Annals of Surgical Oncology最新文献

{"title":"ASO Author Reflections: CT-Based Radiomics for Pathological T Staging in Clear Cell Renal Cell Carcinoma: Insights from Intratumoral and Peritumoral Features.","authors":"Yuanhao Xia, Zehua Sun, Jiakang Xu, Chunjie Xu, Heng Ma, Hao Guo, Wenjuan Li","doi":"10.1245/s10434-025-17174-3","DOIUrl":"10.1245/s10434-025-17174-3","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"6191-6192"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Same Day Discharges Among Elderly Mastectomy Patients: A Single Institution Prospective Study.","authors":"Jessica C Gooch, Qi Ying McClelland, Kathryn Paschalis, Jenna Dobbins, Allison Magnuson, Chelsea Marin, Maya Anand, Kristin Skinner, Ann Olzinski-Kunze, Anna Weiss","doi":"10.1245/s10434-025-17436-0","DOIUrl":"10.1245/s10434-025-17436-0","url":null,"abstract":"<p><strong>Background: </strong>Same-day mastectomy is safe and high value. However, patients ≥ 65 years are less likely to be discharged compared with younger patients. Our aim was to implement a protocol to increase the rate of elderly same-day discharge.</p><p><strong>Patients and methods: </strong>Patients were screened by 5-factor modified frailty index and notification of frailty status was sent to surgeons. Patients with moderate-to-high frailty were encouraged to have prehabilitation. Chart review collected demographic/clinicopathologic variables, length of stay, and complications. The primary endpoint was same-day discharge, and sample size determination was 50 patients. Our discharge rate was compared with our historic rate (18.8% March 2022 to February 2023) by Fisher's exact test.</p><p><strong>Results: </strong>From March 2023 to January 2024, 306 patients aged ≥ 65 years were screened. Overall, 55 patients underwent a total of 57 mastectomies (18.6%). Median age was 72 years (range: 65-99). Frailty scores ranged from 0 to 4. In total, 11 patients (19.3%) had a score of zero, 41 (71.9%) scored 1 or 2, and 5 patients (8.8%) scored 3 or 4. Seven patients were referred to geriatric oncology for prehabilitation: one non-frail, four with low frailty, and two with moderate frailty. The median length of stay (LOS) was 0 days (range: 0-21). Thirty-two mastectomies had same-day discharge (56.1%), significantly higher than historic data (P < 0.00001).</p><p><strong>Conclusions: </strong>We increased same-day discharges for patients ≥ 65 years from 18.8% to 56.1%. This protocol included a simple frailty screening and a weekly email. Future directions include increasing the proportion of patients who receive geriatric oncology prehabilitation referrals and evaluating patient-reported outcomes.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5521-5527"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Evaluation of Fertility-Sparing Surgery in Patients with Epithelial Ovarian Cancer: A Population-Based Analysis.","authors":"Lina Yan, Lingli Zeng, Shuoyan Jiang, Ting Wang, Xuemei Jia, Fang Wang","doi":"10.1245/s10434-025-17298-6","DOIUrl":"10.1245/s10434-025-17298-6","url":null,"abstract":"<p><strong>Background: </strong>Indications of fertility-sparing surgery (FSS) for young women with early stage epithelial ovarian cancer (EOC) are controversial. We aimed to evaluate the impact of FSS on the prognosis of patients.</p><p><strong>Methods: </strong>Patients diagnosed with EOC, whose tumors were limited to unilateral ovaries and American Joint Committee of Cancer stage 1 or 2, were identified in the Surveillance, Epidemiology, and End Results database (2004-2017). Propensity score matching, restricted mean survival time, subgroup analysis, log-rank test, and two-stage test were used to evaluate the effect of FSS on cancer-specific survival (CSS).</p><p><strong>Results: </strong>A total of 1836 patients with stage 1 or 2 were identified and divided into FSS and non-FSS groups. After propensity score matching, 172 pairs of patients were included. Before and after propensity score matching, log-rank test and restricted mean survival time results showed FSS had no significant effect on CSS at 3, 5, and 10 years. After propensity score matching, univariate and multivariate Cox regression analysis confirmed FSS was not a risk factor for CSS. The study population was stratified according to variables examined by Cox regression analysis (age, race, tumor grade, stage, chemotherapy). Subgroup analysis based on log-rank and two-stage test showed FSS had no significant effect on CSS in any subgroup except the subgroup of stage 2.</p><p><strong>Conclusions: </strong>Fertility-sparing surgery does not lead to worse outcomes than non-FSS among stage 1 EOC patients younger than 50 years. Thus, indications of FSS for early-stage EOC patients with a strong desire for fertility preservation should be appropriately broaden.