Annals of Surgical Oncology最新文献

{"title":"ASO Author Reflections: Robotic Pancreatoduodenectomy: Standardizing the Journey, Not Just the Destination.","authors":"Luca Morelli, Annalisa Comandatore, Gregorio Di Franco, Niccolò Furbetta, Giovanni Caprili, Niccolò Ramacciotti, Bianca Bechini, Raffaele Gaeta, Luca Pollina, Claudia Cariello, Elisa Giovannetti, Simone Guadagni","doi":"10.1245/s10434-026-20445-2","DOIUrl":"10.1245/s10434-026-20445-2","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"10742-10743"},"PeriodicalIF":3.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICG-only Sentinel Lymph Node Biopsy in Breast Cancer: A Prospective UK Cohort Demonstrating Consistent Detection Across Patient and Tumour Characteristics-A Follow-on to the INFLUENCE Trial.","authors":"Vassilis Pitsinis, Nadia Khitab, Lee Jordan, Alessio Vinci, Rahul Kanitkar, Emad Elseedawy, Jennifer Smith","doi":"10.1245/s10434-026-20316-w","DOIUrl":"10.1245/s10434-026-20316-w","url":null,"abstract":"<p><strong>Background: </strong>Sentinel lymph node biopsy (SLNB) using dual tracer techniques remains the gold standard for axillary staging in early breast cancer. However, reliance on radioisotope mapping introduces logistical complexity, cost, and radiation exposure. Indocyanine green (ICG) fluorescence imaging has emerged as a potential single-tracer alternative, but concerns remain regarding its reliability across heterogeneous patient populations.</p><p><strong>Methods: </strong>A prospective single-centre cohort study was conducted including 300 consecutive SLNB procedures across 292 unique patients using ICG as the sole tracer. The primary endpoints were nodal procedural detection rate and ICG nodal detection rate. Secondary outcomes included: nodal positivity, number of nodes retrieved, operative time, the influence of patient, tumour, and procedural variables. Statistical analysis included linear and logistic regression and correlation analysis.</p><p><strong>Results: </strong>Procedural nodal detection was achieved in 99.7% (299/300) of procedures, while ICG fluorescent nodal detection was achieved in 97.7% (293/300). Median surgeon-pathologist nodal concordance was 100% (IQR 50-100%), with complete count agreement in 50.7% of procedures. Detection was not influenced by age, body mass index (BMI), tumour size, or procedure type. Operative time increased significantly with BMI (p = 0.0118) and breast-conserving surgery (p < 0.0001).</p><p><strong>Conclusions: </strong>This large UK prospective series demonstrates that ICG-only fluorescence guidance is safe, efficient, and reproducible, with high procedural and nodal detection rates. Naked-eye visibility of ICG was observed in a subset of cases, further supporting its practicality. Performance was consistent across surgical procedures and patient BMI. These findings support broader adoption of ICG as a single tracer for SLNB.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"10558-10563"},"PeriodicalIF":3.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Neuron Projection Guidance-A transcriptomic perspective on tumor-induced neural recruitment in breast cancer.","authors":"Kei Kawashima, Kohei Chida, Masanori Oshi, Akimitsu Yamada, Kazutaka Narui, Shipra Gandhi, John M L Ebos, Scott I Abrams, Arin Bhattacharjee, Itaru Endo, Kazuaki Takabe","doi":"10.1245/s10434-026-20049-w","DOIUrl":"10.1245/s10434-026-20049-w","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"10461-10462"},"PeriodicalIF":3.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Two Decades of Progress in Curative Treatment of Locally Recurrent Rectal Cancer.","authors":"F E C Vande Kerckhove, D M J Creemers, E Banken, F Piqeur, S H J Ketelaers, R R J Coebergh van den Braak, J Tolenaar, R J Schipper, G A P Nieuwenhuijzen, W Setz-Pels, T R van Oudheusden, A W Daniëls-Gooszen, S G van Ravensteijn, I E G van Hellemond, A E Verrijssen, H M U Peulen, J G Bloemen, J Nederend, H J T Rutten, J W A Burger","doi":"10.1245/s10434-026-20584-6","DOIUrl":"10.1245/s10434-026-20584-6","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"10651-10652"},"PeriodicalIF":3.