Archives of Osteoporosis最新文献

{"title":"Antiresorptive injections in older adult patients with prior osteoporotic fractures: a real-world observational study","authors":"Chun-Feng Huang,&nbsp;Shiue-Ming Lin,&nbsp;Jason C. Hsu,&nbsp;Russell O. Kosik,&nbsp;Wing P. Chan","doi":"10.1007/s11657-025-01510-x","DOIUrl":"10.1007/s11657-025-01510-x","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Injectable antiresorptive drugs may reduce refracture risk in older adults with previous fractures, though further research is needed to explore related factors, including the crucial role of consistent adherence.</p><h3>Purpose</h3><p>Osteoporosis increases fracture risk, particularly in older adults. Spinal and hip fractures are common and costly complications. To examine the effectiveness of parenteral antiresorptive medications—denosumab and zoledronate—in reducing refracture rates among older adults with prior spinal or hip fractures.</p><h3>Methods</h3><p>A nationwide retrospective cohort study was conducted using data from Taiwan’s National Health Insurance Research Database (2011–2020). Patients aged 50 and older with spinal or hip fractures were divided into a treatment group (received zoledronate or denosumab) and a control group (no osteoporosis treatment). A 1:1 matching based on age, sex, and Charlson Comorbidity Index was performed. Kaplan–Meier method and Cox proportional hazards regression were used for analysis.</p><h3>Results</h3><p>Out of 23,331 eligible patients, 582 were in the treatment group and 17,281 in the control group. After matching, 211 patients received zoledronate and 367 received denosumab. The treatment group showed a trend toward lower refracture risk compared to the control group, though not statistically significant. Hazard ratios were 0.63 for zoledronate and 0.80 for denosumab, indicating potential benefits. There was no substantial difference between the two medications.</p><h3>Conclusion</h3><p>This is the first real-world study to assess the effectiveness of complete adherence to parenteral antiresorptive medications in reducing the risk of refractures among older adults with prior spinal or hip fractures. However, further research is needed to confirm these findings and investigate long-term effects.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the various physical activity patterns with low bone mineral density in Americans aged 20–60","authors":"Yi Wang,&nbsp;Ling Long,&nbsp;Lei Liu,&nbsp;Pan Fan,&nbsp;Xin Zheng,&nbsp;Xi Li,&nbsp;Yun-Tao Wang,&nbsp;Bao-Shan Xu,&nbsp;Yu-Ao Tao","doi":"10.1007/s11657-024-01479-z","DOIUrl":"10.1007/s11657-024-01479-z","url":null,"abstract":"<div><h3>Summary</h3><p>Through analyzing the data of the NHANES 2007–2020 cycle, this study concluded that high-intensity exercise 1–2 sessions a week can help maintain bone mass, and there is no significant difference from regular exercise more than 3 times a week.</p><h3>Purpose</h3><p>This study aims to explore the relationship between the various physical activity(PA) patterns and the risk of low bone mineral density(BMD) in Americans of working age.</p><h3>Method</h3><p>A total of 6482 participants aged 20–60 were selected from the National Health and Nutrition Survey (NHANES) conducted from 2007 to 2020. The PA data of the participants were obtained through individual interviews, and the participants were divided into four groups (inactive, insufficiently active, less frequent but sufficiently active(1–2 sessions a week and PA ≥ 150 min), and regularly active). Weighted logistic regression was used to analyze the correlation between PA patterns and the risk of low BMD. Subgroup analyses were applied to display the correlation between PA patterns and low BMD in different subgroups.</p><h3>Result</h3><p>After adjusting for confounding factors, the multiple logistic regression model showed that compared with inactive individuals, sufficiently active and regularly active individuals had a 35% (OR, 0.65; 95% CI, 0.46–0.92) and 24% (OR, 0.76; 95% CI, 0.62–0.93) lower risk of low BMD, respectively. Compared with regularly active adults, inactive adults had a 32% (OR, 1.32; 95% CI, 1.07–1.62) increased risk of low BMD, while sufficiently active individuals (OR, 0.85; 95% CI, 0.59–1.23) showed no significant difference compared with regularly active adults.