Anaerobe最新文献

{"title":"Effects of common cosmetic ingredients on growth of dominant human skin inhabitant Cutibacterium acnes","authors":"Osamu Funatsu ,&nbsp;Itaru Dekio ,&nbsp;Hiroko Ishii ,&nbsp;Reiko Shimatsu ,&nbsp;Yutaka Shimokawa ,&nbsp;Akihiko Asahina","doi":"10.1016/j.anaerobe.2025.102999","DOIUrl":"10.1016/j.anaerobe.2025.102999","url":null,"abstract":"<div><h3>Objectives</h3><div>Cosmetic products, which typically contain multiple ingredients such as ethanol, glycerol and Tween 80 (polysorbate 80), may influence the homeostasis of the skin microbiome. However, the effect of common ingredients on the anaerobic members of human skin microbiome is poorly studied. In this study, we directly evaluated the effects of common cosmetic ingredients on a dominant human skin anaerobe <em>Cutibacterium acnes</em> using <em>in vitro</em> techniques.</div></div><div><h3>Materials and methods</h3><div>Five cosmetic ingredients were added to seven <em>C</em>. <em>acnes</em> strains, including type strains of the three subspecies (types I, II, and III), and their effects were evaluated by monitoring growth curves based on turbidity measurements.</div></div><div><h3>Results</h3><div>All strains exhibited growth inhibition in response to high concentrations (10 % v/v) of ethanol and glycerol, whereas low concentrations (3 % and/or 1 % v/v) of ethanol enhanced bacterial growth. The nonionic detergent Tween 80 significantly enhanced the growth of type I strains, with some strains also producing insoluble precipitates, which may relate to comedogenesis. In contrast, type III strains did not produce precipitates. The two polyamines, putrescine and spermidine, elicited a biphasic response, with growth inhibition observed at higher concentrations and growth promotion at lower concentrations.</div></div><div><h3>Conclusion</h3><div>The response of <em>C. acnes</em> subspecies/strains to the cosmetic components varied with the different ingredient concentrations, often exhibiting opposite effects.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"96 ","pages":"Article 102999"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and risk factor analysis of Clostridioides difficile infection in patients with malignant tumours","authors":"Limin Guo ,&nbsp;Zhen Zhang ,&nbsp;Xianqin Cao ,&nbsp;Weihua Guo ,&nbsp;Aimin Yue ,&nbsp;Yuhou Shen","doi":"10.1016/j.anaerobe.2025.102993","DOIUrl":"10.1016/j.anaerobe.2025.102993","url":null,"abstract":"<div><h3>Objective</h3><div>To identify risk factors for <em>Clostridioides difficile</em> infection (CDI) in patients with malignant tumours and establish a predictive model for clinical prevention and early intervention.</div></div><div><h3>Methods</h3><div>This retrospective study included 92 patients with malignant tumours (46 CDI-positive, 46 CDI-negative) admitted to our hospital. Demographic characteristics, clinical parameters, laboratory indicators and treatment factors were collected and analyzed. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for CDI, and a predictive model was established and evaluated using receiver operating characteristic curve analysis.</div></div><div><h3>Results</h3><div>Patients with CDI had significantly lower serum albumin levels (30.12 ± 5.86 vs 34.15 ± 7.88 g/L, P = 0.007) and higher C-reactive protein (CRP) levels (89.38 ± 91.01 vs 49.17 ± 51.78 mg/L, P = 0.011) than patients without CDI. The CDI-positive group had significantly higher rates of multiple antibiotic use (52.2 % vs 10.9 %, P &lt; 0.001) and corticosteroid/immunosuppressant use (58.7 % vs 30.4 %, P = 0.007) than the CDI-negative group. Multivariate logistic regression analysis identified four independent risk factors for CDI: multiple antibiotic use (odds ratio [OR] = 7.56, 95 % confidence interval [CI]: 2.41–23.73, P &lt; 0.001), corticosteroid/immunosuppressant use (OR = 2.81, 95 % CI: 1.08–7.32, P = 0.035), serum albumin (per g/L increase: OR = 0.94, 95 % CI: 0.88–1.00, P = 0.049) and CRP (per mg/L increase: OR = 1.01, 95 % CI: 1.00–1.01, P = 0.047). The multivariate predictive model demonstrated excellent discriminative ability (area under the curve = 0.907).</div></div><div><h3>Conclusion</h3><div>Multiple antibiotic use, corticosteroid/immunosuppressant therapy, hypoalbuminaemia and elevated CRP are independent risk factors for CDI in patients with malignant tumours. The predictive model established in this study may help identify patients at high risk who could benefit from preventive interventions.