Applied Radiation and Isotopes最新文献

筛选
英文 中文
Cross-sections for 43Sc, 44mSc, and 44gSc from two heavy ion reactions 来自两个重离子反应的 43Sc、44mSc 和 44gSc 的截面。
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-10-28 DOI: 10.1016/j.apradiso.2024.111560
{"title":"Cross-sections for 43Sc, 44mSc, and 44gSc from two heavy ion reactions","authors":"","doi":"10.1016/j.apradiso.2024.111560","DOIUrl":"10.1016/j.apradiso.2024.111560","url":null,"abstract":"<div><div>Two different heavy ion reactions were used to produce <sup>43</sup>Sc (t<span><math><msub><mrow></mrow><mrow><mfrac><mrow><mn>1</mn></mrow><mrow><mn>2</mn></mrow></mfrac></mrow></msub></math></span> = 3.891 h), <span><math><msup><mrow></mrow><mrow><mn>44</mn><mi>g</mi></mrow></msup></math></span>Sc (t<span><math><msub><mrow></mrow><mrow><mfrac><mrow><mn>1</mn></mrow><mrow><mn>2</mn></mrow></mfrac></mrow></msub></math></span> = 4.042 h), and <span><math><msup><mrow></mrow><mrow><mn>44</mn><mi>m</mi></mrow></msup></math></span>Sc (t<span><math><msub><mrow></mrow><mrow><mfrac><mrow><mn>1</mn></mrow><mrow><mn>2</mn></mrow></mfrac></mrow></msub></math></span> = 58.61 h) among other stable or long-lived chemically separable products. Production cross sections for <sup>19</sup>F + <sup>27</sup>Al and the reverse kinematic reaction <sup>35</sup>Cl + <span><math><msup><mrow></mrow><mrow><mi>n</mi><mi>a</mi><mi>t</mi></mrow></msup></math></span>B were measured using an MC-SNICS ion source and the Notre Dame FN Tandem Accelerator. <sup>19</sup>F beams from 35 to 60 MeV were produced with beam currents between 40–80 pnA and <sup>35</sup>Cl beams were produced at six entrance energies with comparable beam currents. This work reports nuclear reaction cross sections <sup>27</sup>Al (<sup>19</sup>F, x) <sup>43</sup>Sc, <sup>27</sup>Al (<sup>19</sup>F, pn) <span><math><msup><mrow></mrow><mrow><mn>44</mn><mi>g</mi></mrow></msup></math></span>Sc, and <sup>27</sup>Al (<sup>19</sup>F, pn) <span><math><msup><mrow></mrow><mrow><mn>44</mn><mi>m</mi></mrow></msup></math></span>Sc at six energies between 35 and 60 MeV lab energy. Cross sections within the same energy range were measured for <sup>27</sup>Al (<sup>19</sup>F, 3pn) <sup>42</sup>K and <sup>27</sup>Al (<sup>19</sup>F, 3p) <sup>43</sup>K. Comparative measurements were performed for the same compound nucleus produced from <span><math><msup><mrow></mrow><mrow><mi>n</mi><mi>a</mi><mi>t</mi></mrow></msup></math></span>B(<sup>35</sup>Cl, x) <sup>43</sup>Sc, <span><math><msup><mrow></mrow><mrow><mi>n</mi><mi>a</mi><mi>t</mi></mrow></msup></math></span>B(<sup>35</sup>Cl, pn) <span><math><msup><mrow></mrow><mrow><mn>44</mn><mi>g</mi></mrow></msup></math></span>Sc, and <span><math><msup><mrow></mrow><mrow><mi>n</mi><mi>a</mi><mi>t</mi></mrow></msup></math></span>B(<sup>35</sup>Cl, pn) <span><math><msup><mrow></mrow><mrow><mn>44</mn><mi>m</mi></mrow></msup></math></span>Sc. The measured thin target cross sections show an overestimation by several statistical models for the scandium radioisotopes. This is corroborated by the measured thick target production rates for both entrance channels. This may be due to angular momentum effects of a heavy ion entrance channel compared to light-ion production, but additional work is required to understand this discrepancy. These measurements demonstrate that the medically useful <sup>43</sup>Sc, <span><math><msup><mrow></mrow><mrow><mn>44</mn><mi>g</mi></mrow></msup></math>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
111Ag phantom images with Cerenkov Luminescence Imaging and digital autoradiography within the ISOLPHARM project 在 ISOLPHARM 项目中,利用塞伦科夫发光成像技术和数字自动放射成像技术拍摄 111Ag 模型图像。
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-10-28 DOI: 10.1016/j.apradiso.2024.111562
