Annals of Surgical Oncology最新文献

{"title":"ASO Author Reflections: Plasma Ceramide Levels Aid in Prognosis in Pancreatic Ductal Adenocarcinoma.","authors":"Joshua D Mitchell, Linda R Peterson","doi":"10.1245/s10434-025-17274-0","DOIUrl":"https://doi.org/10.1245/s10434-025-17274-0","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axillary Surgery After Neoadjuvant Chemotherapy for Breast Cancer: Population-Based Trends Over Time.","authors":"Ekaterina Kouzmina, Matthew Castelo, Nicole J Look Hong, Julie Hallet, Natalie Coburn, Frances C Wright, Lena Nguyen, Sonal Gandhi, Katarzyna J Jerzak, Andrea Eisen, Amanda Roberts","doi":"10.1245/s10434-025-17236-6","DOIUrl":"https://doi.org/10.1245/s10434-025-17236-6","url":null,"abstract":"<p><strong>Background: </strong>Sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NAC) is recommended for patients initially presenting with cN1 disease and evidence of clinical/imaging response after NAC. We aimed to describe real-world population changes in management.</p><p><strong>Methods: </strong>We completed a population-based cohort study including adult women undergoing NAC followed by surgery for cT1-3N1 breast cancer between 1 April 2012 and 31 January 2020 in Ontario, Canada. Axillary surgeries (SLNB, axillary lymph node dissection [ALND], or SLNB followed by ALND) were studied over time using the Cochran-Armitage test, while multivariable logistic regression evaluated factors associated with surgery type.</p><p><strong>Results: </strong>Overall, 2563 patients were analyzed (37.9% were HER2-positive [HER2+ve], 42.3% were hormone receptor-positive and HER2-ve [HR+/HER2-ve], and 19.8% were triple-negative [TN]). 593 (23.1%) patients underwent SLNB and 1860 (72.6%) underwent ALND, while 110 (4.3%) patients underwent SLNB + ALND. From 2012 to 2020, SLNB increased from 5.7 to 29.9% (p < 0.01) and SLNB + ALND increased from 1.7 to 4.7% (p < 0.01), while ALND decreased from 92.6 to 65.4% (p < 0.01). Similar trends were identified across all receptor groups. After adjustment, patients who underwent SLNB had fewer comorbidities (odds ratio [OR] 1.82, 95% confidence interval [CI] 1.03-3.19), smaller tumors (T2 vs. T3: OR 1.52, 95% CI 1.21-1.92; T1 vs. T3: OR 1.56, 95% CI 1.14-2.13), and had surgery later in the study period (OR 1.32, 95% CI 1.25-1.38).</p><p><strong>Conclusion: </strong>In alignment with current practice guidelines, de-escalation of axillary surgery to SLNB has increased over time for patients after breast cancer NAC.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Series on The Lancet Oncology Commission on Global Cancer Surgery Action 2: Education and Training.","authors":"Chandrakanth Are, Varnica Bajaj, Makayla Schissel, T S Rao","doi":"10.1245/s10434-025-17272-2","DOIUrl":"https://doi.org/10.1245/s10434-025-17272-2","url":null,"abstract":"<p><strong>Background: </strong>The ability to deliver safe, timely, affordable, and high-quality cancer surgery depends on an adequate cadre of well-trained and competent cancer surgeons. It is well-known that wide variations and inequities exist in the educational platforms for training cancer surgeons on the global stage. The second Lancet Oncology Commission on Global Cancer Surgery Action on education and training is geared toward creating robust, sustainable, and affordable educational platforms for training cancer surgeons globally.</p><p><strong>Methods and results: </strong>This study used the principles of implementation science taken from the Consolidated Framework for Implementation Research to help develop the content and increase the likelihood of success in implementing the recommendations in this Action.</p><p><strong>Conclusion: </strong>The Annals of Surgical Oncology series on the Second Lancet Oncology Commission on Global Cancer Surgery hopes to enhance the visibility of the eight critical actions within this important Commission to the primary stakeholders, the surgeons. Thie authors hope this Action on education and training will help to increase availability and modernize and develop contextually appropriate and resource-stratified educational platforms of appropriate length for training the next generation of competent cancer surgeons.