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A Metabolite Dehydrogenase Pathway Represses Sporulation of Clostridioides difficile. 一种代谢物脱氢酶途径抑制艰难梭菌的产孢。
IF 2.5 3区 生物学
Anaerobe Pub Date : 2025-05-09 DOI: 10.1016/j.anaerobe.2025.102971
Daniela Wetzel, Arshad Rizvi, Adrianne N Edwards, Shonna M McBride
{"title":"A Metabolite Dehydrogenase Pathway Represses Sporulation of Clostridioides difficile.","authors":"Daniela Wetzel, Arshad Rizvi, Adrianne N Edwards, Shonna M McBride","doi":"10.1016/j.anaerobe.2025.102971","DOIUrl":"https://doi.org/10.1016/j.anaerobe.2025.102971","url":null,"abstract":"<p><p>Clostridioides difficile is a major gastrointestinal pathogen that is transmitted as a dormant spore. As an intestinal pathogen, C. difficile must contend with variable environmental conditions, including fluctuations in pH and nutrient availability. Nutrition and pH both influence growth and spore formation, but how pH and nutrition jointly influence sporulation are not known.</p><p><strong>Objectives: </strong>In this study, we investigated the dual impact of pH and pH-dependent metabolism on C. difficile sporulation.</p><p><strong>Methods: </strong>We examined the impacts of pH and the metabolite acetoin on C. difficile growth, gene expression, and sporulation.</p><p><strong>Results: </strong>We found that expression of the predicted acetoin dehydrogenase operon, CD0035-CD0039, was pH-dependent and repressed by acetoin and pyruvate. Regulation of the C. difficile CD0035-CD0039 locus is distinct from characterized orthologous systems and appears to involve a co-transcribed DeoR-family regulator, rather than a sigma<sup>54</sup>-dependent activator. In addition, an CD0036 null mutant produced significantly more spores and initiated sporulation earlier than the parent strain. However, unlike other Firmicutes, growth and culture density of C. difficile was not increased by acetoin availability or disruption of the dehydrogenase pathway.</p><p><strong>Conclusions: </strong>Together, these results indicate that acetoin, pH, and the CD0036-CD0039 dehydrogenase pathway play important roles in nutritional repression of sporulation in C. difficile. However, the data do not support the involvement of the CD0036-CD0039 pathway in acetoin metabolism and acetoin is not a significant stationary phase energy source for C. difficile.</p>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":" ","pages":"102971"},"PeriodicalIF":2.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Disc Diffusion and Sensititre® Broth Microdilution Methods for Antimicrobial Susceptibility Testing of Bacteroides fragilis Group clinical isolates following the French Guidelines. 光盘扩散法和Sensititre®微汤稀释法在法国易碎拟杆菌临床分离株药敏试验中的比较
IF 2.5 3区 生物学
Anaerobe Pub Date : 2025-05-06 DOI: 10.1016/j.anaerobe.2025.102969
Gauthier Delvallez, Laure Diancourt, Julie Germond, Pascal Campagne, Bruno Dupuy
{"title":"Comparison of Disc Diffusion and Sensititre® Broth Microdilution Methods for Antimicrobial Susceptibility Testing of Bacteroides fragilis Group clinical isolates following the French Guidelines.","authors":"Gauthier Delvallez, Laure Diancourt, Julie Germond, Pascal Campagne, Bruno Dupuy","doi":"10.1016/j.anaerobe.2025.102969","DOIUrl":"https://doi.org/10.1016/j.anaerobe.2025.102969","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the concordance between the disc diffusion test (DDT) and custom-designed Sensititre® Broth Microdilution plates and to estimate their respective sensitivity (Se) and specificity (Sp) for antimicrobial susceptibility testing (AST) of Bacteroides fragilis group (BFG) clinical isolates.