Annals of Medicine and Surgery最新文献

{"title":"Determinants of hypertensive retinopathy among non-diabetic adults in comprehensive specialized hospitals of the Amhara region, northwest Ethiopia: a case-control study.","authors":"Sewunet Ademe, Tigist Feleke, Zewdu Bishaw Aynalem, Alamrew Enyew, Aynetaw Abawa, Kelemework G Ferede","doi":"10.1097/MS9.0000000000005696","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005696","url":null,"abstract":"<p><strong>Background: </strong>Hypertensive retinopathy is a common microvascular complication of hypertension associated with visual impairment and increased cardiovascular risk, but evidence regarding its associated factors in Ethiopia is limited. This study aimed to identify factors associated with hypertensive retinopathy among adult hypertensive patients in northwest Ethiopia.</p><p><strong>Methods: </strong>An institution-based unmatched case-control study was conducted from 4 June to 30 June 2024, among 309 participants (76 cases and 233 controls). Cases were hypertensive patients with retinopathy diagnosed by ophthalmologists, while controls were hypertensive patients without retinopathy. Systematic random sampling was used to select study participants. The primary outcome measure was the presence of hypertensive retinopathy (yes/no), as diagnosed and documented in medical records. Data were collected through interviewer-administered questionnaires, medical record reviews, and physical measurements (blood pressure, weight, and height). Self-care and social support were assessed using validated scales. Multivariable logistic regression identified factors associated with retinopathy, and model fit was assessed by the Hosmer-Lemeshow test (<i>P</i> > 0.05). Significance was set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>The mean age of study participants was 51.75 ± 8.84 years. Factors associated with hypertensive retinopathy included: urban residence (AOR = 10.6; 95% CI: 2.9-37.9), BMI ≥25 kg/m² (AOR = 7.9; 95% CI: 2.6-24.2), diastolic BP > 90 mmHg (AOR = 25.3; 95% CI: 3.1-212.1), poor self-care (AOR = 5.6; 95% CI: 2.1-15.9), and lack of social support (AOR = 5.1; 95% CI: 2.1-12.4).</p><p><strong>Conclusion: </strong>Urban residence, elevated BMI, uncontrolled diastolic blood pressure, poor self-care, and lack of social support independently increase the odds of hypertensive retinopathy. Comprehensive management that integrates retinal screening, self-care education, and social support is needed, especially in urban areas.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6467-6476"},"PeriodicalIF":1.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irritable bowel syndrome and restless legs syndrome: a narrative review of epidemiological and pathophysiological overlap.","authors":"Jawaria Firdous, Rai Muhammad Umar Khan, Farha Jabeen, Amna Inayat, Hamza Ashraf, Tayyaba Malik, Mushaim Gillani, Fatima Fazal, Aalaa Saleh","doi":"10.1097/MS9.0000000000005523","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005523","url":null,"abstract":"<p><strong>Background: </strong>Irritable bowel syndrome (IBS) and restless legs syndrome (RLS) are chronic, multifactorial disorders that have considerable impact on quality of life and common comorbidity with mood and sleep disorders.</p><p><strong>Objectives: </strong>The present narrative review consolidates existing literature to examine the epidemiological connection, shared pathophysiological mechanisms, and clinical implications of IBS-RLS comorbidity.</p><p><strong>Methods: </strong>A literature search was conducted using PubMed and Google Scholar (2015-2025). The inclusion criteria were adult population and peer-reviewed, full-text studies on co-occurrence or mechanism between RLS and IBS. There were 48 included articles after independent screening.</p><p><strong>Results: </strong>Observational studies report RLS prevalence in IBS patients of about 10-46%, compared with 3-14% in controls, indicating a likely bidirectional association. Both conditions share risk factors like female sex, psychiatric comorbidity, and autonomic dysfunction, and overlap in mechanisms including iron deficiency, neuroinflammation, neurotransmitter imbalance, gut-brain axis disruption, and microbial dysbiosis. This supports a neurogastroenterological link and suggests shared etiologic pathways, highlighting the value of routine reciprocal screening to improve diagnosis and quality of life.</p><p><strong>Conclusion: </strong>The co-occurrence of IBS and RLS underscores the necessity of increased clinical vigilance and combined care. Shared mechanisms increase the potential for specific therapy approaches, including dopaminergic drugs, iron supplementation, microbiota modifications, and mast cell stabilizers. Further longitudinal and mechanistic studies are needed to clarify causality and evaluate potential dual-purpose interventions, as current evidence is largely observational and limits causal inference.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6606-6617"},"PeriodicalIF":1.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extravasation of TPN into the pleural space, a rare complication of central venous catheter placement: a case report.","authors":"Gabriel A Molina, Rommel Ojeda, Galo E Jimenez, Andres V Ayala, Karina Naranjo, Anita G Finke","doi":"10.1097/MS9.0000000000005526","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005526","url":null,"abstract":"<p><strong>Background: </strong>Complications associated with central venous catheters are well documented in the literature, most of which relate to catheter placement or infections. Nonetheless, on rare occasions, the catheter can erode the arterial wall, allowing medication, fluids, or even total parenteral nutrition to pass into the pleural space.