Archives of Microbiology最新文献

{"title":"Characterization of the NRPS operon homolog for surfactin A and surfactin C synthesis in Bacillus spp.","authors":"Kojiro Ito, Mana Adachi, Minenosuke Matsutani, Ryota Kataoka, Gen Enomoto, Akinobu Kajikawa, Kenji Yokota","doi":"10.1007/s00203-025-04341-z","DOIUrl":"10.1007/s00203-025-04341-z","url":null,"abstract":"<p><p>Surfactin is a cyclic lipopeptide produced by Bacillus spp., consisting of a β-hydroxy fatty acid and a heptapeptide synthesized by non-ribosomal peptide synthetases. Surfactin congeners (A, B, and C) differ in amino acid substitutions, with Leu7 in surfactin A replaced by Val in B and Ile in C. Our LC-MS analysis revealed that the elution profiles of surfactin-producing strains could be classified into two distinct patterns under identical culture conditions, corresponding to surfactin A and C production. This suggests that endogenous factors influence surfactin production. Therefore, we aimed to identify the genetic factor that regulates surfactin congener production. The srfA operon for surfactin A biosynthesis in B. subtilis, composed of four open reading frames (ORFs), is srfAABCD. Comparative genomic analysis between the B. subtilis JCM 1465 srfA operon and the TUA12 surfactin biosynthesis genes examined in this study revealed that the operon responsible for surfactin A biosynthesis is distinct, exhibiting 68.7%, 69.2%, 84.7%, and 67.4% homology with the four ORFs, respectively. Similarly, the operon for Ptrs2 surfactin C biosynthesis showed 68.7%, 69.2%, 64.4%, and 67.1% homology. These differences indicate that the identified surfactin A and C biosynthetic operons are novel genetic variants. Further analysis identified the adenylation domain responsible for selecting Ile7 in surfactin C via domain substitution in a surfactin A-producing strain. Average nucleotide identity analysis showed that the surfactin A and C operons were found in B. velezensis and B. amyloliquefaciens, respectively. Our findings suggest that surfactin congener production is species-dependent, with the srf operon specifically distributed in Bacillus spp.</p>","PeriodicalId":8279,"journal":{"name":"Archives of Microbiology","volume":"207 7","pages":"161"},"PeriodicalIF":2.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic and transcriptomic insights into the cellulose-degrading mechanism of Bacillus subtilis DC-11 and its novel cellulose catabolic pathway.","authors":"Chen Chen, Minqi Zhang, Yuanhao Zhang, Xueping Jiang, Jia Kong, Jieling Zhou, Gaiqun Huang, Ran Zhang, Hao Li, Zhongzheng Gui","doi":"10.1007/s00203-025-04356-6","DOIUrl":"10.1007/s00203-025-04356-6","url":null,"abstract":"<p><p>The accumulation of silkworm excrement poses a significant environmental challenge, contributing to pollution and resource squandering. Unraveling the novel mechanism governing bacterial cellulose degradation represents a vital avenue for augmenting cellulose conversion efficiency. This study investigated the cultivation of Bacillus subtilis DC-11 with different carbon sources, utilizing transcriptome sequencing to identify metabolic pathways and differentially expressed genes (DEGs) closely related to cellulose degradation. Transcriptome analysis revealed 3,917 DEGs between the carboxymethyl cellulose sodium (CMC-Na) treatment group and the glucose-supplemented (GLU) control group. Compared to the control group, the CMC-Na treatment group exhibited upregulation of 942 genes, while 1,996 genes were downregulated. KEGG pathway analysis of DEGs indicated the involvement of that carbohydrate metabolism and phosphotransferase system (PTS) pathways in response to cellulose degradation. Real-time quantitative PCR validation confirmed that the expressions of key genes, namely ytoP, bglH, gmuD, licH, licC, ywbA, licA, gmuA, and gmuB, associated with the PTS pathway were consistent with the transcriptomics data. These results suggest that B. subtilis DC-11 degrades cellulose via carbohydrate metabolism and PTS pathways. This study offers new insights into the cellulose metabolism pathway of B. subtilis DC-11, providing both a theoretical basis and innovative strategies for the efficient degradation of cellulose.