Annals of Gastroenterology最新文献

{"title":"Association between <i>SIRT1</i> rs3758391 genetic variant and susceptibility to pancreatic and gastric cancer.","authors":"Ilias Papantzimas, Rana Ozer, Dimitrios Linardoutsos, Emmanouil Kritsotakis, Konstantinos Georgiou, Maria Gazouli","doi":"10.20524/aog.2026.1036","DOIUrl":"https://doi.org/10.20524/aog.2026.1036","url":null,"abstract":"<p><strong>Background: </strong>The <i>SIRT1</i> gene encodes a NAD⁺-dependent deacetylase that regulates apoptosis, metabolism and genomic stability through interaction with p53 and other transcription factors. Functional single nucleotide polymorphisms within <i>SIRT1</i> may alter gene expression and affect cancer susceptibility. The rs3758391 and rs369274325 polymorphisms have been implicated in various malignancies; however, their role in pancreatic and gastric cancer remains unclear.</p><p><strong>Methods: </strong>This case-control study included 94 patients with pancreatic ductal adenocarcinoma (PDAC), 38 patients with gastric cancer (GC), and 74 healthy controls, all of Greek origin. Genomic DNA was extracted from peripheral blood samples. Genotyping was performed by RFLP-PCR for rs3758391 and tetra-primer ARMS-PCR for rs369274325. Genotype and allele frequencies were compared using χ² test and odds ratios (ORs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>A significant association was identified between <i>SIRT1</i> rs3758391 and PDAC and GC susceptibility. The TT genotype was overrepresented among PDAC patients, while the TC genotype conferred a protective effect against both PDAC (P=0.0039; OR 0.35, 95%CI 0.17-0.62) and GC (P=0.0059; OR 0.26, 95%CI 0.10-0.66). The C allele was more frequent in healthy controls compared to PDAC patients (P<0.001; OR 0.39, 95%CI 0.25-0.62). No significant association was observed for rs369274325 in either cancer type or with clinicopathological parameters.</p><p><strong>Conclusions: </strong>This is the first study to evaluate <i>SIRT1</i> genetic variants in PDAC and GC. The rs3758391 polymorphism appears to influence susceptibility to both malignancies, potentially via altered p53-mediated regulation of <i>SIRT1</i>. These findings suggest <i>SIRT1</i> as a candidate biomarker for gastrointestinal cancer risk, meriting further validation in larger, ethnically diverse cohorts.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 2","pages":"221-227"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic distribution and demographic patterns of primary biliary cholangitis and autoimmune hepatitis in Colombia: a national population-based administrative study (2018-2024).","authors":"Juan Pablo García-Marmolejo, Juan Samuel Hernández-Meza, Maria Ximena Corredor-Gaitán, Fredy Ávila-Almanza, Carmen Yanette Suárez-Quintero","doi":"10.20524/aog.2026.1043","DOIUrl":"https://doi.org/10.20524/aog.2026.1043","url":null,"abstract":"<p><strong>Background: </strong>Autoimmune liver diseases, including primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH), are rare chronic conditions with significant morbidity. However, population-based epidemiological data from Latin America remain limited. This study aimed to describe the geographic distribution and demographic patterns of PBC and AIH in Colombia between 2018 and 2024.</p><p><strong>Methods: </strong>A descriptive, cross-sectional population-based study was conducted using data from the Comprehensive Social Protection Information System (SISPRO) of the Colombian Ministry of Health. Individuals with at least 1 recorded diagnosis coded as K74.3 (PBC) or K75.4 (AIH) according to the International Classification of Diseases, 10^th Revision (ICD-10), were identified. Administrative prevalence estimates were calculated per 100,000 population, using official population projections from the National Administrative Department of Statistics (DANE). Age- and sex-specific distributions were analyzed, and geographic variation was visualized using choropleth maps at the regional level.</p><p><strong>Results: </strong>A total of 6504 PBC cases and 11,225 AIH cases were identified. The estimated national administrative prevalence was 14.7 per 100,000 population for PBC and 17.0 per 100,000 for AIH. Both conditions showed marked female predominance. PBC was more frequent in women aged 50-69 years. However, AIH demonstrated a broader age distribution, affecting individuals from young adulthood to older age. Higher prevalence estimates were observed in multiple northern regions, particularly in the Caribbean region.</p><p><strong>Conclusions: </strong>This first nationwide administrative assessment of PBC and AIH in Colombia demonstrates marked sex differences and regional variation, highlighting the need to improve diagnostic awareness and strengthen epidemiological surveillance of autoimmune liver diseases in Latin America.