Annals of Medicine and Surgery最新文献

{"title":"Erratum: A \"Mismatched\" Connection: a Rare Case of Indirect or Dural Carotid-cavernous Fistula: a Case Based Review: Erratum.","authors":"","doi":"10.1097/MS9.0000000000002893","DOIUrl":"10.1097/MS9.0000000000002893","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/MS9.0000000000002669.].</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 2","pages":"1086"},"PeriodicalIF":1.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Spinal hydatid disease: a case report - an uncommon differential diagnosis in LMICs: Erratum.","authors":"","doi":"10.1097/MS9.0000000000002894","DOIUrl":"10.1097/MS9.0000000000002894","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/MS9.0000000000002691.].</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 2","pages":"1085"},"PeriodicalIF":1.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Social Determinants of Self-Medication Practice by Caregivers Among Pediatrics Population in Pakistan: A Logistic Regression Analysis of a Prospective Cross-Sectional Study: Retraction.","authors":"","doi":"10.1097/MS9.0000000000003086","DOIUrl":"10.1097/MS9.0000000000003086","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/MS9.0000000000002678.].</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 2","pages":"1087"},"PeriodicalIF":1.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital diaphragmatic hernia presenting as tension hydropneumothorax: surgical dilemma.","authors":"Jayalaxmi Shripati Aihole","doi":"10.1097/MS9.0000000000002779","DOIUrl":"10.1097/MS9.0000000000002779","url":null,"abstract":"<p><strong>Introduction: </strong>Congenital diaphragmatic hernia (CDH) most commonly seen on the left side, presenting usually in neonates and infants with respiratory distress.</p><p><strong>Importance: </strong>CDH presenting as tension hydropneumothorax requiring urgent intercostal chest tube drainage (ICD) and subsequently inducing the injury to the herniated bowel and lung, is not an uncommon event, rarely reported in toddlers as well as its management.</p><p><strong>Case presentation: </strong>Two such rare cases of CDH presenting with tension hydropneumothorax requiring ICD insertion and their consequences have been discussed here.</p><p><strong>Clinical discussion: </strong>CDH can present later in life due to consequent recurrent bronchopneumonia and failure to thrive.</p><p><strong>Conclusion: </strong>Clinical history and clinical judgement can only aid the surgeon in avoiding such confusing clinical scenarios.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 2","pages":"991-993"},"PeriodicalIF":1.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing hypertension management: the role of zilebesiran as an siRNA therapeutic agent.","authors":"Erum Siddiqui, Abdul Hannan Siddiqui, Abdul Moeed, Fatima Laique, Hala Najeeb, Md Al Hasibuzzaman","doi":"10.1097/MS9.0000000000002696","DOIUrl":"10.1097/MS9.0000000000002696","url":null,"abstract":"<p><p>Elevated blood pressure poses a significant global health challenge, affecting over 1.28 billion adults worldwide, with a staggering 46% unaware of their condition. Despite its pervasive impact and association with cardiovascular disease, hypertension remains inadequately controlled, highlighting the urgent need for innovative treatment approaches. This review explores the potential of small interfering RNA (siRNA) therapeutics, focusing on zilebesiran, as a promising strategy for hypertension management. SiRNA therapy represents a groundbreaking approach to selectively modulate protein production, offering targeted intervention in the pathophysiological mechanisms underlying hypertension. Zilebesiran, a siRNA, targets hepatic angiotensinogen (AGT) synthesis through interaction with the asialoglycoprotein receptor, ultimately reducing angiotensin II levels and reducing blood pressure. Zilebesiran demonstrates remarkable pharmacokinetic properties, with sustained efficacy observed after single-dose administration. Clinical trials evaluating zilebesiran have shown significant reductions in blood pressure, with effects lasting up to 24 weeks post-administration. Moreover, combination therapy with angiotensin receptor blockers has demonstrated enhanced efficacy, highlighting the potential for synergistic effects in hypertension management. Importantly, zilebesiran exhibits a favorable safety profile, with manageable adverse events, primarily injection site reactions. Zilebesiran represents a transformative therapy in hypertension management, offering targeted and potent blood pressure reduction with favorable safety and dosing characteristics. Its emergence highlights the ongoing evolution of cardiovascular pharmacology and underscores the importance of innovative approaches to address the global burden of hypertension. Moving forward, concerted efforts in research and clinical practice are necessary to realize the benefits of zilebesiran into hypertension management protocols, ultimately advancing cardiovascular health worldwide.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 2","pages":"577-582"},"PeriodicalIF":1.