Archives of Osteoporosis最新文献

{"title":"Risk of fragility fracture of pelvis in endometrial cancer survivors : A national claim database study","authors":"Ki-Tae Park,&nbsp;Jung-Wee Park,&nbsp;Dong-Hoon Lee,&nbsp;Ye Jhin Jeon,&nbsp;Jean Kyung Bak,&nbsp;Bit-Na Yoo,&nbsp;Youn Kyung Chung,&nbsp;Byung-Ho Yoon,&nbsp;Young-Kyun Lee","doi":"10.1007/s11657-025-01577-6","DOIUrl":"10.1007/s11657-025-01577-6","url":null,"abstract":"<div><h3>Summary</h3><p>This study investigates the incidence and risk factors of pelvic fragility fractures in endometrial cancer survivors using a national claims database. The incidence was 0.6%, with older age as a significant risk factor. These findings emphasize the need for careful detection and management to improve outcomes.</p><h3>Purpose</h3><p>This study aimed to evaluate the incidence of fragility fracture of pelvis (FFP) in endometrial cancer survivors and identify associated risk factors using data from the Korean National Claims Database.</p><h3>Methods</h3><p>A total of 6923 endometrial cancer patients were identified between 2007 and 2016 using data from the linkage between the Korea National Health Insurance Service and Korea Central Cancer Registry. The incidence of FFP was estimated and risk factors, such as age, radiation therapy (RT) status, medical institution type, residential area, income level, insurance type, and comorbidities, were assessed using a Cox proportional hazards regression.</p><h3>Results</h3><p>The overall incidence of FFP was 0.6%, with a higher incidence in patients who underwent RT (0.8%) compared to those who did not (0.5%). However, the difference was not statistically significant (<i>P</i> = 0.355). Older age was significantly associated with an increased risk of FFPs (adjusted HR = 1.101, 95% CI 1.066–1.138; <i>P</i> &lt; 0.001).</p><h3>Conclusions</h3><p>The incidence of FFP in endometrial cancer survivors was 0.6%, with a slightly higher rate in those who received RT. Older age was a significant risk factor of FFP. These findings emphasize the need for careful detection and management of FFP, particularly in older patients, to improve long-term outcomes in endometrial cancer survivors.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical insights into the role of smoking, diabetes, and rheumatoid arthritis in osteoporotic fractures","authors":"Md. Saddam Hussain,&nbsp;Tarequl Islam,&nbsp;Md. Safiqul Islam,&nbsp; Danishuddin,&nbsp;Md Azizul Haque","doi":"10.1007/s11657-025-01575-8","DOIUrl":"10.1007/s11657-025-01575-8","url":null,"abstract":"<div><h3>Background</h3><p>Osteoporotic fractures pose a significant public health challenge, with various risk factors contributing to their incidence. Smoking, diabetes mellitus (DM), and rheumatoid arthritis (RA) are known to disrupt bone metabolism and increase fracture susceptibility. Moreover, smoking is a well-known risk factor of DM and RA, and thereby imposes a greater impact on osteoporotic fractures. This review explores the impact of these conditions on osteoporotic fractures, emphasizing the underlying mechanisms and clinical implications.</p><h3>Methods</h3><p>A comprehensive literature review was conducted to examine the biochemical and physiological effects of smoking, DM, and RA on bone metabolism. The review focused on key regulatory pathways, including the role of parathyroid hormone (PTH), vitamin D, receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), and inflammatory cytokines.</p><h3>Results</h3><p>Smoking contributes to osteoporotic fractures by altering bone metabolism through multiple mechanisms, including dysregulation of PTH, vitamin D, and the RANKL/OPG balance. RA disrupts bone homeostasis by increasing osteoclast activity, reducing osteoblast function, and elevating pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α. Additionally, RA treatment with glucocorticoids further impairs calcium balance and bone integrity. DM accelerates bone resorption by upregulating osteoclastogenic factors (e.g., TNF-α, VEGF, RANKL) and suppressing osteoblastogenic pathways (e.g., Runx2). It also reduces essential bone-forming substances, including PTH and osteocalcin, while promoting the accumulation of advanced glycation end-products and adiposity, both of which negatively impact bone health.