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 2","pages":"208-213"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pediatric gastrointestinal disorders on learning and cognitive development in schoolchildren.","authors":"Artemis Katsiaflaka, Michael Doulberis, Maria Podaropoulou, Georgia Katsiaflaka, Xenia Anastassiou-Hadjicharalambous","doi":"10.20524/aog.2026.1044","DOIUrl":"https://doi.org/10.20524/aog.2026.1044","url":null,"abstract":"<p><p>Schoolchildren nowadays encounter multiple challenges within the teaching process. Learning disabilities (LD) are characterized as complex conditions that affect academic achievement and cognitive performance. LD are typically linked to neurodevelopmental and genetic factors. However, emerging evidence suggests they may be associated with gastrointestinal (GI) pathologies, including celiac disease, inflammatory bowel disease, irritable bowel syndrome, gastroesophageal reflux disease and <i>Helicobacter pylori</i> infection. The aforementioned GI disorders have been (indirectly) linked with a spectrum of outcomes, such as school functioning, attention regulation, fatigue, and broader cognitive and psychosocial development. The gut-brain axis enacts a crucial role in both cognition and behavior. Furthermore, functional GI disorders may also coexist with somatic symptom anxiety, including school refusal and hypervigilance to bodily sensations. A typical paradigm is emetophobia, an intense fear of vomit, which might result in food avoidance, social withdrawal or even academic disengagement. Moreover, iron and vitamin deficiencies, as manifestation of a malabsorption due to GI diseases, might impact concentration and memory. Additionally, sleep disturbances, chronic discomfort and psychological stress could deteriorate cognitive and educational functioning. This work reviews current evidence linking GI health to LD and related neurodevelopmental/psychological outcomes. Timely diagnosis and treatment, targeting both GI and psychological factors, might improve cognitive outcomes and learning potential in schoolchildren with LD. Future studies with longitudinal and interventional designs are warranted, in order to elucidate any causal relationships and to determine whether targeted treatment of GI disorders leads to objective improvement in learning and cognitive outcomes.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 2","pages":"174-183"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' reply.","authors":"Stergios N Kouvaras, Ioannis G Koumarianos, Konstantinos Ekmektzoglou, George A Kounis, Charikleia Spiliadi, Sotirios D Georgopoulos, Theodoros Rokkas","doi":"10.20524/aog.2026.1052","DOIUrl":"https://doi.org/10.20524/aog.2026.1052","url":null,"abstract":"","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 2","pages":"279-280"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated immune-mediated enteritis in patients treated with immune checkpoint inhibitor therapy.","authors":"Sharada Wali, Rohan Srinivas Patel, Maria Julia Moura Nascimento Santos, Anirudha Chatterjee, Sophia Chenyu Fan, Sean Ngo, Tanvi Gupta, Kian Abdul Baki, Lucie Heinzerling, Bryan J Schneider, Kathryn Bollin, Jessica Philpott, Anusha Thomas, Yinghong Wang","doi":"10.20524/aog.2026.1032","DOIUrl":"https://doi.org/10.20524/aog.2026.1032","url":null,"abstract":"<p><strong>Background: </strong>Immune checkpoint inhibitors (ICIs) commonly cause colitis, but isolated immune-mediated enteritis (IMEN) is poorly characterized. This study describes the clinical features, diagnostic findings, and outcomes of IMEN.</p><p><strong>Method: </strong>We retrospectively identified adults with cancer who developed IMEN within one year of ICI initiation, confirmed as duodenitis, ileitis, or both.</p><p><strong>Results: </strong>Among 20,991 ICI-treated patients, 30 (0.143%) developed isolated IMEN. Median age was 69.5 years; 73.3% were male, and 80% white. The most common malignancies were gastrointestinal/hepatobiliary (26.7%) and melanoma (23.3%). Presenting symptoms included nausea (66.7%), diarrhea (53.3%), and vomiting (46.7%); 62.5% of patients with diarrhea had grade ≥2 severity. Disease involved duodenitis plus ileitis in 50%, isolated duodenitis in 30%, and isolated ileitis in 20%. Median fecal calprotectin levels were highest in duodenitis plus ileitis (1335.5 μg/g), followed by ileitis (319 μg/g) and duodenitis (78 μg/g). Endoscopy showed nonulcerative inflammation in 60% and ulceration in 20%. Hospitalization was longest in duodenitis plus ileitis (median 13.5 days). Corticosteroids were required in 66.7% of ileitis cases; additional immunosuppression was needed in 33.3% of ileitis and 66.7% of duodenitis plus ileitis. Isolated duodenitis improved with supportive therapy alone. Remission occurred in 63.3% overall. ICI therapy was resumed in 12.5%, exclusively in patients with isolated duodenitis. Complications included fistula formation (10%); all-cause mortality was 36.7%.</p><p><strong>Conclusions: </strong>IMEN is a rare but clinically significant ICI-related toxicity. Fecal calprotectin correlates with ileitis severity and not duodenitis, and small-bowel endoscopy facilitates diagnosis and management.