Annals of Surgical Oncology最新文献

{"title":"ASO Author Reflections: Management of Melanoma In-Transit Metastasis with Isolated Limb Infusion or Perfusion as First-Line versus Second-Line Therapy.","authors":"Michelle M Dugan, Roger Olofsson Bagge, Jonathan S Zager","doi":"10.1245/s10434-025-17461-z","DOIUrl":"10.1245/s10434-025-17461-z","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5402-5403"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Toward Precision Chemotherapy in Colorectal Liver Metastases: Integrating Genomics into Predictive Modeling.","authors":"Li-Jun Wang, Quan Bao, Jing-Qing Zhang, Zhong-Wu Li, Bao-Cai Xing","doi":"10.1245/s10434-025-17533-0","DOIUrl":"10.1245/s10434-025-17533-0","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"6102-6103"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Machine Learning for Postoperative Frailty Prediction in NSCLC-From Model Development to Clinical Translation.","authors":"Xuee Su, Baoyuan Xie","doi":"10.1245/s10434-025-17509-0","DOIUrl":"10.1245/s10434-025-17509-0","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5969"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: More Attention to Fertility-Sparing Surgery for Epithelial Ovarian Cancer Women.","authors":"Lina Yan, Lingli Zeng, Shuoyan Jiang, Ting Wang, Xuemei Jia, Fang Wang","doi":"10.1245/s10434-025-17410-w","DOIUrl":"10.1245/s10434-025-17410-w","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5628-5629"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for Appendiceal and Colorectal Adenocarcinoma with Peritoneal Metastasis.","authors":"Justin M Bader, Ava Ospina, Sean Liu, Biren Reddy, Princy Gupta, Ricarda Tomlin, Michael Cecchini, Raghav Sundar, Kiran Turaga","doi":"10.1245/s10434-025-17517-0","DOIUrl":"10.1245/s10434-025-17517-0","url":null,"abstract":"<p><strong>Background: </strong>Current treatment of metastatic peritoneal surface malignancies (PSM) arising from colorectal cancer (CRC) and appendiceal cancer involves cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) [Elias (J Clin Oncol 28:63-68, 2010), McMullen (Oncotarget 8: 43481-43490, 2017), Lemoine (Int J Hyperthermia 33:582-592, 2017)]. There have been several intraperitoneal (IP) trials of appendix and colon cancer with conflicting results and insufficient evidence regarding both HIPEC efficacy and optimal HIPEC regimens [Quenet (Lancet Oncology 22:256-266, 2021), Arjona-Sánchez (JAMA Surgery 158:683, 2023), Verwaal (Ann Surg Oncol 12:65-71, 2004), Benzaquen (Can J Surg 64: E111-E118, 2021), Turaga (Ann Surg Oncol 21: 1501-1505, 2014), Nash (J Clin Oncol 41: 160, 2023)]. Given the heterogeneity of prior data and the variability in patient responses to different HIPEC regimens, further research is needed to optimize and personalize treatment.</p><p><strong>Methods: </strong>This is a single-center, phase II, open-label clinical trial evaluating the feasibility of performing mass-based response testing to identify and deliver personalized intraperitoneal chemotherapy regimens to patients with unresectable high-grade appendiceal or colorectal peritoneal metastases undergoing HIPEC. Per SOC, there are currently multiple chemotherapy combinations used for HIPEC [Lemoine (Int J Hyperthermia 33:582-592, 2017), Dubé (Curr Oncol 22:100-112, 2015), Valle (Indian J Surg Oncol 7:152-159, 2016)]. MRT analysis will identify which SOC regimen to use for HIPEC based on the patient's tumor susceptibility.</p><p><strong>Discussion: </strong>Mass-based response testing (MRT) is a novel screening tool that enables rapid and reliable assessment of tumor susceptibility to various HIPEC drugs. MRT generates a report of patient-specific intraperitoneal chemotherapy sensitivities by analyzing a portion of biopsy tissue collected from the patient's standard of care (SOC) diagnostic laparoscopy [Kimmerling (J Clin Oncol 41: 3132, 2024)]. With multiple HIPEC regimens currently used as the SOC for PSM from appendiceal and colorectal cancer, MRT facilitates the selection of personalized SOC regimens tailored to each patient.Results of this study will inform future clinical trials evaluating the efficacy of MRT-selected HIPEC regimens for patients with PM from appendiceal cancer and CRC.