Annals of Surgical Oncology最新文献_第9页

Lumpectomy Patients are at Highest Risk for Opioid Overprescription: A Comparison Between Practice Patterns and OPEN National Guidelines. 乳房肿瘤切除术患者阿片类药物过度处方的风险最高：实践模式和开放国家指南之间的比较。

IF 3.4 2区医学

Annals of Surgical Oncology Pub Date : 2025-01-12 DOI: 10.1245/s10434-024-16823-3

Emily P Swafford, Sadhana Anantha, Jenna Davis, Rainya Heath, Allison Draper, Sarah Tevis, Neha Goel, Susan B Kesmodel, Kristin E Rojas

{"title":"Lumpectomy Patients are at Highest Risk for Opioid Overprescription: A Comparison Between Practice Patterns and OPEN National Guidelines.","authors":"Emily P Swafford, Sadhana Anantha, Jenna Davis, Rainya Heath, Allison Draper, Sarah Tevis, Neha Goel, Susan B Kesmodel, Kristin E Rojas","doi":"10.1245/s10434-024-16823-3","DOIUrl":"https://doi.org/10.1245/s10434-024-16823-3","url":null,"abstract":"Background: Nearly 25% of opioid-related deaths are from prescribed opioids, and the exacerbation of the opioid epidemic by the coronavirus disease 2019 (COVID-19) pandemic underscores the urgent need to address superfluous prescribing. Therefore, we sought to align local opioid prescribing practices with national guidelines in postoperative non-metastatic breast cancer patients.Methods: A single-institution analysis included non-metastatic breast surgery patients treated between April 2020 and July 2021. 'Overprescription' was defined as a discharge prescription quantity of oral morphine equivalents (OMEs) greater than the upper limit of the procedure-specific Michigan Opioid Prescribing Engagement Network (OPEN) recommendations. Univariable and multivariate analyses identified risk factors associated with opioid prescribing.Results: Overall, 464 patients met the inclusion criteria: 280 patients underwent lumpectomy, and 184 patients underwent mastectomy. 52% of patients were overprescribed opioids, including 74% of lumpectomy patients (p < 0.001) and 90% of patients undergoing lumpectomy with axillary surgery (p < 0.001). Mastectomy patients were overprescribed less frequently (< 25%). The quantity of opioids prescribed at discharge did not correlate to inpatient opioid requirements (r = 0.024, p = 0.604). Increased age, tobacco use, and long surgery duration were associated with higher quantities of opioids prescribed at discharge.Conclusion: Patients undergoing less aggressive breast surgery are at very high risk of overprescription, and real-life prescribing patterns do not correlate to national guidelines or inpatient need. Future work will optimize adherence to procedure-specific guidelines and implement tailored discharge protocols.","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASO Author Reflections: Understanding Barriers to Diversity in Surgical Oncology. ASO作者反思：理解肿瘤外科多样性的障碍。

IF 3.4 2区医学

Annals of Surgical Oncology Pub Date : 2025-01-12 DOI: 10.1245/s10434-024-16859-5

Misha Armstrong, Michael D'Angelica

引用次数: 0

Balancing Local and Systemic Control in Esophageal Cancer. 食管癌局部与全身控制的平衡。

IF 3.4 2区医学

Annals of Surgical Oncology Pub Date : 2025-01-12 DOI: 10.1245/s10434-024-16835-z

Thomas Kim, Dian Wang

引用次数: 0

ASO Author Reflections: Breast Cancer-Related Lymphedema Prevention: The Impact of Prophylactic Lymphovenous Bypass. ASO作者反思：乳腺癌相关淋巴水肿预防：预防性淋巴静脉旁路的影响。

IF 3.4 2区医学

Annals of Surgical Oncology Pub Date : 2025-01-12 DOI: 10.1245/s10434-024-16824-2

