Archives of Osteoporosis最新文献

{"title":"Acquired hypophosphatemic osteomalacia: case series from a Peruvian referral center (1999–2023)","authors":"José Paz-Ibarra,&nbsp;Sofía Sáenz-Bustamante,&nbsp;Manuel Inostroza-Fernández,&nbsp;Paola Sifuentes Hermenegildo,&nbsp;Liliana Ancajima Lescano,&nbsp;Marcio Concepción-Zavaleta,&nbsp;Alejandro Román-González,&nbsp;Alfredo Adolfo Reza-Albarrán","doi":"10.1007/s11657-024-01476-2","DOIUrl":"10.1007/s11657-024-01476-2","url":null,"abstract":"<div><h3>Background</h3><p>Acquired hypophosphatemic osteomalacia (AHO) is a rare metabolic bone disorder characterized by hypophosphatemia and impaired bone mineralization. Tumor-induced osteomalacia (TIO) is the most common cause of AHO, caused by phosphaturic tumors that overproduce fibroblast growth factor 23 (FGF-23).</p><h3>Objective</h3><p>To present the clinical characteristics, diagnostic challenges, and outcomes of seven cases of AHO in Peruvian patients between 1999 and 2023.</p><h3>Methods</h3><p>A retrospective review of seven patients diagnosed with AHO was conducted. Clinical data, including diagnostic procedures, treatments, and outcomes, were collected.</p><h3>Results</h3><p>Seven cases of AHO were reviewed. In case one, osteomalacia did not improve despite supraphysiological doses of vitamin D (ergocalciferol/cholecalciferol), and no tumor was detected with available tests, resulting in the patient’s death. Cases two and three involved tumors located in the right leg and right hemithorax, respectively, with symptom resolution following total resection. In cases four, five, and seven, exhaustive exams failed to locate tumors. Cases four, six, and seven showed elevated FGF-23 levels, while case five had inappropriately normal FGF-23 levels. Case seven was the first patient in Peru to receive burosumab treatment. In case six, a tumor in the head of the femur was identified, but the patient opted for nonsurgical management.</p><h3>Conclusion</h3><p>The diagnosis of AHO is challenging, requiring a high index of clinical suspicion and biochemical confirmation. TIO is the most common cause of AHO, emphasizing the importance of locating the phosphaturic tumor. However, in some cases, the tumor remains elusive despite exhaustive diagnostic workups. This is particularly challenging in developing countries like Peru, where resources are limited.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applicability of Vfrac in men: a qualitative study of an osteoporotic vertebral fracture screening tool for use in older people with back pain","authors":"Karen L. Barker,&nbsp;Francine Toye,&nbsp;Sarah Drew,&nbsp;Tanzeela Y. Khalid,&nbsp;Emma M. Clark","doi":"10.1007/s11657-024-01470-8","DOIUrl":"10.1007/s11657-024-01470-8","url":null,"abstract":"<div><h3>Summary</h3><p>The Vfrac clinical screening tool was developed to help primary care healthcare practitioners decide if an older woman with back pain is at high risk of a vertebral fragility fracture (VFF) and requires a spinal radiograph to confirm diagnosis. The Vfrac tool developmental work was carried out in women because of the higher background prevalence of VFF. We now wish to assess Vfrac in men.</p><h3>Purpose</h3><p>To understand and characterise pain symptoms of men with VFF, to evaluate the wording of the Vfrac tool from men’s perspective, and to establish if a gender-specific version of the Vfrac tool was needed.</p><h3>Methods</h3><p>Individual interviews were conducted with 15 men using an interview topic guide based on the original Vfrac topic guide with the addition of a ‘think aloud’ section to discuss the wording of the current questions within the Vfrac tool. Thematic analysis was conducted by two researchers.</p><h3>Results</h3><p>Seven themes highlight that physical measurements can be potentially upsetting for those being measured (‘Weighed, measured and found wanting’), that closed questions cannot capture the complexity of experience (there is no room on the paper; pain is dynamic, not static; walking can make it better or worse; well, it depends on which chair), and that gendered roles are varied and dynamic (I try to do my share of domestic work; no more do-it-yourself).</p><h3>Conclusions</h3><p>This research has allowed the male perspective of osteoporosis to be heard and importantly identified that the Vfrac tool had no gender-specific barriers.