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5784-5794"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Controversies at the Tumor Board-The Gray Areas in the Multimodality Treatment of Resectable Non-small Cell Lung Cancer.","authors":"Wara Naeem, Arsalan A Khan, Christopher W Seder","doi":"10.1245/s10434-025-17459-7","DOIUrl":"10.1245/s10434-025-17459-7","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5974-5975"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Training, Knowledge and Attitudes Related to Oncoplastic Surgery in Brazil.","authors":"Francisco Pimentel Cavalcante, Augusto Tufi Hassan, Rene Aloisio da Costa Vieira","doi":"10.1245/s10434-025-17549-6","DOIUrl":"10.1245/s10434-025-17549-6","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5574-5575"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Central Pancreatectomy with Omental Pedicle Flap: Tactics and Tips.","authors":"Fumihiro Kawano, Megan A Lim, Helen J Kemprecos, Kathryn Tsai, Daniel Cheah, Annie Tigranyan, Kanakaraju Kaviamuthan, Arundhati Pillai, Jaime Chian-Ruey Chen, Gregory Polites, Yoshihiro Mise, Mark Cohen, Akio Saiura, Claudius Conrad","doi":"10.1245/s10434-025-17530-3","DOIUrl":"10.1245/s10434-025-17530-3","url":null,"abstract":"<p><strong>Background: </strong>Robotic central pancreatectomy is increasingly used for pre- or low-grade malignant tumors in the pancreatic body balancing preservation of pancreatic function while removing the target lesion.^1-3 Today, there is no established reconstruction method and high rates of postpancreatectomy fistulas (POPF) remain a significant concern. ^4,5 We developed novel technique involving transgastric pancreaticogastrostomy with an omental pedicle advancement flap to reduce the risk of POPF. Additionally, preoperative deep-learning 3D organ modeling plays a crucial role in enhancing spatial understanding to enhance procedural safety.^6,7 METHODS: A 76-year-old female patient with a 33-mm, biopsy-confirmed high-risk IPMN underwent robotic-assisted central pancreatectomy. Preoperative CT was processed with a deep-learning system to create a patient-specific 3D model, enabling virtual simulation of port configurations. The optimal setup was selected based on the spatial relationship between port site, tumor location, and anatomy A transgastric pancreaticogastrostomy with omental flap reinforcement was performed to reduce POPF leading to a simpler reconstruction compared to pancreaticojejunostomy. The procedure lasted 218 min with minimal blood loss (50 ml). No complications occurred, and the patient was discharged on postoperative Day 3 after drain removal. Final pathology showed low-grade dysplasia.</p><p><strong>Conclusions: </strong>This approach, facilitated by robotic assistance, effectively preserves pancreatic function while treating a low-grade malignant tumor. Preoperative 3D organ modeling enhances the spatial understanding with the goal to increase procedural safety. Finally, the omental pedicle advancement flap technique shows promise in possibly reducing the incidence or at least the impact of POPF.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5421-5422"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Anastomotic Leaks on Long-Term Survival in Patients with Esophageal Squamous Cell Carcinoma Following McKeown Esophagectomy: A Propensity Score-Matched Analysis.","authors":"Chufeng Zeng, Xu Zhang, Bei Jia, Yi Hu, Peng Lin, Jianhua Fu, Hao Long, Tiehua Rong, Xiaodong Su","doi":"10.1245/s10434-025-17206-y","DOIUrl":"10.1245/s10434-025-17206-y","url":null,"abstract":"<p><strong>Background: </strong>The impact of anastomotic leak (AL) on the long-term survival of patients with esophageal squamous cell carcinoma (ESCC) remains unclear. This study investigated whether AL influences the long-term survival of patients with ESCC following McKeown esophagectomy.