Annals of Gastroenterology最新文献

{"title":"Temporal trends in colorectal cancer mortality in Greece, 2014-2022: a Joinpoint regression analysis.","authors":"Tommy Rizkala, Cesare Hassan","doi":"10.20524/aog.2026.1066","DOIUrl":"10.20524/aog.2026.1066","url":null,"abstract":"","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 3","pages":"281-282"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of colorectal cancer incidence and mortality after removals of polyps: a cohort study using the UK Biobank.","authors":"Ziqi Wan, Hanze Du, Xing Kang, Shiyu Jiang, Jiarui Mi, Zhengye Liu, Ruwen Zhou, Lingjuan Jiang, Nan Zhao, Guanqiao Li, Wei Han, Sunny Hei Wong, Xiaoyin Bai, Hong Yang","doi":"10.20524/aog.2026.1064","DOIUrl":"10.20524/aog.2026.1064","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is a leading cause of cancer death worldwide, however, the risk of newly-diagnosed CRC and its related mortality after polypectomy have not been conclusively determined.</p><p><strong>Methods: </strong>Prospective cases with polypectomy were identified in the UK Biobank. The age- and sex-standardized incidence ratio (SIR) and standardized mortality ratio (SMR) were calculated to assess the risk of CRC between the removal group and both the non-index-colonoscopy group (no record of diagnostic colonoscopy) from the UK Biobank and the general population in England. We also estimated the effect of removal compared with the polyp-free group using a competing risk model.</p><p><strong>Results: </strong>During a median follow up of 10 (1-44) years (51,136 person-years), 78 incident CRCs (153/100,000 person-years), and 16 CRC-specific deaths (31/100,000 person-years) were identified in the removal group. Compared with the general population in England, the removal group had a similar risk of incident CRC (SIR 0.81, 95% confidence interval [CI] 0.64-1.01; P=0.060), whereas the CRC-specific mortality was 52% lower (SMR 0.48, 95%CI 0.28-0.78; P=0.004). Compared with the non-index-colonoscopy group, CRC-specific deaths after polyp removal were not significantly different (SMR 1.64, 95%CI 0.94-2.66; P=0.050). Compared with the polyp-free group, the risks of incidence and mortality in the removal group were both greater (incidence: adjusted hazard ratio [HR] 6.17, 95%CI 4.36-8.74; P<0.001; mortality: adjusted HR 3.25, 95%CI 1.65-6.41; P<0.001).</p><p><strong>Conclusion: </strong>Polypectomy reduced but not eliminated the risk of CRC for polyp-positive participants to the level of the general population, reinforcing the importance of procedural quality and tailored surveillance strategies.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 3","pages":"360-371"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' reply.","authors":"Felix W Leung, Sergio Cadoni, Long Chen, Yu Chen, Chi-Liang Cheng, Ramsey Cheung, Vivek Dixit, David Elashoff, Shai Friedland, Paolo Gallittu, Yu-Hsi Hsieh, Chia Hsin Cheng, Noam Jacob, Nora Jamgotchian, Hui Jia, Yen-Lin Kuo, Bai-Ping Lee, Joseph W Leung, Donatella Mura, Jennifer Yi-Jiun Pan, Yanglin Pan, Susan Y Quan, Angshuman Saha, Aliya Shaikh, James Sul, Chih-Wei Tseng, Yi-Ning Tsui, Holly Wilhalme, Robert J Wong, Andrew W Yen, Linhui Zhang","doi":"10.20524/aog.2026.1069","DOIUrl":"10.20524/aog.2026.1069","url":null,"abstract":"","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 3","pages":"378-379"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on modeling strategy and data handling in a meta-analysis of anti-integrin αvβ6 for primary sclerosing cholangitis.","authors":"Javier Arredondo Montero","doi":"10.20524/aog.2026.1057","DOIUrl":"10.20524/aog.2026.1057","url":null,"abstract":"","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 3","pages":"379-382"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of self-care among informal caregivers of patients with inflammatory bowel disease: a cross-sectional study.","authors":"Daniele Napolitano, Paolo Iovino, Fabrizio Benedetti, Negin Dorri, Barbara Riegel, Ercole Vellone","doi":"10.20524/aog.2026.1055","DOIUrl":"10.20524/aog.2026.1055","url":null,"abstract":"<p><strong>Background: </strong>Informal caregivers of individuals with inflammatory bowel disease (IBD) face unpredictable responsibilities that may compromise their health. While caregiver burden and psychological distress are well-documented, little is known about caregivers' self-care practices and their determinants.</p><p><strong>Methods: </strong>A multicenter cross-sectional study was conducted across 9 Italian IBD Units between April and June 2024. Caregivers completed validated measures of self-care (Self-Care of Informal Caregivers Inventory), caregiver burden (Zarit Burden Interview), and psychological distress (Depression Anxiety Stress Scales-21). Logistic regression models were used to identify predictors of inadequate self-care behaviors.