Annals of Medicine and Surgery最新文献

{"title":"Combined open and minimally invasive strategy for thoracic ossification of posterior longitudinal ligament: a case report and technical notes.","authors":"Shenghui Tang, Junhua Zuo, Hui Ren, Binwei Chen, Xiaobin Jiang","doi":"10.1097/MS9.0000000000004943","DOIUrl":"https://doi.org/10.1097/MS9.0000000000004943","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Thoracic ossification of the posterior longitudinal ligament (T-OPLL) causes severe neurological deficits. Surgical management is challenging due to the thoracic spine's anatomical complexity. This case report aims to describe a novel hybrid open-endoscopic technique for the treatment of severe thoracic OPLL, with the objective of demonstrating its feasibility and safety in a high-risk obese patient.</p><p><strong>Presentation of case: </strong>A 29-year-old male with class III obesity was hospitalized for progressive bilateral lower extremity weakness over 2 months, recently worsening with new-onset numbness. Examination revealed hypoesthesia below the costal margin, decreased lower extremity motor strength, and reduced anal tone. Imaging showed T-OPLL at T5/6 with significant spinal cord compression and stenosis. Complete 360° decompression was achieved via posterior open laminectomy using an ultrasonic bone scalpel, combined with ventral decompression via minimally invasive endoscopy. The patient had satisfactory outcomes without complications.</p><p><strong>Clinical discussion: </strong>The full endoscopic transforaminal approach has been successfully used in ventral thoracic spinal cord compression. However, due to the narrow spinal canal and small intervertebral foramina in the thoracic region, the limited operational space during cannula placement and removal of ventral ossified lesions still leads to complications. To address this, we first performed a total laminectomy in this case to achieve indirect dorsal decompression, followed by foraminotomy under direct visualization. This preparatory step created sufficient working space for subsequent cannula insertion and ventral decompression, minimizing spinal cord manipulation and effectively reducing iatrogenic spinal cord injury.</p><p><strong>Conclusion: </strong>This study introduces a combined surgical approach. Integrating open and minimally invasive endoscopic techniques achieves comprehensive 360° decompression while minimizing trauma and complications. This hybrid technique is an alternative for severe thoracic spinal stenosis primarily from ventral compression.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 5","pages":"2954-2959"},"PeriodicalIF":1.6,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using human placenta as a simulation model for neurosurgical training: enhancing micro-vascular dissection skills.","authors":"Reem Yousef AlMarshad, Ahmed Hafez Mousa, Zahraa AlSadah, Faisal AlMatrafi, May Adel AlHamid, Hosam Al-Jehani","doi":"10.1097/MS9.0000000000004817","DOIUrl":"https://doi.org/10.1097/MS9.0000000000004817","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluates the use of human placenta as a simulation model for improving micro-vascular dissection skills among neurosurgical trainees.</p><p><strong>Methods: </strong>Thirteen neurosurgical residents (PGY1-PGY6) participated in this study. They completed a 15-question qualitative survey adapted from the Objective Structured Assessment of Technical Skills (OSATS) following two simulation sessions.</p><p><strong>Results: </strong>Ten residents reported improvements in key areas such as tissue handling, hand-eye coordination, and instrument control. All participants appreciated the feedback received and expressed interest in attending future sessions. Additionally, ten residents were willing to mentor junior colleagues.</p><p><strong>Conclusion: </strong>The human placenta offers a highly beneficial simulation model for neurosurgical training, particularly in micro-vascular dissection. It provides a low-stress, educational environment that promotes skill development, making it an ideal tool for surgical trainees.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 5","pages":"2751-2755"},"PeriodicalIF":1.6,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DCBLD1 as a novel prognostic biomarker and therapeutic target in breast cancer: clinical validation and mechanistic insights.","authors":"Zhi-Yong Liu, Hong Hu","doi":"10.1097/MS9.0000000000004870","DOIUrl":"https://doi.org/10.1097/MS9.0000000000004870","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the expression of DCBLD1 (discoidin, CUB, and LCCL domain-containing protein 1) in breast cancer tissues and its correlation with patient prognosis, and evaluate its potential as a novel prognostic marker and therapeutic target.