利用超低剂量胸部CT评估囊性纤维化患者的骨密度。

IF 2.8 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Sahil Shet, Catherine Henry, Mairead O'Donnell, Eid Kakish, Muhammad Ghauri, Patrick O'Regan, Kevin Deasy, Hisham Ibrahim, Michael Maher, Barry Plant, David J Ryan
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引用次数: 0

摘要

在这项研究中,我们使用常规的超低剂量计算机断层扫描囊性纤维化患者来预测骨密度(BMD)。胸椎小梁骨的衰减与股骨近端和腰椎的骨密度之间有很强的相关性。目的:骨质疏松症是一个严重的全球健康问题,全世界有数百万人受到影响。囊性纤维化(CF)患者是骨质疏松症的易感人群。骨密度(BMD)通常用双能x射线吸收仪(DEXA)扫描测量;然而,这是以医疗系统和暴露于电离辐射为代价的。在我们的机构,囊性纤维化患者接受常规超低剂量计算机断层扫描(ULDCT)以监测疾病进展。本研究的目的是评估使用ULDCT扫描数据估计BMD的有效性。方法:纳入成人CF患者,如果他们在DEXA扫描后12个月内进行了常规ULDCT扫描。另外,选择100例非cf患者进行非对比剂标准剂量CT扫描作为对照组。在Hounsfield单位(HU) PACS上测量T4、T7和T10的骨小梁密度(T-BD),并与DEXA扫描结果和用于预测骨密度的公式进行比较。结果:女性52例,男性62例,平均年龄34.4岁,平均年龄35.1岁。结论:在ULDCT上测量T-BD可能是早期识别CF患者骨质疏松风险的一种有价值的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Opportunistic assessment of bone mineral density in cystic fibrosis patients using ultra-low dose thoracic CT.

In this study, we used routine ultra-low dose computed tomography scans of patients with cystic fibrosis to predict bone mineral density (BMD). A strong correlation was found between the attenuation of trabecular bone in thoracic vertebrae and the BMD in the proximal femur and lumbar spine as measured on DEXA.

Purpose: Osteoporosis is a serious global health concern with millions of people affected worldwide. A particularly vulnerable cohort in developing osteoporosis are patients with cystic fibrosis (CF). Bone mineral density (BMD) is typically measured with dual energy X-ray absorptiometry (DEXA) scanning; however, this comes at a cost to the healthcare system and an exposure to ionising radiation. In our institution, patients with cystic fibrosis undergo routine ultra-low dose computed tomography (ULDCT) for monitoring of disease progression. The aim of this study was to assess the validity of estimating BMD using data derived from ULDCT scans.

Methods: Adult CF patients were included if they had undergone a routine ULDCT scan within 12 months of a DEXA scan. Additionally, 100 non-CF patients with non-contrast standard dose CT scans were selected to act as the control group. Trabecular bone density (T-BD) at T4, T7 and T10 was measured on PACS in Hounsfield units (HU) and compared to DEXA scan results and a formula developed to the predict BMD.

Results: Fifty-two female and 62 male patients were included with mean ages of 34.4 and 35.1 respectively. Moderately strong correlation was found between the T-BD and BMD of both the lumbar spine (r = 0.629, p < 0.001) and proximal femur (r = 0.649, p < 0.001). Receiver operator characteristic (ROC) curve analysis found a sensitivity and specificity of 0.700 and 0.714 respectively at predicting osteoporosis at T-BD of 193.33 HU or below.

Conclusion: T-BD measured on ULDCT may be a valuable tool in the early identification of CF patients at risk of osteoporosis.

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来源期刊
Archives of Osteoporosis
Archives of Osteoporosis ENDOCRINOLOGY & METABOLISMORTHOPEDICS -ORTHOPEDICS
CiteScore
5.50
自引率
10.00%
发文量
133
期刊介绍: Archives of Osteoporosis is an international multidisciplinary journal which is a joint initiative of the International Osteoporosis Foundation and the National Osteoporosis Foundation of the USA. The journal will highlight the specificities of different regions around the world concerning epidemiology, reference values for bone density and bone metabolism, as well as clinical aspects of osteoporosis and other bone diseases.
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