</p><p><strong>Methods: </strong>AST was performed on 126 BFG isolates using both DDT and Sensititre® methods according to the 2024 CA-SFM guidelines. Cohen's kappa coefficients were used to assess concordance, while a Bayesian approach estimated Se and Sp with 95% confidence intervals (95% CIs) for amoxicillin-clavulanate (AMC), piperacillin-tazobactam (PTZ), imipenem (IPM), clindamycin (CLI), metronidazole (MTR), and moxifloxacin (MXF).</p><p><strong>Results: </strong>Cohen's kappa coefficients with 95% CIs for AMC, PTZ, IPM, CLI, MTR, and MXF were 0.92 (0.85-1.00), 0.70 (0.56-0.83), 0.96 (0.92-1.00), 0.98 (0.94-1.00), 0.96 (0.89-1.00), and 0.70 (0.58-0.82), respectively. DDT demonstrated Se > 0.8 for all antibiotics, and Sp > 0.8 except for PTZ (0.51; 0.37-0.65) and CLI (0.71; 0.58-0.82). Sensititre® exhibited Se > 0.9 for all antibiotics except for PTZ (0.86; 0.70-0.99), and Sp > 0.9 except for MXF (0.88; 0.75-0.99).</p><p><strong>Conclusions: </strong>DDT and Sensititre® Broth Microdilution demonstrated strong concordance for most antibiotics. Predictive values estimated using Bayesian model showed that Sensititre® offered the highest overall Se and Sp.</p>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":" ","pages":"102969"},"PeriodicalIF":2.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic analysis and mobile genetic elements carriage of Clostridium perfringens type A A型产气荚膜梭菌基因组分析及可移动遗传元件携带。
IF 2.5 3区 生物学
Anaerobe Pub Date : 2025-05-03 DOI: 10.1016/j.anaerobe.2025.102970
Yajun Jiang , Haoran Zheng , Lulu Bai, Yuanyuan Wang, Jiaxin Zhong, Wenzhu Zhang, Telong Xu, Yuanhang Pan, Jingjing Tang, Jinxing Lu, Bike Zhang, Yuan Wu
{"title":"Genomic analysis and mobile genetic elements carriage of Clostridium perfringens type A","authors":"Yajun Jiang ,&nbsp;Haoran Zheng ,&nbsp;Lulu Bai,&nbsp;Yuanyuan Wang,&nbsp;Jiaxin Zhong,&nbsp;Wenzhu Zhang,&nbsp;Telong Xu,&nbsp;Yuanhang Pan,&nbsp;Jingjing Tang,&nbsp;Jinxing Lu,&nbsp;Bike Zhang,&nbsp;Yuan Wu","doi":"10.1016/j.anaerobe.2025.102970","DOIUrl":"10.1016/j.anaerobe.2025.102970","url":null,"abstract":"<div><h3>Objectives</h3><div>To explore a comprehensive genomic analysis of <em>Clostridium perfringens</em> type A strains from diverse regions in China, investigating their virulence genes, antibiotic resistance genes, and mobile genetic elements (MGEs) to inform strategies for infection control and resistance gene surveillance.</div></div><div><h3>Methods</h3><div>We conducted whole-genome sequencing on 168 <em>C. perfringens</em> type A strains from nine provinces in China (2016–2021). Previously described alpha-toxin (PLC) sequence typing for <em>C. perfringens</em> was used for comparisons with core genome multilocus sequence typing. Virulence genes, antibiotic resistance genes, and MGEs, including CRISPR/Cas, prophages, and plasmids of <em>C. perfringens</em> type A were investigated by molecular and bioinformatic methods.</div></div><div><h3>Results</h3><div>PLC type II contained the largest number of isolates (n = 44). The same type strains were largely clustered in the same branches. Tetracycline resistance genes <em>tetA(P)</em> and <em>tetB(P)</em> had high prevalence in type A isolates. 395 prophages were predicted including 265 “incomplete,” 55 “questionable,” and 75 “intact” prophages. CRISPR/Cas systems were more common in isolates from humans (63 %) than in those from animals and food (52 % and 46 %, respectively). Fifty-seven percent of strains likely had the tcp conjugation locus (<em>tcpC</em> to <em>tcpH</em>), and 12 isolates likely carried the conjugative pCW3 plasmid. Type A strains exhibited fewer plasmid-encoded toxins.