</p><h3>Conclusions</h3><p>Smoking, DM, and RA significantly contribute to osteoporotic fractures by disrupting bone metabolism through direct biochemical alterations and treatment-related effects. Furthermore, smoking exacerbates both DM and RA, compounding the risk of fractures. Effective clinical management of these risk factors is essential to reducing the burden of osteoporotic fractures and improving patient outcomes.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidity burden, management, and in-hospital outcomes in centenarians with proximal hip fracture: a nationwide cohort study (2004–2020)","authors":"Juan Carlos Piñeiro-Fernández,&nbsp;Ramón Rabuñal-Rey,&nbsp;Eva Romay-Lema,&nbsp;David Rubal-Bran,&nbsp;Cristina Pedrosa-Fraga,&nbsp;Ana María Santos-Martínez,&nbsp;Yoana Besteiro-Balado,&nbsp;Roi Suárez-Gil,&nbsp;Sonia Pértega-Díaz","doi":"10.1007/s11657-025-01576-7","DOIUrl":"10.1007/s11657-025-01576-7","url":null,"abstract":"<div><h3>Summary</h3><p>This study analyses comorbidity, surgical management, and complications and their impact on in-hospital outcomes in centenarian hip fracture patients admitted in Spain, 2004–2020. It provides evidence on the prognostic impact of comorbidity and in-hospital complications and highlights the need for specific interventions to improve care in this vulnerable population.</p><h3>Purpose</h3><p>This work aims to describe the clinical characteristics, in-hospital progress, and risk factors for worse in-hospital outcomes in centenarian patients with proximal hip fracture (PHF).</p><h3>Methods</h3><p>A retrospective nationwide cohort study was conducted that included all centenarian patients hospitalized for PHF (2004–2020) according to the Spanish National Health System’s Minimum Basic Data Set. Demographic, clinical, and hospitalization-related variables were analyzed. Univariate and multivariate analyses were performed.</p><h3>Results</h3><p>This study included 4261 patients (83.3% women). The mean Charlson comorbidity index (CCI) was 0.9 ± 1.2; 11.4% had severe comorbidity. Surgery was performed in 87.2% of patients and in 44.5% after 48 h of admission. Higher CCI scores (OR 1.3, 95% CI 1.0–1.7) and admission to medical departments (OR 4.11, 95% CI 3.0–5.6) were associated with nonsurgical management. Surgical delays ≥ 48 h were associated with admissions on Saturdays (OR 1.9, 95% CI 1.3–2.8) or to medical departments (OR 2.79, 95% CI 1.34–5.83) and with the development of ≥ 3 complications (OR 1.5, 95% CI 1.1–2.0). Overall, 15% of patients died during hospitalization, with significantly higher mortality in nonsurgical patients (31.8% vs. 12.5%, <i>p</i> &lt; 0.001). In surgical patients, mortality and prolonged hospital stays were primarily related to higher CCI scores and complications.</p><h3>Conclusions</h3><p>Centenarians with PHF have a low severe disease burden but high in-hospital mortality risk. Key predictors of mortality in surgical patients include higher CCI scores and in-hospital complications. This highlights the relevance of integrated care and early optimization of clinical status. Prospective studies with long-term follow-up are needed to better characterize prognostic factors.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparisons of reference curves for femoral neck geometric parameters between Changsha-Chinese women and women of three ethnic groups in the United States","authors":"Lin Li,&nbsp;Yi Shen,&nbsp;Hong Zhang,&nbsp;Ru-Chun Dai,&nbsp;Ling-Qing Yuan,&nbsp;Zhi-Feng Sheng,&nbsp;Xi-Yu Wu","doi":"10.1007/s11657-025-01571-y","DOIUrl":"10.1007/s11657-025-01571-y","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Factors underlying ethnic differences in the incidence of femoral fractures are not fully understood. Reference curves of femoral neck geometric parameters (FNGPS) between Changsha-Chinese women and three United States (US) ethnic groups of women varied by ethnicity, age, and measurement parameters. Further investigations might better explain fracture-rate differences.