Annals of Surgical Oncology最新文献

{"title":"ASO Author Reflections: Old Truths, New Data: Intraductal Oncocytic Papillary Neoplasm-Derived Pancreatic Cancer Requires Continued Surveillance.","authors":"Camila Hidalgo Salinas, Joseph R Habib, Ammar A Javed, Greg D Sacks","doi":"10.1245/s10434-025-18007-z","DOIUrl":"10.1245/s10434-025-18007-z","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"7457-7458"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should Muscle Mass be Incorporated into Surgical Decision-Making for Early-Stage Lung Cancer?","authors":"Xiaohan Jin, Haoji Yan, Dong Tian","doi":"10.1245/s10434-025-17792-x","DOIUrl":"10.1245/s10434-025-17792-x","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"7956-7957"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homecare After Cancer Surgery for Older Adults: Derivation and Validation of a Predictive Tool.","authors":"Julie Hallet, Tiago Ribeiro, Alyson L Mahar, Wing C Chan, Daniel I McIsaac, Anna Gombay, Anna Ding, Jessica Armah, Natalie Coburn, Amy T Hsu","doi":"10.1245/s10434-025-17824-6","DOIUrl":"10.1245/s10434-025-17824-6","url":null,"abstract":"<p><strong>Background: </strong>Need for home support after surgery is a patient-centred outcome and marker of functional recovery for older adults. We developed a risk prediction model, HOMECARE, to estimate the risk of using homecare for older adults after cancer surgery.</p><p><strong>Methods: </strong>We conducted a population-based retrospective cohort study of adults ≥ 70 years having surgery for solid malignancy (2007-2019). Candidate predictors were preoperative sociodemographic and clinical factors. Receipt of immediate (within 1 month) and chronic (at 7-12 months) homecare was predicted. Internal validation used bootstraps with 500 samples with replacement. Logistic regression models were used. The predictive model included age, sex, rural residence, previous cancer diagnosis, frailty, prior homecare use, cancer site, cancer stage, and type of surgery. We performed bootstrap validation by using 500 samples with replacement.</p><p><strong>Results: </strong>Of 93,883 patients included, 39,169 (41.7%) required immediate homecare; of the 88,252 alive after month 6 postoperatively, 22,031 (25%) required chronic homecare. For immediate homecare, the area-under-the-curve was 0.77 and the deviation of predicted from observed probability was - 0.002% (95% CI 0.004 to - 0.009). For chronic homecare, the area-under-the-curve was 0.76, and the deviation of predicted from observed probabilities was - 0.004% (95% CI 0.002 to - 0.009). Deviation between predicted and observed probabilities ranged from - 0.04 to 0.03% across risk deciles for immediate homecare and - 0.05 to 0.04% for chronic homecare.</p><p><strong>Conclusions: </strong>The HOMECARE tool presents good discrimination and is well calibrated. Implemented as an online calculator, individualized risk estimates from this tool could support risk communication with older adults selected for cancer surgery.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"7680-7692"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Neoadjuvant Targeted Therapy in Locally Advanced Non-small Cell Lung Cancer.","authors":"Zhao An, Xiaodong Yang, Chenyang Dai","doi":"10.1245/s10434-025-17882-w","DOIUrl":"10.1245/s10434-025-17882-w","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"7944-7945"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: MicroRNAs as Predictive Biomarkers for Axillary Lymph Node Metastasis in Breast Cancer.","authors":"Yuan Lin, Yan-Yan Wang, Zhi-Bao Xu, Lei Dong, Can Liu, Ya-Wen Wang, Xu Chen, Kai Zhang","doi":"10.1245/s10434-025-18075-1","DOIUrl":"10.1245/s10434-025-18075-1","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"8064-8065"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: How to Visualize Pancreatic Duct Injury During Pancreatic Enucleation.","authors":"Zhengle Zhang, Jing Tao, Zhongchao Zhu","doi":"10.1245/s10434-025-18018-w","DOIUrl":"10.1245/s10434-025-18018-w","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"7463-7464"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Approaching a Novel Paradigm for the Management of Oligometastatic Lung Disease.","authors":"Ioana B Florea, David D Shersher","doi":"10.1245/s10434-025-18010-4","DOIUrl":"10.1245/s10434-025-18010-4","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"7942-7943"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conversion Surgery After Trastuzumab-Based Chemotherapy and Immunotherapy for Stage IV HER2-Positive Gastric Cancer: A Retrospective Multicenter Cohort Study.","authors":"Huayuan Liang, Chengcai Liang, Jiaguang Zhang, Xiaowen Sun, Kaihua Huang, Huimin Zhang, Guoxin Li, Xiaofeng Chen, Liying Zhao","doi":"10.1245/s10434-025-17729-4","DOIUrl":"10.1245/s10434-025-17729-4","url":null,"abstract":"<p><strong>Background: </strong>The efficacy and safety of conversion surgery after immunotherapy combined with trastuzumab-based chemotherapy for patients with stage IV human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) remains unclear.</p><p><strong>Methods: </strong>This retrospective multicenter study included patients with stage IV HER2-positive GC treated between February 2012 and October 2024 across three centers in China. Eligible patients had histologically confirmed HER2-positive GC with unresectable stage IV disease treated with trastuzumab-based chemotherapy and/or immunotherapy. Conversion surgery was performed for patients who achieved substantial tumor shrinkage enabling R0 resection.