{"title":"111Ag phantom images with Cerenkov Luminescence Imaging and digital autoradiography within the ISOLPHARM project","authors":"","doi":"10.1016/j.apradiso.2024.111562","DOIUrl":"10.1016/j.apradiso.2024.111562","url":null,"abstract":"<div><div>Targeted Radionuclide Therapy (TRT) is a medical technique exploiting radionuclides to combat cancer growth and spread. TRT requires a supply of radionuclides that are currently produced by either cyclotrons or nuclear research reactors. In this context, the ISOLPHARM project investigates the production of innovative radionuclides for medical applications. This production will be based on the forthcoming SPES facility at the Legnaro National Laboratories (LNL) of the National Institute for Nuclear Physics (INFN), an ISOL facility where high-purity radioactive beams will be used to produce carrier-free radiopharmaceuticals. Previous studies demonstrated that a significant amount of <sup>111</sup>Ag, an innovative <span><math><mi>β</mi></math></span>/<span><math><mi>γ</mi></math></span> emitter suitable for TRT with theranostic applications, can be obtained at the SPES facility. The present work describes the first imaging study on phantoms with <sup>111</sup>Ag performed by the ISOLPHARM collaboration. This is a fundamental step to pave the way for the upcoming <em>in vivo</em> studies on the <sup>111</sup>Ag-based radiopharmaceutical currently being developed. The imaging potential of this radionuclide was investigated by acquiring phantom images with Cerenkov Luminescence Imaging (CLI) and digital autoradiography (ARG).</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of radioactive nuclides and heavy metals in soil and drink water in Lahij city, Yemen 评估也门拉希杰市土壤和饮用水中的放射性核素和重金属。
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-10-28 DOI: 10.1016/j.apradiso.2024.111566
{"title":"Assessment of radioactive nuclides and heavy metals in soil and drink water in Lahij city, Yemen","authors":"","doi":"10.1016/j.apradiso.2024.111566","DOIUrl":"10.1016/j.apradiso.2024.111566","url":null,"abstract":"<div><div>This study was conducted in Lahij city, Yemen, to evaluate the concentrations and potential health risks of natural radioactive nuclides and heavy metals in soil and drinking water. A total of 21 soil samples and 17 water samples were collected from various locations. A high-purity germanium gamma detector HPGe was used to measure the concentrations of <sup>40</sup>K, <sup>232</sup>Th, and <sup>226</sup>Ra in all samples, along with the concentrations of heavy metals. In soil samples, the average concentrations of <sup>40</sup>K, <sup>232</sup>Th, and <sup>226</sup>Ra were 731.5, 30.7, and 28.16 Bq kg<sup>−1</sup>, respectively. While some samples showed higher than permissible levels for <sup>226</sup>Ra and <sup>232</sup>Th, the overall average remained within acceptable limits. However, <sup>40</sup>K levels were almost twice the recommended global limits. In water samples, the average concentrations of these nuclides were 5.38, 0.73, and 0.66 Bq L<sup>−1</sup>, all within the global safety limits. Radiological risk assessments for soil indicated an average radium equivalent activity (Ra<sub>eq</sub>) of 124.4 Bq kg<sup>−1</sup>, absorbed dose rate in air of 59.9 nGy h<sup>−1</sup>, annual effective dose rate of 0.07 mSv y<sup>−1</sup>, outdoor excess lifetime cancer risk (ELCR) of 0.26 × 10<sup>−3</sup>, and annual gonad equivalent dose (AGED) of 336.6 mSv y<sup>−1</sup>. Risk indices, including the activity concentration index (I<sub>γ</sub>), external hazard index (H<sub>ex</sub>), and internal hazard index (H<sub>in</sub>), averaged 0.48, 0.34, and 0.41, respectively, all below global limits except for AGED, which slightly exceeded the recommended level. For drinking water, the total ingestion dose was calculated for different age groups. The average doses for infants, children, and adults were 0.15, 0.27, and 0.19 mSv y<sup>−1</sup>, respectively. The doses for children and adults exceeded the permissible limits, while those for infants were within safe levels. Heavy metal concentrations were measured in all samples, and the Hazard Quotient (HQ) was calculated. In soil samples, HQ values for all metals &gt;1, indicating potential health risks. In water samples, HQ values were also &gt;1 for all metals except vanadium (V) and iron (Fe). To reduce the dangers associated with radioactive nuclides and heavy metals, regular monitoring and cleanup are crucial, and further research is needed to understand contamination sources and long-term health impacts.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foam separation of radio-molybdenum oxyanions (99MoO42−) incorporated into Co(II)/Al(III) layered double hydroxide using anionic surfactant 使用阴离子表面活性剂对掺入 Co(II)/Al(III) 双层氢氧化物中的放射性钼氧阴离子 (99MoO42-) 进行泡沫分离。
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-10-28 DOI: 10.1016/j.apradiso.2024.111577