</p><h3>Purpose</h3><p>Osteoporotic fractures are associated with race, and the risk of femoral neck fractures is associated with FNGPs. We compared age-related FNGPs of Changsha-Chinese women with those of three ethnic groups of women in the US.</p><h3>Methods</h3><p>Data on 4236 Changsha-Chinese women and non-Hispanic Whites (NHWs), non-Hispanic Blacks (NHBs) and Mexican women (aged 20–91 years) from a laboratory database and research literature, were analyzed to measure their FNGPs: outer diameter (OD), cross-sectional area (CSA), averaged cortical thickness (ACT), endocortical diameter (ED), buckling ratio (BR), section modulus (SM), and cross-sectional moment of inertia (CSMI).</p><h3>Results</h3><p>The overall means of the OD, ED, SM, and CSMI of the Changsha-Chinese women were significantly lower than those of the NHWs. Their CSA, ACT, SM, and CSMI were significantly lower than that of the NHBs and the age-related reference curves of their CSA, ACT, SM, and CSMI were significantly lower than those of the NHWs, NHBs, and Mexican women. Their OD and ED reference curves were significantly lower than those of the NHWs and NHBs; their OD, CSA, and ACT reference curves were lower than those of the NHWs; and their CSA, ACT, and SM were significantly lower than those of the NHBs. However, their buckling ratio (BR) reference curve was significantly higher than that of the NHWs, NHBs, and Mexican women in the US.</p><h3>Conclusion</h3><p>Ethnic differences in the FNGPs of Changsha-Chinese women and US ethnic groups may explain differences in hip-fracture rates among different ethnic groups.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12238157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive update on the cost-effectiveness of 10-year denosumab vs alendronate in postmenopausal women with osteoporosis in the United States","authors":"Eric Yeh,&nbsp;Matia Saeedian,&nbsp;Jack Badaracco","doi":"10.1007/s11657-025-01564-x","DOIUrl":"10.1007/s11657-025-01564-x","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>In postmenopausal women with osteoporosis, 10-year denosumab was estimated to be cost-effective vs 5 years of oral alendronate, a 2-year drug holiday, and subsequently 3-years of alendronate with an estimated incremental cost-effectiveness ratio of $97,574 per quality-adjusted life-years gained. Cost-effectiveness was demonstrated in most of the scenario simulations.</p><h3>Purpose</h3><p>A previous economic analysis estimated that 5-year denosumab was cost-effective compared with 5-year alendronate in women with postmenopausal osteoporosis (PMO) in the United States (US). Emerging literature has provided data on the long-term clinical benefits of denosumab. Therefore, the cost-effectiveness analysis was updated to understand the potential implications of a longer treatment duration (10-year) with denosumab vs generic oral alendronate or no treatment from a US third-party payer perspective.</p><h3>Methods</h3><p>A lifetime Markov cohort model was used to compare 10-year denosumab treatment to 5 years of alendronate, followed by a 2-year drug holiday and, then an additional 3 years of alendronate. The target population consisted of PMO women in the US with a starting age of 72 years. Recent publicly available data, including epidemiology, treatment efficacy, persistence, and costs, were used to inform model inputs. Scenario analyses and a probabilistic sensitivity analysis (PSA) were conducted to account for uncertainty.</p><h3>Results</h3><p>Estimated mean total lifetime cost and quality-adjusted life years (QALYs), respectively, were $81,003 and 8.035 for denosumab, and $75,358 and 7.977 for alendronate, resulting in denosumab having an incremental cost-effectiveness ratio of $97,574 per QALY gained. At a threshold of $150,000 per QALY, the PSA demonstrated that denosumab was considered cost effective in 62.1% of simulations. Denosumab was dominant over no treatment.