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-024-01470-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A surrogate FRAX model for Nepal","authors":"H. Johansson,&nbsp;D. Pandey,&nbsp;M. Lorentzon,&nbsp;N. C. Harvey,&nbsp;E. V. McCloskey,&nbsp;J. A. Kanis","doi":"10.1007/s11657-024-01474-4","DOIUrl":"10.1007/s11657-024-01474-4","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>A surrogate FRAX® model for Nepal has been constructed using age- and sex-specific hip fracture rates for Indians living in Singapore and age- and sex-specific mortality rates from Nepal.</p><h3>Introduction</h3><p>FRAX models are frequently requested for countries with little or no data on the incidence of hip fractures. In such circumstances, the development of a surrogate FRAX model is recommended based on country-specific mortality data but using fracture data from a country, usually within the region, where fracture rates are considered to be representative of the index country.</p><h3>Objective</h3><p>This report describes the development and characteristics of a surrogate FRAX model for Nepal.</p><h3>Methods</h3><p>The FRAX model used the ethnic-specific incidence of hip fracture in the Indian community of Singapore, combined with the death risk for Nepal in 2015–2019. The number of hip fractures in 2015 and 2050 was estimated based on the United Nations’ predicted changes in population demography.</p><h3>Results</h3><p>The surrogate model gave similar hip fracture probabilities to estimates from Sri Lanka, India and Pakistan but lower 10-year fracture probabilities for men and women at older ages compared to the model for Singapore, reflecting a higher mortality risk in Nepal compared with Singapore. There were very close correlations in fracture probabilities between the Nepalese and the Singapore models (<i>r</i> <u>&gt;</u> 0.995) so that the use of the Nepalese model had little impact on the rank order of risk, i.e. a person at the <i>x</i>th percentile of risk with one model will be at the <i>x</i>th percentile of risk with the other. It was estimated that 6897 hip fractures arose in 2015 in individuals aged 50 years and older in Nepal, with a predicted 3-fold increase expected by 2050, when 23,409 hip fractures are expected nationally.</p><h3>Conclusion</h3><p>The surrogate FRAX model for Nepal provides an opportunity to determine fracture probability within the Nepalese population and help guide decisions about treatment.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-024-01474-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142636697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total, dietary, and supplemental calcium intake and risk of all-cause, cardiovascular, and cancer mortality among U.S. adults: a prospective cohort study from the National Health and Nutrition Examination Survey","authors":"Ran Chen,&nbsp;Ying Tang,&nbsp;Shunzheng Fang,&nbsp;Kai Gong,&nbsp;Dong Liu,&nbsp;Yu Xie,&nbsp;Guo Liu,&nbsp;Yu Tian,&nbsp;Lianyang Zhang,&nbsp;Yang Li,&nbsp;Siru Zhou","doi":"10.1007/s11657-024-01457-5","DOIUrl":"10.1007/s11657-024-01457-5","url":null,"abstract":"<div><h3>Summary</h3><p>Calcium intake is widely recommended, but its association with mortality remains unclear. This study indicated higher levels of calcium intake were associated with lower mortality in American adults. However, a nonlinear association between calcium intake and mortality suggested that excessive calcium intake beyond a certain threshold may increase mortality risk.</p><h3>Purpose</h3><p>The study aimed to investigate the association of total, dietary, or supplemental calcium intake with all-cause, cardiovascular, and cancer mortality in American adults.</p><h3>Methods</h3><p>This prospective cohort study used the National Health and Nutrition Examination Survey from 2005 to 2018. Participants were categorized into tertiles based on calcium intake. Risks of all-cause, cancer, or cardiovascular mortality and the dose–response relationship were estimated using weighted Cox proportional hazard regression and restricted cubic splines, with adjustments for demographic characteristics, comorbidities, laboratory parameters, and dietary data.