</p><p><strong>Case presentation: </strong>We present the case of a 68-year-old male who was critically ill in the intensive care unit and required total parenteral nutrition. A central venous catheter was placed, and the patient's condition improved. While in the intensive care unit, it became necessary to change the central line, and a new catheter was placed. Subsequently, he experienced respiratory distress and impaired oxygenation, with a significant pleural effusion. When the chest tube was placed, a milky-white fluid was detected, and subsequent tests revealed it to be an effusion of total parenteral nutrition. Following this event, the catheter was immediately changed, and with subsequent treatment, the patient recovered completely.</p><p><strong>Conclusion: </strong>Identification and management of central line complications are essential in patients with vascular access. These rare complications must always be considered in the differential diagnosis and recognized early to avoid potentially dangerous outcomes.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6753-6756"},"PeriodicalIF":1.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of I-PASS handover training on compliance and communication quality: a clinical audit at a teaching hospital.","authors":"Malaz Kamaleldin Omer, Yousuf Alnoor Younis Mohammed, Hibatalla Elamin Hussein Adam, Mazin Abdalaal Hussien Helali, Mohamed Elsheikh Farah Mohamed Elhassan, Mahmoud Osman Mohammed Suleiman, Sirageldeen Abdallah Hamza Khidir, Morouj Hussien Mohammed, Ibtehal Abdalwahid Abdalmjeed Omer, Husam Aldeen Atif Abdolraheem Mohammed, Osman Mohammed Osman Abdallah, Eilaf Fadel Elmawla, Mohammed Osman Ahmed Osman, Gasm Alseed Abdelmonim Gasm Alseed Fadlalmoula","doi":"10.1097/MS9.0000000000005694","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005694","url":null,"abstract":"<p><strong>Background: </strong>Clinical handover between the emergency department (ED) and inpatient units is a high-risk process prone to communication errors and patient harm. This audit evaluated ED-to-internal medicine handover practices and assessed the impact of implementing an I-PASS-based standardized framework.</p><p><strong>Methods: </strong>A prospective closed-loop clinical audit was conducted at a public teaching hospital in Sudan in April 2024. Baseline data were collected via a structured questionnaire assessing compliance with I-PASS criteria, with a target standard of 100%. Thirteen questionnaire responses were analyzed in the first cycle. Following gap identification, a structured bedside I-PASS handover was implemented and reassessed in a second cycle.</p><p><strong>Results: </strong>Baseline handovers were informal and unstructured, with no standardized tool in use. All handovers were verbal; 30.8% occurred via telephone. Critical safety elements were inconsistently communicated: pending investigations were mentioned in 15.4% of cases, isolation precautions in 7.7%, risk identification in 46.2%, and next-step review in 38.5%. Patient or family involvement occurred in only 7.7% of cases. Following I-PASS implementation, structured bedside handovers were universally adopted. Core clinical elements achieved complete or near-complete compliance. Patient or family involvement increased from 7.7 to 92.3%.</p><p><strong>Conclusion: </strong>Baseline handover practices were variable and nonstandardized. I-PASS implementation was associated with improved handover compliance and perceived communication quality across all measured domains. Standardized handover is feasible in resource-limited settings, although further studies incorporating clinical outcome measures are needed.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6477-6484"},"PeriodicalIF":1.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic potential of microRNA signatures in differentiating GLP-1-associated accelerated skin senescence from intrinsic aging in facelift candidates.","authors":"Fnu Uzma, Fnu Zeeshan, Ali Saqlain","doi":"10.1097/MS9.0000000000005380","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005380","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6912-6913"},"PeriodicalIF":1.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current applications of transauricular vagus nerve stimulation in orthopedics: a narrative review of the literature.","authors":"Petros Kitsis, Thea Zisimou, Egor Kostin, Paraskevas Miltiadou, Charalampos Charalampidis, Ioannis Orfanos","doi":"10.1097/MS9.0000000000005582","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005582","url":null,"abstract":"<p><strong>Objectives: </strong>Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neuromodulation technique with emerging applications in various medical fields. While its role has been explored in neurological, psychiatric, and inflammatory conditions, its potential in orthopedics has not been reviewed in depth. Our objective was to synthesize current evidence on the use of taVNS in orthopedic conditions.</p><p><strong>Methods: </strong>A PubMed search was conducted for articles published between January 2010 and July 2025 using the terms \"transcutaneous\" AND \"vagus nerve\" AND \"stimulation.