</p><p><strong>Methods: </strong>Differential expression of DCBLD1 between breast cancer and normal tissues was analyzed using GEO and METABRIC databases, combined with survival analysis and Cox multivariate regression analysis to evaluate its prognostic value. Effective interference sequences were screened using quantitative polymerase chain reaction, and knockdown efficiency was validated by quantitative reverse transcription polymerase chain reaction and Western blot. The effects of DCBLD1 on breast cancer cell proliferation, apoptosis, migration, and invasion were investigated using CCK-8, flow cytometry, Transwell migration and invasion assays, and wound healing assays.</p><p><strong>Results: </strong>DCBLD1 was significantly overexpressed in breast cancer tissues (<i>P</i> = 0.0113), and patients with high expression exhibited shorter overall survival [<i>P</i> = 1.93e-6, hazards ratio (HR) = 1.33]. Cox multivariate analysis confirmed DCBLD1 as an independent prognostic factor (HR = 1.14, <i>P</i> = 0.0302), and it was positively correlated with tumor grade (<i>P</i> < 0.001), stage (<i>P</i> = 0.003), and metastasis (<i>P</i> = 0.009). Knockdown of DCBLD1 significantly inhibited breast cancer cell proliferation, colony formation, migration, and invasion capacities while promoting apoptosis.</p><p><strong>Conclusion: </strong>DCBLD1 exhibits oncogene functions in breast cancer and can serve as an independent prognostic marker and potential therapeutic target, with its expression level closely correlated to tumor malignancy and metastasis risk.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 5","pages":"2791-2806"},"PeriodicalIF":1.6,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late antenatal care and preeclampsia prevention in hargeisa, somaliland.","authors":"Nasiim Abdirahman Omar","doi":"10.1097/MS9.0000000000004886","DOIUrl":"https://doi.org/10.1097/MS9.0000000000004886","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 5","pages":"2992-2993"},"PeriodicalIF":1.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Think before prescribing oral contraceptive pills - pulmonary embolism in an obese hypertensive woman: a case report.","authors":"Syeda Rafiza Sultana, Muhammad Shoaib Momen Majumder, Tarikul Hamid, Mohammad Ali, Anindita Das Barshan, Mohammad Jahid Hasan","doi":"10.1097/MS9.0000000000004878","DOIUrl":"https://doi.org/10.1097/MS9.0000000000004878","url":null,"abstract":"<p><strong>Introduction and importance: </strong>This case highlights the importance of suspicion of pulmonary embolism (PE) even after low-dose combined oral contraceptive pills (LD-OCPs) and early diagnosis and prompt thrombolytic therapy administration, especially in resource-constrained settings such as Bangladesh.</p><p><strong>Case presentation: </strong>A 40-year-old female of Asian origin, Class I obese (BMI 32 kg/m²), presented to the emergency department with acute severe dyspnea, pleuritic chest pain, and palpitations. Her medical history was notable for obesity and hypertension, which had been managed with antihypertensive medication for the past 3 years. Additionally, she had been taking a LD-OCP for 4 months for menstrual irregularity. Despite initial management with low-molecular-weight heparin and supportive measures, the patient's condition rapidly deteriorated to severe cardiogenic shock, necessitating urgent intervention. Thrombolytic therapy with alteplase was administered, which significantly improved the patient's hemodynamic status. Follow-up imaging revealed a reduction in the thrombus burden and resolution of deep vein thrombosis.</p><p><strong>Clinical discussion: </strong>This case highlights the critical role of early diagnosis and prompt thrombolytic therapy, such as alteplase, in managing acute PE. Rapid intervention can prevent severe complications. Clinicians must maintain high suspicion in symptomatic patients, especially women on hormonal therapy, and use timely diagnostics like D-dimer and CT angiography.</p><p><strong>Conclusion: </strong>In resource-limited settings, the timely administration of thrombolytic agents such as alteplase can significantly improve patient outcomes, as demonstrated in this case.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 5","pages":"2945-2949"},"PeriodicalIF":1.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of implant protrusion length on intrasinus bone formation in transalveolar sinus lift without grafting: a meta-analysis.","authors":"Ziad Albash, Ali Khalil, Ihsan Almomani, Mahmoud Ali, Wajih Kashkash, Ghassan Almohammad","doi":"10.1097/MS9.0000000000004796","DOIUrl":"https://doi.org/10.1097/MS9.0000000000004796","url":null,"abstract":"<p><strong>Background: </strong>Transalveolar sinus floor elevation (TSFE) without bone grafting has gained attention as a minimally invasive approach for vertical bone augmentation in the atrophic posterior maxilla. Although implant protrusion length (IPL) is theorized to be a key determinant of intrasinus bone gain, the existing evidence is inconsistent.</p><p><strong>Objective: </strong>The purpose of this systematic review and meta-analysis is to evaluate the effect of IPL on intrasinus bone gain following transalveolar sinus floor elevation performed without bone graft materials.