Annals of Surgical Oncology最新文献

{"title":"Analysis of Multiple Programmed Cell Death Patterns and Functional Validations of Apoptosis-Associated Genes in Lung Adenocarcinoma.","authors":"Yu Peng, Nan Jia, Jingyu Wang, Shilei Dong, Shujun Li, Wei Qin, Hongyun Shi, Kuan Liu","doi":"10.1245/s10434-025-17224-w","DOIUrl":"10.1245/s10434-025-17224-w","url":null,"abstract":"<p><strong>Background: </strong>Lung adenocarcinoma (LUAD) is marked by its considerable aggressiveness and pronounced heterogeneity. Programmed cell death (PCD) plays a pivotal role in the progression of tumors, their aggressive behavior, resistance to treatment, and recurrence of the disease.</p><p><strong>Patients and methods: </strong>Using expression data from 878 patients across four multicenter cohorts, we identified 13 consensus prognostic genes from 1481 genes associated with PCD. We employed 10 machine-learning algorithms, generating 101 combinations, from which the optimal algorithm was chosen to develop an artificial intelligence-derived cell death index (CDI) on the basis of the average C-index.</p><p><strong>Results: </strong>The training cohort and three external validation cohorts consistently demonstrated that CDI could accurately predict LUAD prognosis. Moreover, CDI showed significantly greater accuracy than traditional clinical variables, molecular characteristics, and 22 previously published signatures. Patients in the low-CDI group had a more favorable prognosis, higher levels of immune cell infiltration, better responsiveness to immunotherapy, and a higher likelihood of displaying the \"hot tumor\" phenotype. Single-cell analysis revealed that neutrophils had the highest CDI scores and exhibited significant differences in marker gene expression.</p><p><strong>Conclusions: </strong>Pseudotime trajectory analysis indicated that BCL2L14 plays a crucial role in the developmental pathway of neutrophils, potentially influencing the fate of LUAD cells. Knockdown of BCL2L14 significantly reduced the growth, proliferation, and colony formation abilities of LUAD cells, while also enhancing apoptosis rates.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"6005-6022"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Benign Anastomotic Stenosis After Esophagectomy for Cancer.","authors":"Dillen C van der Aa, Jelle Boonstra, Wietse J Eshuis, Freek Daams, Roos E Pouw, Suzanne S Gisbertz, Mark I van Berge Henegouwen","doi":"10.1245/s10434-025-17401-x","DOIUrl":"10.1245/s10434-025-17401-x","url":null,"abstract":"<p><strong>Background: </strong>Benign stenosis frequently occurs after esophagectomy, causing dysphagia, eating problems, and diminished quality of life. This study aimed to identify risk factors for benign anastomotic stenosis after esophagectomy for cancer.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed patients who underwent esophagectomy at Amsterdam UMC from 2012 until 2022. Intrathoracic and cervical anastomoses were examined separately. Benign anastomotic stenosis was defined as stenosis at the anastomosis causing dysphagia (Ogilvie score ≥2) and requiring at least one endoscopic dilation. Predictive factors were identified using logistic regression.</p><p><strong>Results: </strong>The study enrolled 902 patients: 605 with intrathoracic and 297 with cervical anastomosis. Of these cases, 91.1 % were a minimally invasive esophagectomy. Stenosis occurred in 18.4 % of the intrathoracic cases and 49.8 % of the cervical cases (p < 0.001). The patients required medians of 4 and 7 dilations, respectively (p = 0.001). The median time to stenosis was 99 days for the intrathor days for the cervical anastomoses (p = 0.001). Intrathoracic stenosis was independently associated with anastomotic leakage (odds ratio [OR], 2.034; 95 % confidence interval [CI], 1.116-3.708). For the patients without leakage, a 2 mm versus a 25 mm circular stapler reduced stenosis risk (OR, 0.486; 95 % CI, 0.294-0.803), whereas use of immunosuppressants (OR, 3.492; 95 % CI, 1.186-10.279]) and chronic pulmonary disease (OR, 2.717; 95 % CI, 1.293-5.707) increased it. For cervical anastomoses, hand-sewn end-to-side anastomosis was protective (OR, 0.454; 95 % CI, 0.234-0.879).