</p><p><strong>Results: </strong>A total of 229 caregivers were included (mean age 52.2±13.6 years; 59% women). Adequate self-care was high for routine behaviors such as daily hygiene (98.7%) and regular meals (87.8%), but low for emotionally and socially demanding behaviors, including professional counseling (18.3%), asking for assistance (12.2%), and accepting help (20.6%). Being unpartnered was associated with a higher likelihood of inadequate physical activity (odds ratio [OR] 2.38, 95% confidence interval [CI] 1.32-4.17). Higher anxiety was related to inadequate attention to bodily discomfort (OR 1.32, 95%CI 1.11-1.56), whereas higher caregiver burden and depression were associated with a lower likelihood of inadequate emotional wellbeing strategies (OR 0.97, 95%CI 0.95-0.99), and inadequate help-seeking (OR 0.80, 95%CI 0.68-0.93), respectively.</p><p><strong>Conclusions: </strong>Caregivers maintain basic health habits but show marked vulnerabilities in emotional and social self-care domains. Psychological distress and relational factors play a key role, underscoring the need for caregiver-centered interventions that promote emotional wellbeing, resilience, and help-seeking.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 3","pages":"326-335"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver fibrosis severity evaluated by shear-wave elastography is associated with procoagulant and systemic inflammatory activity in patients with cirrhosis.","authors":"Georgios Kalambokis, Nikolaos Aggelis, Ilias Tsiakas, Dimitrios Biros, Grigorios Despotis, Evangelia Papapetrou, Christina Tsaousi, Georgios S Markopoulos, Georgios Kolios, Reveka Konstantopoulou, Stavroula Tsiara, Gerasimos Baltayiannis, Haralampos Milionis","doi":"10.20524/aog.2026.1060","DOIUrl":"10.20524/aog.2026.1060","url":null,"abstract":"<p><strong>Background: </strong>Hemostatic and inflammatory pathways may drive liver fibrogenesis. We investigated whether coagulation and systemic inflammatory activities influence liver fibrosis severity in patients with cirrhosis and thrombocytopenia.</p><p><strong>Methods: </strong>Two patient groups were evaluated according to liver stiffness measurement (LSM) through shear wave elastography: ≥25 kPa (n=100) vs. <25 kPa (n=100). Anti-hemostatic parameters (platelet count, factors II, V, VII, IX, X, XI, XII, and XIII, fibrinogen, and a2-antiplasmin), pro-hemostatic parameters (factor VIII [FVIII], protein C [PC], protein S, antithrombin, von Willebrand factor-antigen [vWf-Ag], plasminogen, and plasminogen activator inhibitor-1), the FVIII-to-PC ratio as procoagulant imbalance index, and systemic inflammation markers (serum lipopolysaccharide-binding protein [LBP], tumor necrosis factor [TNF]-α, and interleukin [IL]-6) were measured. Cirrhosis severity was evaluated by model for end-stage liver disease (MELD) score.</p><p><strong>Results: </strong>Patients with LSM≥25 kPa exhibited significantly higher decompensation rates, MELD score, FVIII-to-PC ratio, and levels of FVIII, PC, protein S, vWf-Ag, LBP, TNF-α, and IL-6, and significantly lower levels of anti-hemostatic parameters than those with LSM<25 kPa. In multivariate analysis evaluating coagulation parameters alone or alongside inflammatory markers, FVIII-to-PC ratio (P=0.01/P=0.03) and LBP (P=0.01) were linked to LSM≥25 kPa after adjusting for MELD score and prior decompensation. LSM correlated significantly with FVIII-to-PC ratios, and levels of FVIII, PC, vWf-Ag, LBP, TNF-α and IL-6, in both the total cohort and patients with LSM≥25 kPa. LBP, TNF-α and IL-6 levels correlated significantly with the FVIII-to-PC ratios and vWf-Ag levels in both LSM subgroups.</p><p><strong>Conclusion: </strong>Higher procoagulant and systemic inflammatory activities are associated with greater liver fibrosis severity in cirrhotic patients.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 3","pages":"310-318"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrophic gastritis of distinct etiologies: malignant potential in <i>Helicobacter pylori</i>-associated and autoimmune forms.","authors":"Theodore Rokkas, Massimo Rugge","doi":"10.20524/aog.2026.1065","DOIUrl":"10.20524/aog.2026.1065","url":null,"abstract":"<p><p>Atrophic gastritis is an important step in the Correa cascading pathway. It forms a pivotal period between chronic inflammation and a biologically-disrupted mucosal epithelial phenotype leading to gastric neoplasia. From a more than superficial perspective, both <i>Helicobacter pylori</i> (<i>H. pylori</i>)-associated atrophic gastritis and autoimmune atrophic gastritis converge on glandular loss and metaplastic reprogramming, but their etiologic pathways, molecular mediators, topographic distribution and neoplastic characteristics differ drastically. <i>H. pylori</i> infection induces multifocal atrophy and incomplete intestinal metaplasia and is the typical path to intestinal-type gastric adenocarcinoma, while autoimmune gastritis results in corpus-restricted oxyntic destruction, severe hypochlorhydria, hypergastrinemia, and a distinctive predisposition to type I gastric neuroendocrine neoplasms. Despite <i>H. pylori</i> eradication, the epigenetic landscape of metaplastic mucosa often persists, requiring risk-adapted surveillance approaches underpinned by histologic systems such as OLGA and OLGIM. This narrative review aggregates mechanistic, epidemiologic and clinical evidence establishing malignant potentials for both etiologies of atrophic gastritis, and offers an integrated framework for surveillance and prevention.