</p><h3>Conclusion</h3><p>Compared with inactive adults, less frequent but sufficiently active adults have a lower risk of low BMD and showed benefits similar to those in regularly active groups. The sufficiently active pattern may become a new trend in modern working-age adults’ PA patterns.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The positive impact of a quality improvement collaborative on process indicators for geriatric hip fracture care","authors":"Ellen Coeckelberghs,&nbsp;Deborah Seys,&nbsp;Charlotte Lens,&nbsp;Kris Vanhaecht,&nbsp;Fien Claessens,&nbsp;Caroline Weltens,&nbsp;Dirk De Ridder,&nbsp;Eline Depuydt,&nbsp;Wim De Weerdt,&nbsp;Thierry De Baets,&nbsp;Jessy Eysackers,&nbsp;Stijn Hermans,&nbsp;Michiel Herteleer,&nbsp;Geert Leirs,&nbsp;Sofie Lynen,&nbsp;Frederik Matthys,&nbsp;Ben Molenaers,&nbsp;Alexander Mulliez,&nbsp;Christophe Pattyn,&nbsp;Jan Somers,&nbsp;Mike Tengrootenhuysen,&nbsp;Maxence Vanderkerckhove,&nbsp;Marleen Van Esbroeck,&nbsp;Kyri Van Hecke,&nbsp;Eline Van Hove,&nbsp;Stefaan Nijs,&nbsp;An Sermon","doi":"10.1007/s11657-025-01504-9","DOIUrl":"10.1007/s11657-025-01504-9","url":null,"abstract":"<div><h3>Summary</h3><p>Adherence to guidelines for geriatric patients with a hip fracture is challenging. With this study, adherence to important quality indicators in geriatric hip fracture care was improved. A quality improvement collaborative including benchmarking and knowledge sharing showed to be effective in improving quality of care.</p><h3>Background</h3><p>Adherence to guidelines for geriatric patients with an osteoporotic hip fracture is challenging. Therefore, the aim of this study was to improve the adherence to quality indicators (QIs) for these patients using benchmarking and knowledge sharing.</p><h3>Method</h3><p>A prospective multicenter study was initiated throughout 19 hospitals in Flanders, Belgium. Adherence to 23 QIs was measured. Two retrospective audits (based on patient record analyses) were conducted in 2018–2019 (measurement period (MP) 1) and 2021 (MP 2). Between both audits, anonymous benchmarking was provided to the participating centers and three educative sessions on specific topics were performed.</p><h3>Results</h3><p>A total of 1044 patients were included in the study. At MP 1, QIs showing the lowest adherence rates were the administration of nerve blocks, steroids, and tranexamic acid, applied in only 8.0%, 9.7% and 22.2% of the patients, respectively. At MP 2, these adherence rates significantly improved up to 25.4%, 26.4% and 30.7%, respectively (<i>p</i> &lt; 0.001). The indication of the start of discharge planning also significantly improved between both periods (89.3% in MP 1 vs. 93.7% in MP 2, <i>p</i> = 0.043), while the avoidance of intra-operative hypotension was less well realized (56.2% in MP 1 vs. 52% in MP2, <i>p</i> = 0.026). Overall adherence significantly increased from 61.7 to 64.5% (<i>p</i> &lt; 0.001). Delirium was significantly reduced (from 22.1% in MP 1 to 17.4% in MP 2, <i>p</i> = 0.030).</p><h3>Conclusion</h3><p>Benchmarking in combination with a peer-reviewed and knowledge sharing intervention increases the adherence to quality indicators for patients with a geriatric hip fracture.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of imminent osteoporotic fracture risk in Danish postmenopausal women—can the addition of self-reported clinical risk factors improve the prediction of the register-based FREM algorithm?","authors":"Emilie Rosenfeldt Christensen,&nbsp;Kasper Westphal Leth,&nbsp;Frederik Lykke Petersen,&nbsp;Tanja Gram Petersen,&nbsp;Sören Möller,&nbsp;Bo Abrahamsen,&nbsp;Katrine Hass Rubin","doi":"10.1007/s11657-024-01493-1","DOIUrl":"10.1007/s11657-024-01493-1","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Obtaining accurate self-reports on clinical risk factors, such as parental hip fracture or alcohol and tobacco use, limits the utility of conventional risk scores for fracture risk. We demonstrate that fracture-risk prediction based on administrative health data alone performs equally to prediction based on self-reported clinical risk factors.</p><h3>Background</h3><p>Accurate assessment of fracture risk is crucial. Unlike established risk prediction tools that rely on patient recall, the Fracture Risk Evaluation Model (FREM) utilises register data to estimate the risk of major osteoporotic fracture (MOF). We investigated whether adding self-reported clinical risk factors for osteoporosis to the FREM algorithm improved the prediction of 1-year fracture risk by comparing three approaches: the FREM algorithm (FREM^orig), clinical risk factors (CRF^only), and FREM combined with clinical risk factors (FREM-CRF).