Archives of Osteoporosis最新文献

{"title":"Impact of the dietary antioxidant index on bone mineral density gain among mexican adults: a prospective study","authors":"Rogelio F. Jiménez-Ortega,&nbsp;Tania V. López-Pérez,&nbsp;Adriana Becerra‑Cervera,&nbsp;Diana I. Aparicio-Bautista,&nbsp;Nelly Patiño,&nbsp;Guadalupe Salas-Martínez,&nbsp;Jorge Salmerón,&nbsp;Rafael Velázquez‑Cruz,&nbsp;Berenice Rivera‑Paredez","doi":"10.1007/s11657-025-01518-3","DOIUrl":"10.1007/s11657-025-01518-3","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>In the Mexican population, low dietary antioxidant intake (DAI) is associated with reduced bone mineral density (BMD). A decline in DAI over time further contributes to BMD loss, particularly at the total hip, femoral neck, and lumbar spine, with a more pronounced effect in women over 45 years old.</p><h3>Purpose</h3><p>Bone remodeling, balancing resorption and formation, is crucial for bone health. Aging shifts this balance, reducing BMD and increasing osteoporosis risk. Reactive oxygen species (ROS) contribute to bone loss through oxidative stress. Antioxidants may help mitigate this damage, but their impact on BMD in populations with inadequate nutrient intake, like Mexicans, needs to be better understood. This study explores the association between DAI changes and BMD in a Mexican population.</p><h3>Methods</h3><p>Data were sourced from the Health Worker Cohort Study (HWCS), including 1,318 participants (aged ≥ 20) with BMD measurements and complete dietary information at two time points. The study employed a longitudinal design was used, whit data from two waves of the study (2010–2012 and 2017–2019), providing a median follow-up time of 6.4 years for men and 6.8 years for women. Dietary antioxidant intake was assessed using a validated Food Frequency Questionnaire for the Mexican diet. BMD was measured at the femoral neck, total hip, and lumbar spine using dual-energy X-ray absorptiometry (DEXA). Fixed-effects regression models were applied to analyze the association between DAI and BMD at different sites, adjusting for time-varying covariates.</p><h3>Results</h3><p>Changes in DAI scores were associated with lower BMD at various sites. Each unit decrease in DAI over time was associated with a BMD loss of -0.002,-0.004 g/cm² at the total hip, femoral neck, and lumbar spine. Notable declines were observed in women, particularly those over 45 years old, where specific antioxidant components, like zinc, magnesium, and selenium, were linked to lower BMD.</p><h3>Conclusion</h3><p>This study underscores the role of reduced dietary antioxidant intake in contributing lower BMD, particularly among older adults. Diets low in antioxidant may increase the risk of osteoporosis, especially in populations with insufficient nutrient intake.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01518-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An update in bone mineral density status in Spain: the OsteoSER study","authors":"Carmen Gómez-Vaquero,&nbsp;Marta Domínguez-Álvaro,&nbsp;Daniel Seoane-Mato,&nbsp;Pilar Peris Bernal,&nbsp;Santos Castañeda,&nbsp;Eduardo Kanterewicz Binstock,&nbsp;Ramón Mazzucchelli Esteban,&nbsp;Luis Arboleya Rodríguez,&nbsp;Miguel Bernard,&nbsp;Antonio Álvarez-Cienfuegos,&nbsp;Blanca Correa,&nbsp;Luis María Jiménez Liñán,&nbsp;Carmen Mateo Pascual,&nbsp;Ma Mercedes Molina del Rio,&nbsp;Mercedes Retamal Ortiz,&nbsp;Aida Fátima López Laguna,&nbsp;Ruth Molera Valero,&nbsp;Sara Alvar Pariente,&nbsp;Antonio Pascual-Vergara,&nbsp;Adolfo Arias Senso,&nbsp;Nuria Pérez Gutiérrez,&nbsp;Soledad García Frías,&nbsp;David Bouza Alvárez,&nbsp;Susana Sostrés,&nbsp;Daniel Suárez Hernandez,&nbsp;Ana Zamora Casal,&nbsp;Cristina García Ramírez,&nbsp;Enrique González-Dávila,&nbsp;on behalf of the OsteoSER Project Collaborative Group","doi":"10.1007/s11657-025-01520-9","DOIUrl":"10.1007/s11657-025-01520-9","url":null,"abstract":"<div><h3>Summary</h3><p>Bone mineral density (BMD) reference data for the Spanish population come from the Multicenter Research Project on Osteoporosis (MRPO) in 1989. The OsteoSER study updated Spanish BMD reference data, showing similarities with MRPO and NHANES III. Peak bone mass occurred at 20–39 years, positively associated with physical activity and negatively with smoking. Osteopenia affected 54.4%, and osteoporosis 10.7% of adults ≥ 50 years, with higher prevalence in women and increasing with age.