</p>","PeriodicalId":8279,"journal":{"name":"Archives of Microbiology","volume":"207 7","pages":"158"},"PeriodicalIF":2.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant expression and characterization of a neutral xyloglucanase MtXG from Mycothermus thermophilus.","authors":"Sulei Li, Liwei Gao, Zhiguang Ren, Minchong Shen, Yingjie Guo, Peng Zhang","doi":"10.1007/s00203-025-04363-7","DOIUrl":"10.1007/s00203-025-04363-7","url":null,"abstract":"<p><p>Xyloglucanase cleaves the β-1,4-glycosidic bond in xyloglucan and has been used in the food, feed, and paper industries. This study presents the cloning, heterologous expression, and characterization of a neutral xyloglucanase, designated as MtXG, derived from the thermophilic fungus Mycothermus thermophilus. The recombinant MtXG enzyme expressed in Pichia pastoris exhibited optimal activity at pH 7.0 and 75 ℃, demonstrating remarkable stability over a broad range of pH (4.0 to 7.5) and temperature (up to 60 ℃ for 2 h). Furthermore, MtXG demonstrated high specificity towards xyloglucan and showed varying degrees of tolerance to various metal ions, with notable resistance to Zn²⁺, NH₄⁺, K⁺, Mn²⁺, and Na⁺. The removal of the linker and carbohydrate-binding module from MtXG significantly affected its enzymatic properties, including a reduction in optimal pH and temperature but improved pH and temperature stabilities. Notably, the addition of MtXG to a commercial cellulase preparation resulted in a significant enhancement of reducing sugar yield from tobacco leaves, indicating its potential to facilitate the enzymatic degradation of lignocellulosic biomass for industrial applications. This study highlights the unique properties of MtXG and its potential as a valuable tool for lignocellulose bioconversion processes.</p>","PeriodicalId":8279,"journal":{"name":"Archives of Microbiology","volume":"207 7","pages":"159"},"PeriodicalIF":2.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycobacterium tuberculosis curli pili (MTP) and heparin-binding hemagglutinin adhesin (HBHA) facilitate regulation of central carbon metabolism, enhancement of ATP synthesis and cell wall biosynthesis.","authors":"T J Naidoo, S Senzani, R Singh, B Pillay, M Pillay","doi":"10.1007/s00203-025-04352-w","DOIUrl":"10.1007/s00203-025-04352-w","url":null,"abstract":"<p><p>Functional 'omics' studies previously identified the M. tuberculosis surface located adhesins, heparin-binding hemagglutinin adhesin (HBHA) and curli pili (MTP) as significant potential targets for the design of tuberculosis (TB) point-of-care diagnostics, effective drugs, and vaccines. Little is known on the effect of these adhesins on the pathogen's transcriptome. The current study, via transcriptomics, elucidated whether the deletion of the single genes, hbhA and mtp, and double genes, hbhA-mtp, via specialised transduction, affected global bacterial gene expression. RNA sequencing of M. tuberculosis wild-type V9124 (WT), single and double deletion HBHA and MTP mutant strains were confirmed by reverse transcription quantitative polymerase chain reaction (RT-qPCR) on selected genes, and a functional bacterial ATP bioluminescence assay. The 43 significantly differentially expressed genes amongst the deletion mutants were functionally categorized into central carbon metabolism (CCM), cell wall biosynthesis and cell wall transport and processes. The increased expression of genes associated with ATP synthase and cell wall processes were confirmed by RT-qPCR. In the absence of the adhesins, a decreased ATP concentration was observed suggesting either increased utilization or alterations to the proton motive force (PMF) that resulted in a potential inhibition of ATP synthesis. Therefore, deletions of the mtp and hbhA genes were associated with significant perturbations in CCM regulation/function, and transport of proteins to the cell wall, indicating the significant contribution of these adhesins in fundamental processes contributing to TB pathogenesis. Thus, this study indicates that MTP and HBHA influence gene expression in M. tuberculosis and represent important targets for TB diagnostic/therapeutic interventions and should be investigated as vaccine and adjunctive therapies.