</p><h3>Method</h3><p>Clinical risk factor information was obtained through questionnaires sent to women aged 65–80 years living in the Region of Southern Denmark in 2010, who participated in the Risk-stratified Osteoporosis Strategy Evaluation study. Register data was obtained through national health registers and linked to the survey data. Positive and negative predictive values and concordance statistics were calculated for the performance of each approach using logistic regression and Cox proportional hazards models.</p><h3>Results</h3><p>Of the 18,605 women included, 280 sustained a MOF within 1 year. All three approaches performed similarly in 1-year fracture risk prediction for low- and high-risk individuals. However, the FREM^orig and FREM-CRF approach slightly overestimated fracture risk for medium-risk individuals.</p><h3>Conclusion</h3><p>Adding self-reported clinical data to FREM did not increase precision in predicting 1-year MOF risk. The discrimination of FREM^orig was similar to that of CRF^only, suggesting it may be possible to estimate fracture risk with the same precision by using register data instead of self-reported risk information. Register-based prediction models may be applicable in individualised risk monitoring or large-scale osteoporosis screening programmes.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-024-01493-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143361650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tea consumption and bone health in postmenopausal women: a systematic review and meta-analysis","authors":"Minjun Zhang,&nbsp;Shuxia Li,&nbsp;Shishi Wu,&nbsp;Dang Zhou,&nbsp;Mengni Lu,&nbsp;Chuyan Lin,&nbsp;Chengjiang Liu,&nbsp;Qingmei Xie","doi":"10.1007/s11657-025-01506-7","DOIUrl":"10.1007/s11657-025-01506-7","url":null,"abstract":"<div><h3>Objective</h3><p>The impact of tea on bone health in postmenopausal women has generated conflicting opinions. The current study pooled previous research to evaluate the relationship between tea consumption and bone health in postmenopausal women.</p><h3>Methods</h3><p>Relevant papers published before October 2024 were included by conducting a comprehensive literature search in the Embase, PubMed, Scopus, and The Cochrane Library databases. Observational studies reporting the association between tea consumption and bone mineral density (BMD) or the risk of osteoporosis and fractures in women after menopause were deemed eligible. The weighted mean difference (WMD) for BMD and the pooled odds ratio (OR) for osteoporosis and fractures were calculated, together with their corresponding 95% confidence intervals (CIs).</p><h3>Results</h3><p>The meta-analysis examined 18 studies with a total of 48,615 individuals. The combined results indicated that postmenopausal women who consumed tea had higher BMD at several skeletal sites, including the lumbar spine (WMD, 0.02; 95% CI, 0.01–0.04; <i>P</i> &lt; 0.001), greater trochanter (WMD, 0.02; 95% CI, 0.02–0.03; <i>P</i> &lt; 0.001), femoral neck (WMD, 0.01; 95% CI, 0.00–0.02; <i>P</i> = 0.049), and ward’s triangle (WMD, 0.02; 95% CI, 0.01–0.03; <i>P</i> = 0.002). Additionally, these women had a lower risk of osteoporosis (OR, 0.41; 95% CI, 0.26–0.67; <i>P</i> &lt; 0.001) and fracture (OR, 0.81; 95% CI, 0.67–0.98; <i>P</i> = 0.031).</p><h3>Conclusions</h3><p>The findings of this meta-analysis suggest that postmenopausal women who regularly consumed tea saw an increase in BMD and a decreased likelihood of developing osteoporosis and experiencing fractures. Future research should give priority to conducting prospective cohort studies with a more stringent methodology to verify the dose–response connection between tea consumption and the risk of osteoporosis or fracture in postmenopausal women.</p><p>Systematic review registration: PROSPERO registration number CRD42019112196.