Archives of Osteoporosis最新文献

{"title":"The association between the number of chronic conditions and treatment of patients who are at high risk for future fracture in the Ontario Fracture Screening and Prevention Program (FSPP)","authors":"Anum Ali,&nbsp;Ella Huszti,&nbsp;Shahryar Noordin,&nbsp;Earl Bogoch,&nbsp;Alan Yang,&nbsp;Ravi Jain,&nbsp;Jennifer Weldon,&nbsp;Joanna E. M. Sale","doi":"10.1007/s11657-025-01503-w","DOIUrl":"10.1007/s11657-025-01503-w","url":null,"abstract":"<div><h3>Summary</h3><p>We compared medication prescription and initiation proportions among high-risk Fracture Screening and Prevention Program patients with multiple chronic conditions. Patients with two conditions were more likely to receive prescriptions and initiate prescribed medication than those with none. Post hoc analysis showed that patients with ≥ 3 conditions were less likely to be prescribed and to initiate medication, compared to those with two conditions. Tailored interventions are important for improving post-fracture care outcomes.</p><h3>Purpose</h3><p>To investigate the association between the number of chronic conditions and pharmacological treatment outcomes in high-risk patients who were screened through the Fracture Screening and Prevention Program (FSPP).</p><h3>Methods</h3><p>A retrospective cohort study was employed to determine the association between the number of chronic conditions and treatment outcomes. All high-risk patients who were enrolled in the FSPP between June 1, 2017, and June 30, 2022, were included in the study. The number of self-reported chronic conditions available in the FSPP data was classified into four categories: (1) 0 condition; (2) 1 condition; (3) 2 conditions; and (4) ≥ 3 conditions. Multivariable logistic regression models were created with prescription and initiation as outcomes.</p><h3>Results</h3><p>In total, 11,245 patients were identified as high-risk for future fracture. Patients with two chronic conditions demonstrated a 26% higher odds of receiving a medication prescription, and those with two chronic conditions and prescribed bone-active medication had a 57% increased odds of initiating the treatment compared to individuals without chronic conditions. No significant differences in medication prescription or initiation were seen in those with 1 or ≥ 3 chronic conditions compared to those without chronic conditions. In post hoc testing, we saw a 25–30% significantly lower odds of medication prescription and initiation in patients reporting ≥ 3 chronic conditions when compared to those who reported only two chronic conditions.</p><h3>Conclusion</h3><p>The findings suggest that a large provincial secondary fracture prevention program resulted in higher odds of prescription and initiation of treatment in patients with two chronic conditions compared to those having no chronic conditions. Potential inequities in these treatment outcomes were found with a threshold of three or more chronic conditions. This highlights the need for tailored interventions and comprehensive support systems to improve fracture prevention outcomes for high-risk patients with multiple chronic conditions.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01503-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term effect of sunshine duration on daily emergency visits for hip fractures in Beijing, China: a time-series study","authors":"Jia Chen,&nbsp;Xue-Jiao Liu,&nbsp;Geng Liu,&nbsp;Ning Li,&nbsp;Wei Deng,&nbsp;Xiao-Jie Xu,&nbsp;Jing-Hong Gao,&nbsp;Yan-Lin Niu,&nbsp;Bai-Chao Zhang,&nbsp;Zhao-Xing Tian,&nbsp;Xie-Yuan Jiang","doi":"10.1007/s11657-024-01483-3","DOIUrl":"10.1007/s11657-024-01483-3","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This study employs a time-series analysis to investigate how sunshine duration associates hip fractures in China and found both short and long durations of sunshine increased the risk of hip fractures. The findings can guide strategies for reducing hip fractures and enhance health education on fracture prevention.</p><h3>Background</h3><p>Studies on the associations between sunshine duration and emergency visits for hip fractures (HF) are limited. This study aimed to assess the short-term effect of sunshine duration on the risk of emergency visits for HF.