</p>","PeriodicalId":8279,"journal":{"name":"Archives of Microbiology","volume":"207 7","pages":"156"},"PeriodicalIF":2.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broad host range phage LPC-1 reduce the risk of Listeria monocytogenes contamination in different food matrices.","authors":"Qian Chong, Ziqiu Fan, Yonghui Ma, Kunzhong Zhang, Jing Deng, Jinrui Ma, Xuehui Zhao, Ji Zhi, Haohao Zhang, Zengwen He, Qing Cao, Huiwen Xue, Huitian Gou","doi":"10.1007/s00203-025-04348-6","DOIUrl":"10.1007/s00203-025-04348-6","url":null,"abstract":"<p><p>Listeria monocytogenes forms biofilms in food and food-processing environments, entering food through cross-contamination. Phages, as antimicrobial agents, have demonstrated efficacy in addressing this issue. This study demonstrated that the LM (Listeria monocytogenes, LM) lytic phage LPC-1 isolated from livestock slaughterhouse effluent effectively lysed LM, Listeria welshimeri, Listeria innocua, and Enterococcus faecium ATCC 35667. Phage LPC-1 is a tailed phage with a non-contractile long tail, has a short incubation period, high cleavage capacity, and can be adsorbed onto the surface of bacteria within a short period. The LPC-1 phage has a genome spanning 43,466 bp with a GC content of 39% and encompasses 67 coding sequences. Notably, LPC-1's genome displayed significant homologies to various non-Listeria phages. Experimental tests under simulated refrigerated conditions revealed that LPC-1 effectively diminished the presence of LM in milk, pork, and both eggshells and egg liquid, indicating its bacteriostatic properties. Moreover, LPC-1 hindered biofilm formation and enhanced biofilm eradication. Consequently, these findings endorse the potential of phage LPC-1 as a prospective antimicrobial agent specifically suited for controlling LM contamination in the food industry, given its proven safety and efficacy.</p>","PeriodicalId":8279,"journal":{"name":"Archives of Microbiology","volume":"207 7","pages":"155"},"PeriodicalIF":2.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein kinase G-a key regulator of pathogenesis in Mycobacterium tuberculosis infection.","authors":"Anjali K Mahato, Rupal Rai, Rashmi Chourasia, Anirudh K Singh, Shivendra K Chaurasiya","doi":"10.1007/s00203-025-04355-7","DOIUrl":"10.1007/s00203-025-04355-7","url":null,"abstract":"<p><p>Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), remains a leading global health threat, exacerbated by rising drug resistance and the ability of this pathogen to persist within host macrophages. Central to the intracellular survival of M. tuberculosis is Protein Kinase G (PknG), a secreted, eukaryotic-like serine/threonine kinase that subverts host immune defenses and modulates bacterial physiology. This review provides a comprehensive overview of structural features and the multifaceted role of PknG in M. tuberculosis pathogenesis, including inhibition of phagosome-lysosome fusion, acid tolerance, metabolic reprogramming, autophagy suppression, and cell wall remodelling. Additionally, we discuss recent advancements in targeting PknG with small-molecule inhibitors, highlighting its promise as a therapeutic target. By delineating PknG's central role in host-pathogen interactions and stress adaptation, this review underscores its potential in shaping future anti-TB strategies, especially against drug-tolerant and latent infections..</p>","PeriodicalId":8279,"journal":{"name":"Archives of Microbiology","volume":"207 7","pages":"154"},"PeriodicalIF":2.