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Trial on Electroacupuncture for Recovery of Postoperative Gastrointestinal Function Based on Long-Term Monitoring Device.","authors":"Yuling Cai, Haoyang Li, Haiou Nan, Pengyan Xu, Jiayu Li, Huafeng Pan, Haifeng Wang, Miaomiao Ge, Junjie Guan, Zhiwei Jiang, Gang Wang","doi":"10.1245/s10434-025-17239-3","DOIUrl":"https://doi.org/10.1245/s10434-025-17239-3","url":null,"abstract":"<p><strong>Background: </strong>This research aimed to explore the efficacy and safety of electroacupuncture in promoting the recovery of postoperative gastrointestinal function and to discuss the potential mechanism on the basis of heart rate variability (HRV).</p><p><strong>Patients and methods: </strong>This was a randomized controlled study. Postoperative patients with gastric cancer received either electroacupuncture (EA) or sham electroacupuncture (SEA) 2 h after surgery and on the morning of the first 2 days after surgery, with each session lasting 30 min. The acupoints, treatment timepoints, and treatment durations in the SEA group were kept consistent with those in the EA group, but the intervention was SEA. Both groups were equipped with artificial intelligence HRV monitoring devices to monitor perioperative HRV and continuous bowel sound auscultation recorders to monitor perioperative bowel sound recovery in real time. Gastrointestinal function recovery indicators, HRV indicators, inflammatory markers, the incidence of postoperative complications, and adverse events were analyzed.</p><p><strong>Results: </strong>There was no statistically significant difference (P > 0.05) in baseline. First flatus time, first oral feeding time, intestinal function recovery time, and length of postoperative hospitalization of EA group were better than those of the SEA group, (P < 0.05). On day 3 after surgery, in EA group, C-reactive protein, interleukin-1 beta (IL-1β) were lower than those in SEA group (P < 0.05). HRV indicators such as standard deviation of the average NN intervals, percentage of successive RR intervals that differ by more than 50 ms (PNN50), and high frequency were higher in EA group than those in SEA group (P < 0.05).</p><p><strong>Conclusions: </strong>EA can safely and effectively promote gastrointestinal function rehabilitation in postoperative patients with gastric cancer, whose mechanism may be associated with higher tension in the vagus nerve, affected by EA.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: The Five-Item Modified Frailty Index in Breast Cancer Surgery: Past Insights, Present Evidence, and Future Directions.","authors":"Laetitia S Chiarella, Lioba Huelsboemer, Fortunay Diatta, Felix J Klimitz, Alexander J Kammien, Alejandro Kochen, Sam Boroumand, Omar Allam, Martin Kauke-Navarro, Bohdan Pomahac","doi":"10.1245/s10434-025-17273-1","DOIUrl":"https://doi.org/10.1245/s10434-025-17273-1","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Medicaid Expansion on Rural Medicare Beneficiaries Undergoing Colon Cancer-Directed Surgery in the United States.","authors":"Andrew P Loehrer, Qianfei Wang, A James O'Malley, Sandra L Wong, Anna N A Tosteson","doi":"10.1245/s10434-025-17266-0","DOIUrl":"https://doi.org/10.1245/s10434-025-17266-0","url":null,"abstract":"<p><strong>Background: </strong>The 2010 Affordable Care Act increased access to colon cancer care for millions of non-elderly adults; however, the direct and indirect impact of Medicaid expansion on Medicare beneficiaries with cancer remains less clear, especially for elderly beneficiaries in rural communities.</p><p><strong>Methods: </strong>Medicare Provider Analysis and Review file was queried for all fee-for-service (FFS) beneficiaries undergoing cancer-directed surgery for colon cancer between 2012 and 2019. Our primary outcomes included 90-day postoperative morbidity, mortality, return to an emergency department, or readmission in the form of an inpatient hospitalization. Multivariable hierarchical logistic regression analyses akin to a difference-in-difference model were performed, allowing the intervention units (US states) to undergo expansion at different times while also controlling for demographic, clinical, and residential geospatial characteristics. Secondary analyses examined for an interaction between rurality and expansion.