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"96 ","pages":"Article 102993"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taxonomy for clinicians – recent changes in names of anaerobic species with pathogenic or probiotic properties","authors":"Lyudmila Boyanova,&nbsp;Raina Gergova,&nbsp;Rumyana Markovska","doi":"10.1016/j.anaerobe.2025.103002","DOIUrl":"10.1016/j.anaerobe.2025.103002","url":null,"abstract":"","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"96 ","pages":"Article 103002"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic plasticity enables Clostridioides difficile growth in coculture with neutrophils and other mammalian cells","authors":"Jucy Gabriel ,&nbsp;Eleanor Keil ,&nbsp;Sanath Chandramouli ,&nbsp;Faiza Khondokar ,&nbsp;Rachel Wilkinson ,&nbsp;Jennifer Trannguyen ,&nbsp;Senu Apewokin ,&nbsp;Anushri Shankar ,&nbsp;Shinsmon Jose","doi":"10.1016/j.anaerobe.2025.103007","DOIUrl":"10.1016/j.anaerobe.2025.103007","url":null,"abstract":"<div><h3>Objectives</h3><div><em>Clostridioides difficile</em> infection (CDI) is a significant healthcare burden, characterized by severe colitis and high recurrence rates. Although neutrophils migrate rapidly to the colon infected with <em>C. difficile</em>, it does not lead to pathogen clearance. Understanding how pathogen survives within the host remains a knowledge gap. This study investigates host-pathogen interactions in controlled <em>in vitro</em> settings.</div></div><div><h3>Methods</h3><div>Multiple strains of <em>C. difficile</em> (M7404, VPI10463, R20291, and clinical isolates) were co-cultured with neutrophils, macrophages, and intestinal epithelial cells (IECs) under anaerobic conditions, and bacterial growth was assessed by optical density and micro-replicator-mediated colony assays. Microbial transcriptomics and pathway enrichment analyses were performed 18 h after M7404-neutrophil coculture to understand the metabolic adaptations.</div></div><div><h3>Results</h3><div>Neutrophils significantly accelerated the growth of <em>C. difficile</em> in anaerobic co-culture. Transcriptomic analysis revealed extensive metabolic reprogramming in <em>C. difficile</em>, including upregulation of oxidative phosphorylation, carbon fixation, and fermentation pathways, suggesting that the bacterium exploits host-derived nutrients to its advantage. Further highlighting the microbial metabolic switch towards utilizing host-derived nutrients, we observed the upregulation of glycerol kinase and the ethanolamine utilization protein. The downregulation of TCA cycle enzymes and upregulation of catalases suggested a shift away from oxidative metabolism and an effort to mitigate neutrophil-induced stress. <em>C. difficile</em> bacterium underwent similar transcriptional programming in coculture with macrophages and IECs.</div></div><div><h3>Conclusions</h3><div>The transcriptional regulation of <em>C. difficile</em> metabolic genes in the presence of mammalian cells reveals a key virulence trait that enables pathogen persistence within a host. This study also highlights a paradoxical role of neutrophils in CDI, where it's presence may inadvertently enhance pathogen survival. Targeting these metabolic interactions could lead to novel therapeutic strategies for mitigating CDI severity.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"96 ","pages":"Article 103007"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome and metabolome changes after fecal microbiota, live-jslm, administration are associated with health-related quality of life improvements","authors":"Rohan Mishra ,&nbsp;Adam Harvey ,&nbsp;Amy Guo ,&nbsp;Glenn Tillotson ,&nbsp;Paul Feuerstadt ,&nbsp;Sahil Khanna ,&nbsp;William D. Shannon ,&nbsp;Ken F. Blount","doi":"10.1016/j.anaerobe.2025.103006","DOIUrl":"10.1016/j.anaerobe.2025.103006","url":null,"abstract":"<div><h3>Objectives</h3><div>Increasing evidence indicates a gut microbiome-brain axis, but more robust statistical methods are needed to solidify this connection. In a large phase 3, randomized, placebo-controlled clinical trial (PUNCH CD3; NCT03244644), fecal microbiota, live-jslm (REBYOTA; RBL, previously RBX2660), was effective in preventing recurrent <em>Clostridium difficile</em> infections, and trial participants had significant gut microbiome and metabolome shifts concurrent with significant changes in health-related quality of life (HRQOL). Advanced statistical methods were applied to data from this trial to further explore and demonstrate associations between changing HRQOL and microbiome or metabolome changes.</div></div><div><h3>Methods</h3><div>A categorical statistical analysis queried whether patient-reported Cdiff32 HRQOL scores were more likely to improve after RBL than after placebo among PUNCH CD3 participants, and a Dirichlet-multinominal recursive partitioning model assessed whether mental domain Cdiff32 HRQOL scores were linked to participants’ fecal microbiome or bile acid compositions.</div></div><div><h3>Results</h3><div>Cdiff32 mental domain HRQOL scores were more likely to be improved after RBL administration compared with placebo among treatment responders. Cdiff32 mental domain scores were associated with changing gut microbiome and metabolome compositions, with a gradient of increased Clostridia and Bacteroidia and increased secondary bile acid predominance associated with better Cdiff32 scores.