{"title":"Foam separation of radio-molybdenum oxyanions (99MoO42−) incorporated into Co(II)/Al(III) layered double hydroxide using anionic surfactant","authors":"","doi":"10.1016/j.apradiso.2024.111577","DOIUrl":"10.1016/j.apradiso.2024.111577","url":null,"abstract":"<div><div>Foam separation of radio-molybdenum oxyanions (<sup>99</sup>MoO<sub>4</sub><sup>2−</sup>) incorporated into in-situ formed Co(II)/Al(III) layered double hydroxide (LDH) particles was applied for recovery of these anionic species from aqueous solutions. The results showed that Co(II)/Al(III) molar ratios of 2 and 2.5 resulted into not only high recovery values for <sup>99</sup>MoO<sub>4</sub><sup>2−</sup> (R &gt; 0.97), but also high decontamination factor (DF = 33 and 36, respectively). Almost complete recovery was achieved for <sup>99</sup>MoO<sub>4</sub><sup>2−</sup> coprecipitated with Co(II)/Al(III) LDH in the pH range 9.9–10.5. Ageing time of 5 min was sufficient to completely coprecipitate the concerned anionic species. Sodium dodecyl sulfate (SDS) concentrations in the range 1.5 × 10<sup>−3</sup> - 3 × 10<sup>−3</sup> mol/L had the ability to efficiently form hydrophobic <sup>99</sup>MoO<sub>4</sub><sup>2-</sup>-Co(II)/Al(III)-LDH particles, where recovery values of about 0.96 were achieved with high DF values. The influence of the coexistence of different foreign anions (Cl<sup>−</sup>, NO<sub>3</sub><sup>−</sup>, HCO<sub>3</sub><sup>−</sup>, CO<sub>3</sub><sup>2−</sup> and SO<sub>4</sub><sup>2−</sup>) during coprecipitation process of <sup>99</sup>MoO<sub>4</sub><sup>2−</sup> and foam separation of the resultant particles was investigated. The suggested strategy in the present study was effectively applied for recovery of <sup>99</sup>MoO<sub>4</sub><sup>2−</sup> anions from ground water (R ≈ 0.98 and enrichment ratio (ER ≈ 7172) and radioactive process wastewater (R ≈ 0.96 and ER = 3887). Based on characterization of Co(II)/Al(III) LDH using Fourier transform infrared (FTIR) and X-ray diffraction (XRD) before and after foam separation process using SDS and the obtained data, the recovery mechanism of <sup>99</sup>MoO<sub>4</sub><sup>2−</sup> was proposed.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monte Carlo modeling and simulation of a new 3D printed phantom for WBC calibration with ballistic gel as a tissue substitute 利用弹道凝胶作为组织替代物,对用于白细胞校准的新型 3D 打印模型进行蒙特卡洛建模和模拟。
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-10-24 DOI: 10.1016/j.apradiso.2024.111565
{"title":"Monte Carlo modeling and simulation of a new 3D printed phantom for WBC calibration with ballistic gel as a tissue substitute","authors":"","doi":"10.1016/j.apradiso.2024.111565","DOIUrl":"10.1016/j.apradiso.2024.111565","url":null,"abstract":"<div><div>Whole-body counter (WBC) systems are used for <em>in vivo</em> monitoring in occupational internal dosimetry, typically calibrated using physical anthropomorphic phantoms. Our research group previously 3D-printed the Reference Female Phantom for Internal Dosimetry (RFPID) without internal organs specifically designed for WBC calibration. The RFPID and it is intended to fill it homogenously with ballistic gel, which is commonly used as a tissue equivalent in ballistic studies. However, comprehensive characterization of its physicochemical properties and radiological behavior as a tissue surrogate for dosimetry is limited. This study aims to evaluate the suitability of ballistic gel as a tissue substitute for physical phantoms in WBC system calibration and to analyze the RFPID as a model for WBC calibration. Ballistic gel tests determined its density and attenuation coefficients, comparing it to muscle, water, and PMMA. The RFPID was modeled and simulated using MCNP6.2 code and placed in an <em>in vivo</em> monitoring system using an 8”x4″ NaI(Tl) scintillator detector previously validated. The simulations were repeated with the RCP_AF of ICRP-110. Results indicate that ballistic gel has a density approximately 6% different from muscle and shows similar linear attenuation coefficients to muscle at intermediate and high energy levels (186–2200 keV). Simulations revealed a disparity of less than 9% in counting efficiency between RFPID and RCP_AF for energies from 100 to 3000 keV, confirming the phantom's suitability for WBC calibration and ballistic gel's viability as a tissue surrogate in internal dosimetry.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic variability increase by gamma irradiation of soybean seeds 用伽马射线照射大豆种子可提高遗传变异性。