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of Lymph Node Metastases After Multimodality Therapy in Esophageal Carcinoma Treated with Robot-Assisted Minimally Invasive Esophagectomy (RAMIE).","authors":"Maxime E Sanders, Eline de Groot, Robin B den Boer, Jan Erik Freund, Nadia Haj Mohammad, Gert J Meijer, Stella Mook, Jelle P Ruurda, Richard van Hillegersberg","doi":"10.1245/s10434-026-20410-z","DOIUrl":"10.1245/s10434-026-20410-z","url":null,"abstract":"<p><strong>Background: </strong>Lymph node metastases (LNMs) in esophageal carcinoma demonstrate extensive and variable dissemination. Previous mapping studies are limited to region-based reporting, heterogeneous classification systems, and absence of contemporary multimodality-treated cohorts. This study aimed to characterize the station-level distribution of LNMs after standardized robot-assisted minimally invasive transthoracic esophagectomy (RAMIE) with two-field lymphadenectomy and to evaluate patterns in relation to key preoperative parameters.</p><p><strong>Methods: </strong>A prospective, single-center observational cohort of patients undergoing transthoracic RAMIE for adenocarcinoma (AC) or squamous cell carcinoma (SCC) between 2018 and 2024 was analyzed. The primary outcome was station-level distribution of LNMs in relation to histology, tumor location, clinical T stage, clinical N stage, and receipt of neoadjuvant therapy. Analyses were descriptive.</p><p><strong>Results: </strong>Among 210 patients (74% AC, 26% SCC), median lymph node yield was 44 (interquartile range [IQR], 34-52). Lymph node metastases were present in 42% of the patients, with a median of two positive nodes (IQR, 1-4). Although 91% received neoadjuvant therapy (85% CROSS, 7% FLOT), residual nodal disease remained frequent and widely distributed. Metastases occurred most frequently in the paraesophageal (11%) subcarinal (10%) mediastinal stations, and along the left gastric artery (22%) and right paracardial (15%) nodes. Thoracic duct LNM was identified in 9% of the patients. Patterns were similar across preoperative parameters. Occult nodal disease was observed in 32% of cN0 patients.</p><p><strong>Conclusions: </strong>Lymphatic dissemination in esophageal cancer remains extensive and unpredictable, even after multimodality therapy. The persistence of cross-diaphragmatic nodal involvement across subgroups underscores the ongoing necessity of a systematic two-field lymphadenectomy to achieve optimal locoregional control and accurate pathologic staging.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"10335-10345"},"PeriodicalIF":3.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Beyond Pathologic Complete Response-Why Treatment Strategy Matters.","authors":"Giovanni Maria Garbarino, Carlo Castoro, Lorenzo Giorgi, Luca Risi","doi":"10.1245/s10434-026-20443-4","DOIUrl":"10.1245/s10434-026-20443-4","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"10401-10402"},"PeriodicalIF":3.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Real-World Insights into Melanoma Biopsy Selection and Staging Accuracy.","authors":"Lindy Davis, Amelia Stapleton Van Doren","doi":"10.1245/s10434-026-20478-7","DOIUrl":"10.1245/s10434-026-20478-7","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"10800-10801"},"PeriodicalIF":3.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic Hyperthermic Intraperitoneal Chemotherapy in Locally Advanced Colorectal Cancer: Systematic Review and Meta-Analysis.","authors":"Yi-Chang Chen, Sheng-Chi Chang, Yuan-Yao Tsai, Tao-Wei Ke, Abe Fingerhut, William Tzu-Liang Chen","doi":"10.1245/s10434-026-20393-x","DOIUrl":"10.1245/s10434-026-20393-x","url":null,"abstract":"<p><strong>Background: </strong>Hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to be effective to treat peritoneal carcinomatosis (PM). However, the benefits of prophylactic HIPEC in patients with locally advanced colorectal cancer remains unknown. This meta-analysis aimed to determine the impact of prophylactic HIPEC in this setting.</p><p><strong>Methods: </strong>We performed a systematic literature review using PubMed, Embase, and Web of Science databases according to pre-defined inclusion and exclusion criteria. Oncological parameters were extracted and pooled to analyze peritoneal metastasis-free survival, disease-free survival, and overall survival.