</p><h3>Purpose</h3><p>This study aimed to estimate the distribution of BMD in lumbar spine, femoral neck, and total hip in the Spanish population aged ≥ 20 years and compare it with MRPO and NHANES III data.</p><h3>Methods</h3><p>A multicenter cross-sectional observational study was conducted in a White Spanish population aged 20–80 years across 12 urban and rural municipalities. Participants were selected by primary care physicians based on inclusion criteria (stratified by sex, age, and BMI) and exclusion criteria (artifacts in BMD imaging in participants of all ages and conditions affecting bone density in younger participants). A vehicle with a Hologic® Horizon W densitometer traveled to each municipality.</p><h3>Results</h3><p>A total of 1522 participants underwent densitometry (51.8% men). Peak bone mass is reached at ages 20–39 years in both sexes at all sites. BMD was positively associated with height, BMI, and physical activity and negatively with smoking (<i>p</i> &lt; 0.05). The distribution of BMD by age and sex was comparable to MRPO and NHANES III. We found that 54.4% of postmenopausal women and men ≥ 50 years had osteopenia, while osteoporosis was observed in 10.7%, with higher prevalence in women (18.6% vs. 2.6%) and increasing with age. Using MRPO criteria, osteoporosis prevalence rose to 14.8%.</p><h3>Conclusion</h3><p>The BMD of the OsteoSER study population is similar to that of MRPO and NHANES III. Physical activity positively influences peak bone mass, while smoking has detrimental effects.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weaker subchondral bone and thinner articular cartilage of the knee are associated with elevated baseline fracture risk independently of osteoarthritis risk factors","authors":"Andy K. O. Wong,&nbsp;Anthony Pokhoy,&nbsp;Ali M. Naraghi,&nbsp;Rakesh Mohankumar","doi":"10.1007/s11657-025-01517-4","DOIUrl":"10.1007/s11657-025-01517-4","url":null,"abstract":"<div><h3>Summary</h3><p>Knee osteoarthritis involves damaged bones beneath joint surfaces but how current bone health predicts future disease state is unclear. We discovered higher osteoporotic fracture risk (FRAX) was linked to compromised knee bone quality and thinner cartilage. Integrating FRAX into osteoarthritis care could identify who may develop worse disease outcomes.</p><h3>Objectives</h3><p>To examine how well fracture risk predicts subchondral bone and cartilage morphometry independently of osteoarthritis (OA) clinical risk factors.</p><h3>Methods</h3><p>Male and female participants in the Osteoarthritis Initiative (OAI) at visit 5 (36 months) were evaluated for fracture risk using FRAX and categorized into low-, moderate-, or high-risk groups. These groups were compared for bone marrow lesion (BML) size, number and effusion, subchondral bone structure, density, and cartilage morphometry in the most affected knee at either same time point, 1 or 2 years later, using general linear models. Sex interactions were examined in each case and probed if significant.</p><h3>Results</h3><p>Among 1240 participants (58.8% female, age: 63.7 ± 8.8 years, and BMI: 30.1 ± 4.9 kg/m²), 20.32% had moderate or high FRAX and showed lower subchondral bone density (− 0.12 to − 0.25 g/cm²), less intact trabeculae, and thinner cartilage (− 0.14 to − 0.47 mm) compared to low FRAX (<i>p</i> &lt; 0.05). Males showed larger positive FRAX correlations with bone density, and females had protective effects of FRAX against BML numbers, although the effects were small (sex interaction, <i>p</i> &lt; 0.05). All FRAX models adjusting for OA risk factors yielded better model fit than OA risk factors alone. Having moderate/high versus low FRAX at baseline predicted a 1.36 (1.00, 1.86)-fold higher odds of reaching a Kellgren-Lawrence score of 3 or 4 within a year.