</p><p><strong>Conclusions: </strong>The key risk factors for intrathoracic benign anastomotic stenosis are anastomotic leakage, smaller circular stapler size, use of immunosuppressants, and chronic pulmonary disease. For cervical anastomoses, the hand-sewn end-to side technique is protective compared with the end-to-end technique, whereas use of immunosuppressants and chronic pulmonary disease increases the risk.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5919-5927"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Enhancing Recurrence-Free Survival Prediction in Hepatocellular Carcinoma: A Time-Updated Model Incorporating Tumor Burden and AFP Dynamics.","authors":"Miho Akabane, Timothy M Pawlik","doi":"10.1245/s10434-025-17342-5","DOIUrl":"10.1245/s10434-025-17342-5","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5724-5725"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AT101 Suppresses Gastrointestinal Stromal Tumor Growth and Promotes Apoptosis via YAP/TAZ-CCND1 and FBXW7-MCL1 Axes.","authors":"Xiyu Wu, Kohei Yamashita, Meiyue Lou, Chihiro Matsumoto, Weiliyun Zhang, Hideo Baba, Masaaki Iwatsuki","doi":"10.1245/s10434-025-17247-3","DOIUrl":"10.1245/s10434-025-17247-3","url":null,"abstract":"<p><strong>Background: </strong>Imatinib (IM), a tyrosine kinase inhibitor (TKI), is the first-line treatment for patients with gastrointestinal stromal tumors (GISTs). However, its efficacy is limited due to acquired resistance induced by secondary KIT mutations in most patients with GIST. Furthermore, new challenges have emerged following the clarification that KIT-independent GISTs exhibit strong resistance to small molecule inhibitors targeting KIT/ platelet-derived growth factor receptor alpha (PDGFRA). Therefore, investigating the underlying therapeutic targets for imatinib-resistant GISTs is urgently necessitated.</p><p><strong>Patients and methods: </strong>Through both in vitro and in vivo experiments, along with the analysis of alterations in the FBXW7-MCL1 axis and the YAP/TAZ-CCND1 pathway in patients with GISTs, before and after IM treatment.</p><p><strong>Results: </strong>MCL1 overexpression and activation of the YAP/TAZ-CCND1 pathway are induced in IM-resistant GIST cells and post-IM GIST samples. AT101, a BCL-2 inhibitor, exerts a pro-apoptotic effect on GIST cells by suppressing MCL1 overexpression, and the combination therapy of AT101 and IM exerts a stronger pro-apoptotic effect through modulation of IM activity regulated by the FBXW7-MCL1 axis. Furthermore, the suppression of AT101 on GIST growth and metastasis, by targeting the YAP/TAZ-CCND1 pathway, was confirmed through xenograft and metastasis mouse models. Notably, the antitumor activity of AT101 is maintained regardless of the IM sensitivity of GIST cells, whereas AT101 enhances and restores IM activities in both GIST-T1 and IM-resistant GIST cells.</p><p><strong>Conclusions: </strong>AT101 exerts a strong antitumor activity by targeting both the FBXW7-MCL1 axis and the YAP/TAZ-CCND1 pathway, suggesting that AT101 monotherapy, and its combination with IM, are worth further investigating in clinical trials.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5991-6004"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Sectionectomy Extended to the Right Hepatic Vein: A Robotic Approach with a Video.","authors":"Perrine Côme, Farouk Mourthadhoi, Bertrand Le Roy","doi":"10.1245/s10434-025-17275-z","DOIUrl":"10.1245/s10434-025-17275-z","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5713-5714"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Impact of the Pathologic Response of Patients with Hepatocellular Carcinoma After Preoperative Treatments.","authors":"Hongwei Xu, Haili Zhang, Yani Liu, Haojun Wu, Bo Li, Kefei Chen, Yonggang Wei","doi":"10.1245/s10434-025-17453-z","DOIUrl":"10.1245/s10434-025-17453-z","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) exhibits varying degrees of tumor regression after preoperative treatments. However, the relationship between a tumor residual and its impact on recurrence-free survival (RFS) remains poorly defined. This study aimed to assess the effect of pathologic response on RFS in HCC patients undergoing preoperative treatments.