</p><h3>Conclusions</h3><p>Ten-year denosumab treatment would be cost-effective compared with 5 years of alendronate, followed by a 2-year drug holiday and 3 years of alendronate at the threshold of $150,000. Cost-effectiveness was demonstrated across most scenarios with robust PSA results.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Sarcopenic Obesity and Osteoporosis in Postmenopausal Women: Risk Factors and Protective Effects of Hormonal Therapy and Nutritional Status","authors":"Oracha Chucherd,&nbsp;Orawin Vallibhakara,&nbsp;Sakda Arj-Ong Vallibhakara,&nbsp;Areepan Sophonsritsuk,&nbsp;Kitti Chattrakulchai,&nbsp;Makaramas Anantaburarana","doi":"10.1007/s11657-025-01573-w","DOIUrl":"10.1007/s11657-025-01573-w","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;\u0000 &lt;i&gt;Summary&lt;/i&gt;\u0000 &lt;/h3&gt;&lt;p&gt;The cross-sectional study of postmenopausal Thai women discovered a strong association between both sarcopenia and sarcopenic obesity and osteoporosis. The risk of sarcopenic obesity was found to increase with poor nutritional status, while a history of menopausal hormone therapy was shown to offer protection.&lt;/p&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;p&gt;The study aims to investigate the association between sarcopenic obesity and osteoporosis in postmenopausal women and to identify risk factors for sarcopenic obesity.&lt;/p&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;Our comprehensive cross-sectional study involved 248 Thai postmenopausal women aged 45-80. Osteoporosis was defined as a bone mineral density (BMD) T-score of less than −2.5 at the lumbar spine, total hip, or femoral neck, as measured by dual-energy X-ray absorptiometry (DXA). Sarcopenic obesity is defined as the co-existence of obesity and sarcopenia according to the criteria established by the European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO). Sarcopenia was defined as skeletal muscle mass adjusted by weight (SMM/W) &lt;35.6%, assessed via Bioelectrical Impedance Analysis (BIA), and compromised muscle function, which includes low hand grip strength (&lt;18 kg) or poor physical performance (chair-stand test time ≥17 seconds). Obesity was defined as a fat mass percentage &gt;41%, a body mass index (BMI) ≥25 kg/m&lt;sup&gt;2&lt;/sup&gt;, or a waist circumference ≥80 cm. Moreover, a questionnaire of baseline characteristics and the factor associated with sarcopenic obesity was collected, including age, years since menopause, history of menopausal hormone therapy, underlying diseases, medications, nutritional status assessed by the Mini Nutritional Assessment (MNA), and physical activity assessed by The Global Physical Activity Questionnaire (GPAQ). Univariate and multiple logistic regression analyses were used to examine the associated factors with sarcopenic obesity.&lt;/p&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;The prevalence of sarcopenic obesity was 13.3%, and sarcopenia was present in 28.63%, while osteoporosis affected 39.91% of the participants. Sarcopenia and sarcopenic obesity were significantly associated with osteoporosis (odds ratio (OR) 3.05; 95% CI, 1.69-5.49; &lt;i&gt;p&lt;/i&gt; &lt; 0.05 and OR 2.65; 95% CI, 1.23-5.68; &lt;i&gt;p&lt;/i&gt; &lt; 0.05, respectively). In univariate and stepwise logistic regression analyses, a lower MNA score was significantly associated with an increased risk of sarcopenic obesity. Specifically, participants with an MNA score of 8–11 had an OR of 2.26; 95% CI,1.04-4.92; &lt;i&gt;p&lt;/i&gt; &lt; 0.04, while those with a score &lt;8 exhibited a markedly elevated risk (OR 25.6; 95% CI, 1.04–4.92; &lt;i&gt;p&lt;/i&gt; &lt; 0.05). Conversely, the use of menopausal hormone therapy (MHT) was identified as a significant protective factor against sarcopenic obesity (OR 0.29; 95% CI, 0.10–0.79; &lt;i&gt;p&lt;/i&gt; &lt; 0.05).