</p><p><strong>Results: </strong>We included 2023 patients (1470 in the control group and 553 in the prophylactic HIPEC group) originating from nine studies. One-year, 3-year, and 5-year peritoneal metastasis-free survival, 3-year and 5-year disease-free survival were better in the prophylactic HIPEC group than in the control group (hazard ratio [HR] 0.521, 95% confidence interval [CI] [0.292-0.930], P = 0.028; HR 0.333, 95% CI [0.152-0.731], P = 0.006; HR 0.334, 95% CI [0.125-0.887], P < 0.028; HR 0.701, 95% CI [0.574-0.855], P < 0.001; HR 0.714, 95% CI [0.590-0.864], P = 0.001), respectively. There was no statistically significant difference in overall survival, postoperative major complications, leakage, or surgical site complications between groups.</p><p><strong>Conclusions: </strong>While prophylactic HIPEC appears to improve peritoneal metastasis-free survival and disease-free survival, the findings should be interpreted cautiously and require confirmation through future high-quality randomized studies and collaborative individual patient data meta-analyses.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"10223-10233"},"PeriodicalIF":3.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Practice Guidelines Series: Resectable Colorectal Cancer.","authors":"Ramy Behman, George J Chang","doi":"10.1245/s10434-026-20216-z","DOIUrl":"10.1245/s10434-026-20216-z","url":null,"abstract":"<p><p>Colorectal cancer remains a leading cause of cancer morbidity and mortality worldwide. Despite biologic similarities, colon and rectal cancers require distinct management strategies. Rapid advances molecular characterization (including mismatch repair status) as well as paradigm shifts in neoadjuvant therapy and organ-preservation strategies have expanded the range of treatment approaches while increasing the need for clear, guideline-anchored decision-making. This Practice Guidelines Series article summarizes contemporary guidance from major international guidelines (National Comprehensive Cancer Network (NCCN), European Society for Medical Oncology (ESMO), and Japanese Society for Cancer of the Colon and Rectum (JSCCR)), highlighting areas of recent evolution and ongoing debate.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"10603-10615"},"PeriodicalIF":3.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Pathological Complete Response: Long-term Outcomes in Esophageal and Esophagogastric Junction Adenocarcinoma After Multimodal Therapy-A Systematic Review and Individual Patient-Data Meta-Analysis.","authors":"Luca Risi, Renato De Martino, Lorenzo Giorgi, Paolo Enrico Meneghesso, Andrea Pansa, Silvia Basato, Carlo Castoro, Rita Alfieri, Giovanni Maria Garbarino","doi":"10.1245/s10434-026-20296-x","DOIUrl":"10.1245/s10434-026-20296-x","url":null,"abstract":"<p><strong>Background: </strong>Neoadjuvant chemotherapy (nCT) for esophageal and esophagogastric junction (EGJ) adenocarcinoma is associated with better survival but worse pathological complete response (pCR) rate as compared with neoadjuvant chemoradiotherapy (nCRT). The aim of the present study is to compare long-term outcomes in patients with esophageal or EGJ adenocarcinoma and pCR after nCT or nCRT.</p><p><strong>Patients and methods: </strong>A systematic review of the literature in PubMed, Embase and web sources was performed up to November 2025. Studies comparing nCT and nCRT in patients with esophageal or EGJ adenocarcinoma and pCR were identified. An individual patient-data (IPD) meta-analysis was performed for overall survival (OS) and disease-free survival (DFS).</p><p><strong>Results: </strong>Overall, 1454 patients from six different studies were included (374 in nCT group and 1080 in nCRT group). 1-, 3-, and 5-year OS was superior in the nCT group as compared with nCRT group, being 95.4% versus 87.8%, 81.5% versus 64.8% and 73.8% versus 56%, respectively (p < 0.001). Analogously, superior DFS was observed for the nCT group at one, three and 5 years (p < 0.001). In the one-stage meta-analysis nCT was associated with decreased risk of death (HR = 0.49, p < 0.001) and recurrence (HR = 0.24, p <0.001).</p><p><strong>Conclusions: </strong>The present study showed better long-term outcomes in patients with pCR after nCT when compared with nCRT, highlighting the better systemic disease control offered by the first. This consideration suggests that pCR cannot be considered as a prognostic surrogate per se but the integration of this concept with the type of preoperative strategy is crucial.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"10301-10311"},"PeriodicalIF":3.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}