Min-Jeong Cho, Sydney Chratian, Roman Skoracki

引用次数: 0

ASO Author Reflections: New Persistent Benzodiazepine Use following Cancer Surgery. ASO作者反思：癌症手术后新的持续苯二氮卓类药物使用。

IF 3.4 2区医学

Annals of Surgical Oncology Pub Date : 2025-01-10 DOI: 10.1245/s10434-024-16861-x

Zayed Rashid, Timothy M Pawlik

引用次数: 0

Age Matters: Early-Onset Rectal Cancer Exhibits Higher Rates of Pathological Complete Response: A Retrospective Analysis of the Influence of Young Age on Treatment Success in Stage II-III Rectal Cancer. 年龄影响：早发性直肠癌表现出更高的病理完全缓解率：年龄对II-III期直肠癌治疗成功影响的回顾性分析

IF 3.4 2区医学

Annals of Surgical Oncology Pub Date : 2025-01-09 DOI: 10.1245/s10434-024-16773-w

Annaclara Sileo, Richard Sassun, Jyi Cheng Ng, Sara Aboelmaaty, Ibrahim A Gomaa, Giulio Mari, Nicholas P McKenna, Kristen K Rumer, Kellie L Mathis, David W Larson

{"title":"Age Matters: Early-Onset Rectal Cancer Exhibits Higher Rates of Pathological Complete Response: A Retrospective Analysis of the Influence of Young Age on Treatment Success in Stage II-III Rectal Cancer.","authors":"Annaclara Sileo, Richard Sassun, Jyi Cheng Ng, Sara Aboelmaaty, Ibrahim A Gomaa, Giulio Mari, Nicholas P McKenna, Kristen K Rumer, Kellie L Mathis, David W Larson","doi":"10.1245/s10434-024-16773-w","DOIUrl":"https://doi.org/10.1245/s10434-024-16773-w","url":null,"abstract":"Background: The incidence of rectal cancer has decreased overall, but the incidence of early-onset rectal cancer (eoRC) has increased. Early-onset rectal cancer and late-onset rectal cancer (loRC) differ due to phenotypical, genetic characteristics, and higher stage presentations in eoRC. Thus, eoRC patients undergo more aggressive neoadjuvant treatments. This paper was designed to evaluate the impact of age on the pathological complete response rates in sporadic locally advanced rectal cancer.Methods: All patients with stage II-III rectal cancer who underwent neoadjuvant therapy and curative rectal resection between January 2018 and December 2023 were included and allocated to eoRC (<50 years) and loRC (≥50 years) groups based on their age at diagnosis.Results: A total of 381 patients were included (93 eoRC and 288 loRC). Preoperative radiological imaging revealed higher clinical nodal staging in the eoRC group (p = 0.002). A higher proportion of eoRC resulted in a pathological complete response compared with loRC (29% vs. 18.8%, p = 0.035). The rate of pathological complete response in eoRC and loRC did not differ between patients treated by total neoadjuvant therapy (TNT) and those treated by standard chemoradiotherapy (29.2% vs. 28.6%, p = 0.95 in eoRC and 21.7% vs. 25.9%, p = 0.097 in loRC). Multivariable analysis resulted in young age of onset (odds ratio 2.68; 95% confidence interval 1.11-6.51; p = 0.029) and KRAS wildtype (odds ratio 3.37; 95% confidence interval 1.25-9.07; p = 0.016) as being independent predictors of pathological complete response.Conclusions: Sporadic eoRC and KRAS wildtype tumors are predictive factors for pathological complete response in stage II-III rectal cancer.","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASO Author Reflections: Trajectory of Treatment-Related Adverse Events During Neoadjuvant Immunochemotherapy in Esophageal Cancer: A Further Step Toward Personalized Medicine. ASO作者反思：食管癌新辅助免疫化疗期间治疗相关不良事件的发展轨迹：个性化医疗的又一步。

IF 3.4 2区医学

Annals of Surgical Oncology Pub Date : 2025-01-09 DOI: 10.1245/s10434-024-16867-5