</p><h3>Conclusions</h3><p>High FRAX predicts thinner cartilage and weaker subchondral bone within a year. Complementing standard OA clinical risk factors with FRAX calculation could help identify individuals likely to develop worse knee OA radiologic outcomes.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trabecular bone score to assess bone microarchitecture in end-stage renal disease patients","authors":"Antoine Bouquegneau,&nbsp;François Jouret,&nbsp;Laurence Seidel,&nbsp;Catherine Bonvoisin,&nbsp;Laurent Weekers,&nbsp;Clio Ribbens,&nbsp;Olivier Bruyere,&nbsp;Etienne Cavalier,&nbsp;Pierre Delanaye,&nbsp;Olivier Malaise","doi":"10.1007/s11657-025-01519-2","DOIUrl":"10.1007/s11657-025-01519-2","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p><b>Rationale</b>: This study evaluates TBS for estimating bone microarchitecture in ESRD patients using HR-pQCT as the reference technique. <b>Main results</b>: TBS correlates significantly with vBMD and bone microarchitecture, unlike aBMD. <b>Significance</b>: TBS may complement bone health assessment in ESRD patients by offering additional information alongside aBMD.</p><h3>Purpose</h3><p>Given the high fracture risk, non-invasive techniques for assessing bone fragility in chronic kidney disease (CKD) remain important. Trabecular bone score (TBS) may provide additional information that could help guide treatment and follow-up decisions. The aim of this study is to investigate whether TBS reflects bone microarchitecture in end-stage renal disease (ESRD) patients, using high-resolution peripheral quantitative computed tomography (HR-pQCT) as the reference technique. Additionally, we aim to identify parameters associated with a low TBS.</p><h3>Methods</h3><p>Seventy-five ESRD patients were included at the time of kidney transplantation (KTx). Areal bone mineral density (aBMD) was analyzed using dual-energy X-ray absorptiometry (DXA). TBS was assessed from the L1-L4 area during DXA. Volumetric BMD (vBMD) and bone microarchitecture at tibia and radius sites were analyzed using HR-pQCT.</p><h3>Results</h3><p>In ESRD patients, those with TBS &lt; 1.370 were older and had a higher body mass index (BMI). In contrast to T-score-based classification (≤ -2.5 or &gt; -2.5), low TBS was linked to significantly lower trabecular and cortical vBMD, reduced trabecular bone volume fraction (BV/TV) and trabecular number (Tb.N), and increased trabecular separation (Tb.Sp). In multivariate analysis, older age, higher BMI, and lower Tb.N remained independently associated with low TBS, while no HR-pQCT parameters were linked to low aBMD (T-score ≤ -2.5).</p><h3>Conclusion</h3><p>TBS correlates with both trabecular and cortical parameters measured by HR-pQCT, potentially offering a complementary perspective on bone microstructure compared to aBMD. At the time of KTx, a low TBS appears to better discriminate patients with significantly lower vBMD than aBMD alone.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the FLS model on patients with major fracture in Gran Canaria: 2018–2022 experience","authors":"Antonio Naranjo,&nbsp;Cristian Sarmiento,&nbsp;Amparo Molina,&nbsp;Sonia Fuentes,&nbsp;Laura Cáceres,&nbsp;Soledad Ojeda","doi":"10.1007/s11657-025-01514-7","DOIUrl":"10.1007/s11657-025-01514-7","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>We analyzed 5396 patients with fragility fracture, their inclusion by the FLS, and prescription of treatment. Thirty-four percent of potential cases were attended by the FLS, and at the healthcare level, the impact of FLS model resulted in an increase of treated patients from 20% in standard care to 41%.