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 2","pages":"262-269"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic submucosal dissection and submucosal tunneling endoscopic resection of gastric subepithelial lesions originating from the muscle layer: a multicenter retrospective study.","authors":"Stavros Dimitriadis, Stamatina Vogli, Gianluca Adrisani, George Tribonias, Domenico Galasso, Shaimaa Elkholy, Shivam Khare, Juliette Leroux, Harold Eduardo Benites Goñi, Stefan Seewald, Khanh Do-Cong Pham, Pedro Rosón Rodriguez, Ahmad Madkour, Sandro Sferrazza, Hany Shehab, Sridhar Sundaram, Mihai Ciocîrlan, Amr Fouly, Luis Marín Calderón, Paulo Bardalez Cruz, Hany Hagag, Mohamed El-Sherbiny, Kareem Essam, Rossella Maresca, Jijo Varghese, Federico Barbaro, Cristiano Spada, Matteo Marasco, Francesco Maria Di Matteo, Maria Zachou, Georgios Mavrogenis","doi":"10.20524/aog.2026.1035","DOIUrl":"https://doi.org/10.20524/aog.2026.1035","url":null,"abstract":"<p><strong>Background: </strong>Gastric subepithelial lesions (SELs) from the <i>muscularis propria</i> are usually managed surgically or with surveillance. Advances in endoscopic techniques now permit safe <i>en bloc</i> resection, even for lesions with extraluminal growth, but data from outside East Asia are scarce.</p><p><strong>Methods: </strong>We performed a multicenter retrospective study across 18 centers in Europe, the Middle East, South America and South Asia, including patients with gastric SELs from the <i>muscularis propria</i> resected by endoscopic submucosal dissection (ESD) or submucosal tunneling endoscopic resection (STER) between 2017 and 2024. Outcomes included <i>en bloc</i> resection, safety, complications, and recurrence.</p><p><strong>Results: </strong>Eighty-two patients (62.2% women; median age 59 years) were included. Median lesion size was 2cm (range 0.6-8). Lesions were located in the cardia (18.3%), fundus (18.3%), body (40.2%), and antrum (23.2%). Histology showed gastrointestinal stromal tumors in 78.0%, leiomyomas in 19.5%, and schwannomas in 2.5%. Most were endoluminal (80.5%), 19.5% were extraluminal, and 7.3% extended beyond the serosa. ESD was performed in 65.9% and STER in 34.1%. Median procedure time was 120 min. Deliberate perforation was performed in 31.7%, while 92.3% were managed endoscopically. <i>En bloc</i> resection was achieved in 96.3%, with defect closure in 90.2%. Complications occurred in 7%, with no mortality. Local relapse occurred in 2.5% after a median 9-month follow up. One-third of procedures took place in non-academic centers.</p><p><strong>Conclusions: </strong>ESD and STER are safe and effective alternatives to surgery or surveillance for gastric SELs from the <i>muscularis propria</i>, including lesions with extraluminal growth. Long-term, comparative studies alongside laparoscopic surgery are warranted.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 2","pages":"254-261"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion-weighted imaging increases the diagnostic performance of magnetic resonance imaging in assessing rectal cancer T stage and reduces intra- and interobserver variability.","authors":"Alfredo Clemente, Fabrizio Urraro, Gabriella Teresa Capolupo, Filippo Carannante, Fiammetta Cappabianca, Alessandro Costa, Valerio Nardone, Gianluca Costa, Alfonso Reginelli","doi":"10.20524/aog.2026.1038","DOIUrl":"https://doi.org/10.20524/aog.2026.1038","url":null,"abstract":"<p><strong>Background: </strong>Accurate preoperative staging is pivotal in guiding rectal cancer treatment, and in particular for selecting appropriate neoadjuvant therapies and surgical approaches. Magnetic resonance imaging (MRI) remains the standard modality for local staging. However, it has some limitations, particularly in tumors at intermediate clinical stages. Recent evidence has shown that incorporating diffusion-weighted imaging (DWI) can improve diagnostic performance, although its role in T staging has not been completely elucidated.</p><p><strong>Methods: </strong>The diagnostic performance of conventional MRI alone vs. MRI plus DWI in rectal cancer staging was retrospectively evaluated. The correlation between preoperative MRI findings and postoperative histopathological staging was examined. Intra- and interobserver agreement among radiologists with various levels of experience were assessed, both with and without DWI.</p><p><strong>Results: </strong>DWI-MRI improved staging accuracy, particularly for T2 and T3 tumors. The sensitivity and specificity for T2 staging increased from 68% and 96% (MRI alone) to 91% and 98% (DWI-MRI), respectively, while the sensitivity and specificity for T3 staging improved from 91% to 97%, and from 78% to 92%, respectively. The intraobserver agreement increased from 90.60% to 94.02% in experienced readers, and from 81.2% to 87.18% in less experienced ones. The interobserver agreement for DWI-MRI increased from 83.76% to 88.03%.