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between antibiotic resistance and biofilm-forming capacity with RND efflux pumps expression in clinical Acinetobacter baumannii isolates","authors":"Zahra Farshadzadeh,&nbsp;Saeed Khoshnood,&nbsp;Sousan Akrami,&nbsp;Effat Abbasi Montazeri,&nbsp;Melika Moradi,&nbsp;Sara Masihzadeh,&nbsp;Sara Daneshfar,&nbsp;Tahereh Navidifar","doi":"10.1007/s00203-025-04347-7","DOIUrl":"10.1007/s00203-025-04347-7","url":null,"abstract":"<div><p>This study investigated the gene expression pattern of resistance-nodulation-division (RND) efflux pumps, in <i>Acinetobacter baumannii</i> isolates with a focus on their association with carbapenem resistance and biofilm formation ability. A collection of 102 <i>A. baumannii</i> isolates was evaluated for antibiotic susceptibility testing using an automated broth microdilution technique. The ability of these isolates to form biofilms was evaluated using a standardized protocol. The isolates were genotyped using the Multiple-Locus Variable number tandem repeat Analysis-8 (MLVA-8) method and the gene expression levels of the RND efflux pump genes were quantified by real-time PCR. Results showed widespread antibiotic resistance, with 85% of isolates classified as multidrug resistant. Genotyping results identified 32 different MLVA types organized into six clusters (A–F) and 17 unique genotypes. The majority of isolates demonstrated the ability to form biofilms, and an inverse relationship was observed between biofilm formation and carbapenem resistance. The expression of the <i>adeB</i> gene was significantly increased in carbapenem-non-susceptible <i>A. baumannii</i> isolates. In addition, the expression of the <i>adeG</i> gene was 2.08 times higher in isolates capable of forming moderate to strong biofilms compared to those forming weak biofilms. The novelty of this study is a new insight into the relationship between efflux pump expression, antibiotic resistance and biofilm formation in <i>A. baumannii</i>, as well as AdeABC overexpression in carbapenem-resistant isolates and AdeFGH overexpression in biofilm-forming strains, providing potential therapeutic targets. These findings suggest that targeting RND efflux pumps may be a promising strategy to control survival and antibiotic resistance of <i>A. baumannii</i> isolates through biofilm inhibition.</p></div>","PeriodicalId":8279,"journal":{"name":"Archives of Microbiology","volume":"207 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral tropism in plants, reproductive tissues, and seeds","authors":"Leandro Alberto Núñez-Muñoz,&nbsp;Berenice Calderón-Pérez,&nbsp;Roberto Ruiz-Medrano,&nbsp;Beatriz Xoconostle-Cázares,&nbsp;Rodolfo de la Torre-Almaraz","doi":"10.1007/s00203-025-04353-9","DOIUrl":"10.1007/s00203-025-04353-9","url":null,"abstract":"<div><p>Plant viral tropism refers to virus ability for infecting and replicating within specific cell types, tissues or hosts. Plant viral tropism is shaped by the absence of specific membrane-associated viral receptors and the supracellular nature of viral transport through plasmodesmata and vascular tissues. This review focuses on the molecular and cellular determinants of plant viral tropism, including modifications in plasmodesmal permeability, host-mediated RNA silencing, and tissue-specific viral protein localization. We discuss how certain viruses target reproductive organs, meristems, and seeds, overcoming antiviral barriers to establish persistent infections. Additionally, we explore the role of host factors in shaping viral distribution. Advances in super-resolution microscopy, single-cell transcriptomics, and proteomics have significantly expanded our ability to dissect virus-host interactions at the nanoscale, uncovering new mechanisms of viral accumulation. Understanding these processes is essential not only for improving crop resistance and designing integrated disease management strategies, but also for repurposing plant viruses as tools for targeted delivery and biotechnological applications.