</p><h3>Introduction</h3><p>Patients with fragility fractures are at high risk of new fractures, with a negative impact on their quality of life, as well as higher mortality and costs for the health system, especially for hip fractures. Less than 20% of patients receive treatment (lifestyle advice, calcium, vitamin D, and bisphosphonate) after a fracture. The fracture liaison service (FLS) is the most effective model for secondary prevention.</p><h3>Objectives</h3><p>To analyze the incidence of fragility fractures in the area of Gran Canaria North and the impact of the FLS unit on the prevention of new fractures.</p><h3>Methods</h3><p>Patients &gt; 50 years were attended at the emergency department for fractures of the proximal femur, proximal humerus, distal forearm, pelvis, or vertebra during the period 2018–2022 were included. A file was constructed containing demographic data, type of fracture, inclusion in the FLS, and the initiation of treatment to prevent new fractures. A sample of patients not treated at the FLS was selected for estimating the prophylaxis of fractures under standard care management.</p><h3>Results</h3><p>A total of 5396 patients were included, 74.2% women, with a mean age of 74 years. After excluding 558 traumatic fractures (10.3%), 318 (5.9%) deaths, and 167 (3.1%) cases due to a lack of criteria, the sample of potential patients who were candidates for FLS was 4353. This represented 80.6% of the initial sample, of which 1497 patients (34.4%) were attended at the unit. Factors independently associated with referral to the FLS were younger age (OR 0.97; 95% CI 0.97–0.98), female sex (OR 2.24; 95% CI 1.91–2.61), and humerus fracture (OR 1.34; 95% CI 1.16–1.55). Treatment to prevent fractures was verified in 1189 patients (79.4%) in the FLS group and in 585 (20.4%) of those with fragility fractures who were not included. At the healthcare level, the services provided by the FLS resulted in an increase in treated patients from 20% in standard care to 41% with the FLS model.</p><h3>Conclusions</h3><p>In terms of treatment initiation to new fracture prevention at the healthcare level, the FLS achieved a twofold increase. The high incidence of fractures and the progressive aging of the population underline the effectiveness of the FLS secondary prevention model.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01514-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing bone health with bisphosphonate therapies in pediatric osteogenesis imperfecta: a network meta-analysis of randomized trials","authors":"Ying-Yu Wang,&nbsp;Yu-Cheng Su,&nbsp;Pei-Chun Lai,&nbsp;Yen-Yin Chou,&nbsp;Po-Ting Wu,&nbsp;Meng-Che Tsai,&nbsp;Ta-Wei Tai,&nbsp;Chih-Hsing Wu,&nbsp;Yin-Fan Chang,&nbsp;Yu-Kang Tu,&nbsp;Ching-Ju Fang,&nbsp;Chii-Jeng Lin,&nbsp;Fa-Chuan Kuan,&nbsp;Kai-Lan Hsu,&nbsp;Chih-Kai Hong,&nbsp;Wei-Ren Su,&nbsp;Ming-Tung Huang,&nbsp;Chien-An Shih","doi":"10.1007/s11657-025-01515-6","DOIUrl":"10.1007/s11657-025-01515-6","url":null,"abstract":"<div><h3>Summary</h3><p>This study compares the efficacy of various bisphosphonate treatments for pediatric osteogenesis imperfecta (OI) in terms of lumbar spine areal bone mineral density (LS-aBMD), Z-scores, bone turnover markers (BTMs), fracture rates, and adverse events.</p><h3>Purpose</h3><p>The optimal bisphosphonate treatment for pediatric OI remains uncertain. This study aims to analyze the comparative effectiveness of different bisphosphonate therapies for children with OI.</p><h3>Methods</h3><p>A network meta-analysis (NMA) was conducted following PRISMA guidelines, screening clinical trials involving oral or intravenous bisphosphonate therapy in pediatric OI. The primary outcomes included changes in LS-aBMD and Z-scores over 1 and 2 years and fracture events. Secondary outcomes included BTM (uNTX/Cr) over 1 and 2 years and adverse event rates.