Zijie Li, Shujie Huang, Rixin Chen, Guibin Qiao

引用次数: 0

Total Pelvic Exenteration with Presacral Fascia and Pelvic Musculature Excision for Pelvic Recurrence of Rectal Cancer. 全盆腔切除加骶前筋膜及盆腔肌肉切除治疗直肠癌盆腔复发。

IF 3.4 2区医学

Annals of Surgical Oncology Pub Date : 2025-01-09 DOI: 10.1245/s10434-024-16793-6

Anqi Wang, Peng Zhang, Jia Zang, Xu Zhang, Jian Zhang, Haiyang Zhou

{"title":"Total Pelvic Exenteration with Presacral Fascia and Pelvic Musculature Excision for Pelvic Recurrence of Rectal Cancer.","authors":"Anqi Wang, Peng Zhang, Jia Zang, Xu Zhang, Jian Zhang, Haiyang Zhou","doi":"10.1245/s10434-024-16793-6","DOIUrl":"https://doi.org/10.1245/s10434-024-16793-6","url":null,"abstract":"Background: Local relapse has not been eradicated even in the era of total mesorectum excision.1,2 Although various approaches have been attempted, R0 resection remains the only potentially curative treatment.3,4 PATIENT AND METHODS: A 45-year-old woman with a history of laparoscopic abdominoperineal resection was diagnosed with pelvic recurrence 7 months ago. Then, she received chemoradiotherapy. Magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT) showed pelvic recurrences at the surface of the right piriformis and obturator internus, posterior vaginal wall, and presacral fascia. The patient also had bilateral hydronephrosis. No distant metastasis was found. First, the lateral pelvic lymph nodes were removed. Then, the internal iliac arteries and veins were transected. Next, the fibrotic ureters were isolated and cut. Then, presacral fascia at the S4 and S5 levels was excised. Anteriorly, the urethra and vagina were transected. Lastly, the suspected pelvic recurrent lesions were resected en bloc with partial right piriformis, obturator internus, and gluteus maximus through a combined abdominal and perineal approach. Greater omental pedicle flap was transplanted into the pelvic cavity and pelvic floor was reconstructed.Results: The operative time was 600 min, and blood loss was 400 ml. Postoperative course was uneventful, and the patient was discharged 14 days after surgery. Pathology report showed a moderately differentiated rectal adenocarcinoma invading the vagina, presacral fascia, and pelvic musculature. All margins were negative.Conclusions: As demonstrated by this case, image-guided total pelvic exenteration with presacral fascia and sidewall musculature excision provides an opportunity to cure pelvic recurrence of rectal cancer.5.","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Neoadjuvant Immunotherapy Followed by Surgery Compared with Upfront Surgery Alone in Operable Colon Cancer with Deficient Mismatch Repair: Modeling Oncological Outcomes and Numbers Needed to Treat. 修正：新辅助免疫治疗后手术与单纯术前手术治疗可手术结肠癌错配修复缺陷的比较：模拟肿瘤结果和需要治疗的数量。

IF 3.4 2区医学

Annals of Surgical Oncology Pub Date : 2025-01-09 DOI: 10.1245/s10434-025-16888-8

Arezo Kanani, Torhild Veen, Dordi Lea, Claudia Zaharia, Martin Watson, Marina Alexeeva, Kenneth Thorsen, Kjetil Søreide

引用次数: 0

ASO Visual Abstract: Commission on Cancer Center Performance with the New Breast Cancer Quality Measures: A Review of Historical Data. 癌症中心绩效委员会与新的乳腺癌质量指标：历史数据回顾。

IF 3.4 2区医学

Annals of Surgical Oncology Pub Date : 2025-01-09 DOI: 10.1245/s10434-024-16777-6

Marie L Fefferman, Danielle M Thompson, Lee G Wilke, Shelley Hwang, Richard Bleicher, Laura M Freedman, Jane L Meisel, Kristine Kuchta, Katharine Yao

引用次数: 0