用液体闪烁光谱仪通过粒子计数测量2111at活度。

IF 1.8 3区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR
Applied Radiation and Isotopes Pub Date : 2025-11-01 Epub Date: 2025-08-12 DOI:10.1016/j.apradiso.2025.112093
Chihiro Shimodan, Kasumi Arai, Masataka Imamura, Tetsuro Matsumoto, Akihiko Masuda, Seiya Manabe, Rio Furukawa, Ryan Smith, Hideki Harano, Yasushi Sato
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引用次数: 0

摘要

α粒子发射器作为治疗性放射性药物已经引起了相当大的兴趣,2111at成为一种可行的候选者。在本研究中,用液体闪烁光谱仪通过α粒子计数测定了211At溶液的活度浓度。对用于脉冲高度光谱测量的感兴趣区域中的α粒子进行计数,并根据使用241Am标准源确定的α粒子计数效率对计数进行校正。粒子计数效率的不确定性是总体不确定性的最大贡献者。这一结果表明,通过改进评价粒子计数效率的方法,可以降低综合不确定度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Measurement of the 211At activity via alpha-particles counting with a liquid scintillation spectrometer.

Alpha-particle emitters have garnered considerable interest as therapeutic radiopharmaceuticals, with 211At emerging as a viable candidate. In this study, the activity concentration of an 211At solution was determined via alpha-particle counting with a liquid scintillation spectrometer. Alpha-particles, in the region of interest set for pulse-height spectral measurement, were counted, and the counts were corrected for alpha-particle counting efficiency determined using 241Am standard source. The uncertainty in the alpha-particle counting efficiency was the largest contributor to the overall uncertainty. This result suggests that the combined uncertainty can be reduced by improving the method for evaluating alpha-particle counting efficiency.

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来源期刊
Applied Radiation and Isotopes
Applied Radiation and Isotopes 工程技术-核科学技术
CiteScore
3.00
自引率
12.50%
发文量
406
审稿时长
13.5 months
期刊介绍: Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.
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