</p><h3>Methods</h3><p>Daily emergency visits for HF at Beijing Jishuitan Hospital from 2015 to 2019 and contemporaneous meteorological and air pollutant data were collected. A Poisson generalized linear regression model combined with a distributed lag non-linear model was applied to analyze the lag-exposure–response relationship between sunshine duration and HF. Stratified analysis was performed by gender and age.</p><h3>Results</h3><p>A total of 10,874 cases were identified. The overall cumulative exposure–response curve showed a U-shaped relationship between sunshine duration and HF. With 7.2 h as the reference (lowest HF emergency visit risk), significant single-day effects of short sunshine duration (0 h, 2.5th percentile) were observed from the 11th to the 13th day, peaking on lag day 13 (RR = 1.033, 95% CI: 1.003–1.065), while its cumulative effects lasted from lag days 0–11 to 0–14, with the highest RR of 1.327 (95% CI: 1.088–1.619) at lag day 0–14. Significant single-day effects of long sunshine duration (12.7 h, 97.5th percentile) occurred from the 10th to the 12th day, peaking on the 12th day (RR = 1.030, 95% CI: 1.000–1.061), but no cumulative lag effects were found. This U-shaped pattern was consistent across subgroups, especially among female patients and those aged 66–79 years; conversely, the risk of HF-related emergency visits decreased with increasing sunshine duration in patients aged 40–65 years with a relatively high uncertainty.</p><h3>Conclusions</h3><p>Both short and long durations of sunshine are associated with an increased risk of HFs emergency visits. Females and patients aged 66–79 years might be more vulnerable to short sunshine duration.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of a fracture liaison service for patients with femoral fractures on subsequent fractures and mortality: focusing on systematic literature review and metaanalysis","authors":"Min Soo Kim,&nbsp;Jeong-Min Yang,&nbsp;Yonghan Cha,&nbsp;Seung Hoon Kim,&nbsp;Minah Park,&nbsp;Jae-Hyun Kim","doi":"10.1007/s11657-025-01505-8","DOIUrl":"10.1007/s11657-025-01505-8","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>The purpose of this study is to scientifically and systematically investigate the clinical effectiveness of a fracture liaison service (FLS) for patients with femoral fractures.</p><h3>Methods</h3><p>The international databases Ovid-MEDLINE, EMBASE, and The Cochrane Library and the Korean databases KISS, RISS, KoreaScience, Koreamed, and Kmbase were used. Risk of bias assessment was conducted at the study design level, and meta-analysis utilized both random-effects and fixed-effects models, along with subgroup analysis.</p><h3>Results</h3><p>From the 32 selected articles, 14 articles related to subsequent fracture and 18 articles related to mortality were included in the meta-analysis. As a result of the meta-analysis, the risk of subsequent fracture in the group that participated in the fracture liaison service was 46% lower than that in the non-participated group, and this difference was statistically significant (RR = 0.54, 95% CI = 0.50–0.59). The risk of death in the group that participated in the FLS was 17% lower than that in the non-participating group, and this difference was not statistically significant as well (RR = 0.83, 95% CI = 0.67–1.03). As a result of subgroup analysis, there was a statistically significant difference in the reduction of subsequent fracture in the clinical outcomes, and there was a significant difference in mortality in the intervention follow-up period and clinical outcomes.</p><h3>Conclusion</h3><p>The global implementation of FLS has played a crucial role in enhancing the clinical management and treatment of patients with femoral fractures, contributing to a decrease in subsequent fracture and mortality. This indicates the significant role of FLS in minimizing the disease burden associated with femoral fractures worldwide.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A surrogate FRAX model for Mongolia","authors":"M. Jaalkhorol,&nbsp;H. Johansson,&nbsp;S. Avirmed,&nbsp;A. Dashtseren,&nbsp;O. Bruyère,&nbsp;M. Lorentzon,&nbsp;N. C. Harvey,&nbsp;E. V. McCloskey,&nbsp;J. A. Kanis","doi":"10.1007/s11657-025-01501-y","DOIUrl":"10.1007/s11657-025-01501-y","url":null,"abstract":"<div><h3>Summary</h3><p>A surrogate FRAX® model for Mongolia has been constructed using age- and sex-specific hip fracture rates for mainland China and age- and sex-specific mortality rates from Mongolia.