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting ectopic thymus in thymoma-associated myasthenia gravis through flow cytometry analysis of CD3^mediumTCRvβ^mediumCD4⁺CD8⁺ T cells and its clinical significance.","authors":"Yongqiang Ao, Jie Deng, Jiahao Jiang, Min Yao, Jian Gao, Shuai Wang, Chun Jin, Qiuyue Liu, Yunze Zhai, Fengxue Du, Yu Zhang, Juan Zhang, Yuejuan Zheng, Jiazi Ren, Zuoren Yu, Yunli Shen, Aiwu Ke, Yongbing Cao, Haikun Wang, Jianyong Ding","doi":"10.1097/MS9.0000000000002921","DOIUrl":"10.1097/MS9.0000000000002921","url":null,"abstract":"<p><strong>Background: </strong>Traditional histological methods for identifying ectopic thymus (ET) have significant limitations including high risk of false negatives. This study aims to evaluate the effectiveness of flow cytometry in detecting ETs in patients undergoing total thymectomy.</p><p><strong>Methods: </strong>We analyzed 864 samples from 103 patients using flow cytometry and hematoxylin and eosin (H&E) staining. ETs were identified by the presence of CD3^mediumTCRvβ^mediumCD4⁺CD8⁺ T cells in flow cytometry or Hassall's corpuscles in H&E staining.</p><p><strong>Results: </strong>In the discovery set, flow cytometry detected ETs in 69.2% of samples, compared to 23.6% by histological methods. The validation set showed a higher incidence of ETs in myasthenia gravis (MG) patients than in non-MG patients (73.5% vs. 58.0%, <i>P</i> < 0.0001) and in those with thymic epithelial tumors versus normal thymus (68.1% vs. 58.1%, <i>P</i> = 0.0088). MG patients exhibited a higher prevalence of active ETs, characterized by a high proportion of CD4⁺CD8⁺ T cells, indicating robust thymopoiesis, compared to those without MG (<i>P</i> = 0.0001). Specific regions, such as the left cervical root, areas along the right and left phrenic nerves, and the left innominate vein, showed significantly higher activity (<i>P</i> < 0.05). Additionally, ETs were more frequently found in the cervical region than in the mediastinum (75.0% vs. 60.8%, <i>P</i> = 0.0012), and in patients aged 40 years or younger compared to those older than 40 years (73.0% vs. 60.6%, <i>P</i> = 0.0027).</p><p><strong>Conclusions: </strong>Flow cytometry is a viable alternative for ET detection, providing a novel distribution map that enhances surgical decision-making in MG treatment.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 2","pages":"515-526"},"PeriodicalIF":1.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete mesocolic excision versus D2 lymphadenectomy in right hemicolectomy: a meta-analysis of propensity score matched studies and randomized controlled trials.","authors":"Bernardo Fontel Pompeu, Eric Pasqualotto, Patrícia Marcolin, Lucas Monteiro Delgado, Beatriz D'Andrea Pigossi, Sergio Mazzola Poli de Figueiredo, Fernanda Bellotti Formiga","doi":"10.1097/MS9.0000000000002829","DOIUrl":"10.1097/MS9.0000000000002829","url":null,"abstract":"<p><strong>Introduction: </strong>The complete mesocolic excision (CME) in right-sided hemicolectomy could result in higher lymph node yield and decreased local recurrence. However, this approach could increase intraoperative and postoperative complications. Therefore, our meta-analysis aims to demonstrate the outcomes of CME versus D2 conventional lymphadenectomy in right-side colon cancer.</p><p><strong>Methods: </strong>We searched MEDLINE, Cochrane Central Register of Clinical Trials, and Scopus for studies published until April 2024. Odds ratios (OR) with 95% confidence intervals (CIs) were pooled using a random-effects model. Heterogeneity was assessed using the Cochran Q test and <i>I</i> ² statistics, with <i>P</i> values <0.10 and <i>I</i> ² >25% considered significant. Statistical analysis was performed using R Software, version 4.1.2.</p><p><strong>Results: </strong>Three randomized controlled trials and four observational studies comprising 2296 patients were included, of whom 1138 (49.6%) were submitted to the CME and 1158 (50.4%) to the conventional D2 lymphadenectomy. CME was associated with decreased local recurrence rates (OR 0.07; 95% CI 0.001 to 0.36; <i>P</i> = 0.002). There were no significant differences between groups in overall complications, severe complications, intraoperative complications, blood loss, and 30-day mortality. No difference between groups was observed in distance metastasis and 3-year disease-free survival.</p><p><strong>Conclusion: </strong>In this meta-analysis, CME significantly decreases local recurrence rates compared with D2 conventional lymphadenectomy in patients with right-side colon cancer. No significant difference was observed between groups in rates of overall complications, severe complications, intraoperative complications, blood loss, and 30-day mortality.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 2","pages":"855-866"},"PeriodicalIF":1.