&lt;/p&gt;&lt;h3&gt;Co","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of biological age and age acceleration on 1-year mortality rates in elderly hip fracture patients: a prospective cohort study","authors":"Zachary D. Randall,&nbsp;Helena F. Barber,&nbsp;Katherine E. Buesser,&nbsp;Mitchel R. Obey,&nbsp;Jenna-Leigh Wilson,&nbsp;Christopher M. McAndrew,&nbsp;Marschall B. Berkes","doi":"10.1007/s11657-025-01572-x","DOIUrl":"10.1007/s11657-025-01572-x","url":null,"abstract":"","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the shared genetic architecture of type 2 diabetes mellitus and bone mineral density","authors":"Xinran Feng,&nbsp;Hongbin Xu,&nbsp;Qian Guo,&nbsp;Zeying Wang,&nbsp;Ruikai Ba,&nbsp;Kun Xuan,&nbsp;Jinghao Ban","doi":"10.1007/s11657-025-01568-7","DOIUrl":"10.1007/s11657-025-01568-7","url":null,"abstract":"<div><h3>Summary</h3><p>There is a link between type 2 diabetes mellitus (T2DM) and bone mineral density (BMD), but the genetic reasons behind it are not yet clear. Our study found shared genetic markers and key genes connecting T2DM and BMD. This finding helps us understand their co-occurrence and may lead to new therapeutic strategies.</p><h3>Purpose</h3><p>To explore the genetic correlation, causal relationships, and shared risk loci with potential functions between T2DM and BMD.</p><h3>Methods</h3><p>Using data from genome-wide association studies (GWAS), we explored the genetic correlation and causality between T2DM and BMD through linkage disequilibrium score regression and bidirectional Mendelian randomization. The phenotype-cell-gene association (PCGA) platform was employed to investigate single-nucleotide polymorphism (SNP) enrichment at the tissue and cell-type levels. Shared risk SNPs were identified through cross-trait meta-analyses and Heritability Estimation from Summary Statistics. We further explored biologically relevant genes using summary-data–based Mendelian randomization (SMR).</p><h3>Results</h3><p>Our study revealed a significant positive genetic correlation between T2DM and BMD (<i>r</i>_g = 0.0822, <i>P</i> = 3.84E − 06). The causality between T2DM and BMD was supported by our analyses, showing that T2DM affects BMD (IVW <i>β</i> = 0.035, <i>P</i> = 0.030; GSMR <i>β</i> = 0.107, <i>P</i> = 0.008) and BMD influences T2DM (IVW <i>β</i> = 0.085, <i>P</i> = 0.009; GSMR <i>β</i> = 0.094, <i>P</i> = 0.008). Cross-trait analysis identified 19 shared risk SNPs, including 3 novel pleiotropic SNPs. Tissue-specific SNP heritability enrichment for T2DM and BMD was observed in artery and adipose tissue. Additionally, cell-type-specific SNP heritability enrichment was found in macrophages, endothelial cells, fibroblasts, T cells, and mast cells. SMR identified three shared biologically relevant genes (BTBD16, RNF146, and CENPW) between T2DM and BMD.</p><h3>Conclusions</h3><p>These discoveries elucidate the intertwined genetic structures of T2DM and BMD, enhancing our comprehension of the co-occurrence of T2DM and osteoporosis and paving the way for the innovation of targeted therapeutic strategies.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors preventing early surgery for hip fractures in elderly patients: The osteoporosis liaison service (OLS)-Kashiwa study","authors":"Yukihiro Kokubu,&nbsp;Aya Obi,&nbsp;Yuka Kimura,&nbsp;Aya Hattori,&nbsp;Hisanori Nemoto,&nbsp;Yujiro Matsuda,&nbsp;Yuho Oki,&nbsp;Ryo Amamiya,&nbsp;Keita Ogine,&nbsp;Masaru Misawa,&nbsp;Tomoko Shimaoka,&nbsp;Keisuke Hirose,&nbsp;Yoshiaki Ando,&nbsp;Toshinori Kurashige,&nbsp;Kiyoma Marusugi,&nbsp;Shuichi Kaneyama,&nbsp;Hiroshi Kawaguchi","doi":"10.1007/s11657-025-01567-8","DOIUrl":"10.1007/s11657-025-01567-8","url":null,"abstract":"<div><h3>Summary</h3><p>Despite a recent reimbursement policy promoting early surgery for hip fractures in Japan, more than half of elderly patients experienced delays. Referral refusals, weekend admissions, comorbidity-related evaluations, and arthroplasty were key predictors. System-level reforms are needed to improve timely surgical access in Japan’s aging population.</p><h3>Purpose</h3><p>To identify pre-admission and post-admission factors associated with surgical delays for hip fractures in elderly patients, despite the recent implementation of the Japanese Ministry of Health, Labour and Welfare (MHLW) reimbursement policy incentivizing early surgery within 48 h.