</p><h3>Results</h3><p>The NMA included 9 RCTs with 595 children. For LS-aBMD changes, no bisphosphonates showed differences at 1 year; at 2 years, all active treatments improved LS-aBMD compared to placebo, with pamidronate showing greatest improvement (208.73 mg/cm², 95% CI 60.48, 356.98; CoE, moderate). Zoledronic acid demonstrated superior LS Z-scores at both 1 year (1.63 points, 95% CI 0.07, 3.19; CoE, low) and 2 years (1.37 points, 95% CI 0.95, 1.79; CoE, low). In the limited fracture analysis, only olpadronate reduced total fracture numbers compared to placebo (− 1.65, 95% CI − 3.05, − 0.26; CoE, moderate). For BTMs, all treatments reduced 1-year uNTX/Cr versus placebo, with only alendronate maintaining reduction at 2 years (− 182.38 nmol/mmol, 95% CI − 283.67, − 81.09; CoE, moderate). Zoledronic acid showed higher adverse event rates versus placebo (5.49, 95% CI 1.66, 18.19; CoE, low).</p><h3>Conclusion</h3><p>Among various bisphosphonates, pamidronate demonstrated superior improvements in LS-aBMD, while zoledronic acid achieved the most substantial Z-score gains but exhibited increased adverse event rates. Evidence gaps, particularly in direct comparative trials, limit definitive conclusions regarding fracture prevention and bone turnover markers. Future large-scale head-to-head trials comparing oral and intravenous formulations are essential to establish evidence-based treatment protocols for pediatric osteogenesis imperfecta.</p><p>Trial registration.</p><p>This research is registered with PROSPERO, registration number CRD42024571408.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143553830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hip fractures in older patients: analysing the activity of an orthopaedic department to design an optimized pathway of fracture care","authors":"H. Temido,&nbsp;E. Coeckelberghs,&nbsp;R. Ramalho,&nbsp;R. Cavaca,&nbsp;A. Henriques,&nbsp;F. Fonseca,&nbsp;P. Boto","doi":"10.1007/s11657-025-01513-8","DOIUrl":"10.1007/s11657-025-01513-8","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Substandard management of hip fractures in older patients has serious consequences in outcomes. Assessing care provided and institutional characteristics is essential to identify aspects to improve for better results. Delay to surgery, inadequate pain management, and delay in urinary catheter removal were especially inadequate and needed correction to better patient recovery.</p><h3>Introduction</h3><p>Hip fractures in older patients are a public health issue due to their prevalence and consequences. This study is an assessment of treatment currently provided to older patients with hip fractures in a tertiary hospital as a way of measuring standard care and guiding the design of a hospital-specific care pathway for the treatment of these patients.</p><h3>Methods</h3><p>A total of 250 patients over 65 years old were analysed. The overall population and its subgroups (early or late surgery and admitted to orthopaedic or non-orthopaedic ward) were characterized through descriptive statistical analysis, and the results were compared through inferential and regression analysis.</p><h3>Results</h3><p>Aspects requiring improvement were identified: inadequate pain management in the emergency department, increased time to surgery, excessive length of stay, increased time to first ambulation and to urinary catheter removal, medical complications and decrease in functional capacity at discharge. The mortality rate at discharge and up to 6 months was similar to what is described in the literature, in spite of the issues identified. Although further analysis is needed, some empirical reasons for these results are proposed.</p><h3>Discussion</h3><p>Some of the results described can be attributed to common hospital characteristics or non-modifiable patient characteristics but others can be corrected by suitable interventions.