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-10-23 DOI: 10.1016/j.apradiso.2024.111563
{"title":"Genetic variability increase by gamma irradiation of soybean seeds","authors":"","doi":"10.1016/j.apradiso.2024.111563","DOIUrl":"10.1016/j.apradiso.2024.111563","url":null,"abstract":"<div><div>The increase of genetic variability by the appearance of new genes of agronomic interest may be favored by the use of gamma radiation. The objective of this study was to evaluate different doses of gamma irradiation on dry seeds of VX04-5692 soybean line, aiming to increase the genetic variability and, with this, the identification of possible mutant plants. The doses of 0, 50, 150 and 250 Gy of gamma radiation were applied from a<sup>60</sup>Co source. The newly irradiated seeds were sown in the field, giving rise to the M1 cycle. Selected plants originated the M2 cycle. The number of seedlings was counted on the 21st day after sowing. Ten plants of each row were identified and evaluated for the various agronomic characteristics and for chemical composition. The data were submitted to analysis of variance. The F test was applied and the results were presented by boxplots and biplot (canonical variables). There was effect of gamma radiation doses at plant height at full bloom and maturity, number of nodes, pods with one seed and seeds per pod. The use of gamma radiation increases the variability in soybean, with consequent increase in the probabilities of identification of new mutants and gains in the chemical composition, useful for breeding programs that aim at better agronomic performance and gains in oil and protein contents. More satisfactory results in the generation of variability are obtained by the application of gamma radiation on soybean dry seeds between 50 and 150 Gy.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and manufacturing of a dynamically deformable liver phantom for radiotherapy 设计和制造用于放射治疗的动态可变形肝脏模型。
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-10-22 DOI: 10.1016/j.apradiso.2024.111561
{"title":"Design and manufacturing of a dynamically deformable liver phantom for radiotherapy","authors":"","doi":"10.1016/j.apradiso.2024.111561","DOIUrl":"10.1016/j.apradiso.2024.111561","url":null,"abstract":"<div><div>Phantoms representing anatomical deformations are necessary to investigate and improve dynamic treatments. In this study, we aimed to produce a deformable liver phantom by simulating respiratory motion.</div><div>The dynamically <strong>DE</strong>formable <strong>L</strong>iver <strong>P</strong>hantom (DELP) is designed to create a human-specific respiratory model and to produce synchronised, repeatable motion with this model. For the deformation effect of this movement, an artificial liver was created using silicone material and mold. A stepper motor was used to compress the liver in the inferior direction according to an adjustable respiratory motion. Reference markers (fiducial) placed on the DELP helped to verify the movement and calculate the deformation. In dynamic deformation tests, the greatest amount of deformation was found in the edge region of the silicone liver. The average deformation was 3.45 ± 0.93 mm when 5 mm amplitude movement was applied and 5.98 ± 0.01 mm when 10 mm amplitude movement was applied.</div><div>DELP is a deformable liver phantom with motion reproducibility. Its performance in radiotherapy application was evaluated using dosimetric equipment.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Near-infrared scintillation properties of Nd-doped CaYAl3O7 single crystals 掺钕 CaYAl3O7 单晶体的近红外闪烁特性。
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-10-22 DOI: 10.1016/j.apradiso.2024.111559
{"title":"Near-infrared scintillation properties of Nd-doped CaYAl3O7 single crystals","authors":"","doi":"10.1016/j.apradiso.2024.111559","DOIUrl":"10.1016/j.apradiso.2024.111559","url":null,"abstract":"<div><div>We prepared Nd-doped CaYAl<sub>3</sub>O<sub>7</sub> single crystals with different Nd concentrations of 0.1, 0.5, 1.0, 5.0, 10, and 20% by the floating zone method. Photoluminescence (PL) and scintillation properties of all the samples were investigated, and the performance as near-infrared (NIR) scintillators was evaluated. All the samples exhibited some luminescence peaks of 4f-4f transitions of Nd<sup>3+</sup> in PL and scintillation spectra at around 890, 1060, and 1300 nm. The 5.0% Nd-doped sample showed the highest PL quantum yield of 49.5%. In addition, the 5.0% Nd-doped sample had the highest scintillation intensity under X-ray irradiation among the samples, and the lowest detectable dose rate was 0.001 Gy/h.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimating Uncertainty in Actinide Intake Due to Unknown Time of Exposure 估算因暴露时间未知而导致的锕系元素摄入量的不确定性。