</div></div><div><h3>Conclusions</h3><div>cgMLST analysis demonstrated some micro-evolution and regional transmission trends within type A, which exhibited partial correlated with PLC typing. This study highlights the need for enhanced surveillance of antimicrobial resistance and pathogenicity-associated MGEs in <em>C. perfringens</em> type A.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"93 ","pages":"Article 102970"},"PeriodicalIF":2.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical characteristics of Bacteroides pyogenes infections: A combined analysis of 34 cases from a Japanese tertiary hospital and 29 cases from the literature 化脓性拟杆菌感染的临床特点:日本某三级医院34例及文献29例的综合分析
IF 2.5 3区 生物学
Anaerobe Pub Date : 2025-05-02 DOI: 10.1016/j.anaerobe.2025.102963
Tomonori Takano , Haruka Koji , Tadatomo Oyanagi , Hiroyuki Kunishima
{"title":"Clinical characteristics of Bacteroides pyogenes infections: A combined analysis of 34 cases from a Japanese tertiary hospital and 29 cases from the literature","authors":"Tomonori Takano ,&nbsp;Haruka Koji ,&nbsp;Tadatomo Oyanagi ,&nbsp;Hiroyuki Kunishima","doi":"10.1016/j.anaerobe.2025.102963","DOIUrl":"10.1016/j.anaerobe.2025.102963","url":null,"abstract":"<div><div>Diseases such as cholangitis and sinusitis may be caused by <em>Bacteroides pyogenes</em>, frequently isolated from patients with underlying malignancies. Head and neck infections involving <em>B. pyogenes</em> have high recurrence rates and may require 1–3 months of antibiotic therapy. Careful monitoring and appropriate treatment are crucial for managing these infections.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"93 ","pages":"Article 102963"},"PeriodicalIF":2.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An older man with Bifidobacterium breve bacteremia, a rare condition in adults: A case report 一个老年男子与短双歧杆菌菌血症,一个罕见的条件在成人:一个病例报告。
IF 2.5 3区 生物学
Anaerobe Pub Date : 2025-04-26 DOI: 10.1016/j.anaerobe.2025.102968
Miku Muramatsu , Dai Akine , Teppei Sasahara , Takayuki Suzuki , Tomohiro Tamura , Takayuki Kaburagi , Shinya Watanabe
{"title":"An older man with Bifidobacterium breve bacteremia, a rare condition in adults: A case report","authors":"Miku Muramatsu ,&nbsp;Dai Akine ,&nbsp;Teppei Sasahara ,&nbsp;Takayuki Suzuki ,&nbsp;Tomohiro Tamura ,&nbsp;Takayuki Kaburagi ,&nbsp;Shinya Watanabe","doi":"10.1016/j.anaerobe.2025.102968","DOIUrl":"10.1016/j.anaerobe.2025.102968","url":null,"abstract":"<div><div><em>Bifidobacterium breve</em> is an anaerobic, gram-positive rod commonly found in the human intestinal microbiota. While rarely associated with bacteremia, most cases occur in neonates receiving <em>B. breve</em>-containing probiotics. Here, we report a rare case of <em>B. breve</em> bacteremia in an 80-year-old man presenting in cardiopulmonary arrest, despite not taking <em>B. breve</em>-containing probiotics. Blood cultures identified <em>B. breve</em>, and an 18-day course of antibiotics resolved the bacteremia. The rarity of adult cases may reflect age-related microbiota shifts and potential underdiagnosis due to the limited accuracy of rapid identification kits used in clinical practice.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"93 ","pages":"Article 102968"},"PeriodicalIF":2.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The genus Fervidobacterium, its thermoenzymes and biotechnological potential: an integrative review 热杆菌属、热酶及其生物技术潜力综述
IF 2.5 3区 生物学
Anaerobe Pub Date : 2025-04-25 DOI: 10.1016/j.anaerobe.2025.102967
Bruna Kelly de Oliveira Silva , José do Carmo Barbosa Neto , Laisa Gabriele Batista de Jesus , Fabrício Motteran , Marcos Antonio De Morais Jr.