</p><h3>Introduction</h3><p>FRAX models are frequently requested for countries with little or no data on the incidence of hip fracture. In such circumstances, the development of a surrogate FRAX model is recommended based on country-specific mortality data but using fracture data from a country, usually within the region, where fracture rates are considered to be representative of the index country.</p><h3>Objective</h3><p>This report describes the development and characteristics of a surrogate FRAX model for Mongolia.</p><h3>Methods</h3><p>The FRAX model used the ethnic-specific incidence of hip fracture in mainland China, combined with the death risk for Mongolia in 2015–2019. Intervention thresholds were developed based on fracture probabilities equivalent to women with a prior fragility fracture, and their impact was assessed in a referral cohort comprising men at age 50 and above and postmenopausal women. The number of hip fractures in 2015 and 2050 was estimated based on United Nations’ predicted changes in population demography.</p><h3>Results</h3><p>The surrogate model gave similar hip fracture probabilities to estimates from China. Age-dependent intervention thresholds for a major osteoporotic fracture ranged from a 10-year probability of 2.4% at the age of 40 years to 13.7% at the age of 90 years. In the cohort of those eligible for assessment, 46% of men and 36% of women were eligible for treatment because of a prior fracture. Based on intervention thresholds, a further 0.5% of men and 7.0% of women would be eligible for treatment. It was estimated that 440 hip fractures arose in 2015 in individuals aged 50 years and older in Mongolia, with a predicted 4.3-fold increase expected by 2050, when 1896 hip fractures are expected nationally.</p><h3>Conclusion</h3><p>The surrogate FRAX model for Mongolia provides an opportunity to determine fracture probability within the Mongolian population and help guide decisions about treatment.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01501-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiresorptive injections in older adult patients with prior osteoporotic fractures: a real-world observational study","authors":"Chun-Feng Huang,&nbsp;Shiue-Ming Lin,&nbsp;Jason C. Hsu,&nbsp;Russell O. Kosik,&nbsp;Wing P. Chan","doi":"10.1007/s11657-025-01510-x","DOIUrl":"10.1007/s11657-025-01510-x","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Injectable antiresorptive drugs may reduce refracture risk in older adults with previous fractures, though further research is needed to explore related factors, including the crucial role of consistent adherence.</p><h3>Purpose</h3><p>Osteoporosis increases fracture risk, particularly in older adults. Spinal and hip fractures are common and costly complications. To examine the effectiveness of parenteral antiresorptive medications—denosumab and zoledronate—in reducing refracture rates among older adults with prior spinal or hip fractures.</p><h3>Methods</h3><p>A nationwide retrospective cohort study was conducted using data from Taiwan’s National Health Insurance Research Database (2011–2020). Patients aged 50 and older with spinal or hip fractures were divided into a treatment group (received zoledronate or denosumab) and a control group (no osteoporosis treatment). A 1:1 matching based on age, sex, and Charlson Comorbidity Index was performed. Kaplan–Meier method and Cox proportional hazards regression were used for analysis.</p><h3>Results</h3><p>Out of 23,331 eligible patients, 582 were in the treatment group and 17,281 in the control group. After matching, 211 patients received zoledronate and 367 received denosumab. The treatment group showed a trend toward lower refracture risk compared to the control group, though not statistically significant. Hazard ratios were 0.63 for zoledronate and 0.80 for denosumab, indicating potential benefits. There was no substantial difference between the two medications.</p><h3>Conclusion</h3><p>This is the first real-world study to assess the effectiveness of complete adherence to parenteral antiresorptive medications in reducing the risk of refractures among older adults with prior spinal or hip fractures. However, further research is needed to confirm these findings and investigate long-term effects.