</p><p><strong>Results: </strong>Final analysis included 221,814 Medicare beneficiaries who underwent colon cancer-directed surgery between 2012 and 2019. Overall, 141,159 (63.6%) beneficiaries resided in states that adopted expanded Medicaid eligibility. Controlling for confounding factors, Medicaid expansion was not associated with postoperative surgical outcomes, including 90-day morbidity (p = 0.56), mortality (p = 0.30), presentation to an emergency department (p = 0.79), or readmission to an inpatient hospital (p = 0.43). Similarly, analyses evaluating differential association of expansion on rural beneficiaries found no significant differences associated with Medicaid expansion for rural compared with metropolitan beneficiaries.</p><p><strong>Conclusions: </strong>In these analyses of over 200,000 Medicare beneficiaries across the United States, we found that Medicaid expansion was not associated with any changes in postoperative outcomes for Medicare beneficiaries undergoing colon cancer-directed surgery, either overall or by rural place of residence.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes in Locally Advanced Pancreatic Cancer After Induction Ablative Radiation Therapy and Resection.","authors":"Alex B Blair, Joshua S Jolissaint, Deshka Foster, Kevin C Soares, Vinod P Balachandran, T Peter Kingham, Jeffrey A Drebin, Michael I D'Angelica, William R Jarnagin, Christopher H Crane, Marsha Reyngold, Alice C Wei","doi":"10.1245/s10434-025-17199-8","DOIUrl":"https://doi.org/10.1245/s10434-025-17199-8","url":null,"abstract":"<p><strong>Background: </strong>Ablative-dose radiotherapy (A-RT) may result in durable local control and encouraging survival for patients with locally advanced pancreatic cancer (LAPC). A subset of patients with LAPC are eligible for exploration after completion of induction chemotherapy and A-RT. Outcomes for this subset of patients are yet to be described.</p><p><strong>Methods: </strong>This was a single-institution retrospective analysis of patients who had LAPC treated with induction chemotherapy and A-RT (≥98 Gy biologically effective dose using 15 to 25 fractions in 3- to 4.5-Gy/fraction), then subsequently underwent surgical exploration.</p><p><strong>Results: </strong>During a 6-year period, 34 patients with LAPC underwent exploration after induction chemotherapy and A-RT. Chemotherapy was given before A-RT to all the patients, with the majority receiving FOLFIRINOX (94 %). The median time to exploration after completion of A-RT was 75 days. Pancreaticoduodenectomy was the most frequent procedure (n = 18), followed by distal pancreatectomy (n = 7), and resection was aborted in nine patients (26 %) after discovery of distant (n = 6) or locally unresectable (n = 3) disease. Vascular resection or divestment was required for 56 % of the patients. There were no postoperative pancreatic fistulae. However, clinically significant ascites were observed in 36 % of the resected patients. A major pathologic response was observed in 17 % of the resected specimens upon final pathologic review. Postoperative mortality within 90 days occurred for two patients (5.9 %). The median overall survival for the entire cohort was 31 months from the date of diagnosis and 24 months from completion of A-RT.</p><p><strong>Conclusions: </strong>Resection of LAPC is feasible for a select cohort of patients after A-RT, with encouraging 2-year overall survival.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Visual Abstract: Rate of Neoplasia in Patients with Complicated Acute Appendicitis Managed Nonoperatively-A Prospective Study.","authors":"Jessica J Lie, Kylie Nabata, Jenny W Zhang, Sabrina Rai, Darren Zhao, S Morad Hameed, Philip Dawe, Trevor D Hamilton","doi":"10.1245/s10434-025-17165-4","DOIUrl":"https://doi.org/10.1245/s10434-025-17165-4","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: New Insights into Cisplatin Distribution During HIPEC from a Porcine Model.","authors":"Christina Harlev, Mats Bue, Elisabeth Krogsgaard Petersen, Andrea René Jørgensen, Bo Martin Bibby, Pelle Hanberg, Anne Vibeke Schmedes, Lone Kjeld Petersen, Maiken Stilling","doi":"10.1245/s10434-025-17171-6","DOIUrl":"https://doi.org/10.1245/s10434-025-17171-6","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Enhancing Safety in Minimally Invasive Left Pancreatectomy with Polyglycolic Acid Mesh Wrapping.","authors":"Hayato Baba, Atsushi Oba, Yosuke Inoue, Kosuke Kobayashi, Yoshihiro Ono, Takafumi Sato, Hiromichi Ito, Yu Takahashi","doi":"10.1245/s10434-025-17263-3","DOIUrl":"https://doi.org/10.1245/s10434-025-17263-3","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}