abdoreza Mousavi, Rajabali Daroudi, Noushin Fahimfar, Afshin Ostovar, Ali Akbari Sari, Mozhdeh Zabihiyeganeh, Mohammad Javad Mansourzadeh, Fatemeh Hajivalizadeh, Bagher Larijani, Alireza Raeisi","doi":"10.1007/s11657-025-01555-y","DOIUrl":"https://doi.org/10.1007/s11657-025-01555-y","url":null,"abstract":"<p><p>This study evaluates the cost-effectiveness of a Fracture Liaison Service (FLS) compared to current practice for individuals aged 50 and older with fragility fractures in Iran. The FLS was associated with an additional cost of $50 and a gain of 0.03 QALYs, resulting in an incremental cost-effectiveness ratio of $1663 per QALY, demonstrating its cost-effectiveness.</p><p><strong>Purpose: </strong>This study aimed to assess the cost-effectiveness of a FLS program compared to current practice in Iran, from a societal perspective.</p><p><strong>Methods: </strong>The target population was patients aged 50 years or older with recent sentinel fragility fractures. Data were collected using various resources, including previously published literature, treatment guidelines, and hospitals. A state-based microsimulation model with a lifetime horizon was designed to simulate costs and quality-adjusted life years (QALYs). Treatment pathways for patients under current practice and FLS were compared using incremental cost-effectiveness ratios (ICERs).</p><p><strong>Results: </strong>For patients aged 50 years and older with a sentinel fragility fracture, FLS was associated with an incremental cost of $50 and a gain of 0.03 QALYs compared to current practice. Consequently, the ICER was estimated at $1663 per QALY gained, which is below the willingness-to-pay (WTP) threshold of one GDP per capita ($4466 per QALY). Simulations showed that comparing the current practice, FLS could prevent 59 new fractures and 10 related deaths per 1000 patients. The one-way sensitivity analysis indicated that treatment efficacy and medication costs exert the greatest influence on the ICER.</p><p><strong>Conclusion: </strong>The findings of this study demonstrate that FLS is cost-effective compared to current practice in Iran. Given the significant prevalence of osteoporosis and the increasing aging population in Iran, these results underscore the potential of FLS to enhance patient outcomes.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"72"},"PeriodicalIF":3.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can supplements with prebiotic fibres positively influence bone health in type 2 diabetes? Insights from a randomised controlled crossover trial.","authors":"Eline Birkeland, Wuraola Aduke Bamigbetan, Kristine Duus Molven, Per M Thorsby, Hanne L Gulseth, Anne-Marie Aas, Cecilie Dahl","doi":"10.1007/s11657-025-01556-x","DOIUrl":"10.1007/s11657-025-01556-x","url":null,"abstract":"<p><p>Inulin-type fructans did not significantly improve serum levels of calcium, magnesium, vitamin D, or bone turnover markers in people with type 2 diabetes (T2D). However, interactions between gut microbiota and bone health were suggested, indicating the need for further research in this population.</p><p><strong>Background: </strong>Evidence suggests that a healthy gut microbiome benefits bone health, especially in immunocompromised populations like the elderly and people with T2D.</p><p><strong>Objective: </strong>We investigated the effect of prebiotics (inulin-type fructans) on serum concentrations of calcium, magnesium, 25(OH) vitamin D, and the bone turnover markers N-terminal propeptide of type 1 collagen (P1NP), and C-terminal telopeptide of type 1 collagen (CTX-1) in people with T2D.</p><p><strong>Design: </strong>Participants (29) were treated for 6 weeks with 16 g inulin-type fructans and 16 g control supplement (maltodextrin) in randomised and double-blind crossover design, with a 4-week washout between treatments.</p><p><strong>Results: </strong>Compared to the control, inulin-type fructans did not significantly affect serum concentrations (mean ± SEM) of calcium (0.05 ± 0.02 mmol/L vs. 0.02 ± 0.03 mmol/L, p = 0.324), magnesium (0.02 ± 0.01 mmol/L vs. 0.00 ± 0.01 mmol/L, p = 0.352), 25(OH) vitamin D (-3.60 ± 1.94 nmol/L vs. -2.00 ± 1.97 nmol/L, P = 0.564), P1NP (0.81 ± 0.95 ug/L vs. -0.89 ± 0.97 ug/L, p = 0.210), or CTX-1 (-0.01 ± 0.01 ug/L vs. 0.00 ± 0.01 ug/L, p = 0.438). However, post hoc analyses of correlations between changes support that cross-talk between the human host and gut microbiota may influence bone health in this population.