Archives of Osteoporosis最新文献

{"title":"Bridging academia and public interest: the impact of Altmetrics on osteoporosis treatment research","authors":"Özge Özpolat Bulut, Bülent Alyanak, Burak Tayyip Dede, Mustafa Hüseyin Temel, Mustafa Turgut Yıldızgören, Fatih Bağcıer","doi":"10.1007/s11657-025-01500-z","DOIUrl":"10.1007/s11657-025-01500-z","url":null,"abstract":"","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of low-sodium salt intervention with osteoporosis: A cross-sectional study based on the SSaSS study","authors":"Xilei Li,&nbsp;Xin Wang,&nbsp;Yuyi Peng,&nbsp;Qiu Xia,&nbsp;Yue Lu,&nbsp;Hao Sun,&nbsp;Bo Zhou","doi":"10.1007/s11657-024-01495-z","DOIUrl":"10.1007/s11657-024-01495-z","url":null,"abstract":"<div><h3>Mini abstract</h3><p>Low-sodium salt has a protective effect on BMD and also reduces the risk of osteopenia due to elevated blood glucose. This provides a direct and effective way to improve bone health in patients with hyperglycemia.</p><h3>Objective</h3><p>There is no consensus on the relationship between salt type and bone mineral density (BMD). This study examined the factors affecting osteoporosis and the relationship between low-sodium salt consumption with osteoporosis based on the Substitute Salt and Stroke Study (SSaSS).</p><h3>Methods</h3><p>This study was a cross-sectional study and compares the prevalence and characteristics of osteoporosis and osteopenia. Multiple linear regression and restricted spline models were used to analyze the factors affecting BMD and its dose–response relationship with osteoporosis and to compare the effects of different salts.</p><h3>Results</h3><p>The rates of osteoporosis and osteopenia were lower in those consuming low-sodium salt (31.11% and 38.52%) than in those consuming normal salt (38.65% and 41.10%). BMD was higher in the population consuming low-sodium salt than in that using normal salt (= 0.64, 95%CI: 0.25, 0.97). Age, gender, and blood glucose level interacted with low-sodium salt and together affected BMD. Analysis of the dose–response relationship revealed a positive linear association between elevated blood glucose and the risk of osteopenia (<i>P</i> for overall &lt; 0.05, <i>P</i> for nonlinear = 0.77), but intake of low-sodium salt significantly reduced this risk. The risk of OP increased with age (<i>P</i> for overall &lt; 0.05, <i>P</i> for nonlinear = 0.72); low-sodium salt intake reduced this risk, with the effect being more pronounced among individuals &lt; 70 years old.</p><h3>Conclusion</h3><p>Low-sodium salt has a positive effect on maintaining BMD. Elevated blood glucose and age &lt; 70 years increase the risk of osteoporosis, but use of low-sodium salt mitigates this risk.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary acidity and bone mass in minority children and adolescents: a cross-sectional analysis from the MetA-Bone trial","authors":"Ashley Petrie,&nbsp;Maria Angélica Trak-Fellermeier,&nbsp;Jacqueline Hernandez,&nbsp;Alison Macchi,&nbsp;Preciosa Martinez-Motta,&nbsp;Rodolfo Galván,&nbsp;Yolangel Hernandez,&nbsp;Rebeca Martinez,&nbsp;Cristina Palacios","doi":"10.1007/s11657-025-01497-5","DOIUrl":"10.1007/s11657-025-01497-5","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Dietary acid load could be associated with bone mass, but there are limited and conflicting results. This secondary cross-sectional analysis evaluated these associations among 123 children/adolescents, mostly Hispanics. Dietary acid load seems to be associated with bone mass in boys, but these results should be confirmed through long-term studies.</p><h3>Background</h3><p>Childhood/adolescence is key for developing strong bones. With the continuing rise in osteoporosis rates in Western societies, attention has turned to the possible impact of diets that create high levels of acid in the body. Some studies have shown an association between dietary acid load and bone mass, but there are limited studies in children/adolescents and none in Hispanics.</p><h3>Objective</h3><p>This study aimed to evaluate the associations between dietary acid load (assessed as dietary potential renal acid load, PRAL, and protein to potassium ratio) and whole-body bone mineral content (BMC) and density (BMD) in a sample of 123 children and adolescents of predominantly Hispanic ethnicity.