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased risk of mortality in lung transplant patients with fragility fractures","authors":"Marine Forien,&nbsp;Vincent Bunel,&nbsp;Anna Moltó,&nbsp;Kinan El Husseini,&nbsp;Hervé Mal,&nbsp;Esther Ebstein,&nbsp;Pierre Antoine Juge,&nbsp;Sébastien Ottaviani,&nbsp;Philippe Dieudé","doi":"10.1007/s11657-025-01502-x","DOIUrl":"10.1007/s11657-025-01502-x","url":null,"abstract":"<div><h3>Summary</h3><p>Osteoporosis and fragility fractures are frequent complications of lung transplantation patients. Among 131 patients included, 35 (26.5%) patients had a diagnosis of fractures after transplantation. Low bone mineral density was associated with fractures. Fractures post transplantation were identified as an independent risk factor for overall mortality.</p><h3>Introduction</h3><p>The prevalence of osteoporosis among lung transplant candidates has been estimated at 31% to 46%, and significant bone loss occurs after lung transplantation, predominantly in the first year, with increased risk of incident fractures. This study aimed to evaluate the prevalence of fragility fractures in a population of lung transplant recipients and the associated risk factors as well as mortality after a fragility fracture.</p><h3>Patients and methods</h3><p>This was a cross-sectional monocentric study that included patients with lung transplantation occurring &lt; 10 years and &gt; 1 year who were undergoing lung transplantation monitoring. All patients underwent bone mineral density evaluation by dual-energy X-ray absorptiometry and radiography to establish the presence of vertebral fractures. Mortality was assessed 2 years after the last inclusion.</p><h3>Results</h3><p>We included 131 patients (82 men, 62.6%), with mean age 56.8 ± 10.8 years. The mean time from lung transplantation to inclusion was 3.5 ± 3.5 years. Overall, 35 (26.5%) patients had a diagnosis of fractures after transplantation; 67 fractures were confirmed (average of 2 per patient), including 48 (71.6%) vertebral fractures. Odds of low bone mineral density at the femoral neck, total hip and spine was associated with fracture: odds ratio 0.007 [0.0002–0.3], 0.001 [0.0002–0.05], and 0.03 [0.001–0.6], respectively. Fracture post transplantation was significantly associated with death (hazard ratio 2.32 [1.01–5.33]).</p><h3>Conclusion</h3><p>This study confirmed a high prevalence of vertebral fracture in lung transplant patients. Fracture after lung transplant was associated with mortality. Bone fragility needs more attention to reduce the fracture risk.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum hemoglobin level and bone mineral density in adults: Iranian multi-center osteoporosis study (IMOS)","authors":"Mohammad amin Khadembashiri,&nbsp;Shahrzad Mohseni,&nbsp;Amirhossein Aghakhani,&nbsp;Kazem Khalagi,&nbsp;Mohammad Javad Mansourzadeh,&nbsp;Mahnaz Pejman Sani,&nbsp;Mohammadreza Mohajeri-Tehrani,&nbsp;Farshad Farzadfar,&nbsp;Noushin Fahimfar,&nbsp;Afshin Ostovar","doi":"10.1007/s11657-025-01507-6","DOIUrl":"10.1007/s11657-025-01507-6","url":null,"abstract":"<div><h3>Summary</h3><p>The associations between serum hemoglobin (Hb) levels and bone mineral density (BMD) were investigated in population of the 4th Iranian Multicenter Osteoporosis Study (IMOS). A positive relationship between Hb levels and BMD at hip and femoral neck were detected only in men.</p><h3>Purpose</h3><p>Previous studies have investigated the relationship between hemoglobin (Hb) levels and bone mineral density (BMD) with controversial findings. This study aimed to evaluate this association using data from the 4th Iranian Multicenter Osteoporosis Study (IMOS), a population-based national survey, including a population sample aged 50 years and older.</p><h3>Methods</h3><p>The present study was conducted as a cross-sectional data analysis derived from the fourth round of the IMOS. Demographic information, Hb levels, and BMD measurements were collected. BMD was measured with dual-energy X-ray absorptiometry (DXA). Low BMD (osteopenia/osteoporosis) and osteoporosis were defined as a T-score less than -1 and less than -2.5 at each site including hip, femoral neck, or lumbar spine, respectively. Multiple linear regression analysis was used to assess the relationship between Hb levels and BMD.</p><h3>Results</h3><p>This study included 1,426 participants (54.2% female) with the mean age of 62.6 ± 8.0 years. The mean Hb levels among patients with or without osteoporosis were 12.9 ± 2.0 mg/dl and 13.1 ± 1.9 mg/dl, respectively (p-value = 0.08). It was demonstrated a positive relationship between Hb levels and BMD at hip (β = 0.0079, 95% CI: 0.002- 0.0135, p-value = 0.006) and femoral neck (β = 0.0064, 95% CI: 0.0015- 0.0113, p-value = 0.01) in only men. However, there was no significant correlation between Hb levels with low BMD and osteoporosis in either gender.