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the various physical activity patterns with low bone mineral density in Americans aged 20–60","authors":"Yi Wang,&nbsp;Ling Long,&nbsp;Lei Liu,&nbsp;Pan Fan,&nbsp;Xin Zheng,&nbsp;Xi Li,&nbsp;Yun-Tao Wang,&nbsp;Bao-Shan Xu,&nbsp;Yu-Ao Tao","doi":"10.1007/s11657-024-01479-z","DOIUrl":"10.1007/s11657-024-01479-z","url":null,"abstract":"<div><h3>Summary</h3><p>Through analyzing the data of the NHANES 2007–2020 cycle, this study concluded that high-intensity exercise 1–2 sessions a week can help maintain bone mass, and there is no significant difference from regular exercise more than 3 times a week.</p><h3>Purpose</h3><p>This study aims to explore the relationship between the various physical activity(PA) patterns and the risk of low bone mineral density(BMD) in Americans of working age.</p><h3>Method</h3><p>A total of 6482 participants aged 20–60 were selected from the National Health and Nutrition Survey (NHANES) conducted from 2007 to 2020. The PA data of the participants were obtained through individual interviews, and the participants were divided into four groups (inactive, insufficiently active, less frequent but sufficiently active(1–2 sessions a week and PA ≥ 150 min), and regularly active). Weighted logistic regression was used to analyze the correlation between PA patterns and the risk of low BMD. Subgroup analyses were applied to display the correlation between PA patterns and low BMD in different subgroups.</p><h3>Result</h3><p>After adjusting for confounding factors, the multiple logistic regression model showed that compared with inactive individuals, sufficiently active and regularly active individuals had a 35% (OR, 0.65; 95% CI, 0.46–0.92) and 24% (OR, 0.76; 95% CI, 0.62–0.93) lower risk of low BMD, respectively. Compared with regularly active adults, inactive adults had a 32% (OR, 1.32; 95% CI, 1.07–1.62) increased risk of low BMD, while sufficiently active individuals (OR, 0.85; 95% CI, 0.59–1.23) showed no significant difference compared with regularly active adults.</p><h3>Conclusion</h3><p>Compared with inactive adults, less frequent but sufficiently active adults have a lower risk of low BMD and showed benefits similar to those in regularly active groups. The sufficiently active pattern may become a new trend in modern working-age adults’ PA patterns.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The positive impact of a quality improvement collaborative on process indicators for geriatric hip fracture care","authors":"Ellen Coeckelberghs,&nbsp;Deborah Seys,&nbsp;Charlotte Lens,&nbsp;Kris Vanhaecht,&nbsp;Fien Claessens,&nbsp;Caroline Weltens,&nbsp;Dirk De Ridder,&nbsp;Eline Depuydt,&nbsp;Wim De Weerdt,&nbsp;Thierry De Baets,&nbsp;Jessy Eysackers,&nbsp;Stijn Hermans,&nbsp;Michiel Herteleer,&nbsp;Geert Leirs,&nbsp;Sofie Lynen,&nbsp;Frederik Matthys,&nbsp;Ben Molenaers,&nbsp;Alexander Mulliez,&nbsp;Christophe Pattyn,&nbsp;Jan Somers,&nbsp;Mike Tengrootenhuysen,&nbsp;Maxence Vanderkerckhove,&nbsp;Marleen Van Esbroeck,&nbsp;Kyri Van Hecke,&nbsp;Eline Van Hove,&nbsp;Stefaan Nijs,&nbsp;An Sermon","doi":"10.1007/s11657-025-01504-9","DOIUrl":"10.1007/s11657-025-01504-9","url":null,"abstract":"<div><h3>Summary</h3><p>Adherence to guidelines for geriatric patients with a hip fracture is challenging. With this study, adherence to important quality indicators in geriatric hip fracture care was improved. A quality improvement collaborative including benchmarking and knowledge sharing showed to be effective in improving quality of care.</p><h3>Background</h3><p>Adherence to guidelines for geriatric patients with an osteoporotic hip fracture is challenging. Therefore, the aim of this study was to improve the adherence to quality indicators (QIs) for these patients using benchmarking and knowledge sharing.</p><h3>Method</h3><p>A prospective multicenter study was initiated throughout 19 hospitals in Flanders, Belgium. Adherence to 23 QIs was measured. Two retrospective audits (based on patient record analyses) were conducted in 2018–2019 (measurement period (MP) 1) and 2021 (MP 2). Between both audits, anonymous benchmarking was provided to the participating centers and three educative sessions on specific topics were performed.