Annals of Surgical Oncology最新文献

{"title":"The Survival for Pneumonectomy After Neoadjuvant Therapy in Non-small Cell Lung Cancer: A Retrospective Study from the National Cancer Center in China.","authors":"Sikai Wu, Xiaowei Chen, Bo Zhang, Ershu Bo, Haixiao Diao, Jianfei Shen, Zimin Wang, Yang Liu, William C Cho, Zhenlin Yang, Shugeng Gao","doi":"10.1245/s10434-025-18436-w","DOIUrl":"https://doi.org/10.1245/s10434-025-18436-w","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the impact of pneumonectomy after neoadjuvant therapy by assessing postoperative outcomes, survival prognosis, and recurrence patterns.</p><p><strong>Methods: </strong>A retrospective analysis of patients with non-small cell lung cancer (NSCLC) who underwent pneumonectomy between January 2017 and December 2022 was performed. The patients were divided into two groups based on whether they received neoadjuvant therapy, resulting in the neoadjuvant therapy group and the non-neoadjuvant therapy group. Propensity score-matching was performed to balance the cohorts. Perioperative outcomes, survival outcomes, and recurrence patterns were compared between the two groups.</p><p><strong>Results: </strong>The entire cohort comprised 455 patients. Using a 2:1 propensity score-matching method, 229 patients in the non-neoadjuvant therapy group and 137 patients in the neoadjuvant therapy group were enrolled in the subsequent analysis. Univariate logistic regression analysis showed that postoperative intensive care unit (ICU) stay, open thoracotomy, operation time, intraoperative blood transfusion, and postoperative hospital stay were risk factors for postoperative complications. The neoadjuvant therapy group had a longer postoperative ICU stay (6.1% vs 12.4%; P = 0.036). However, postoperative morbidity did not differ significantly between the two groups (P = 0.134). The pathologic complete response rate for the patients receiving chemoimmunotherapy was significantly higher than for those receiving chemotherapy alone. Subgroup analyses indicated that only neoadjuvant chemoimmunotherapy significantly improved overall survival (hazard ratio [HR], 0.34; range, 0.14-0.85; P = 0.020).</p><p><strong>Conclusion: </strong>The study confirmed that neoadjuvant therapy was safe and effective for patients with pneumonectomy, and that neoadjuvant chemoimmunotherapy had a favorable impact on patient prognosis.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Visual Abstract: Thirteen Years of Immediate Lymphatic Reconstruction (ILR) for the Prevention of Lymphedema: A Meta-analysis of Prospective Clinical Trials.","authors":"Stav Brown, Yizhuo Shen, Felix J Klimitz, Meera Nair, Alexzandra Mattia, Martin Kauke-Navarro, Olivier F Noel, Luccie Wo, Bohdan Pomahac, Parisa Lofti, Mehra Golshan, Siba Haykal","doi":"10.1245/s10434-025-18550-9","DOIUrl":"https://doi.org/10.1245/s10434-025-18550-9","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axillary Sentinel Lymph Node Biopsy for Cutaneous Melanoma: More Work Is Not Needed.","authors":"Aubrey C Swilling, Luke V Selby","doi":"10.1245/s10434-025-18443-x","DOIUrl":"https://doi.org/10.1245/s10434-025-18443-x","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Radiology Meets Pathology-Identifying the Right Patients for CRS-HIPEC in Colorectal Cancer.","authors":"Jessica Cyr-Cronier","doi":"10.1245/s10434-025-18523-y","DOIUrl":"https://doi.org/10.1245/s10434-025-18523-y","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Robotic-Assisted Portal Vein Resection and Reconstruction in Hepato-Pancreato-Biliary Surgery with a Video.","authors":"Côme Perrine, Boudjema Karim, Mourthadhoi Farouk, Pella Charlotte, Le Roy Bertrand","doi":"10.1245/s10434-025-18470-8","DOIUrl":"https://doi.org/10.1245/s10434-025-18470-8","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Visual Abstract: Impact of Social Vulnerability and Allostatic Load on Postoperative Outcomes.","authors":"Mujtaba Khalil, Selamawit Woldesenbet, Jasmine King, Shreya Shaw, Zayed Rashid, Abdullah Altaf, Shahzaib Zindani, Samilia Obeng-Gyasi, Timothy M Pawlik","doi":"10.1245/s10434-025-18469-1","DOIUrl":"https://doi.org/10.1245/s10434-025-18469-1","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Visual Abstract: Impact of Screening Mammography on Breast Cancer Outcomes in Women Aged 80 Years and Over.","authors":"Siu-Yuan Huang, Makaelah Murray, Angelique Rubio, Nneoma Okoro, Mina S Sedrak, Susan A McCloskey, Nicholas Jackson, Mediget Teshome, Nimmi S Kapoor","doi":"10.1245/s10434-025-18488-y","DOIUrl":"https://doi.org/10.1245/s10434-025-18488-y","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Current Status of De Novo Metastatic Breast Cancer Surgery in China and the USA: A Multicenter Real-World Study.","authors":"Dongxu Ma, Heng Cao, Jiang Wu, Tongxuan Shang, Zizhao Guo, Lin Cong, Ziqi Jia, Yuchen Liu, Jiaqi Liu, Xiang Wang","doi":"10.1245/s10434-025-18490-4","DOIUrl":"https://doi.org/10.1245/s10434-025-18490-4","url":null,"abstract":"<p><strong>Background: </strong>De novo metastatic breast cancer-defined by distant metastases at diagnosis-poses treatment challenges. While systemic therapy is standard, the benefit of primary tumor surgery remains debated. This study compared surgical patterns and survival in China versus the USA to provide evidence for personalized strategies.