</div></div><div><h3>Conclusions</h3><div>The microbiota-gut-brain axis is posited to modulate health-related quality of life, microbiome, and metabolome changes through immune, gastrointestinal, and central nervous system functions in patients with recurrent <em>C. difficile</em> infection following RBL administration. These analyses provide a novel approach for investigating multi-omics data and categorical health-related quality of life questionnaires and generate new insights for further clinical studies.</div></div><div><h3>Clinical trial registration</h3><div>NCT03244644.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"96 ","pages":"Article 103006"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milestones in Clostridium perfringens research since 1995","authors":"Bruce A. McClane ,&nbsp;Jihong Li ,&nbsp;Francisco A. Uzal ,&nbsp;Julian I. Rood","doi":"10.1016/j.anaerobe.2025.103011","DOIUrl":"10.1016/j.anaerobe.2025.103011","url":null,"abstract":"<div><div><em>Clostridium perfrin</em>gens is an important human and veterinary pathogen, as well as a common member of the normal intestinal microbiota. By applying molecular approaches, substantial progress has been achieved since 1995 in understanding the pathogenicity and biology of this gram-positive, anaerobic, spore-forming bacterium. For example, there is now a much improved understanding of the structure and action of its “legacy” toxins (i.e., CPA, PFO, ETX, CPB, ITX and CPE) and the pathogenic importance of many of those toxins has now been clearly demonstrated. In addition, several new toxins have been discovered since 1995 and at least one of those new toxins (NetB) has been clearly linked to disease. The importance and diversity of mobile genetic elements, particularly conjugative plasmids, for pathogenicity and antibiotic resistance is now established. Several regulators controlling virulence gene expression have been identified and, in some cases, their regulatory mechanisms have been clarified. For some regulators, their importance for virulence has also been demonstrated. Lastly, there is also improved knowledge of sporulation and germination mechanisms for <em>C. perfringens</em>, as well as how sporulation contributes to disease transmission and pathogenesis for this bacterium. Despite these advances, some important questions about <em>C. perfringens</em> remain to be explored.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"96 ","pages":"Article 103011"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145457051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binding to thrive: Decoding Atopobium spp. interactions with host proteins and immune cells","authors":"Inga-Maria Frick,&nbsp;Ariane Neumann","doi":"10.1016/j.anaerobe.2025.102998","DOIUrl":"10.1016/j.anaerobe.2025.102998","url":null,"abstract":"<div><h3>Objectives</h3><div>Gram-positive anaerobic cocci are opportunistic pathogens that exploit immune suppression or tissue injury to establish infections. <em>Atopobium</em> spp. are clinically relevant, being linked to bacterial vaginosis, abdominal wounds, pelvic abscesses, and dental infections. While clinical reports describe the involvement in detrimental host conditions, in-depth knowledge is missing to understand how these bacteria acquire essential nutrients to evade immune responses and directly interact with the human host.</div></div><div><h3>Methods</h3><div>Here we analyzed the growth of three blood-isolated <em>Atopobium</em> strains in different media and compared them to <em>Finegoldia magna</em>. Using radioactive binding studies, human serum albumin (HSA), a major component of serum, was identified as the primary binding partner, subsequently facilitating bacterial growth by providing essential nutrients. Next, we investigated the ability of <em>Atopobium</em> to interact with human blood-isolated neutrophils.</div></div><div><h3>Results</h3><div>Interestingly, <em>Atopobium</em> triggered neutrophil activation, detected by increased reactive oxygen species (ROS) production, secretion of the sepsis marker heparin-binding protein (HBP), and the induction of extracellular trap (NET) formation.</div></div><div><h3>Conclusions</h3><div>These findings provide new insights into how <em>Atopobium</em> utilizes host serum components and facilitates host interactions, highlighting their potential role in immune modulation and pathogenesis.