</p><h3>Results</h3><p>A total of 1044 patients were included in the study. At MP 1, QIs showing the lowest adherence rates were the administration of nerve blocks, steroids, and tranexamic acid, applied in only 8.0%, 9.7% and 22.2% of the patients, respectively. At MP 2, these adherence rates significantly improved up to 25.4%, 26.4% and 30.7%, respectively (<i>p</i> &lt; 0.001). The indication of the start of discharge planning also significantly improved between both periods (89.3% in MP 1 vs. 93.7% in MP 2, <i>p</i> = 0.043), while the avoidance of intra-operative hypotension was less well realized (56.2% in MP 1 vs. 52% in MP2, <i>p</i> = 0.026). Overall adherence significantly increased from 61.7 to 64.5% (<i>p</i> &lt; 0.001). Delirium was significantly reduced (from 22.1% in MP 1 to 17.4% in MP 2, <i>p</i> = 0.030).</p><h3>Conclusion</h3><p>Benchmarking in combination with a peer-reviewed and knowledge sharing intervention increases the adherence to quality indicators for patients with a geriatric hip fracture.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of imminent osteoporotic fracture risk in Danish postmenopausal women—can the addition of self-reported clinical risk factors improve the prediction of the register-based FREM algorithm?","authors":"Emilie Rosenfeldt Christensen,&nbsp;Kasper Westphal Leth,&nbsp;Frederik Lykke Petersen,&nbsp;Tanja Gram Petersen,&nbsp;Sören Möller,&nbsp;Bo Abrahamsen,&nbsp;Katrine Hass Rubin","doi":"10.1007/s11657-024-01493-1","DOIUrl":"10.1007/s11657-024-01493-1","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Obtaining accurate self-reports on clinical risk factors, such as parental hip fracture or alcohol and tobacco use, limits the utility of conventional risk scores for fracture risk. We demonstrate that fracture-risk prediction based on administrative health data alone performs equally to prediction based on self-reported clinical risk factors.</p><h3>Background</h3><p>Accurate assessment of fracture risk is crucial. Unlike established risk prediction tools that rely on patient recall, the Fracture Risk Evaluation Model (FREM) utilises register data to estimate the risk of major osteoporotic fracture (MOF). We investigated whether adding self-reported clinical risk factors for osteoporosis to the FREM algorithm improved the prediction of 1-year fracture risk by comparing three approaches: the FREM algorithm (FREM^orig), clinical risk factors (CRF^only), and FREM combined with clinical risk factors (FREM-CRF).</p><h3>Method</h3><p>Clinical risk factor information was obtained through questionnaires sent to women aged 65–80 years living in the Region of Southern Denmark in 2010, who participated in the Risk-stratified Osteoporosis Strategy Evaluation study. Register data was obtained through national health registers and linked to the survey data. Positive and negative predictive values and concordance statistics were calculated for the performance of each approach using logistic regression and Cox proportional hazards models.</p><h3>Results</h3><p>Of the 18,605 women included, 280 sustained a MOF within 1 year. All three approaches performed similarly in 1-year fracture risk prediction for low- and high-risk individuals. However, the FREM^orig and FREM-CRF approach slightly overestimated fracture risk for medium-risk individuals.</p><h3>Conclusion</h3><p>Adding self-reported clinical data to FREM did not increase precision in predicting 1-year MOF risk. The discrimination of FREM^orig was similar to that of CRF^only, suggesting it may be possible to estimate fracture risk with the same precision by using register data instead of self-reported risk information. Register-based prediction models may be applicable in individualised risk monitoring or large-scale osteoporosis screening programmes.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-024-01493-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143361650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased risk of mortality in lung transplant patients with fragility fractures","authors":"Marine Forien,&nbsp;Vincent Bunel,&nbsp;Anna Moltó,&nbsp;Kinan El Husseini,&nbsp;Hervé Mal,&nbsp;Esther Ebstein,&nbsp;Pierre Antoine Juge,&nbsp;Sébastien Ottaviani,&nbsp;Philippe Dieudé","doi":"10.1007/s11657-025-01502-x","DOIUrl":"10.1007/s11657-025-01502-x","url":null,"abstract":"<div><h3>Summary</h3><p>Osteoporosis and fragility fractures are frequent complications of lung transplantation patients. Among 131 patients included, 35 (26.5%) patients had a diagnosis of fractures after transplantation. Low bone mineral density was associated with fractures. Fractures post transplantation were identified as an independent risk factor for overall mortality.