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkey pox resurgence in South Asia: Pakistan's 2024 case highlights global health challenges.","authors":"Ahmed Sanan, Sarshaar Qadir, Hamza Irfan, Maher Ali Rusho, Aymar Akilimali","doi":"10.1097/MS9.0000000000002950","DOIUrl":"10.1097/MS9.0000000000002950","url":null,"abstract":"<p><p>The World Health Organization (WHO) has issued a serious worldwide notice regarding Monkey pox (Mpox), designating it as a public health emergency. Mpox, which began from West and Central Africa, has since migrated to non-endemic areas, such as South Asia. In 2024, Pakistan reported the first incidence of the disease, which was connected to a visitor from Saudi Arabia. The virus, which was previously primarily harming youth in Africa, is increasingly impacting a wider demographic, especially adults and men who have sex with other men (MSM) which usually are occurring in sexual health clinics. Engaging in sexual intercourse, inhaling droplets, and coming into contact are the three ways that the disease escalates. The risk is highest in underprivileged communities that are often stigmatized and have little access to primary healthcare. Antivirals such as brincidofovir, cidofovir, and tecovirimat are now used in treatment; in an emergency, vaccinations like JYNNEOS and Vaccinia Immune Globulin Intravenous (VIGIV) are also available. In regions where vaccine supplies are scarce, targeted and ring vaccination programs are essential. To cease the transmission of Mpox and lessen its effects on public health, increased surveillance, travel restrictions, and focused preventative efforts are crucial to aid non endemic countries from these catastrophes.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 2","pages":"1082-1084"},"PeriodicalIF":1.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-assisted anterior resection of rectal cancer in a patient with abdominal aortic aneurysm using a monitoring laparoscope: a case report.","authors":"Junpei Takashima, Hirotoshi Kobayashi, Ayaka Koizumi, Fumi Shigehara, Kenji Yamazaki, Daisuke Fujimoto, Fumihiko Miura, Keizo Taniguchi","doi":"10.1097/MS9.0000000000002936","DOIUrl":"10.1097/MS9.0000000000002936","url":null,"abstract":"<p><strong>Introduction and importance: </strong>We present the first case of robot-assisted anterior resection for rectal cancer in a patient with abdominal aortic and common iliac aneurysms using a monitoring laparoscope for enhanced safety.</p><p><strong>Case presentation: </strong>An 86-year-old man presented with bloody stool and was diagnosed with Stage IIIB rectal cancer (T3N1aM0). Preoperative computed tomography revealed a 39-mm abdominal aortic aneurysm and 25-mm left common iliac aneurysm. Robot-assisted anterior resection with D2 lymph node dissection was performed using a 5-mm laparoscope to avoid contact between robotic forceps and aneurysm. The procedure was successful, and he was discharged from the hospital on the ninth postoperative day.</p><p><strong>Clinical discussion: </strong>Robotic surgery, owing to the lack of tactile sensation, is generally contraindicated in cases of abdominal aortic aneurysms because of the risk of vascular injury. However, this case demonstrates that real-time monitoring with a 5-mm laparoscope can effectively prevent accidental vascular injury during robotic surgery for rectal cancer.</p><p><strong>Conclusion: </strong>This case illustrates the appropriate modifications by which robotic surgery for rectal cancer can be safely performed in patients with abdominal aortic or common iliac artery aneurysms.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 2","pages":"944-948"},"PeriodicalIF":1.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hidden pharmacokinetic challenge: diarrhea's influence on cyclosporine therapy: a case series.","authors":"Riya Mary Richard, Jefry Winner G, Ann Mary Shaibu, Bimal Raj Pandey, Praveen Thapa","doi":"10.1097/MS9.0000000000002930","DOIUrl":"10.1097/MS9.0000000000002930","url":null,"abstract":"<p><strong>Background: </strong>Cyclosporine is used as an immunosuppressive drug to improve graft survival rates in the field of organ transplantation. Therapeutic drug monitoring [TDM] of cyclosporine in transplant patients is crucial for optimizing drug dosage and minimizing the risks. Diarrhea is a common gastrointestinal condition, resulting in pharmacokinetic, malabsorption, and clinical consequences for people who rely on cyclosporine medication.</p><p><strong>Case presentations: </strong>The case series discusses three pediatric patients who underwent therapeutic drug monitoring of cyclosporine to guide their treatment. The first two cases involved post-renal transplant patients with glomerulonephritis, while the third case involved a patient with tubulointerstitial kidney disease. TDM was employed to guide dose adjustments. The first patient initially received 15 mg/kg but showed high trough concentration. The dosage was gradually reduced, while diarrhea was managed. The second and third patients exhibited a similar trend which also necessitated dose adjustments.</p><p><strong>Clinical discussion: </strong>Diarrhea was identified as a factor impacting cyclosporine levels. This case series evaluated the impact of diarrhea on cyclosporine therapeutic levels in three pediatric renal transplant patients. TDM in cyclosporine therapy is significant due to its narrow therapeutic index and variable pharmacokinetics. Elevated trough concentrations led to a gradual dose reduction to achieve the target levels.</p><p><strong>Conclusion: </strong>This case series highlights the importance of TDM-guided dosing of cyclosporine, particularly in patients with diarrhea, to maintain target trough concentrations.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 2","pages":"466-470"},"PeriodicalIF":1.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}