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"96 ","pages":"Article 102998"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finegoldia magna, a neglected cause of endocarditis – case report","authors":"Charlie Zins ,&nbsp;Loic Biere ,&nbsp;Mohamed Braham ,&nbsp;Rachel Chenouard ,&nbsp;Matthieu Eveillard ,&nbsp;Marie Kempf ,&nbsp;Vincent Dubée ,&nbsp;Hélène Pailhoriès","doi":"10.1016/j.anaerobe.2025.102997","DOIUrl":"10.1016/j.anaerobe.2025.102997","url":null,"abstract":"<div><div><em>Finegoldia magna</em> endocarditis is a rare and underdiagnosed condition, primarily affecting prosthetic valves. We report a case, along with a comprehensive literature review, highlighting its subacute presentation and the challenges in diagnosis due to frequent negative blood cultures. Molecular detection methods and prolonged delay for anaerobic cultures are crucial for identifying <em>F. magna</em>. Given the high risk of significant valvular damage, including abscess formation, surgical intervention might be required. Antibiotic treatments in the literature include penicillins, with or without metronidazole. Clinicians should consider this underestimated pathogen as a potential cause of early prosthetic valve endocarditis, particularly in cases of sterile blood cultures.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"96 ","pages":"Article 102997"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleural empyema due to polymicrobial Clostridioides difficile, Clostridium tertium and Robinsoniella peoriensis following C. difficile peritonitis","authors":"Edward Lovering ,&nbsp;Obaid Haque ,&nbsp;Marcos Wolff","doi":"10.1016/j.anaerobe.2025.103013","DOIUrl":"10.1016/j.anaerobe.2025.103013","url":null,"abstract":"<div><div>We report a case of a male in his late-60s who presented with acute onset chest pain of one day duration and worsening dyspnea on exertion for more than one week, with chest radiograph notable for right-sided pleural effusion. Pleural fluid analysis revealed an exudative effusion and cultures from pleural fluid grew <em>Clostridioides difficile</em>, <em>Clostridium tertium</em>, and <em>Robinsoniella peoriensis.</em> His past medical history was significant for polymicrobial <em>C. difficile</em> and <em>Escherichia coli</em> peritonitis with a negative stool glutamate dehydrogenase assay. The patient was treated with six-week course of metronidazole. This is the first reported case of <em>Robinsoniella peoriensis</em> empyema and highlights the rarity of polymicrobial extra-intestinal anaerobic infection and the serious challenges in treatment due to the lack of established guidelines.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"96 ","pages":"Article 103013"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145443730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and molecular types of Clostridioides (Clostridium) difficile on Australian retail vegetables and household surfaces","authors":"Deirdre A. Collins ,&nbsp;Su Chen Lim ,&nbsp;Jessica Chisholm ,&nbsp;Molly Lattin ,&nbsp;Linda Selvey ,&nbsp;Simon Reid ,&nbsp;Thomas V. Riley","doi":"10.1016/j.anaerobe.2025.103000","DOIUrl":"10.1016/j.anaerobe.2025.103000","url":null,"abstract":"<div><h3>Objectives</h3><div>Community-onset <em>Clostridioides</em> (<em>Clostridium</em>) <em>difficile</em> infection (CDI) has risen to &gt;80 % of all CDI cases in Australia. High prevalence of <em>C. difficile</em> contamination has been reported in many community sources including retail root vegetables. Household surfaces may become contaminated with <em>C. difficile</em> when storing and handling contaminated vegetables. This study aimed to determine the prevalence and molecular types of <em>C. difficile</em> present on retail root vegetables and household surfaces.</div></div><div><h3>Methods</h3><div>From April 2023 to March 2024, retail potatoes (n = 255) and onions (n = 305) were sampled at 3-monthly intervals. Environmental samples were collected from homes of householders in Queensland (n = 105) and Western Australia (n = 124) who regularly purchased unwashed potatoes. Swabs were collected from their countertop/chopping board, vegetable storage area and an unwashed potato. Pooled potato peels, pooled onion roots and household swab samples underwent enrichment culture for <em>C. difficile</em>. <em>C. difficile</em> isolates were characterized by PCR ribotyping and detection of toxin genes.</div></div><div><h3>Results</h3><div><em>C. difficile</em> was cultured from 5.6 % of all 679 household samples, 35.3 % of 255 retail potato samples and 20.3 % of retail onion 305 samples. At least one environmental/potato sample was positive for 15.7 % of all 229 households. Among 84 <em>C. difficile</em> ribotypes (RTs), 056, 286, 101 and 125 predominated on vegetables in Western Australia and RTs 101, QX 098, 014/020 and QX 601 were most common on Queensland vegetables.</div></div><div><h3>Conclusions</h3><div>Toxigenic strains of <em>C. difficile</em> were identified on retail vegetables and within households, highlighting potential for CDI to be acquired within households. Populations at high risk of CDI e.g. patients with inflammatory bowel disease or cancer, could benefit from education on safe handling and cleaning of potential sources of <em>C. difficile</em> in their homes.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"96 ","pages":"Article 103000"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}