</p><p><strong>Conclusion: </strong>This study does not support that inulin-type fructans may improve serum levels of calcium, magnesium, or 25(OH) vitamin D, nor that they affect bone turnover markers in people with T2D over 6 weeks. Interactions between microbiota and bone health in this population warrants further investigations. The trial is registered at clinicaltrials.gov (NCT02569684).</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"71"},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital integration and sociocultural tailoring in standardized care-FracTurk: the national digital fracture liaison service database by the Turkish Osteoporosis Society.","authors":"Şansın Tüzün, Mustafa Hüseyin Temel, Zeynep Ülkü Akarırmak, Fatih Bağcıer, Yeşim Kirazlı, Yeşim Gökçe Kutsal, Dilşad Sindel","doi":"10.1007/s11657-025-01562-z","DOIUrl":"https://doi.org/10.1007/s11657-025-01562-z","url":null,"abstract":"<p><p>The FracTurk database integrates fracture liaison services with cultural and clinical practices in Türkiye, enhancing post-fracture care through digital tools. By tailoring treatment to the local context, it improves patient outcomes and reduces costs, with the potential to serve as a global model for culturally adapted healthcare solutions.</p><p><strong>Background: </strong>Fracture liaison services (FLS) are specialized programs that aim to identify, treat, and manage patients who have experienced fragility fractures, with the overarching goal of preventing future fractures. Recognizing the need for a culturally appropriate and coordinated approach, the Turkish Osteoporosis Society has developed FracTurk, a national digitized FLS database tailored to the unique cultural, socioeconomic, and healthcare landscape of Türkiye. This paper provides an overview of the FracTurk system, detailing its development, potential benefits, and significance while also offering insights into future considerations for this initiative. By prioritizing digitalization and standardization within the FLS system, we aimed to pave a smooth patient pathway, ensuring a seamless journey through post-fracture care.</p><p><strong>Material and methods: </strong>The FracTurk database was developed through a systematic process that involved the standardization and digitalization of patient follow-up forms and clinical practices across various institutions in Türkiye with international guidelines under the supervision of mentors certified by the International Osteoporosis Foundation, Capture the Fracture Initiative, which has been active for over 10 years in many countries. Additionally, the system incorporates clinical decision support tools and is customized to align with the Turkish cultural and healthcare landscape.</p><p><strong>Results: </strong>Since its launch, the FracTurk database has been actively utilized by 25 users across 23 centers, with over 731 registered patients. The system continues to expand, demonstrating high levels of adoption and growth, indicating its increasing relevance and impact within the Turkish healthcare system. During the launch, the major difficulties and limitations encountered by the centers were discussed.</p><p><strong>Conclusion: </strong>FracTurk constitutes a noteworthy step forward in digitizing and adapting FLS to the Turkish context. Although obstacles exist regarding data standardization and ensuring equitable access, the database demonstrates promise in enhancing patient outcomes, lowering healthcare expenditures, and serving as a template for other countries to emulate.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"70"},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical femoral fracture associated with sequential zoledronic acid and denosumab therapy: a case report.","authors":"Bo Zhang, Haijun Zhang, Qiaojie Chen, Yang Chen","doi":"10.1007/s11657-025-01558-9","DOIUrl":"https://doi.org/10.1007/s11657-025-01558-9","url":null,"abstract":"","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"69"},"PeriodicalIF":3.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of denosumab in lipid metabolism disorders: clinical significance and potential mechanisms","authors":"Yuan Lou,&nbsp;Huan Chen,&nbsp;Sijia Fei,&nbsp;Xinda Chen,&nbsp;Lixin Guo,&nbsp;Qi Pan","doi":"10.1007/s11657-025-01546-z","DOIUrl":"10.1007/s11657-025-01546-z","url":null,"abstract":"<div><h3>Purpose</h3><p>Lipid metabolism disorders, characterized by abnormal blood lipid levels, are central to the pathogenesis of obesity, nonalcoholic fatty liver disease (NAFLD), and atherosclerosis. These conditions increase the risk of type 2 diabetes, cardiovascular diseases (CVD), and stroke, highlighting the need for novel therapeutic approaches. Emerging evidence suggests a complex interplay between bone and lipid metabolism, with RANKL playing a key role. This review explores the potential of denosumab, a RANKL-targeting monoclonal antibody, in modulating lipid metabolism and its broader metabolic implications.