</p><h3>Results</h3><p>In total, 6172 participants were included (median age: 61 years), and 869 had died (CVD:217, cancer:224) during a median follow-up of 81 months. After adjusting for confounders, higher total calcium(≥ 1660mg/d) [HR, 95%CI: 0.867 (0.865–0.869)], dietary calcium(≥ 1075mg/d) [HR, 95%CI: 0.711 (0.709–0.713)], and supplemental calcium (≥ 600mg/d) [HR, 95%CI: 0.786 (0.784–0.787)] intake groups were associated with lower all-cause mortality risk compared to the lowest intake group. Similar beneficial associations were found for cardiovascular, cancer mortality, and across subgroups of various ages, genders, races and body mass indexes. In the dose–response analysis, a 'J-shaped' nonlinear relationship was observed between calcium intake and the risk of all-cause, cardiovascular, and cancer mortality.</p><h3>Conclusions</h3><p>Higher levels of total, dietary, or supplemental calcium were associated with lower all-cause, cardiovascular, or cancer mortality. However, a nonlinear association between calcium intake and mortality suggested that excessive calcium intake beyond a certain threshold may increase mortality risk.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary recommendations of the Moroccan Society of Rheumatology (SMR) for patients with ostéosarcopenia","authors":"S. Zemrani,&nbsp;S. Rostom,&nbsp;H. El kasmi,&nbsp;B. Amine,&nbsp;L. Tahiri,&nbsp;N. Akasbi,&nbsp;K. Nassar,&nbsp;R. Lahlou,&nbsp;N. Bensaoud,&nbsp;S. Mehdioui,&nbsp;S. Ouakrim,&nbsp;R. Bahiri","doi":"10.1007/s11657-024-01461-9","DOIUrl":"10.1007/s11657-024-01461-9","url":null,"abstract":"<div><h3>Objective</h3><p>The objective of this study was to develop the first Moroccan recommendations concerning nutrition in patients with osteosarcopenia.</p><h3>Material and methods</h3><p>A steering committee consisting of rheumatologists and nutritionists drafted the initial version of the recommendations in light of the literature review and the recommendations of international societies. The draft was reviewed by a reading committee of 13 experts to approve the final version.</p><h3>Results</h3><p>Four overarching principles and ten recommendations were established. The overarching principles emphasize that nutritional advice is not a substitute for the pharmacological treatment of osteosarcopenia. Instead, it should be based on scientific evidence and take into account the specific characteristics of Moroccan society. The recommendations emphasize the significance of adequate calcium and vitamin D intake while evaluating the benefit-risk ratio in instances where calcium supplementation is indicated. A balanced intake of trace elements, vitamins, proteins, and dairy products should be maintained. The Mediterranean diet is recommended, while vegetarian diets and restrictive diets in individuals who are not overweight are not advised. It is recommended that individuals who fast during Ramadan consume a varied and balanced diet. It is recommended that the consumption of soft drinks and alcohol be limited. The consumption of phytoestrogens from food in moderation is considered beneficial as part of a balanced diet. Nevertheless, the use of supplements is not advised.</p><h3>Conclusion</h3><p>The purpose of this work is to provide Moroccan rheumatologists with a practical tool to improve the nutritional aspect in patients with osteosarcopenia.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trabecular bone score as an assessment tool to identify the risk of vertebral fractures in SAPHO syndrome","authors":"Zaizhu Zhang,&nbsp;Yi Zhang,&nbsp;Wei Yu","doi":"10.1007/s11657-024-01472-6","DOIUrl":"10.1007/s11657-024-01472-6","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This is the first study to report that TBS seems not only unaffected by bone artifacts, but also is superior to BMD in the discrimination of vertebral fractures in SAPHO patients, which highlights the importance of adding TBS measurement to DXA images in routine clinical evaluation.</p><h3>Purpose</h3><p>To investigate the impact of bone artifacts on trabecular bone score (TBS) and lumbar spine (LS) bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) and analyze the clinical utility of TBS evaluation for vertebral fracture (VF) risk assessment in SAPHO patients compared with BMD assessment.</p><h3>Methods</h3><p>Seventy SAPHO patients (mean age 50.1 (10.7) years, 81% women) and an equal number of age- and sex-matched controls were enrolled. TBS and BMD were assessed using DXA. Bone artifacts and VF of the spine were evaluated using whole-spine CT. Univariate logistic regression analysis was performed to identify factors associated with VF. Odds ratios (ORs) per standard deviation decrease in TBS and BMDs were estimated from logistic regression models with adjustment for age.