</p><h3>Conclusion</h3><p>Our findings showed a favorable relationship between Hb levels and BMD at the hip and femoral neck, particularly in men. This highlights gender and site-specific distinctions between hematological and skeletal health..Future studies should unravel these possible associations and investigate the underlying mechanisms.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of denosumab and zoledronic acid on postmenopausal osteoporosis, bone density, and fat-free mass","authors":"Jeonghoon Ha,&nbsp;Jinyoung Kim,&nbsp;Chaiho Jeong,&nbsp;Jeongmin Lee,&nbsp;Yejee Lim,&nbsp;Ki-Hyun Baek","doi":"10.1007/s11657-024-01475-3","DOIUrl":"10.1007/s11657-024-01475-3","url":null,"abstract":"<div><h3>Summary</h3><p>This study compared denosumab and zoledronic acid for treating osteoporosis in drug-naïve postmenopausal Korean women. Over 3 years, both drugs significantly increased bone mineral density. However, denosumab also improved fat-free mass, suggesting it may be a better initial treatment for osteoporosis with low muscle mass, assuming all other conditions remain constant.</p><h3>Background</h3><p>Denosumab (DMAB) and zoledronic acid (ZOL), which are strong antiresorptive agents, are used to treat osteoporosis in postmenopause. Nonetheless, the data on their comparative efficacy in drug-naïve patients remain limited. Our research compared the therapeutic efficacy of DMAB and ZOL in drug-naïve postmenopausal Korean women with osteoporosis.</p><h3>Methods</h3><p>In total, 120 women were enrolled and equally divided to the DMAB and ZOL groups. The bone density and biochemical parameters of the patients were monitored over 3 years. Furthermore, the changes in fat-free mass (FFM), which comprises muscle mass, were assessed by bioelectric impedance analysis. Baseline characteristics, including age, BMI, and the prevalence of fractures, were similar between the groups at the onset of the study. Serum 25(OH), calcium and, phosphorus levels and baseline bone mineral density (BMD) were also comparable between the groups.</p><h3>Results</h3><p>Following 3 years of treatment, both groups exhibited a significant increase in BMD versus the baseline value. In particular, BMD increased by 9.7% and 5.1% at the lumber spine and total hip, respectively, in the DMAB group, versus increases of 7.1% and 4.4%, respectively, in the ZOL group. The increase in FFM was greater in the DMAB group. BMI-adjusted FFM decreased by 1.3% in the ZOL group, versus an increase of 3.6% in the DMAB group.</p><h3>Conclusions</h3><p>Conclusively, both DMAB and ZOL are effective antiresorptive agents that improved BMD over 3 years in drug-naïve individuals. Moreover, DMAB might represent a more reliable initial option for patients with osteoporosis accompanied by low muscle mass.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing healthcare disparities and improving osteoporosis management in rural communities: a cluster randomized control trial","authors":"Shau-Huai Fu,&nbsp;Wei-Jhen Lai,&nbsp;Hung-Kuan Yen,&nbsp;Shikha Kukreti,&nbsp;Chung-Yi Li,&nbsp;Chih-Chien Hung,&nbsp;Chen-Yu Wang","doi":"10.1007/s11657-025-01498-4","DOIUrl":"10.1007/s11657-025-01498-4","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Rural communities face healthcare challenges. This study assessed a multicomponent intervention to improve hospital visits and anti-osteoporosis medication (AOM) treatment rates. A total of 567 patients were randomized into three groups. Results showed significant improvements in hospital attendance and AOM treatment in intervention groups compared to usual care group.</p><h3>Purpose</h3><p>Rural communities face limited healthcare access, financial constraints, and transportation barriers leading to health disparities. This study examined interventions that reduced health disparities in increasing the outpatient attendance and treatment rate of anti-osteoporosis medication (AOM), while identifying factors contributing to therapy refusal in rural communities.