{"title":"The genus Fervidobacterium, its thermoenzymes and biotechnological potential: an integrative review","authors":"Bruna Kelly de Oliveira Silva ,&nbsp;José do Carmo Barbosa Neto ,&nbsp;Laisa Gabriele Batista de Jesus ,&nbsp;Fabrício Motteran ,&nbsp;Marcos Antonio De Morais Jr.","doi":"10.1016/j.anaerobe.2025.102967","DOIUrl":"10.1016/j.anaerobe.2025.102967","url":null,"abstract":"<div><div>The genus <em>Fervidobacterium</em> has only seven described species to date, namely <em>F. changbaicum</em>, <em>F. gondwanense</em>, <em>F. islandicum</em>, <em>F. nodosum</em>, <em>F. pennivorans</em>, <em>F. riparium</em> and <em>F. thailandense</em>. These species were first isolated from places with high thermal amplitude, such as hot springs and sites that originated from volcanic activity. With temperatures ranging from 40 °C to 90 °C, they are characteristically considered hyperthermophilic. This genus belongs to the phylum Thermotoga, composed of families of extremophilic organisms, that is, adapted to inhospitable environments. The genus is considered strictly anaerobic and heterotrophic and is widely reported in the literature regarding its biochemical machinery, as it produces a wide variety of enzymes capable of metabolising the most diverse carbon sources. It stands out for the degradation of mostly keratinolytic substrates, such as those composed of feathers of native birds. Therefore, this literature review aimed to gather information about the genus and its enzymology. There are few recent studies that outline the genus <em>Fervidobacterium</em> and the biotechnological and commercial potential added to the genus. The enzymes produced by these species are resistant to several detergents and organic solvents and have a high and remarkable thermal stability. Consequently, these microorganisms hold significant biotechnological potential across various industrial sectors and are also promising candidates for environmental remediation efforts.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"93 ","pages":"Article 102967"},"PeriodicalIF":2.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clostridioides difficile is a bacterial priority pathogen
IF 2.5 3区 生物学
Anaerobe Pub Date : 2025-04-25 DOI: 10.1016/j.anaerobe.2025.102965
Wiep Klaas Smits , Kevin W. Garey , Thomas V. Riley , Stuart Johnson
{"title":"Clostridioides difficile is a bacterial priority pathogen","authors":"Wiep Klaas Smits ,&nbsp;Kevin W. Garey ,&nbsp;Thomas V. Riley ,&nbsp;Stuart Johnson","doi":"10.1016/j.anaerobe.2025.102965","DOIUrl":"10.1016/j.anaerobe.2025.102965","url":null,"abstract":"","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"93 ","pages":"Article 102965"},"PeriodicalIF":2.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CDBN-YGXZ shows highly antibacterial activity against Clostridioides difficile as a potential candidate drug CDBN-YGXZ对艰难梭菌具有较高的抑菌活性,是一种潜在的候选药物
IF 2.5 3区 生物学
Anaerobe Pub Date : 2025-04-25 DOI: 10.1016/j.anaerobe.2025.102964
Xiaoxia Zhang , Min Quan , Xin Lu , Linwan Zhang , Bing Guang , Zhiyong Zong , Xiaohui Wang