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5593-5602"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Improving Urothelial Carcinoma Outcomes: The Powerful Combination of Neoadjuvant and Adjuvant Chemotherapy in the Perioperative Period.","authors":"Jincong Li, Yuxuan Song, Rui Chen, Hanlin Gao, Yang Liu, Yun Peng, Jilin Wu, Shicong Lai, Yiqing Du, Caipeng Qin, Tao Xu","doi":"10.1245/s10434-025-17258-0","DOIUrl":"10.1245/s10434-025-17258-0","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"6187-6188"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Global Research Status of Breast Cancer Stem Cells.","authors":"Chunchun Wu, Hongjie Zhao, Hui Di, Kunming Cheng, Wanqing Li","doi":"10.1245/s10434-025-17457-9","DOIUrl":"10.1245/s10434-025-17457-9","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"6108-6110"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multi-Institutional Analysis of Contralateral Axillary Metastases: Advanced Local-Regional Disease Divergent from Stage IV Breast Cancer.","authors":"Meghan R Flanagan, Astrid M Botty van den Bruele, Stephanie M Downs-Canner, Samantha M Thomas, Kristalyn K Gallagher, James W Jakub, Sarah E A Tevis, Francys C Verdial, Jennifer Q Zhang, Leisha C Elmore, Rita A Mukhtar, Malia Brennan, Margaret Lillie, Tammeza C Gibson, Alexandra Verosky, Jennifer K Plichta, Laura H Rosenberger","doi":"10.1245/s10434-025-17406-6","DOIUrl":"10.1245/s10434-025-17406-6","url":null,"abstract":"<p><strong>Background: </strong>Contralateral axillary metastasis (CAM) is a rare event and is considered stage IV disease. We sought to evaluate outcomes in a CAM cohort treated with curative intent and contemporary systemic and locoregional therapy.</p><p><strong>Patients and methods: </strong>A retrospective multi-institutional review was conducted from 2016 to 2022 of patients with CAM who underwent axillary surgery. Survival outcomes were compared with those with locally advanced breast cancer (LABC) and metastatic breast cancer (MBC).</p><p><strong>Results: </strong>In total, 754 patients were included in the study (63 CAM, 188 LABC, and 503 MBC). The median age at CAM diagnosis was 62 years [(interquartile range (IQR) 49.2-69.3)], and the majority demonstrated invasive ductal histology (74.6%). Over half of the patients with CAM received neoadjuvant chemotherapy (55.6%) followed by axillary dissection (82.5%) and adjuvant radiation (74.6%) in most cases. On unadjusted analysis, the LABC cohort demonstrated the highest 3-year unadjusted overall survival (OS) (89.4%), followed by CAM (79.7%) and MBC (53%) (p < 0.001). On multivariable analysis adjusting for age, race/ethnicity, insurance, and hormone receptor status, patients with MBC had inferior survival compared with LABC [hazard ratio (HR) 6.59, 95% confidence interval (CI) 4.22-10.28, p < 0.001], while CAM had similar survival to that seen in LABC (HR 2.13, 95% CI 0.82-5.52, p = 0.12).</p><p><strong>Conclusions: </strong>Survival was higher for patients with CAM compared with MBC and was similar to patients with LABC. Though the LABC group demonstrated better recurrence-free survival than the CAM group, these numbers were comparable within the first 2 years of follow-up. Our data provides additional support for the consideration of curative intent management for patients with CAM.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5551-5562"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a Web-Based Decision Aid on Socioeconomically Disadvantaged Patients' Engagement in Breast Surgery Decision-Making: Stepped-Wedge Clinical Trial (Alliance-A231701CD).","authors":"Jessica R Schumacher, Bret M Hanlon, David Zahrieh, Paul J Rathouz, Jennifer L Tucholka, Grace McKinney, Angelina D Tan, Catherine R Breuer, Lisa Bailey, Anna M Higham, Julie S Wecsler, Alicia H Arnold, Anthony J Froix, Scott Dull, Andrea M Abbott, Stephanie G Fine, Kandace P McGuire, Anna S Seydel, Patricia McNamara, Selina Chow, Heather B Neuman","doi":"10.1245/s10434-025-17452-0","DOIUrl":"10.1245/s10434-025-17452-0","url":null,"abstract":"<p><strong>Background: </strong>Decision aids (DAs) may increase engagement in decision-making by addressing barriers that disproportionately impact socioeconomically disadvantaged patients. The impact of a breast cancer surgery DA on increasing patient engagement in decision-making was tested in clinics serving a high proportion of socioeconomically disadvantaged patients.