</p><p><strong>Methods: </strong>Electronic searches were conducted in PubMed/Medline, Scopus, Web of Science, and Science Direct until December 2024. Randomized controlled trials, cohort studies, and retrospective analyses reporting IPL and vertical bone gain (VBG) were included. Data were pooled using random-effects meta-analysis, with subgroup analyses by IPL categories (<3 mm, 3-5 mm, >5 mm).</p><p><strong>Results: </strong>Twelve studies (519 implants) met inclusion criteria. Meta-analysis revealed a significant positive association between IPL and VBG (WMD: 1.85 mm, 95% CI: 1.12-2.58; *<i>P</i> < 0.001), with >5 mm protrusions yielding the greatest bone gain (3.25 mm vs. 0.92 mm for <3 mm). Heterogeneity was substantial (I² = 78%). The osteotome technique demonstrated superior consistency compared to threaded expanders.</p><p><strong>Conclusion: </strong>Controlled implant protrusion (3-5 mm) optimizes bone formation in graft-free TSFE, offering a biologically driven alternative to graft-dependent approaches. Standardization of IPL measurement protocols and long-term implant survival studies are warranted to refine clinical guidelines.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 5","pages":"2857-2868"},"PeriodicalIF":1.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sanctions and sovereignty: Venezuela's human health crisis.","authors":"Aneeq Mahmood Khan, Ayesha Mustafa, Mahnoor Fatima","doi":"10.1097/MS9.0000000000004922","DOIUrl":"https://doi.org/10.1097/MS9.0000000000004922","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 5","pages":"3016-3017"},"PeriodicalIF":1.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomal microRNAs as promising indicators of chemoresistance in lung cancer.","authors":"Hira Khalid, Meer Murtaza, Mohammed Hammad Jaber Amin","doi":"10.1097/MS9.0000000000004848","DOIUrl":"https://doi.org/10.1097/MS9.0000000000004848","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 5","pages":"2982-2983"},"PeriodicalIF":1.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiome dysbiosis as a trigger for area postrema syndrome exacerbation in AQP4+ NMOSD with HBV co-exposure.","authors":"Tahir Ullah, Aneeq Mahmood Khan, Ayesha Mustafa, Mahnoor Fatima","doi":"10.1097/MS9.0000000000004906","DOIUrl":"https://doi.org/10.1097/MS9.0000000000004906","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 5","pages":"3002-3003"},"PeriodicalIF":1.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thal versus Nissen fundoplication for the management of pediatric gastroesophageal reflux disease: a systematic review and meta-analysis.","authors":"Shrouk F Mohamed, Ahmed Elsary, Mahmoud Abdelnasser, Baraa Alsharif, Teba Jawad, Ayed S Askar","doi":"10.1097/MS9.0000000000004814","DOIUrl":"https://doi.org/10.1097/MS9.0000000000004814","url":null,"abstract":"<p><strong>Background: </strong>Gastroesophageal reflux disease (GERD) in children is a common condition associated with significant morbidity. Surgery, particularly fundoplication, is performed when conservative management fails. Nissen fundoplication (NF) has been established as the gold standard for surgical management of GERD, but Thal fundoplication (TF) is an alternative that may carry less risk. This systematic review and meta-analysis aimed to compare the efficacy and safety of TF and NF in children diagnosed with GERD.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted through different databases, such as PubMed, Scopus, Web of Science, and Cochrane CENTRAL. Studies that directly compared TF and NF in pediatric populations were eligible. Data were extracted using a standardized data extraction sheet and analyzed using R software.</p><p><strong>Results: </strong>Fifteen studies were included, comparing TF (n = 624) and NF (n = 1260). There was no significant difference in recurrence rates between the two groups (OR 1.23, 95% CI: 0.81-1.85, <i>P</i> = 0.30). The proportion of patients with neurological impairments significantly influenced outcomes. TF was associated with a lower risk of mortality (OR 0.50, 95% CI: 0.26-0.95, <i>P</i> = 0.04) and a lower risk of postoperative dysphagia (OR 0.51, 95% CI: 0.27-0.96, <i>P</i> = 0.0398) compared with NF. No significant differences were observed in other postoperative complications, including hernia, bloating syndrome, or small bowel obstruction.</p><p><strong>Conclusion: </strong>TF effectively manages pediatric GERD, with reflux control outcomes comparable to NF. TF had lower dysphagia rates. Our findings suggest that TF may be a suitable alternative to NF in children with neurological impairments. Further high-quality, randomized controlled trials are needed to confirm these results and accurately define each procedure's indications.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 5","pages":"2845-2856"},"PeriodicalIF":1.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}