</p><h3>Results</h3><p>In patients with bone artifacts, TBS, but not LS BMD, was lower than matched controls, and in those without bone artifacts, both BMDs and TBS were lower than controls. After adjustment, LS BMD was significantly lower in the SAPHO group than in controls. TBS and LS BMD (OR [95% confidence interval], 12.0 [3.6, 40.4] and 4.7 [2.0, 10.9]) showed statistically significant ORs but the others did not. For evaluating VF in SAPHO patients, TBS showed the greatest AUC in the ROC curve, with a value of 0.920 compared with 0.777, 0.690, and 0.652 for LS, FN, and TH BMD, respectively.</p><h3>Conclusion</h3><p>TBS seems not to be influenced by bone artifacts in opposition to LS BMD and has a better discriminatory value than BMD for VF in SAPHO patients.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis incidence and its associated factors in the older Korean population: findings from a population-based cohort study","authors":"Tanmoy Das,&nbsp;Md Abdullah Al Jubayer Biswas,&nbsp;Prosanta Mondal,&nbsp;Sabuj Sarker,&nbsp;Hyun J.“June” Lim","doi":"10.1007/s11657-024-01466-4","DOIUrl":"10.1007/s11657-024-01466-4","url":null,"abstract":"<div><h3>Summary</h3><p>In South Korea, osteoporosis incidence among the elderly was unclear. Our study revealed an incidence of 18.4 per 1000 person-years, with higher rates in females and those with lower education. The findings indicate a need for targeted prevention strategies to guide health policy for improved osteoporosis care for the elderly.</p><h3>Background</h3><p>Although osteoporosis significantly affects morbidity and mortality among the older population in South Korea, the incidence of osteoporosis and its associated factors within this demographic group remains unclear.</p><h3>Method</h3><p>We analyzed data from the Korean National Health Panel Survey, a nationally representative, population-based panel survey covering 2008 to 2018, to compute the incidence of osteoporosis among South Koreans aged 50 and older. Using the stepwise Cox Proportional Hazard model, we then identified and determined the associated factors of osteoporosis.</p><h3>Result</h3><p>Out of the 7304 study participants in our analysis, we identified 792 osteoporosis events, resulting in an overall cumulative incidence rate of 18.4 per 1000 person-years. The incidence of osteoporosis increased steadily with age and was higher among those with lower levels of education. We also found that female study participants were at a statistically significant 7.2-fold higher risk (aHR = 7.2, 95% CI = 5.8–8.8) of developing osteoporosis compared to males. At the same time, those with hyperlipidemia had a statistically significant 1.3-fold increased risk (aHR = 1.3, 95% CI = 1.1–1.4) of developing osteoporosis.</p><h3>Conclusion</h3><p>Our study highlights a significant proportion of the older South Korean population developed osteoporosis, especially among those who are older, females, and who have hyperlipidemia. This indicates the pressing need for the government’s and healthcare systems’ consideration of osteoporosis diagnosis and prevention strategies to ensure the health and well-being of the older South Korean population.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated frequency and economic burden of incident fragility fractures during 2023 in Mexico","authors":"Fernando Carlos-Rivera,&nbsp;Jorge Antonio Guzmán-Caniupan,&nbsp;Luis Miguel Camacho-Cordero,&nbsp;Therese Aubry de Maraumont,&nbsp;Noe Soria-Suárez","doi":"10.1007/s11657-024-01468-2","DOIUrl":"10.1007/s11657-024-01468-2","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Epidemiologic and economic data regarding osteoporotic fractures in Mexico is scarce and mostly outdated. Through a model, we estimated the incidence and costs of osteoporotic fractures in adults ≥ 50 years old in Mexico during the year 2023. Results showed that these events are both frequent and costly, leading to a considerable economic impact.</p><h3>Purpose</h3><p>Osteoporosis and its fractures impose a high clinical and economic burden. The objective of this analysis was to estimate the frequency and costs owing to incident fragility fractures (FFs) during the year 2023 in Mexico.