</p><p><strong>Methods: </strong>A stepped-wedge trial was conducted with 10 National Cancer Institute Community Oncology Research Program clinics (Alliance for Clinical Trials in Oncology, June 2019 to December 2021). The clinics were randomized to time of transition from usual care (UC) to delivery of a web-based DA. Patients with stages 0-3 breast cancer eligible for surgery provided consent before a surgical consultation. Engagement was measured by Patient's Self-Efficacy in Patient-Physician Interactions (PEPPI-5, follow-up survey) and count of Active Patient Behaviors (audio-recorded consultation). Intervention effects were tested with linear mixed-effects models, accounting for surgeon and clinic-level clustering, time, and enrollment after COVID. Heterogeneity of treatment effect by socioeconomic disadvantage (using the Area Deprivation Index) was assessed with an interaction term.</p><p><strong>Results: </strong>The study enrolled 576 patients, and 44 % (136/309) of the patients reviewed the DA. No significant difference in engagement was observed between DA and UC for PEPPI-5 (- 0.8; 95 % CI, - 2.1-0.6; p = 0.260) or Active Patient Behaviors (2.5; 95 % CI, - 4.1-9.2; p = 0.456). No heterogeneity of treatment effect was observed. Socioeconomic disadvantage was associated with fewer Active Patient Behaviors (- 5.9; 95 % CI, - 0.6-- 1.2; p = 0.013).</p><p><strong>Conclusion: </strong>This trial conducted in clinics that serve diverse populations, observed no significant relationship between a web-based DA and patient engagement. Future analyses will explore DA implementation, characteristics of patients who reviewed the DA, and persistent barriers to engagement.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5540-5550"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Long-Term Outcomes Between Near-Infrared Fluorescence Imaging with Indocyanine Green-Guided Mediastinal Lymphadenectomy and Conventional Surgery for Esophageal Cancer.","authors":"Yong Ao, Xiayu Fu, Kongjia Luo, Lu Shao, Junying Chen, Leqi Zhong, Xin Zhang, Shining Li, Xiaodan Lin, Changsen Leng, Jianhua Fu, Yi Hu","doi":"10.1245/s10434-025-17331-8","DOIUrl":"10.1245/s10434-025-17331-8","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the long-term oncologic outcomes of NIRF-guided mediastinal lymphadenectomy during esophagectomy with those of conventional surgery.</p><p><strong>Methods: </strong>The study enrolled consecutive patients who underwent esophagectomy for esophageal cancer by a single surgical team between September 2017 and July 2021. Patients treated after September 2019 received NIRF-guided mediastinal lymphadenectomy (NIRF group) and were compared with the earlier cohort (historical control group). Propensity-matching analysis was used to compare 3-year overall survival (OS), disease-free survival (DFS), and recurrence patterns between the groups. Survival outcomes were analyzed using Kaplan-Meier curves and Cox regression analysis.</p><p><strong>Results: </strong>The final analysis included 118 matched patients (NIRF group, 59; historical control group, 59). The median follow-up period for all the patients was 38 months (range, 33-42 months). The NIRF group showed a significantly higher number of total lymph nodes (P = 0.010) and mediastinal lymph nodes (P = 0.045) dissected than the historical control group. The 1- and 3-year DFS rates were 68.1% and 45.2% for the NIRF group versus 74.3% and 55.2% for the historical control group. The OS rates for the NIRF group were 90.6% (1-year rate) and 72.0% (3-year rate) versus 98.3% (1-year rate) and 76.9% (3-year rate) for the historical control group. Both OS and DFS were comparable between the two groups (P = 0.271 and P = 0.356, log-rank test, respectively). Additionally, the two groups had similar recurrence patterns (P = 0.053).</p><p><strong>Conclusion: </strong>The use of NIRF imaging during esophagectomy facilitates precise resection of mediastinal lymph nodes. However, its impact on patient survival remains limited.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5898-5908"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Animal Models for Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) Research.","authors":"Abdelkader Taibi, Marie-Laure Perrin, Valentin David, Catherine Yardin, Sylvaine Durand Fontanier, Sylvia M Bardet","doi":"10.1245/s10434-025-17378-7","DOIUrl":"10.1245/s10434-025-17378-7","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"6100-6101"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surviving Gallbladder Cancer: When Overall Survival is not Enough.","authors":"Alejandro Brañes","doi":"10.1245/s10434-025-17418-2","DOIUrl":"10.1245/s10434-025-17418-2","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":"5378-5379"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}