</p><h3>Methods</h3><p>A total of 567 patients were randomized at the community level into three groups: multicomponent integrated care (MIC), osteoporosis care only (OC), and usual care (UC). Fracture Risk Assessment Tool and dual-energy X-ray absorptiometry scans were used to evaluate the osteoporosis and osteoporotic fracture risk. High- and moderate-risk patients were advised to pursue further hospital-based assessments and treatment. Both the MIC and OC groups received five interventions to address rural barriers, including specialist access, disease education, overcoming transportation barriers, peer support, and dedicated case managers. However, UC excluded transportation assistance, peer support, and case management. Outcomes measured included outpatient attendance, AOM treatment rates, and factors affecting hospital assessment refusal, analyzed via multivariable logistic modeling.</p><h3>Results</h3><p>In the MIC group, 73.3% of patients attended the outpatient clinic and 58.6% received AOM. In the OC group, 81% patients attended and 69.3% received AOM. Conversely, in the UC group, only 4.1% attended and received AOM. Significant differences in attendance and AOM rates were found between the MIC and UC groups and between the OC and UC groups (<i>p</i> &lt; .001 for both). Common barriers included beliefs that treatment was unnecessary and lack of hospital access. Risk factors hindering outpatient attendance include male sex, low education, low budget, multiple disabilities, and osteopenia diagnosis.</p><h3>Conclusion</h3><p>Addressing transportation barriers and implementing dedicated case management are crucial for improving healthcare access among rural patients.</p><h3>Trial registration</h3><p>ClinicalTrials.gov NCT05104034.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing loss and risk of major osteoporotic fracture: a population-based cohort study in the United Kingdom","authors":"Sara Khalid,&nbsp;Daniel Prieto Alhambra,&nbsp;Seyed Alireza Hasheminasab,&nbsp;Yana Vinogradova,&nbsp;Nadeem Qureshi,&nbsp;Michaela Ratzinger,&nbsp;Vanessa Brunetti,&nbsp;Adrian Salas,&nbsp;Laura Canals","doi":"10.1007/s11657-024-01484-2","DOIUrl":"10.1007/s11657-024-01484-2","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Using the UK Clinical Practice Research Datalink, our cohort study matched 237,297 individuals with hearing loss (HL) to 829,431 without HL. The study found an 8–10% higher risk of major osteoporotic fracture in individuals with HL compared to those without. Additionally, within the HL cohort, we identified risk factors for potential inclusion in fracture risk models.</p><h3>Purpose</h3><p>Assess association between hearing loss (HL) and major osteoporotic fracture (MOF; spine, wrist/forearm, shoulder/proximal humerus, hip) in individuals aged ≥ 60 years, and risk factors for MOF in individuals with HL.</p><h3>Methods</h3><p>From the UK Clinical Practice Research Datalink, our cohort study matched individuals aged ≥ 60 years diagnosed with HL (READ/ICD-10 codes; 01January2001–31December2021; index event), without secondary osteoporosis causes, with up to five individuals without HL (birth, index year, sex, general practice). Incidence rates and Cox proportional hazard ratios (HL vs. no HL; stratified by low/high fracture risk) were calculated for MOF and hip fracture; multivariate logistic regression assessed risk factors for MOF and hip fracture (HL cohort).</p><h3>Results</h3><p>A total of 237,297 individuals with HL matched to 829,431 without HL, with a median age of 74 and 72 years, respectively. Compared with those without HL, individuals with HL had greater frailty (severe electronic frailty index, 5.9% vs. 2.7%), higher incidence of prior falls (14.1% vs. 10.6%), longer mean follow-up with higher incidence of MOF and hip fractures (5.1 vs. 4.4 years, 20.1 and 5.32 vs. 16.58 and 4.54 per 1000 person-years, respectively) and higher risk of MOF and hip fracture (adjusted HR, 1.10 and 1.08, respectively). Significant risk factors for MOF and hip fracture included age ≥ 70 years, fracture history, falls, osteoporosis diagnosis, chronic obstructive pulmonary disorder and cardiovascular disease (HL cohort).</p><h3>Conclusion</h3><p>In individuals with HL, we observed an 8–10% higher risk of MOF and hip fracture versus individuals without HL and identified risk factors for potential inclusion in fracture risk models.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}