</p><h3>Design</h3><p>This study is a secondary cross-sectional analysis.</p><h3>Results</h3><p>Dietary PRAL was positively associated with BMC and BMD overall (<i>p</i> &lt; 0.05) and with BMC in boys (<i>p</i> &lt; 0.05) when adjusted for energy misreporting only. The vegetable protein to potassium ratio was inversely associated with BMC (<i>p</i> = 0.004) in boys only, after adjusting for important factors.</p><h3>Conclusions</h3><p>Dietary acid load seems to be associated with BMC in boys in this sample of primarily Hispanic children. Long-term studies are needed to confirm these results and to understand the importance of protein intake in relation to other key nutrients in bone mass acquisition among Hispanic boys.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lee’s TRIAD—osteoporosis, fragility fracture, and bone health optimization","authors":"Joon-Kiong Lee","doi":"10.1007/s11657-024-01482-4","DOIUrl":"10.1007/s11657-024-01482-4","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Osteoporosis, fragility fractures, and bone health optimization share the same pathophysiology, diagnostic tools, risk assessment, and treatments. Grouping them into “Lee’s TRIAD” allows surgeons and physicians to collaborate more efficiently, using unified principles and strategies for managing these conditions.</p><h3>Purpose</h3><p>The primary goal of osteoporosis management is to prevent fragility fractures, which occur from falls from standing height or less in individuals over fifty. However, the management of bone health optimization is often neglected in patients undergoing elective surgeries, such as arthroplasty and spinal surgeries. The objective of this article is to link all these three conditions into a TRIAD so that surgeons and physicians can collaborate more effectively, utilizing similar principles and strategies for better management.</p><h3>Methodology</h3><p>Clinical approaches based on country-specific guidelines are commonly used to manage osteoporosis. However, skeletal assessments are rarely conducted before or after elective procedures, leading to overlooked conditions such as osteoporosis, osteopenia, and fragility fracture risk factors. These three conditions are illustrated from the patient case study shown, to highlight the importance of not neglecting bone health optimization in high risk individuals undergoing elective surgery, with underlying osteopenia and multiple risk factors who sustained fragility fracture intraoperatively.</p><h3>Result</h3><p>Patients undergoing elective surgeries often have their bone health neglected, leading to a higher incidence of complications such as aseptic loosening and peri-prosthetic fractures due to poor bone quality and density. Bone health assessment and optimization therefore is essential in patients with osteoporosis, osteopenia with clinical risk factors, and patients with history of fragility fracture, to ensure implants sit on bone with good density and quality to minimize the complications.</p><h3>Conclusion</h3><p>By combining osteoporosis, fragility fractures, and bone health optimization into a TRIAD, “Lee’s TRIAD,” surgeons and physicians can collaborate more effectively, utilizing similar principles and strategies for better management.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of using grip strength and hand muscle cross-sectional area to predict secondary fractures post distal radius fracture","authors":"Matthew Tsz Kin Kong,&nbsp;Christian Fang,&nbsp;Colin Shing Yat Yung,&nbsp;Theresa Kwok,&nbsp;Keith Leung,&nbsp;Frankie Leung","doi":"10.1007/s11657-024-01465-5","DOIUrl":"10.1007/s11657-024-01465-5","url":null,"abstract":"<div><h3>Summary</h3><p>Grip strength measurement, as a surrogate of sarcopenia diagnosis, effectively predicts secondary fracture risk in distal radius fracture patients. This simple tool enhances clinical practice by identifying high-risk patients for targeted interventions, potentially preventing or reversing functional decline and recurrent fractures.</p><h3>Purpose</h3><p>To evaluate grip strength and hand muscle cross-sectional area as predictors of secondary fracture risk in patients with a history of distal radius fracture (DRF), serving as surrogates of the diagnosis of sarcopenia.