</p></div>","PeriodicalId":8279,"journal":{"name":"Archives of Microbiology","volume":"207 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00203-025-04353-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling fungal genome editing revolution: pathological and biotechnological application aspects","authors":"Abdallah M. A. Hassane,&nbsp;Marwa Obiedallah,&nbsp;Javad Karimi,&nbsp;Sadat M. R. Khattab,&nbsp;Hussein R. Hussein,&nbsp;Youssef Abo-Dahab,&nbsp;Adel Eltoukhy,&nbsp;Nageh F. Abo-Dahab,&nbsp;Mohamed E. Abouelela","doi":"10.1007/s00203-025-04360-w","DOIUrl":"10.1007/s00203-025-04360-w","url":null,"abstract":"<div><p>Fungi represent a broad and evolutionarily unique group within the eukaryotic domain, characterized by extensive ecological adaptability and metabolic versatility. Their inherent biological intricacy is evident in the diverse and dynamic relationships they establish with various hosts and environmental niches. Notably, fungi are integral to disease processes and a wide array of biotechnological innovations, highlighting their significance in medical, agricultural, and industrial domains. Recent advances in genetic engineering have revolutionized fungal research, with CRISPR/Cas emerging as the most potent and versatile genome editing platform. This technology enables precise manipulation of fungal genomes, from silencing efflux pump genes in <i>Candida albicans</i> (enhancing antifungal susceptibility) to targeting virulence-associated sirtuins in <i>Aspergillus fumigatus</i> (attenuating pathogenicity). Its applications span gene overexpression, multiplexed mutagenesis, and secondary metabolite induction, proving transformative for disease management and biotechnological innovation. CRISPR/Cas9’s advantages—unmatched precision, cost-effectiveness, and therapeutic potential—are tempered by challenges like off-target effects, ethical dilemmas, and regulatory gaps. Integrating nanoparticle delivery systems and multi-omics approaches may overcome technical barriers, but responsible innovation requires addressing these limitations. CRISPR-driven fungal genome editing promises to redefine solutions for drug-resistant infections, sustainable bioproduction, and beyond as the field evolves. In conclusion, genome editing technologies have enhanced our capacity to dissect fungal biology and expanded fungi’s practical applications across various scientific and industrial domains. Continued innovation in this field promises to unlock the vast potential of fungal systems further, enabling more profound understanding and transformative biotechnological progress.</p></div>","PeriodicalId":8279,"journal":{"name":"Archives of Microbiology","volume":"207 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-step narrow-thermal-cycling strand exchange amplification for sensitive detection of porcine reproductive and respiratory syndrome virus","authors":"Linlin Zhuang,&nbsp;Chunlei Song,&nbsp;Li Sun,&nbsp;Haiqiang Xie,&nbsp;Liqun Wang,&nbsp;Qingxin Liu,&nbsp;Hongjing Shi,&nbsp;Jianbo Yang,&nbsp;Qiuping Shen","doi":"10.1007/s00203-025-04351-x","DOIUrl":"10.1007/s00203-025-04351-x","url":null,"abstract":"<div><p>Porcine reproductive and respiratory syndrome (PRRS), which is primarily characterized by respiratory and reproductive dysfunction, is an epidemic disease caused by porcine reproductive and respiratory syndrome virus (PRRSV) that has the potential to economically devastate the global swine industry. Rapid and accurate detection of PRRSV is critical for effective control of PRRS in swine. In this study, a novel one-step, highly sensitive and specific accelerated strand exchange amplification (ASEA) method for the detection of PRRSV was developed. The detection limit of the ASEA method was determined to be 6 copies µL^–1 of PRRSV RNA reference material or PRRSV in spiked swine blood. The ASEA method demonstrated the capacity to discern the currently circulating PRRSV genotypes without cross-reactivity with other porcine-derived pathogens that manifest similar clinical signs. The ASEA method exhibited a detection time of 35 min, and its clinical applicability was validated through the analysis of 5 inactivated blood samples and 62 clinical samples. The method’s potential extends beyond the diagnosis of PRRSV, as it can also be applied to the rapid diagnosis of other RNA pathogens. This capacity is expected to make significant contributions to future epidemic prevention and surveillance efforts.</p></div>","PeriodicalId":8279,"journal":{"name":"Archives of Microbiology","volume":"207 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}