\" Seventeen eligible studies were identified after applying predefined inclusion and exclusion criteria. Randomized controlled trials were assessed for methodological quality using the Risk of Bias 2 tool.</p><p><strong>Results: </strong>Seventeen studies addressed the orthopedic applications of taVNS for chronic low back pain, neck pain, knee osteoarthritis, and in perioperative settings. Across the included studies, taVNS was associated with reductions in pain intensity, although superiority over control interventions was not consistent across trials; additional potential benefits were reported for sleep quality, disability indices, and psychological measures. In perioperative contexts, high-quality randomized trials demonstrated reductions in postoperative pain and analgesic requirements. However, methodological heterogeneity, small sample sizes, and inconsistent stimulation protocols limit the strength of the conclusions.</p><p><strong>Discussion: </strong>taVNS is a safe, accessible, and promising adjunctive therapy for pain management in orthopedics, with potential applications in both chronic and perioperative settings. Larger, high-quality trials are required to establish standardized protocols and clarify clinical efficacy.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6670-6678"},"PeriodicalIF":1.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When weight-loss drugs reduce drinking: glucagon-like peptide-1 receptor agonists as phenotype-enriched harm-reduction therapy for alcohol use disorder.","authors":"Sarah Singh, Mehta Das","doi":"10.1097/MS9.0000000000005709","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005709","url":null,"abstract":"<p><p>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have attracted interest as potential treatments for alcohol use disorder (AUD) after patients receiving these agents for obesity or type 2 diabetes reported a reduced desire to drink. This editorial examines whether current evidence supports their classification as broadly applicable addiction treatments or as phenotype-enriched therapies. Randomized trials evaluating exenatide and semaglutide suggest a clinically relevant but endpoint-selective signal. Reductions have been most consistent in heavy-drinking days, drinks per drinking day, naturalistic craving, alcohol-related consequences, and the World Health Organization (WHO) risk drinking level, whereas effects on total alcohol consumption, drinking frequency, and laboratory cue-elicited craving have been less consistent. Durable abstinence, sustained benefit after treatment discontinuation, prevention of alcohol-related hospitalization in randomized trials, and mortality benefit remain unestablished. Obesity may enrich treatment response and provide an independent metabolic indication, but current evidence neither identifies it as a necessary response biomarker nor establishes that alcohol reduction is mediated by weight loss. We therefore propose a three-axis clinical selection framework based on alcohol phenotype, metabolic phenotype, and treatment safety and feasibility. The strongest current rationale may be for patients with heavy episodic or loss-of-control drinking who also have obesity, type 2 diabetes, or substantial cardiometabolic risk. GLP-1 RAs should presently be regarded as candidate harm-reduction therapies that complement established AUD care, not as treatments for acute alcohol withdrawal or universal substitutes for approved pharmacotherapy. Larger comparative trials incorporating mechanistic outcomes and post-discontinuation follow-up are needed.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6240-6243"},"PeriodicalIF":1.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary team management and the survival of head and neck cancer patients: a systematic review and meta-analysis.","authors":"Hanan M Qasem, Ali O Aldamen, Muhammad Idrees, Ragad Ala'a Tawalbeh, Mohammed Fawaz Alqudah, Ja'Far Mohamad Matalgah, Sakhr Alshwayyat, Ayham Mohammad Hussein, Haya B Abukharmh, Mohammed Al-Mahdi Al-Kurdi","doi":"10.1097/MS9.0000000000005479","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005479","url":null,"abstract":"<p><strong>Introduction: </strong>Multidisciplinary teams (MDTs) in cancer care aim to improve patient outcomes by bringing together healthcare professionals from various specialties. This collaborative approach has been associated with improved decision-making and survival rates, particularly in the management of complex cases, such as head and neck cancer (HNC). Our study aimed to assess the impact of MDTs on overall survival (OS) in patients at different stages of HNC compared with those who received non-MDT care.</p><p><strong>Methods: </strong>A systematic search was performed following PRISMA guidelines in PubMed, Scopus, Embase, and Web of Science databases from inception to June 2024 for studies comparing MDT management of patients with HNC with conventional treatment. The review was registered in PROSPERO under the number CRD420251165637. Data analysis was conducted using Review Manager version 5.4.</p><p><strong>Results: </strong>A systematic review and meta-analysis were conducted, including nine studies with a total of 42 937 patients. The pooled analysis showed that MDT management was associated with a significant 13% improvement in survival rates for HNC patients (HR: 0.87, 95% CI: 0.78-0.97, <i>P</i> = 0.02). For patients with stage IV HNC, MDT care was not associated with a statistically significant survival improvement; however, this subgroup analysis included only three studies and should be interpreted cautiously (HR: 0.80, 95% CI: 0.62-1.03, <i>P</i> = 0.09). Quality assessment of the included studies indicated that most were of good quality, though one study was rated as fair due to methodological limitations.