</p><p><strong>Conclusions: </strong>DWI-MRI can enhance the accuracy of rectal cancer T staging, particularly when assessing rectal wall invasion, and it reduces overstaging. Moreover, it improves diagnostic consistency among radiologists, regardless of experience. Hence, the routine integration of DWI into preoperative MRI protocols can optimize clinical decision-making and treatment planning.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 2","pages":"270-276"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gaps in the diagnosis of small bowel adenocarcinoma among patients with Crohn's disease: a tertiary care perspective.","authors":"Marisa-Nicole S Zayat, Micah Vander Griend, Jana G Hashash, Jami Kinnucan, Michael Picco, Francis A Farraye, Rex K Siu","doi":"10.20524/aog.2026.1047","DOIUrl":"https://doi.org/10.20524/aog.2026.1047","url":null,"abstract":"<p><strong>Background: </strong>Small bowel adenocarcinoma (SBA) is a rare and serious complication of Crohn's disease (CD), with symptoms often mimicking CD-related symptoms. Therefore, preoperative diagnosis of SBA is difficult, since conventional imaging is rarely diagnostic. This study aims to evaluate the utility of imaging and endoscopic modalities in detecting SBA among patients with CD.</p><p><strong>Methods: </strong>A retrospective review of medical records from a multi-institutional tertiary care center was conducted. ICD-10 codes were used to identify patients with CD who were diagnosed with SBA between January 1, 2019, and November 24, 2024.</p><p><strong>Results: </strong>Of 92 patients identified, 36 met the inclusion criteria. Twenty-one (58.3%) were male, and 35 (97.2%) were Caucasian. The median age at SBA diagnosis was 61 years, with a median 19-year interval from initial CD diagnosis to SBA diagnosis. Thirty-one patients (86.1%) had preoperative imaging, but only 7/31 (22.6%) had findings that raised concern for malignancy. Eight (22.2%) of the patients who underwent endoscopy were diagnosed with SBA or dysplasia on endoscopic biopsy; 18 cases were discovered incidentally during surgery. Sixteen patients (44.4%) had stage III or IV cancer at diagnosis, and 18 patients (50.0%) achieved oncologic remission.</p><p><strong>Conclusions: </strong>Among patients with CD diagnosed with SBA, a large proportion of imaging and endoscopic studies failed to suggest malignancy. Given the substantial proportion of patients diagnosed at advanced stages, and the associated poor outcomes, a high index of suspicion and multimodal evaluation could improve the diagnostic yield in long-standing CD patients with new or changing symptoms.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 2","pages":"238-246"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning in predicting treatment response and remission in inflammatory bowel disease: a systematic review.","authors":"Sheza Malik, Renisha Redij, Dushyant Singh Dahiya, Chengu Niu, Douglas G Adler","doi":"10.20524/aog.2026.1041","DOIUrl":"https://doi.org/10.20524/aog.2026.1041","url":null,"abstract":"<p><strong>Background: </strong>The heterogeneity of inflammatory bowel disease (IBD) and its unpredictable course have always been a challenge for gastroenterologists, with regard to predicting the disease response using endoscopic techniques. Machine learning (ML) models have shown some early promise in predicting treatment response in IBD patients.</p><p><strong>Methods: </strong>We conducted a systematic review of studies investigating the application of ML to predict treatment response and remission in IBD patients. We used the CHARMS checklist for data extraction. Bias was assessed with the PROBAST tool.</p><p><strong>Results: </strong>We included in our review 6 studies that evaluated numbers of IBD patients ranging from 67 to 3004. ML models demonstrated low to moderate predictive accuracy for treatment response and remission (area under the receiver operating characteristic curve: 0.489-0.811; sensitivity: 0.46-0.96; specificity: 0.56-0.98). The studies that utilized ML models with more input variables performed better. Furthermore, only 2 studies performed external validation, and half of the studies demonstrated a substantial risk of bias due to missing data/overfitting, and variability in outcome definition.</p><p><strong>Conclusions: </strong>ML models show considerable promise in predicting treatment outcomes and remission in IBD. However, given the substantial bias in studies so far, future studies should use a standardized methodology, external validation, and an interpretable broader input variable.</p>","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 2","pages":"247-253"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the prioritization of cholangioscopy-guided electrohydraulic lithotripsy: the role of stone characteristics and cost-efficacy.","authors":"Koji Takahashi","doi":"10.20524/aog.2026.1050","DOIUrl":"https://doi.org/10.20524/aog.2026.1050","url":null,"abstract":"","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"39 2","pages":"277"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}