</p><h3>Methods</h3><p>A retrospective cohort study of 745 DRF patients was analyzed with their grip strength data using Cox proportional hazards regression, receiver operating characteristic analysis, and Kaplan–Meier analysis to predict secondary fracture risk over an average of 12 years. Hand muscle cross-sectional area was similarly analyzed.</p><h3>Results</h3><p>Patients with a history of DRF were predicted to have a 4.1% higher likelihood of experiencing a secondary fracture per kilogram reduction in their grip strength (<i>p</i> &lt; 0.008), independent of age and sex. Patients were categorized as high-risk (≤ 16 kg), moderate-risk (17–24 kg), or low–risk (≥ 25 kg) (<i>p</i> &lt; 0.001). High-risk patients showed a 2.2-fold (95% CI = 1.55–3.17) higher recurrent fracture risk compared to low-risk patients. Cumulative secondary fracture probabilities of the high-risk group patients at 5, 10, and 15 years were estimated to be 16%, 30%, and 54%, respectively.</p><h3>Conclusions</h3><p>Grip strength measurement, as a surrogate of sarcopenia diagnosis, effectively predicts secondary fracture risk in patients with DRF. This simple tool could improve clinical practice by identifying high-risk patients for targeted interventions to prevent recurrent fractures or even reverse functional decline.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-024-01465-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient perceptions of osteoporosis management: a qualitative pilot study by a patient advisory group","authors":"R. M. Javier,&nbsp;F. Debiais,&nbsp;F. Alliot-Launois,&nbsp;D. Poivret,&nbsp;P. Bosgiraud,&nbsp;F. Barbe,&nbsp;M. Bouyssié,&nbsp;M. Devert,&nbsp;F. Roux,&nbsp;M. P. Sacchi,&nbsp;S. Sirot,&nbsp;P. Halbout,&nbsp;T. Chevalley,&nbsp;J. Y. Reginster,&nbsp;B. Cortet","doi":"10.1007/s11657-024-01486-0","DOIUrl":"10.1007/s11657-024-01486-0","url":null,"abstract":"<div><h3>Summary</h3><p>The management of osteoporosis even after a fracture is declining. Our pilot study in patients with osteoporosis confirms a large ignorance of the disease and major fears and uncertainties about the treatments. Complete and sustained medical information seems essential to counteract the contradictory information, which are exclusively negative.</p><h3>Purpose</h3><p>The management of osteoporosis (OP) even after a fracture has declined over recent years despite the actions of the medical societies concerned with this disease. The objective of this pilot study was to investigate patients’ perceptions of OP, their treatment pathways, and how information is obtained.</p><h3>Methods</h3><p>The Association Française de Lutte Anti-Rhumatismale (AFLAR) constituted an advisory group of 7 French patients (mean age 63.7 years [54–74 years]), with various stages of OP and duration of disease. A qualitative, anonymized study was conducted with an open-ended semi-structured questionnaire, with a contribution of the International Osteoporosis Foundation (IOF) and the “Groupe de Recherche et Informations sur les Ostéoporoses” (GRIO).</p><h3>Results</h3><p>The onset of OP was often sudden, with the fracture occurring in a context of deep misunderstanding of OP by both the public and physicians. The patients have confidence in the physician, mostly a rheumatologist, who informs about OP and initiates the treatment. The main cause of non-adherence being major fears and uncertainties about efficacy and safety of treatments. Medical information is considered as insufficient, or poorly understood. Negative information has the highest impact, even if the sources seem unreliable, such as media. There is no trust in pharmaceutical companies and the ethics of physicians are in question.</p><h3>Conclusion</h3><p>This IOF/GRIO/AFLAR Patient Advisory Group pilot study illustrates the numerous barriers to effective OP management. Complete and sustained medical information, especially at the time of diagnosis and initiation of treatment, seems essential to counteract the contradictory information, which are exclusively negative.