</p><p><strong>Methods: </strong>Data from 400 patients with HCC who received preoperative treatments were retrospectively analyzed. The correlation between tumor residual and RFS was assessed using the \"surv_cutpoint\" function in R software and further validated through Cox proportional hazards regression models, with the objective of identifying a cutoff value that was significantly associated with RFS.</p><p><strong>Results: </strong>The overall analysis showed that pathologic response significantly influenced postoperative recurrence when tumor residual of 15% or less was detected. Multivariate regression analysis found that the independent risk factors for RFS were pathologic satellite nodules (hazard ratio [HR], 1.56; 95% confidence interval [CI] 1.05-2.25; P = 0.047), microvascular invasion (HR, 1.72; 95% CI 1.16-2.55; P = 0007), and advanced tumor stage (HR, 1.60; 95% CI 1.05-2.44; P = 0.031). In contrast, an independent protective factor affecting RFS was found to be residual of 15% or less (HR 0.41; 95% CI 0.26-0.63; P < 0.001). Subgroup analyses showed that RFS was significantly associated with a tumor residual cutoff value of 15% in Barcelona Clinic Liver Cancer (BCLC) stage A, 20% in stage BCLC stage B, and 26% in stage BCLC stage C.</p><p><strong>Conclusions: </strong>This study demonstrated that achieving tumor residual of 15% or less after liver resection significantly reduces postoperative recurrence rates for HCC patients treated with preoperative therapies. The effect of tumor regression on RFS varied according to tumor stages.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5684-5693"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: For Duodenal Bulb Tumors with Submucosal Invasion, Would Distal Gastrectomy with Duodenal Bulb Resection be the Optimal Surgical Procedure?","authors":"Kazuhiko Hisaoka, Satoru Matsuda, Hirofumi Kawakubo, Yuko Kitagawa","doi":"10.1245/s10434-025-17594-1","DOIUrl":"10.1245/s10434-025-17594-1","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5430-5431"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Neighborhood Deprivation with Stage at Diagnosis and Treatment Delay for Breast Cancer in Philadelphia.","authors":"Isabel C Yoon, Stephany Perez-Rojas, Bhavya Ancha, Leisha C Elmore, Alina M Mateo, Margaret S Pichardo, Julia C Tchou, Jennifer Q Zhang, Rebecca A Hubbard, Oluwadamilola M Fayanju","doi":"10.1245/s10434-025-17367-w","DOIUrl":"10.1245/s10434-025-17367-w","url":null,"abstract":"<p><strong>Introduction: </strong>Neighborhood deprivation and other sociodemographic factors are associated with breast cancer outcomes, but in Philadelphia, the country's poorest large city, these factors have been understudied. We examined their association with stage at breast cancer diagnosis and treatment delay (>60 days after diagnosis).</p><p><strong>Methods: </strong>We identified women aged ≥18 years with breast cancer at an academic health system based in Philadelphia from 2011 to 2019. The Area Deprivation Index (ADI) was calculated across the cohort and grouped into quartiles: ADI 1 = least deprived, ADI 4 = most deprived. Multivariable logistic regression estimated sociodemographic associations with advanced stage (III-IV) at diagnosis and treatment delay.