</p><h3>Methods</h3><p>We conducted a comprehensive literature review to analyze the molecular mechanisms by which denosumab influences lipid metabolism, with a focus on the OPG/RANKL/RANK signaling pathway. Additionally, we examined the roles of immune modulation, bone marrow adipose tissue, and gut microbiota in metabolic diseases.</p><h3>Results</h3><p>Denosumab, primarily known for its anti-resorptive effects in osteoporosis, may also exert beneficial effects on lipid metabolism. Preclinical and clinical studies suggest its potential in ameliorating obesity, NAFLD, and atherosclerosis. The OPG/RANKL/RANK axis appears to mediate crosstalk between bone and metabolic pathways, while immune regulation and gut microbiota may further contribute to these effects.</p><h3>Conclusion</h3><p>Denosumab shows promise as a therapeutic agent for lipid metabolism disorders, though long-term metabolic effects remain unclear. Further research is needed to validate its efficacy and elucidate underlying mechanisms, which could pave the way for novel treatments targeting metabolic diseases.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological (secular) trends of pelvic and acetabular fractures (2006–2022) in South Korea using a nationwide cohort data over ages 50: is it osteoporosis related?","authors":"Byung-Ho Yoon,&nbsp;Tae-Young Kim,&nbsp;HoeJeong Chung,&nbsp;Jaiyong Kim,&nbsp;Jihye Kim,&nbsp;Hoyeon Jang,&nbsp;Young-Kyun Lee","doi":"10.1007/s11657-025-01549-w","DOIUrl":"10.1007/s11657-025-01549-w","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Osteoporotic pelvic and acetabular fractures (PAFs) rose significantly from 2006 to 2022, especially among those aged 80–89. Despite increased cases, one-year mortality rates declined from 7.29 to 4.59%. Findings highlight the need for early osteoporosis detection and targeted interventions to address aging demographics and evolving fracture trends.</p><h3>Purposes</h3><p>Osteoporotic fractures present a growing health challenge, especially in the context aging population. The purpose of our epidemiologic study was to determine the current trend in the number and incidence of pelvic and acetabular fractures (PAFs) providing an in-depth analysis of prevalence, demographic patterns, and related mortality.</p><h3>Methods</h3><p>This retrospective cohort study analyzed data from the National Health Insurance Review and Assessment claims database. Men and women who had pelvic and acetabular fractures, aged ≥ 50 years, between January 1 2006, and December 31 2022, were included. After proper identification using International Classification of Diseases, 10th revision (ICD-10) codes, we calculated absolute number and age-gender specific incidence rates for PAFs and one-year mortality rate following index fracture by sex and age groups.</p><h3>Results</h3><p>The total number of PAFs increased considerably during the study period, from 11,607 in 2006 to 35,691 in 2022, 207.5% per 16 years, an average increase of 12.9% a year. When analyzed by age groups, the total number of PAFs increased in all age groups, but showed the highest increase in 80–89. While the crude incidence of PAFs showed a consistency in 50–59, 60–69, and 70–79, a steady increase was noted in 80–89. The annual total mortality rates of PAFs within 1 year showed a decreasing trend from 7.29% in 2006 to 4.59% in 2022. When analyzed by age groups, the highest mortality rates were observed in the 80–89 age group, followed by 70–79, 60–69, and 50–59, with a consistent trend in the latter two age groups but a decreasing trend in the 80–89 age group.</p><h3>Conclusion</h3><p>The secular trend of PAFs reflects features typical of osteoporotic fractures, characterized by age- and gender-dependent pattern, while mortality rates are declining. With the increasing aggressive surgical interventions for PAFs, it is essential to detect osteoporosis early and implement targeted interventions for treatment and prevention in elderly patients.\u0000</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}