{"title":"CDBN-YGXZ shows highly antibacterial activity against Clostridioides difficile as a potential candidate drug","authors":"Xiaoxia Zhang ,&nbsp;Min Quan ,&nbsp;Xin Lu ,&nbsp;Linwan Zhang ,&nbsp;Bing Guang ,&nbsp;Zhiyong Zong ,&nbsp;Xiaohui Wang","doi":"10.1016/j.anaerobe.2025.102964","DOIUrl":"10.1016/j.anaerobe.2025.102964","url":null,"abstract":"<div><div>CDBN-YGXZ shows a low minimal inhibitory concentration range from 0.015 to 0.125 mg/L against clinical <em>Clostridioides difficile</em> strains with diverse genotypes, hardly induces bacterial resistance, and intensively inhibits 86.2 % of <em>C. difficile</em> adhesion to intestinal epithelial cells Caco-2. CDBN-YGXZ shows highly antibacterial activity and is potentially a candidate as a therapeutic drug.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"93 ","pages":"Article 102964"},"PeriodicalIF":2.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An investigation into breast infections caused by Actinomyces species 放线菌引起乳腺感染的调查
IF 2.5 3区 生物学
Anaerobe Pub Date : 2025-04-24 DOI: 10.1016/j.anaerobe.2025.102966
Karla Berry , Aleksandra Marek , Mairi MacLeod , Abhijit M. Bal
{"title":"An investigation into breast infections caused by Actinomyces species","authors":"Karla Berry ,&nbsp;Aleksandra Marek ,&nbsp;Mairi MacLeod ,&nbsp;Abhijit M. Bal","doi":"10.1016/j.anaerobe.2025.102966","DOIUrl":"10.1016/j.anaerobe.2025.102966","url":null,"abstract":"<div><div>We investigated the management of <em>Actinomyces</em> breast infection. Eight different <em>Actinomyces</em> species were isolated from 26 patients during the study period (December 2018–November 2021). All tested isolates were susceptible (at standard or high dose) to penicillin and 75 % to clindamycin. Twenty-three patients had a history of smoking. Three had coexisting breast cancer. Prescribers need to be educated about the lack of activity of metronidazole on <em>Actinomyces</em>.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"93 ","pages":"Article 102966"},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteremia due to Hungatella effluvii in a patient with end-stage renal failure requiring hemodialysis: a case report and literature review of human infections caused by Hungatella spp. 需要血液透析的终末期肾衰竭患者因亨盖特菌流出引起菌血症:亨盖特菌引起的人类感染病例报告和文献综述
IF 2.5 3区 生物学
Anaerobe Pub Date : 2025-04-19 DOI: 10.1016/j.anaerobe.2025.102962
Yukitaka Ito , Yuri Tanaka , Naomi Kaneko , Mieko Yoshida , Nobuhiko Joki
{"title":"Bacteremia due to Hungatella effluvii in a patient with end-stage renal failure requiring hemodialysis: a case report and literature review of human infections caused by Hungatella spp.","authors":"Yukitaka Ito ,&nbsp;Yuri Tanaka ,&nbsp;Naomi Kaneko ,&nbsp;Mieko Yoshida ,&nbsp;Nobuhiko Joki","doi":"10.1016/j.anaerobe.2025.102962","DOIUrl":"10.1016/j.anaerobe.2025.102962","url":null,"abstract":"<div><div><em>Hungatella effluvii</em> infections in humans are rare. We report a case of <em>H. effluvii</em> bacteremia in a Japanese male with chronic kidney disease identified by 16S rRNA gene sequencing after initial misidentification as <em>Clostridium</em> species. Despite treatment, the patient died of sepsis related to a nephrostomy catheter infection. A literature review suggests that <em>Hungatella</em> spp. infections may be associated with severe diseases, such as sepsis and necrotizing fasciitis. This case highlights the difficulty in microbial identification, as biochemical methods were insufficient, requiring molecular biological methods. Antimicrobial susceptibility testing (AST) revealed resistance to benzylpenicillin and moxifloxacin, consistent with prior reports. This is the third documented case of <em>H. effluvii</em> infection, emphasizing the need for accurate pathogen identification and AST to guide optimal treatment in rare infections.</div></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"93 ","pages":"Article 102962"},"PeriodicalIF":2.5,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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