</p><p><strong>Patients and methods: </strong>An original database was queried to identify patients with ESCC who underwent McKeown esophagectomy between 2012 and 2020 at a high-volume cancer center. Overall survival (OS) and disease-free survival (DFS) were compared using Kaplan-Meier (KM) curves. Cox regression analysis was used for multivariate analysis. Propensity score matching (PSM) was used to adjust for the confounding factors.</p><p><strong>Results: </strong>A total of 1614 patients were included, of whom 16.9% developed AL. In patients without neoadjuvant therapy, for patients with and without AL, the 5-year OS was 55.8% and 62.0%, and the 5-year DFS was 48.7% and 59.1%, respectively (OS: p = 0.37, DFS: p = 0.046). In the neoadjuvant cohort, for patients with and without AL, the 5-year OS was 57.9% and 63.2%, and the 5-year DFS was 55.4% and 58.8%, respectively (OS: p = 0.48, DFS: p = 0.78). Moreover, AL significantly increased the risk of distant recurrence in patients without neoadjuvant therapy (p = 0.023).</p><p><strong>Conclusions: </strong>These findings suggest that AL negatively influences DFS in patients without neoadjuvant therapy, but does not significantly affect long-term survival in patients receiving neoadjuvant treatment. Intensive treatment and follow-up plan should be considered when patients without neoadjuvant therapy.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5849-5859"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis of Robot-Assisted Esophagectomy with Thoracic Duct Resection in Esophageal Squamous Cell Carcinoma.","authors":"Boyao Yu, Cong Qi, Bin Li, Zhichao Liu, Zhigang Li, Chunguang Li","doi":"10.1245/s10434-025-17318-5","DOIUrl":"10.1245/s10434-025-17318-5","url":null,"abstract":"<p><strong>Background: </strong>The authors' previous study found no significant difference in short-term clinical outcomes between patients undergoing robot-assisted esophagectomy (RAE) with or without thoracic duct resection (TDR). However, the impact of RAE-TDR on long-term prognosis remains unclear.</p><p><strong>Methods: </strong>From January 2019 to July 2020, the study prospectively and consecutively enrolled 127 thoracic duct (TD)-preserved and 73 TD-resected patients who underwent standard McKeown RAE surgery. The overall survival (OS) and recurrence-free survival (RFS) were compared between these two groups.</p><p><strong>Results: </strong>During a median follow-up period of 48.6 months, the 3-year OS rates were 70.6% and 70.9% in the TD-preserved and TD-resected group, and the 3-year RFS rates were 61.9% and 55.5%, respectively. The TD-preserved and TD-resected groups did not differ significantly in local-regional (12.6% vs. 15.1%; p = 0.623), distant (23.6% vs. 28.8%; p = 0.422), or mixed (2.4% vs. 4.1%; p = 0.670) recurrence. However, among the eight (11%) patients with TD lymph node (LN) metastasis in the TD-resected group, six patients experienced recurrences (1 local-regional and 5 distant). The patients who had thoracic duct lymph node (TDLN) metastasis experienced significantly worse RFS than those who did not (p = 0.04). Additionally, TDLN metastasis was significantly associated with advanced nodal stage (cN2-3, 6/8; p = 0.001) and bulky tumors (pT3, 7/8; p = 0.028).</p><p><strong>Conclusion: </strong>In ESCC, RAE-TDR does not improve recurrence or survival outcomes. However, identification of TDLN metastasis through TDR carries significant prognostic implications considering its strong association with aggressive tumor biology and inferior oncologic outcomes. Therefore, TDR should not be routinely performed, but its selective application for patients with advanced tumors may provide critical staging information to guide tailored postoperative strategies.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5877-5886"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}