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-024-01486-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The development and implementation of a digital platform in a fracture liaison service","authors":"Bernadette Conlon,&nbsp;Helen O’Brien,&nbsp;Vanessa Clarke","doi":"10.1007/s11657-024-01491-3","DOIUrl":"10.1007/s11657-024-01491-3","url":null,"abstract":"<div><h3>Summary</h3><p>The fracture liaison service in the study hospital developed and successfully implemented a digital platform to support the identification of patients while concurrently optimizing participation in the National Fracture Liaison Database. This initiative provides additional evidence of the capacity of digital health to support fracture liaison services.</p><h3>Purpose</h3><p>Resourced fracture liaison services (FLSs) are accepted internationally as the preeminent means of reducing the risk of future fragility fractures. The FLS in the study hospital sought to develop and implement a digital platform to support the identification of patients and concurrently effectively participate in the National Fracture Liaison Service Database (FLS-DB) established to monitor key performance indicators (KPIs).</p><h3>Method</h3><p>Through linkage with the already established hospital’s eTrauma digital system and Inpatient Management System, a bespoke fracture liaison digital platform was developed and introduced. Platform functionality supports automated patient identification and interoperability with the National Fracture Liaison Service Database enabling the anonymized safe transfer of key performance indicator data.</p><h3>Results</h3><p>Through automated identification of patients who require fracture liaison services, rates of identification have improved from 10% in 2021 to 87%. Time previously spent manually identifying patients is now available for clinical care. Key performance indicator data are recorded as part of the assessment and treatment process and successfully anonymized and transferred to the national database.</p><h3>Conclusion</h3><p>This initiative provides additional evidence of the capacity of digital health to support fracture liaison services. In comparable settings nationally and internationally where there are coexisting digital systems to support patient management and a national digital database for FLS key performance indicators, there is potential for the successful introduction of similar FLS digital platforms.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142938849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in osteoporosis assessment, diagnosis after fragility fractures, and treatment for hospitalized patients with osteoporosis or fragility fractures between 2012 and 2021","authors":"Wenhui Zeng,&nbsp;Wei Liu,&nbsp;Lulu Zhang,&nbsp;Yiping Zhang,&nbsp;Yuxiang He,&nbsp;Weijuan Su,&nbsp;Peiying Huang,&nbsp;Caoxin Huang,&nbsp;Mingzhu Lin,&nbsp;Xuejun Li,&nbsp;Xiulin Shi","doi":"10.1007/s11657-024-01492-2","DOIUrl":"10.1007/s11657-024-01492-2","url":null,"abstract":"<div><h3>Summary</h3><p>Our study investigated trends in osteoporosis management in Xiamen from 2012 to 2021, revealing improvements in screening and treatment, although medication use remained low. Additionally, we identified factors that may influence medication use and emphasized the importance of effective osteoporosis management strategies.</p><h3>Purpose</h3><p>The goal of the current study is to explore trends in assessment, diagnosis after fragility fractures, and osteoporosis treatment among hospitalized patients in Xiamen, China, between 2012 and 2021.</p><h3>Methods</h3><p>We conducted a retrospective cross-sectional study, using the Cochran-Armitage trend test to describe trends. Logistic regression was performed to identify the influencing factors of anti-osteoporosis medication (AOM) treatment. We performed a sensitivity analysis to verify the robustness of our findings.</p><h3>Results</h3><p>From 2012 to 2021, the rates of dual-energy X-ray absorptiometry (DXA) scans and bone turnover marker (BTM) examinations increased from 0 to 37% and 36.5%, respectively. 