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of osteoporosis and vertebral fractures with T1- and T2-weighted MRI scans","authors":"Rahman Ud Din,&nbsp;Ling Wang,&nbsp;Xiaoguang Cheng,&nbsp;Haisheng Yang","doi":"10.1007/s11657-025-01509-4","DOIUrl":"10.1007/s11657-025-01509-4","url":null,"abstract":"<div><h3>Summary</h3><p>Osteoporosis is related to changes in vertebral bone marrow tissues, which can be detected by MRI. A novel MRI scoring method based on routine T1 and T2 sequences has been developed and demonstrated capabilities in detecting osteoporosis and discriminating vertebral fractures. The scoring method may provide an alternative tool other than BMD measurement for broad, opportunistic use in clinics.</p><h3>Purpose</h3><p>As a routinely used radiation-free modality at the spine, magnetic resonance imaging (MRI) is promising to assess osteoporosis because it can detect age- or osteoporosis-related changes in bone marrow tissues. Here, we proposed a new MRI scoring method using the patient’s low-back subcutaneous fat and cerebrospinal fluid as reference controls on routine T1 and T2 sequences, respectively, to indicate proton-rich changes in vertebrae for assessing osteoporosis and vertebral fractures.</p><h3>Methods</h3><p>The study included 60 female patients (64.1 ± 15.9 years) who underwent both MRI and quantitative computed tomography (QCT) at spine. T1-based F-score_sc.fat and T2-based W-score_cs.fluid were defined as the median signal intensity (SI) from L1 to L5 over their reference controls. QCT-measured vertebral BMD was used for defining osteoporosis. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic performances of the new scores for osteoporosis and vertebral fractures, which were also compared with L1–L5 signal-to-noise ratio (SNR_L1−L5) or SNR-based vertebral bone quality (VBQ) score.</p><h3>Results</h3><p>The F-score_sc.fat and W-score_cs.fluid increased significantly by 25.3% and 22%, respectively, in patients with osteoporosis compared to non-osteoporosis. Age was also found to be significantly different between non-osteoporosis and osteoporosis (49.92 and 74.03 years, <i>p</i> &lt; .001). ROC analysis indicated that F-score_sc.fat had a greater AUC value (0.85, <i>p</i> &lt; .001) than VBQ score (0.77) and SNR_L1−L5 (0.71) when being used to detect osteoporosis. For separating vertebral fractures from non-fractures, F-score_sc.fat resulted in the largest AUC value of 0.81 (<i>p</i> &lt; .001), compared to W-score_cs.fluid (0.74), VBQ (0.72), and SNR_L1−L5 (0.75).</p><h3>Conclusion</h3><p>A new MRI scoring method based on routine T1 and T2 sequences has been developed and demonstrated improved abilities in detecting osteoporosis and discriminating vertebral fractures over VBQ and SNR.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ukrainian guideline for the prevention and treatment of glucocorticoid-induced osteoporosis","authors":"N. V. Grygorieva,&nbsp;V. M. Kovalenko,&nbsp;M. O. Кorzh,&nbsp;M. D. Tronko,&nbsp;I. Yu. Golovach,&nbsp;N. V. Dedukh,&nbsp;D. G. Rekalov,&nbsp;S. S. Strafun,&nbsp;S. I. Smiyan,&nbsp;O. A. Golubovska,&nbsp;Ya.O. Dziublyk,&nbsp;N. V. Kharchenko,&nbsp;G. O. Protsenko,&nbsp;O. O. Garmish,&nbsp;V. L. Orlenko,&nbsp;F. V. Klymovytskyy,&nbsp;A. S. Musiienko,&nbsp;T. A. Karasevska,&nbsp;Ukrainian Association of Osteoporosis","doi":"10.1007/s11657-025-01512-9","DOIUrl":"10.1007/s11657-025-01512-9","url":null,"abstract":"<div><h3>Introduction</h3><p>Glucocorticoid-induced osteoporosis (GIOP) is a bone metabolic disorder caused by glucocorticoid (GC) use. It is one of the leading causes of secondary osteoporosis, increasing the risk of low-energy fractures, disability, and mortality. Although limited studies on GIOP epidemiology and treatment have been conducted in Ukraine, there were no national guidelines for its management. The aim was to create national guideline for the GIOP diagnosis, prevention, and treatment based on a comprehensive review of modern literature to enhance awareness within Ukraine’s medical community, improve disease management, and reduce its socio-economic impact.