</p><h3>Methods</h3><p>This retrospective cohort study included 366 patients aged ≥ 75 years who underwent surgery for hip fractures at a single acute-care hospital between January 2022 and December 2023. Patients were classified into early surgery (≤ 48 h) and delayed surgery (&gt; 48 h) groups. Time to surgery was divided into pre-admission and post-admission intervals. Variables analyzed included age, sex, residence, referral refusal, admission day of the week, preoperative multi-specialty consultation, anticoagulant use, fracture type, and surgical procedure. Multivariate logistic regression identified independent predictors of delay.</p><h3>Results</h3><p>Of all patients, 48.9% underwent early surgery. The delayed group had significantly longer pre- and post-admission times. Four factors were independently associated with delay: referral refusal (<i>p</i> = 0.027), admission later in the week (<i>p</i> = 0.004), preoperative multi-specialty consultation (<i>p</i> = 0.001), and arthroplasty rather than internal fixation (<i>p</i> = 0.028). In contrast, age, sex, residence, fracture type, and anticoagulant use were not significantly associated. Postoperative hospital stay was paradoxically longer in the early surgery group, primarily due to differences in discharge readiness between nursing home residents and community dwellers.</p><h3>Conclusion</h3><p>Despite financial incentives, surgical delays persist due to both pre- and post-admission factors. System-level reforms—including improved referral systems, coordinated weekend surgical access, streamlined workflows, and adequate implant availability—are needed to enhance the effectiveness of early surgery initiatives in Japan’s aging population.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distal forearm fracture risk in a cohort of female and male immigrants and Norwegian-born residents aged 20 to 79 years in Norway","authors":"Reyhaneh Lashkari,&nbsp;Cecilie Dahl,&nbsp;Tove T. Borgen,&nbsp;Åshild Bjørnerem,&nbsp;Jan-Erik Gjertsen,&nbsp;Torbjørn Wisløff,&nbsp;Jens-Meinhard Stutzer,&nbsp;Wender Figved,&nbsp;Ann Kristin Hansen,&nbsp;Lene B. Solberg,&nbsp;Frede Frihagen,&nbsp;Espen Heen,&nbsp;Tone K. Omsland","doi":"10.1007/s11657-025-01566-9","DOIUrl":"10.1007/s11657-025-01566-9","url":null,"abstract":"<div><h3>Summary</h3><p>The study investigated the risk of distal forearm fractures in adult Norwegian residents according to regions of birth. There were significant differences in fracture risk between the region of birth categories. Although the magnitude of the rates was different between the birth categories, similar sex and seasonal risk patterns were observed.</p><h3>Introduction</h3><p>Worldwide, distal forearm fractures (DFFs) are the most common fractures in adults. This study compared incidence rates of first DFFs in women and men in Norway by region of birth, age, and season.</p><h3>Methods</h3><p>We included Norwegian residents aged 20 to 79 years with a first DFF between 2010 and 2020 using data from the Norwegian Patient Registry and population estimates from Statistics Norway. Three countries of birth groups were compared: Norwegian-born, Global North (most of Europe, North America, Australia, and New Zealand), and Global South (Asia, Africa, Latin America, Oceania).</p><h3>Results</h3><p>Compared to Norwegian-born residents in Norway, immigrants from Global North had 16% and 37% higher age-adjusted DFF incidence rates in women and men, respectively. Compared to Norwegian-born residents, female immigrants from Global South regions had 24% lower rates, whereas male immigrants from Global South regions did not have significantly lower rates. DFF rates were highest in winter for older men and women regardless of birth category, whereas rates in men younger than 50 years were highest during summer months.</p><h3>Conclusion</h3><p>We observed significant differences in DFF rates by sex, region of birth, age, and season. Our findings might have important implications for public health efforts and fracture prevention strategies. Nonetheless, further research is necessary to investigate the underlying risk factors and mechanisms driving these differences.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}