哥斯达黎加一家医院创伤后感染中分离的梭状芽孢杆菌的抗微生物药物耐药性谱

IF 2.5 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2025-03-24 DOI:10.1016/j.anaerobe.2025.102957

Mariela Alvarado-Rodríguez , Carlos Quesada-Gómez

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引用次数: 0

摘要

本研究分析了哥斯达黎加一家创伤医院（2018-2022）收集的119种梭菌的抗微生物药物耐药性。采用MALDI-TOF对分离菌株进行鉴定，并用E-test对其进行药敏试验。产气荚膜梭菌、特氏梭菌和索氏小梭菌是最常见的菌种。所有分离株均对阿莫西林-克拉维酸、利奈唑胺和甲硝唑敏感；万古霉素耐药率为20%，克林霉素耐药率为25%。最小抑菌浓度最高。基于这些发现，医院的经验治疗策略现在优先考虑阿莫西林-克拉维酸、利奈唑胺和甲硝唑，同时由于观察到耐药模式而减少对克林霉素的依赖。

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Antimicrobial resistance profiles of Clostridium species isolated from post-traumatic infections in a Costa Rican hospital

This study analyzed antimicrobial resistance in 119 Clostridium species isolates collected at a Costa Rican trauma hospital (2018–2022). Isolates were identified using MALDI-TOF, and antimicrobial susceptibility was assessed by E-test. C. perfringens, C. tertium, and Paeniclostridium sordellii were most prevalent species. All isolates were susceptible to amoxicillin-clavulanic acid, linezolid, and metronidazole; however, resistance rates of 20 % to vancomycin and 25 % to clindamycin were observed. C. sphenoides showed the highest minimum inhibitory concentration values. Based on these findings, empirical treatment strategies at the hospital now prioritize amoxicillin-clavulanic acid, linezolid, and metronidazole, while reducing reliance on clindamycin due to observed resistance patterns.

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.