</p><h3>Methods</h3><p>This is an incidence-based cost-of-illness study. The target population is adults ≥ 50 years old sustaining a fracture related to osteoporosis (caused by a fall on the same level). The model estimates the costs and productivity losses associated with their treatment within 1 year post-fracture. National epidemiologic databases supplemented with information, derived from literature when appropriate, were used to estimate the frequency of new FFs during 2023 in the study population. Resource use included surgical and non-surgical inpatient or ambulatory care the patients received immediately after fracture plus the outpatient physiotherapy post-discharge and the eventual follow-up with a specialist who may prescribe pharmacotherapy. Sick days taken in employed patients were estimated from the literature. Local unitary costs of services and drugs for both public and private settings as well as average income in those occupied were applied. All costs are reported in Mexican pesos (MXN) from 2023.</p><h3>Results</h3><p>The model estimated a total of 229,239 FFs, among which 63% were classified as a major osteoporotic fracture, including 53,842 and 41,459 fractures located at the hip and vertebral, respectively. The total costs were estimated at 15,593 million MXN; most of them (75.2%) were attributable to acute-phase care.</p><h3>Conclusions</h3><p>Fragility fractures represent a serious health problem for Mexico. Better preventive/therapeutic strategies may help to mitigate their significant financial toll.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-024-01468-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hip structure and incident fracture: a time-updating survival analysis over 20 years of data from the Geelong Osteoporosis Study","authors":"Kara B. Anderson,&nbsp;Mohammadreza Mohebbi,&nbsp;Monica C. Tembo,&nbsp;Pamela Rufus-Membere,&nbsp;Natalie K. Hyde,&nbsp;Julie A. Pasco,&nbsp;Mark A. Kotowicz,&nbsp;Kara L. Holloway-Kew","doi":"10.1007/s11657-024-01471-7","DOIUrl":"10.1007/s11657-024-01471-7","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Hip structural analysis parameters are associated with risk of fracture in women across a long follow-up period, with buckling ratio persisting independent of total hip BMD.</p><h3>Purpose</h3><p>Hip structural analysis (HSA) uses dual X-ray absorptiometry (DXA) hip scans to calculate geometries of narrow neck (NN), intertrochanter (IT), and shaft (S), which may complement bone mineral density (BMD) for assessing fracture risk. We aimed to determine whether HSA parameters were associated with fracture.</p><h3>Methods</h3><p>Participants were women (<i>n</i> = 986, ages 40–94 year) from the Geelong Osteoporosis Study. HSA was calculated from Lunar DPX-L scans. Low-trauma incident fractures were identified radiologically. Participants were followed from baseline to first fracture, death, or end of follow-up period (31/12/16) (13,487 person-years follow-up). Time-updating Cox-proportional hazards modelling investigated associations between HSA parameters and fracture.</p><h3>Results</h3><p>Three hundred thirty-five participants reported fractures (rate: 24.99/1000 person-years [95% CI 22.46–27.80]). Higher NN BMD (HR:0.12, 95% CI:0.05–0.29), cross-sectional area (CSA) (0.37, 0.26–0.52), cross-sectional moment of inertia (CSMI) (0.66, 0.50–0.89), section modulus (SM) (0.40, 0.24–0.68) and cortical thickness (CT) (0.00, 0.00–0.01 due to rounding) were associated with decreased risk. IT BMD (0.08, 0.04–0.20), CSA (0.58, 0.49–0.69), CSMI (0.90, 0.85–0.94), and SM (0.69, 0.59–0.81) were similarly associated. Decreased risk was observed at increased values of S BMD (0.20, 0.10-0.38), CSA (0.60, 0.47–0.76), SM (0.60, 0.43–0.83), and CT (0.03, 0.01–0.14). Higher S endocortical diameter (1.81, 1.29–2.53), and buckling ratio (BR) at all sites (NN: 1.07, 1.04-1.11; IT: 1.08, 1.05–1.11, S: 1.31, 1.19–1.46) were associated with increased risk. After adjustment for total hip BMD, the associations with BR at the shaft (1.14, 1.00–1.30) were sustained. Other associations were attenuated.</p><h3>Conclusion</h3><p>A greater shaft buckling ratio was associated with an increased risk for fracture, independent of total hip BMD.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142595406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing comprehension and fostering involvement in the fracture liaison services system in Türkiye: a call for action","authors":"Mustafa Hüseyin Temel,&nbsp;Fatih Bağcıer,&nbsp;Şansın Tüzün","doi":"10.1007/s11657-024-01473-5","DOIUrl":"10.1007/s11657-024-01473-5","url":null,"abstract":"","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"19 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}