</p><h3>Materials and methods</h3><p>An Expert Group comprising 18 leading Ukrainian scientists from various fields was created for guideline development. A review of modern literature on GIOP epidemiology, risk factors, diagnosis, prevention, treatment, and monitoring was conducted. Evidence synthesis followed the <i>GRADE</i> methodology, and the quality of recommendations was critically evaluated using the <i>AGREE II tool</i>.</p><h3>Results</h3><p>The guideline comprises 12 statements covering GIOP screening, diagnosis, prevention, and treatment. We highlight the need to raise awareness among healthcare providers and patients about the potential effects of GC therapy. Also, we outline approaches to clinical assessment of osteoporotic fracture risk in GC users and detail diagnostic and therapeutic methods currently available in Ukraine for managing GIOP.</p><h3>Conclusion</h3><p>The first Ukrainian national GIOP guideline is critical for healthcare providers across specialities. Endorsed by the Board of the Ukrainian Association of Osteoporosis, it is recommended for use in routine clinical practice to enhance patient outcomes and mitigate the disease’s impact.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The management of osteoporosis in hospitalized patients with fragility hip fractures in western Saudi Arabia: a real-world tertiary center experience","authors":"Fayez S. Alharthy,&nbsp;Abdullah Almalki,&nbsp;Eman A. Alsindi,&nbsp;Saeed S. Majadah,&nbsp;Sahar S. Alahmadi,&nbsp;Renad F. Alharthy,&nbsp;Salwa B. Alaidarous","doi":"10.1007/s11657-025-01511-w","DOIUrl":"10.1007/s11657-025-01511-w","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Osteoporotic fractures, especially fragility hip fractures, are major causes of mortality and morbidity in the elderly. There is a significant gap in the diagnosis and treatment of osteoporosis in patients with fragility fractures. Vitamin D use increased by 18.2% post-admission, while calcium use rose by 21.1%. Additionally, the prescription of bisphosphonates, an osteoclast inhibitor, increased by 1.2% post-admission. The study highlights the urgent need for improved management practices and more proactive care strategies to address osteoporosis and its complications.</p><h3>Introduction</h3><p>Osteoporotic fractures are a major cause of fragility hip fractures, and in Saudi Arabia, the high prevalence of osteoporosis and high costs highlight the need for comprehensive care. This study aimed to evaluate the management of osteoporosis in hospitalized patients with fragility hip fractures in western Saudi Arabia.</p><h3>Methods</h3><p>This retrospective cohort study examined medical records from individuals with fragility hip fractures at King Abdulaziz Medical City in Saudi Arabia, Jeddah, from 2004 to 2024. Data was collected from electronic health records, including demographics, clinical features, comorbidities, fall history, osteoporosis diagnosis, and medication usage.</p><h3>Results</h3><p>The study included 314 patients, with a mean age of 73 years and 31.2% being between 71 and 80 years old. The majority were females, with a mean BMI of 26.6 kg/m². The most common comorbidity was renal failure. The prevalence of pre-admission diagnosis of osteoporosis was 14%. Post-admission DEXA-BMD use was reported by 16.6%. Vitamin D (41.1%) and calcium (42.4%) were higher in post-admission management compared to pre-admission management.</p><h3>Conclusion</h3><p>The study found that most hospitalized patients with fragility hip fractures were female, overweight, had a history of falls, and suffered from renal failure. This study opens new areas for future research that could increase our understanding of osteoporosis management.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}