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 3","pages":"283-293"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147979869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic disparities in documented nonadherence to medication for hepatic encephalopathy: a National Inpatient Sample analysis.","authors":"Christopher Behrend, Yasmin Ali, Joseph A Akambase, Spencer R Goble, Thomas M Leventhal","doi":"10.20524/aog.2026.1056","DOIUrl":"10.20524/aog.2026.1056","url":null,"abstract":"<p><strong>Background: </strong>Medication nonadherence is often cited as a precipitant of hepatic encephalopathy. However, the underlying reasons and clinical implications of medication nonadherence in this population are understudied.</p><p><strong>Methods: </strong>This was a retrospective cross-sectional analysis of hospitalization for hepatic encephalopathy within the National Inpatient Sample from 2016-2022. Multivariate logistic regression analysis was used to assess for patient factors associated with documented nonadherence; results were presented as adjusted odds ratios (aOR) and 95% confidence intervals (CI). Additionally, analysis was performed to assess for associations between documented nonadherence and clinical outcomes.</p><p><strong>Results: </strong>Medication nonadherence was documented in 44,685 of the 250,755 (17.8%) hospitalizations for hepatic encephalopathy. Nonadherence was documented more in Black (aOR 1.35, 95%CI 1.24-1.47; P<0.001) and Hispanic (aOR 1.20, 95%CI 1.12-1.28; P<0.001) patients compared to White patients. Substance use diagnoses (aOR 1.36, 95%CI 1.29-1.43; P<0.001) and housing insecurity (aOR 2.47, 95%CI 2.11-2.90; P<0.001) were both associated with documented nonadherence. Discharge against medical advice was more frequent in patients with documented nonadherence (33.8% vs. 18.8%, P<0.001), whereas mortality, need for mechanical ventilation, cost, and length of stay were all less.</p><p><strong>Conclusions: </strong>Marginalized populations have higher rates of documented medication nonadherence in cases of hospitalization for hepatic encephalopathy. Structural barriers and provider bias could both be contributing to the documented medication nonadherence in this population.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 3","pages":"319-325"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum nonsteroidal anti-inflammatory drug exposure does not increase risk for flare in patients with inflammatory bowel disease.","authors":"Loren G Rabinowitz, Tina Deyhim, Joyce Lee, Jessica D Lee, Amelia Hern, Nicole Lue, Grace Geeganage, Alessandra Saraga, Ajay Gade, Jacqueline Shen, Sarah Ballou, Lauren K Burdine, Benjamin Mecsas-Faxon, Laurie Grossberg, Samantha Zullow, Sarah Flier, Scott A Shainker, Konstantinos Papamichael, Joseph D Feuerstein, Adam S Cheifetz","doi":"10.20524/aog.2026.1054","DOIUrl":"10.20524/aog.2026.1054","url":null,"abstract":"<p><strong>Background: </strong>Postpartum pain management is an important part of maternal healthcare. Nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen are typically offered as first-line pharmacologic therapies for postpartum pain. There is a belief that NSAIDs may play a role in exacerbating inflammatory bowel disease (IBD); as a result, some obstetricians avoid NSAIDs for postpartum pain management in patients with IBD. However, data concerning the relationship between short-term NSAID use and IBD flares are inconsistent. The aim of this study was to assess whether hospital postpartum NSAID use is associated with postpartum IBD flare within 9 months from delivery.</p><p><strong>Methods: </strong>This single-center retrospective cohort study included patients with IBD, aged 18 years or older, who had singleton live births between January 1, 2016, and November 30, 2023. Chart review data for each eligible patient were collected for a 9-month postpartum period.</p><p><strong>Results: </strong>Among the 187 patients included in the study, there was no difference between NSAID-exposed and non-exposed patients in postpartum IBD flare: 10/114 (9%) vs. 10/73 (14%), respectively, P=0.335. Based on multivariate regression analysis, NSAID exposure was not associated with postpartum IBD flare, adjusted for active disease at conception and IBD flare during pregnancy: adjusted odds ratio (aOR) 0.6, 95% confidence interval (CI) 0.2-1.7; P=0.327. The same was true for mode of delivery and inpatient opioid exposure: aOR 0.6, 95%CI 0.1-1.5; P=0.291.</p><p><strong>Conclusions: </strong>Postpartum NSAID use for pain control is not associated with IBD flare 9 months after delivery. Large prospective studies are needed to confirm this finding.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 3","pages":"372-377"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' reply.","authors":"Alexandra Argyrou, Stamatina Vogli, Stavros P Papadakos, Antonios Chatzigeorgiou, Andreas Koutsoumpas, Jiannis Vlachogiannakos, George V Papatheodoridis","doi":"10.20524/aog.2026.1061","DOIUrl":"10.20524/aog.2026.1061","url":null,"abstract":"","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 3","pages":"381-382"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147979863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}