</p><h3>Introduction</h3><p>The prevalence of osteoporosis among lung transplant candidates has been estimated at 31% to 46%, and significant bone loss occurs after lung transplantation, predominantly in the first year, with increased risk of incident fractures. This study aimed to evaluate the prevalence of fragility fractures in a population of lung transplant recipients and the associated risk factors as well as mortality after a fragility fracture.</p><h3>Patients and methods</h3><p>This was a cross-sectional monocentric study that included patients with lung transplantation occurring &lt; 10 years and &gt; 1 year who were undergoing lung transplantation monitoring. All patients underwent bone mineral density evaluation by dual-energy X-ray absorptiometry and radiography to establish the presence of vertebral fractures. Mortality was assessed 2 years after the last inclusion.</p><h3>Results</h3><p>We included 131 patients (82 men, 62.6%), with mean age 56.8 ± 10.8 years. The mean time from lung transplantation to inclusion was 3.5 ± 3.5 years. Overall, 35 (26.5%) patients had a diagnosis of fractures after transplantation; 67 fractures were confirmed (average of 2 per patient), including 48 (71.6%) vertebral fractures. Odds of low bone mineral density at the femoral neck, total hip and spine was associated with fracture: odds ratio 0.007 [0.0002–0.3], 0.001 [0.0002–0.05], and 0.03 [0.001–0.6], respectively. Fracture post transplantation was significantly associated with death (hazard ratio 2.32 [1.01–5.33]).</p><h3>Conclusion</h3><p>This study confirmed a high prevalence of vertebral fracture in lung transplant patients. Fracture after lung transplant was associated with mortality. Bone fragility needs more attention to reduce the fracture risk.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tea consumption and bone health in postmenopausal women: a systematic review and meta-analysis","authors":"Minjun Zhang,&nbsp;Shuxia Li,&nbsp;Shishi Wu,&nbsp;Dang Zhou,&nbsp;Mengni Lu,&nbsp;Chuyan Lin,&nbsp;Chengjiang Liu,&nbsp;Qingmei Xie","doi":"10.1007/s11657-025-01506-7","DOIUrl":"10.1007/s11657-025-01506-7","url":null,"abstract":"<div><h3>Objective</h3><p>The impact of tea on bone health in postmenopausal women has generated conflicting opinions. The current study pooled previous research to evaluate the relationship between tea consumption and bone health in postmenopausal women.</p><h3>Methods</h3><p>Relevant papers published before October 2024 were included by conducting a comprehensive literature search in the Embase, PubMed, Scopus, and The Cochrane Library databases. Observational studies reporting the association between tea consumption and bone mineral density (BMD) or the risk of osteoporosis and fractures in women after menopause were deemed eligible. The weighted mean difference (WMD) for BMD and the pooled odds ratio (OR) for osteoporosis and fractures were calculated, together with their corresponding 95% confidence intervals (CIs).</p><h3>Results</h3><p>The meta-analysis examined 18 studies with a total of 48,615 individuals. The combined results indicated that postmenopausal women who consumed tea had higher BMD at several skeletal sites, including the lumbar spine (WMD, 0.02; 95% CI, 0.01–0.04; <i>P</i> &lt; 0.001), greater trochanter (WMD, 0.02; 95% CI, 0.02–0.03; <i>P</i> &lt; 0.001), femoral neck (WMD, 0.01; 95% CI, 0.00–0.02; <i>P</i> = 0.049), and ward’s triangle (WMD, 0.02; 95% CI, 0.01–0.03; <i>P</i> = 0.002). Additionally, these women had a lower risk of osteoporosis (OR, 0.41; 95% CI, 0.26–0.67; <i>P</i> &lt; 0.001) and fracture (OR, 0.81; 95% CI, 0.67–0.98; <i>P</i> = 0.031).</p><h3>Conclusions</h3><p>The findings of this meta-analysis suggest that postmenopausal women who regularly consumed tea saw an increase in BMD and a decreased likelihood of developing osteoporosis and experiencing fractures. Future research should give priority to conducting prospective cohort studies with a more stringent methodology to verify the dose–response connection between tea consumption and the risk of osteoporosis or fracture in postmenopausal women.</p><p>Systematic review registration: PROSPERO registration number CRD42019112196.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}