CDBN-YGXZ对艰难梭菌具有较高的抑菌活性，是一种潜在的候选药物

IF 2.5 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2025-04-25 DOI:10.1016/j.anaerobe.2025.102964

Xiaoxia Zhang , Min Quan , Xin Lu , Linwan Zhang , Bing Guang , Zhiyong Zong , Xiaohui Wang

引用次数: 0

摘要

CDBN-YGXZ对临床不同基因型艰难梭菌的最低抑菌浓度范围为0.015 ~ 0.125 mg/L，几乎不诱导耐药，并能强烈抑制86.2%的艰难梭菌对肠上皮细胞cco -2的粘附。CDBN-YGXZ具有很强的抗菌活性，是一种潜在的治疗药物。

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CDBN-YGXZ shows highly antibacterial activity against Clostridioides difficile as a potential candidate drug

CDBN-YGXZ shows a low minimal inhibitory concentration range from 0.015 to 0.125 mg/L against clinical Clostridioides difficile strains with diverse genotypes, hardly induces bacterial resistance, and intensively inhibits 86.2 % of C. difficile adhesion to intestinal epithelial cells Caco-2. CDBN-YGXZ shows highly antibacterial activity and is potentially a candidate as a therapeutic drug.

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.