</p><p><strong>Results: </strong>Among 232 patients, 114 received chemotherapy combined with trastuzumab alone, whereas 118 were treated with chemotherapy plus immunotherapy and trastuzumab, 50 of whom subsequently underwent conversion surgery. In the cohort receiving chemotherapy and trastuzumab alone, the median progression-free survival (PFS) was 8.2 months (95 % confidence interval [CI], 6.2-10.2 months), and the median overall survival (OS) was 13.9 months (95 % CI, 10.8-17.1 months). The patients who underwent conversion surgery exhibited significantly longer PFS (37.7 vs 10.8 months; P < 0.001) and OS (50.9 vs 22.0 months; P < 0.001) than the non-surgical patients treated with immunotherapy.</p><p><strong>Conclusions: </strong>Preoperative trastuzumab-based chemotherapy combined with immunotherapy followed by conversion surgery significantly improves survival outcomes for patients with stage IV HER2-positive GC.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"7556-7566"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Outcomes of Intraductal Oncocytic Papillary Neoplasm-Derived Pancreatic Cancer Compared with Tubular and Colloid Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer: An International Multicenter Retrospective Study.","authors":"Joseph R Habib, Camila Hidalgo Salinas, Natalie F Berger, Ingmar F Rompen, Brady A Campbell, Benedict Kinny-Köster, Paul C M Andel, D Brock Hewitt, Jörg Kaiser, Adrian T Billeter, Rafael Perera, Katherine Morgan, Lois A Daamen, Ammar A Javed, Beat P Müller-Stich, Marc G Besselink, Jin He, I Quintus Molenaar, Markus W Büchler, Christopher L Wolfgang, Martin Loos, Greg D Sacks","doi":"10.1245/s10434-025-17810-y","DOIUrl":"10.1245/s10434-025-17810-y","url":null,"abstract":"<p><strong>Background: </strong>Intraductal papillary mucinous neoplasm (IPMN)-derived pancreatic cancer was previously categorized into tubular, colloid, and oncocytic subtypes. Intraductal oncocytic papillary neoplasms (IOPN) has long been associated with superior prognosis/indolent behavior, however, there is discordant emerging evidence. This study aimed to investigate this conflicting literature.</p><p><strong>Methods: </strong>Patients with resected IOPN-derived and IPMN-derived pancreatic cancer were identified from six international centers. Log-rank tests compared time to (TtR) and survival after (SAR) recurrence and five-year overall survival (OS). A multivariable mixed model was used to determine hazard ratios (HR) with confidence intervals (95%CI) for five-year survival.</p><p><strong>Results: </strong>Of 879 patients, 20 (2%) had IOPN-derived pancreatic cancer. Most patients had T1 (55%) or N0 (70%) disease. IOPN and colloid IPMN-derived pancreatic cancers had similar recurrence rates (25% vs. 24%), while recurrence was more common in tubular IPMN-derived pancreatic cancer (42%, p < 0.001). IOPN-derived pancreatic cancer displayed a longer TtR and SAR compared to colloid and tubular IPMN-derived pancreatic cancers. IOPN-derived and colloid IPMN-derived cancers demonstrated significantly lower 5-year mortality risks compared to tubular IPMN-derived cancers (74% and 27% risk reduction, respectively; p < 0.05).</p><p><strong>Conclusion: </strong>IOPN-derived pancreatic cancers have excellent OS. However, some patients have poor prognostic factors and are at risk for both local and systemic recurrence. Given more indolent disease progression given delayed TtR and prolonged SAR compared to colloid and tubular IPMN-derived pancreatic cancers, there may be a role for prolonged surveillance.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"7433-7442"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Exhaled Volatile Organic Compounds as Noninvasive Biomarkers for Pancreatic Adenocarcinoma.","authors":"Kyle R Stephens, Walter R Donica, Prejesh Philips, Robert C G Martin, Kelly M McMasters, Zhenzhen Xie, Kirsten Waits, Xiao-Fu, Toyokazu Endo, Victor Van Berkel, Tyler Jones, Maiying Kong, Michael E Egger, Charles R Scoggins","doi":"10.1245/s10434-025-17685-z","DOIUrl":"10.1245/s10434-025-17685-z","url":null,"abstract":"<p><strong>Background: </strong>Exhaled volatile organic compounds (VOC) have shown promise as noninvasive biomarkers in lung cancer and pulmonary diseases. This study aimed to evaluate the role of VOC as a noninvasive biomarker for pancreatic adenocarcinoma (PDAC) and explore whether elevated VOC levels correlate with clinical characteristics such as tumor size and cancer antigen (CA)19-9 levels.</p><p><strong>Patients and methods: </strong>A total of 25 patients with PDAC and 23 matched control subjects were enrolled. Exhaled breath was collected and analyzed using a silicon microreactor and ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS). Univariate analyses, Spearman correlations, and penalized regression (SCAD), along with area under the receiver-operating characteristic (ROC) curves (AUC) identified the top VOC biomarkers. VOC concentrations exceeding the 75th percentile of controls were deemed elevated with subgroup analysis comparing patients with all three elevated VOC to those without.</p><p><strong>Results: </strong>Five VOC (heptanone, hexanal, hexanone, malondialdehyde (MDA), and acetaldehyde) were consistently and significantly higher in patients with PDAC. The penalized regression and linear discriminant analysis (LDA) identified three top VOC (acetaldehyde, MDA, hexanone) that distinguished PDAC from controls with an AUC of 0.81. Patients exhibiting elevated levels of all three compounds had smaller tumors and lower CA19-9 levels (p < 0.05).</p><p><strong>Conclusions: </strong>A distinctive profile of elevated exhaled VOC, particularly hexanone, acetaldehyde, and MDA, is associated with PDAC. These findings suggest that VOC analysis could be a novel, noninvasive method for early detection of pancreatic cancer. Further studies in larger cohorts are warranted to validate these results.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"7393-7399"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}