</p><p><strong>Conclusion: </strong>MDTs can improve survival rates among patients with HNC. Their effect in stage IV disease remains inconclusive. Further research is needed to explore the economic impact of MDTs and their effectiveness in broader populations and advanced stages.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6585-6594"},"PeriodicalIF":1.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In situ</i> shaped skin grafting following marsupialization for sacrococcygeal pilonidal disease: a retrospective case series.","authors":"Yongchang Zhao, Yuan Tian, Xin Jin, Xiaoshuo Wu, Xun Shen, Feng Sun, Yuying Li","doi":"10.1097/MS9.0000000000005704","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005704","url":null,"abstract":"<p><strong>Background: </strong>Optimal surgical management of pilonidal disease remains controversial, with existing techniques requiring trade-offs between recurrence risk and recovery time. We report our experience with unroofing and marsupialization combined with <i>in situ</i>-shaped skin grafting (SSG), focusing on perioperative outcomes, recovery, and recurrence.</p><p><strong>Methods: </strong>This case series included 53 consecutive patients who underwent SSG. Outcomes analyzed included operative parameters, recovery, recurrence, complications, and patient satisfaction.</p><p><strong>Results: </strong>The median operative time was 61 minutes (IQR, 45-70). The median hospital stay was 4 days (IQR, 3-6), with a median cost of 11 037.9 CNY (IQR, 10 519.0-11 944.0). Patients resumed pain-free activities after a median of 2 days (IQR, 2-4) and returned to work or school after 14 days (IQR, 10-15). Wound healing time was 22 days (IQR, 20-25). At the final follow-up, recurrence occurred in two patients (3.8%). No postoperative complications were observed. Sensory disturbance was reported in four patients (7.5%), none of whom reported interference with daily activities. Overall patient satisfaction was high, with a median score of 5 (IQR, 4-5).</p><p><strong>Conclusions: </strong>This single-center series demonstrates that unroofing and marsupialization, combined with <i>in situ</i> SSG, is a feasible surgical approach, offering rapid functional recovery and low recurrence rates without major complications. SSG may represent an intermediate option between prolonged healing by secondary intention and extensive flap reconstruction. Prospective multicenter comparative studies are warranted to establish optimal patient selection criteria and define the long-term role of this technique.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6485-6491"},"PeriodicalIF":1.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of renal transplantation in Africa: a systematic review and meta-analysis.","authors":"Bekalu Mekonen Belay, Yeshiambaw Eshetie, Mengistu Ewunetu, Abraham Tsedalu Amare, Gebrie Kassaw, Tigabu Munye Aytenew, Birara Ayichew Tilaye, Gebrehiwot Berie Mekonnen, Kumlachew Geta Belete, Yirgalem Abere","doi":"10.1097/MS9.0000000000005714","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005714","url":null,"abstract":"<p><strong>Background: </strong>Although transplantation is considered a treatment for end-stage renal disease, data on post-transplant outcomes remain fragmented.</p><p><strong>Objective: </strong>This study aims to assess the outcomes of renal transplantation in Africa.</p><p><strong>Design: </strong>Studies were searched in MEDLINE, EMBASE, CINAHL, Scopus, Google Scholar, the Transplantation Library, and African Journals Online. A random-effects model was employed to calculate the pooled effect size of each outcome. Heterogeneity was assessed with the <i>I</i> ² test, and publication bias was evaluated using Egger's regression test. Trim-and-fill analysis was employed to manage publication bias. The protocol was registered in the International Prospective Register of Systematic Reviews.</p><p><strong>Studies: </strong>Studies conducted in Africa.</p><p><strong>Participants: </strong>In this study, 16 articles were included, with a total of 3617 participants.</p><p><strong>Result: </strong>Pooled mortality among renal transplant recipients was 14.3% (95% CI: 8.77%-19.84%). Graft survival rates at 1 and 5 years were 91.74% (95% CI: 88.56%-94.93%) and 69.15% (95% CI: 57.39%-80.91%), respectively. Patient survival at 1 and 5 years was 94.72% (95% CI: 92.17%-97.26%) and 81.26% (95% CI: 72.11%-90.4%), respectively. Diabetes mellitus, delayed graft function, acute rejection, and infection were observed as post-transplantation complications.</p><p><strong>Conclusion: </strong>With a few important exceptions, both graft and patient survival were comparable to reports from other nations. Thus, we recommend that clinical practitioners prioritize infection prevention and early screening for complications. Furthermore, policymakers should develop and implement strategies to prevent and screen for post-transplant complications, and improve the accessibility of the service.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6543-6550"},"PeriodicalIF":1.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}