29.3% of patients with fragility fractures were diagnosed with osteoporosis. The use rate of AOM was only 22.7%. There was an upward trend in the prescription of bisphosphonates, increasing from 1% in 2012 to 16.8% in 2021. The use of calcitonin ranged from 4.1% (2014) to 32.7% (2021). Calcium and vitamin D supplementation prescribing increased significantly from 5.6% in 2012 to 78.7% in 2021. Logistic regression analysis showed that old age, female sex, history of fractures, DXA scans, and osteoporosis diagnosis were significantly associated with increased AOM use. Tobacco use, hypertension, diabetes, congestive heart failure, cerebral vascular accidents, and severe liver diseases were associated with a reduced likelihood of AOM treatment.</p><h3>Conclusions</h3><p>Although assessment, diagnosis after fragility fractures, and osteoporosis treatment have increased over the past decade, there are still deficiencies in the management of osteoporosis. In the future, it will be necessary to further strengthen management of osteoporosis.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142938918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of the FRAX® tool and its adjustments in women living with diabetes: a cohort study in primary care in Brazil","authors":"Fernando Meireles de Oliveira,&nbsp;Rafaela Martinez Copês Leal,&nbsp;Fabio Vasconcellos Comim,&nbsp;Melissa Orlandin Premaor","doi":"10.1007/s11657-024-01489-x","DOIUrl":"10.1007/s11657-024-01489-x","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>The FRAX® algorithm showed good accuracy in women living with DM followed in primary care. There were no differences between the ROC curve with and without adjustments for major and hip fractures. The FRAX® 10-year and FRAX® AR were better calibrated in this population.</p><h3>Purpose</h3><p>An increased risk of fractures in people living with diabetes has been described. Screening instruments to calculate this risk have been proposed, including the FRAX® algorithm. Some studies suggest that minor modifications to this instrument can improve its performance. These modifications work well in other countries, but we do not know if they work in Brazil. The objective of our study was to evaluate the performance of the FRAX® algorithm with and without adjustments for women living with DM (WLDM) in primary care in Brazil.</p><h3>Methods</h3><p>A cohort study that included post-menopausal women attending primary care in Santa Maria, Brazil, was conducted from 2013 to 2018. The risk for major and hip fractures was calculated using the FRAX® tool. The FRAX® risk was calculated: (1) without adjustments (unadjusted FRAX®); (2) increasing the entered age by 10 years in individuals with DM (FRAX® 10 years); and (3) inserting the diagnosis of DM as rheumatoid arthritis (FRAX® AR).</p><h3>Results</h3><p>The accuracy for major fracture was 0.948 (unadjusted FRAX®), 0.947 (FRAX® 10 years), and 0.946 (FRAX® AR). For hip fractures, the accuracies were 0.989 (unadjusted FRAX®), 0.988 (FRAX® 10 years), and 0.988 (FRAX® AR). Furthermore, there were no differences between the area under the ROC curve with and without adjustments for major and hip fractures. Conversely, the FRAX® 10 years and the FRAX® AR were better calibrated, presenting a lower Chi-square.</p><h3>Conclusion</h3><p>The FRAX® algorithm showed good accuracy in WLDM followed in primary care. The FRAX® 10 years and FRAX® AR were better calibrated in this population.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare association between ankylosing spondylitis and paget’s disease: A case of pagetic vertebral ankylosis","authors":"Celil Barlas Cengiz,&nbsp;Melih Kızıltepe,&nbsp;Hüseyin Kaplan,&nbsp;Emel Oğuz Kökoğlu,&nbsp;Tuğba Kahraman Denizhan,&nbsp;Abdurrahman Soner Şenel","doi":"10.1007/s11657-024-01490-4","DOIUrl":"10.1007/s11657-024-01490-4","url":null,"abstract":"<div><p>Paget’s disease is a condition marked by abnormal bone remodeling, involving both excessive bone formation and destruction, predominantly in the elderly. Pagetic vertebral ankylosis is a rare manifestation, often associated with Paget’s disease, ankylosing spondylitis, or diffuse idiopathic skeletal hyperostosis. This form of acquired vertebral ankylosis is uncommon and occurs in cases with bone-bridging syndesmophytes or osteophytes. Here, we present a case of delayed diagnosis of Paget’s disease in the lower vertebral column, progressing to cervicothoracic vertebral ankylosis secondary to ankylosing spondylitis.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142889495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}