</p><p><strong>Results: </strong>Overall, 11,108 patients were identified. White patients constituted a larger proportion of the least versus most deprived group (ADI 1 = 84.4% vs. ADI 4 = 50.9%), while the proportion of Black patients was highest in the most deprived group (ADI 1 = 3.9% vs. ADI 4 = 41.5%). Patients in the ADI 4 group (vs. ADI 1; odds ratio [OR] 1.48, 95% confidence interval [CI] 1.19-1.84), who identified as Black (vs. White; OR 1.35, 95% CI 1.11-1.63), and with Medicaid insurance (OR 1.94, 95% CI 1.51-2.49) or no insurance (OR 2.21, 95% CI 1.27-3.67) versus privately insured patients had higher odds of presenting with advanced stage (all p < 0.05). Patients who identified as Asian, had Medicaid insurance or no insurance, were >70 years of age, and presented with advanced stage were less likely to receive treatment within 60 days, while patients in the ADI 2-4 group were twice as likely to receive treatment within 60 days as patients in the ADI 1 group.</p><p><strong>Conclusions: </strong>Neighborhood deprivation was associated with advanced stage at presentation, but not treatment delay, for patients with breast cancer in the Philadelphia metropolitan area, suggesting neighborhood-level opportunities to facilitate screening and more early-stage diagnoses.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5500-5509"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Ratio of the Preoperative Fecal Short-Chain Fatty Acid to Lactic Acid Concentrations as a Predictor of Postoperative Infectious Complications After Esophagectomy.","authors":"Takuya Nagao, Yukihiro Yokoyama, Tetsuya Abe, Kazushi Miyata, Shizuki Sugita, Atsushi Ogura, Yuki Murata, Eiji Higaki, Hironori Fujieda, Takashi Asahara, Yasuhiro Shimizu, Tomoki Ebata","doi":"10.1245/s10434-025-17347-0","DOIUrl":"10.1245/s10434-025-17347-0","url":null,"abstract":"<p><strong>Background: </strong>The ratio of the fecal short-chain fatty acid (SCFA) to lactic acid concentrations (APB-L ratio) is a useful indicator for the healthiness of the intestinal microenvironment. A recent study indicated that the low APB-L ratio can be a predictor of postoperative infectious complications (POICs) in patients undergoing pancreaticoduodenectomy. However, the predictive power of the APB-L ratio in other highly invasive surgeries, such as esophagectomy, is still unclear. This study investigated whether the APB-L ratio can be a sensitive predictor of POICs in patients undergoing esohpagectomy.</p><p><strong>Methods: </strong>A total of 129 patients undergoing esohpagectomy with gastric conduit reconstruction were included in this study. Preoperative fecal samples were analyzed for SCFA and lactic acid concentrations. The associations between clinical characteristics, POICs, and the APB-L ratio were analyzed. Preoperative and intraoperative risk factors for POICs were explored via multivariate logistic regression analysis.</p><p><strong>Results: </strong>Postoperative infectious complications were observed in 34 patients (26%), including surgical site infections in 18 patients (14%). A low APB-L ratio was significantly associated with higher POICs and surgical site infections risk (both p < 0.05). A low APB-L ratio was identified as an independent risk factor for POICs, with an odds ratio of 3.62 (95% confidence interval, 1.44-9.10, p = 0.006).</p><p><strong>Conclusions: </strong>The APB-L ratio measured with preoperative fecal organic acid concentrations is useful to assess the risk of POICs for esohpagectomy. The results also imply the importance of maintaining a healthy intestinal metabolism (thus high APB-L ratio) to reduce POICs before highly invasive surgery.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"6058-6066"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Is Mesothelin a Promising Option for Molecular Targeted Therapies in Triple Negative Breast Cancer?","authors":"Takumi Sato, Brendan L Hagerty, Rongrong Wu, Takashi Ishikawa, Kazuaki Takabe","doi":"10.1245/s10434-025-17314-9","DOIUrl":"10.1245/s10434-025-17314-9","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"6106-6107"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}