</p><p><strong>Patients and methods: </strong>In this multicenter retrospective cohort study, patients with surgically treated de novo metastatic breast cancer were identified from the National Cancer Center Oncology Information Database (NCCOID; n = 2037, 2013-2020) and Surveillance, Epidemiology, and End Results (SEER) (n = 3175, 2013-2020). Clinical features, treatments, and overall survival (OS) were contrasted. Kaplan-Meier curves and multivariable Cox models identified OS predictors.</p><p><strong>Results: </strong>Compared with SEER, NCCOID patients were younger and had more T2 tumors; mastectomy predominated in both, though breast-conserving surgery was more frequent in SEER, and preoperative systemic therapy was more common in NCCOID. NCCOID achieved superior OS (1 year, 3 year, 5 year: 91.5%, 77.4%, 67.9%, respectively) versus SEER (87.7%, 62.8%, 46.4%). Improved survival was seen in hormone-receptor-positive tumors, smaller primary lesions (lower T category), and bone-only metastases. Multivariate analysis confirmed age 35-54 years, HR+ and HER2+ status, and limited (especially bone-only) metastases as independent favorable factors.</p><p><strong>Conclusions: </strong>Surgical management of de novo metastatic breast cancer differs between China and the USA. Select patients-particularly those with HR+ or HER2+ tumors, small primaries, and limited metastases-may benefit from resection, underscoring the need for multidisciplinary, personalized decision-making and prospective validation of optimal surgical timing.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Preoperative Cardiopulmonary Exercise Testing for Complications and Mortality After Esophagectomy: A Meta-analysis.","authors":"Watson Hua-Sheng Tseng, Chien-Hung Chiu, Sing-Ya Chang, Lan-Yan Yang, Shu-Chun Huang","doi":"10.1245/s10434-025-18499-9","DOIUrl":"https://doi.org/10.1245/s10434-025-18499-9","url":null,"abstract":"<p><strong>Background: </strong>Cardiopulmonary exercise testing (CPET) parameters, such as ventilatory equivalent for carbon dioxide (V̇_E/V̇CO₂), peak oxygen consumption (V̇O_2peak), and anaerobic threshold (AT), have been proposed as potential predictors of postoperative complications. Yet, few systematic analyses have examined the association between CPET variables and major complications after esophagectomy, as defined by the Clavien-Dindo classification. Associations with cardiopulmonary complications and mortality also require updating on the basis of trial sequential analysis (TSA).</p><p><strong>Materials and methods: </strong>Systematic searches were conducted to identify relevant studies reporting preoperative CPET values and major complications, cardiopulmonary complications, and 1-year mortality. Standardized mean differences (SMD, random-effects model) were calculated and TSA was conducted to evaluate the robustness of evidence in the previous and current meta-analyses.</p><p><strong>Results: </strong>A total of 12 studies met inclusion criteria. V̇O_2peak was correlated with major complications (SMD = - 0.42; 95% CI - 0.70 to - 0.14, p = 0.0032) and cardiopulmonary complications (SMD = - 0.39; 95% CI - 0.65 to - 0.13, p = 0.0032). AT showed similar but weaker associations with both outcomes (SMD = - 0.33 and - 0.22; 95% CI - 0.63 to - 0.03 and CI - 0.40 to - 0.04, p = 0.033 and 0.018, respectively). V̇_E/V̇CO₂ demonstrated no meaningful relationship with major complications. In addition, the present study found neither V̇O_2peak nor AT was associated with 1-year mortality after esophagectomy.</p><p><strong>Conclusions: </strong>V̇O_2peak and AT were inversely associated with morbidity after esophagectomy, while V̇_E/V̇CO₂ offered limited prognostic value and none predict 1-year survival. V̇O_2peak is a key predictor of major and cardiopulmonary complications after esophagectomy and warrants further investigation, either alone or as part of a composite model.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Author Reflections: Prognostic and Therapeutic Implications of Nodal Burden in HER2-Positive Breast Cancer.","authors":"Adrienne N Cobb, Chandler S Cortina","doi":"10.1245/s10434-025-18525-w","DOIUrl":"https://doi.org/10.1245/s10434-025-18525-w","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}