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-10-19 DOI: 10.1016/j.apradiso.2024.111558
{"title":"Estimating Uncertainty in Actinide Intake Due to Unknown Time of Exposure","authors":"","doi":"10.1016/j.apradiso.2024.111558","DOIUrl":"10.1016/j.apradiso.2024.111558","url":null,"abstract":"<div><div>Bioassay of radiation workers handling actinides in powder form is carried out annually under routine monitoring program. In case of routine monitoring, as the day of intake is unknown, it is assumed that intake has occurred at the midpoint of monitoring interval. However, an uncertainty is introduced in intake estimation due to this assumption. In the present work, uncertainties were evaluated due to unknown time of intake of Type M and S compounds of Pu and U for annual and biennial monitoring interval. Lung and excreta monitoring methods were considered for uncertainty estimation along with the spread of ±1 month or ±2 months in measurements, at the end of monitoring interval. Annual lung monitoring is found to be the most robust and accurate method for assessment of intake of Type S compounds of Pu, Am and U when time of intake is unknown and Pu is detected using <sup>241</sup>Am as a tracer. For Type M compounds, uncertainty was found to be higher than 3 for biennial monitoring interval. Uncertainty is found to be less than 3 for Type S compounds of Pu and U and also for Type M compounds of Pu for both, annual and biennial monitoring intervals using urine analysis. It is higher than 3 for Type M compounds of U for both the monitoring intervals. It is greater than 3 for both Type M and S compounds of Pu and U for both the monitoring intervals using fecal analysis.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of chromatographic methods, TLC and HPLC, to quantify known radiochemical impurities and the radiochemical purity the radiopharmaceutical [177Lu]Lu-PSMA I&T 验证色谱法(TLC 和 HPLC),以量化已知放射性化学杂质和放射性药物[177Lu]Lu-PSMA I&T 的放射性化学纯度
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-10-18 DOI: 10.1016/j.apradiso.2024.111557
{"title":"Validation of chromatographic methods, TLC and HPLC, to quantify known radiochemical impurities and the radiochemical purity the radiopharmaceutical [177Lu]Lu-PSMA I&T","authors":"","doi":"10.1016/j.apradiso.2024.111557","DOIUrl":"10.1016/j.apradiso.2024.111557","url":null,"abstract":"<div><div>The Energy and Nuclear Research Institute (IPEN) is studying the production of the radiopharmaceutical [<sup>177</sup>Lu]Lu-PSMA I&amp;T, in accordance with the good manufacturing practices recommended by the National Health Surveillance Agency (ANVISA), to be used in the therapy of prostate cancer. This work aims to validate chromatographic methods, Thin-Layer Chromatographic (TLC) and high-performance liquid chromatography (HPLC), to determine the radiochemical purity (RCP) of the product. The entire validation process of this work was based on ANVISA's RDC 166, 2017 and the Guide 10, version 1, 2017, guided the statistical treatments adopted. With the selectivity study we can observe that the presence of impurities or excess excipients in the sample does not interfere with the quantification of the product. The proposed methods were linear with linear correlation coefficients (r) above 0.99. The precision and repeatability presented relative standard deviation values lower than specified (RSD &lt;5 %). The small controlled variations in the method suggested for the robustness test also did not affect the radiochemical purity of the product. In view of the results and in accordance with the criteria established by the National Health Surveillance Agency (ANVISA), the two chromatographic methods were validated in accordance with RDC 166, 2017, proving to be selective, precise, linear and robust. The validation of TLC and HPLC methods enables their application in the batch release routine of the new radiopharmaceutical at Radiopharmacy Center of IPEN.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信