Annals of Gastroenterology最新文献_第2页

All you need to know about the overlap between primary sclerosing cholangitis and inflammatory bowel disease. 原发性硬化性胆管炎与炎症性肠病重叠的全部信息。

IF 2.1

Annals of Gastroenterology Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.20524/aog.2025.0945

Joseph Sleiman, Fadi F Francis, Nayantara Coelho-Prabhu, Jana G Hashash

{"title":"All you need to know about the overlap between primary sclerosing cholangitis and inflammatory bowel disease.","authors":"Joseph Sleiman, Fadi F Francis, Nayantara Coelho-Prabhu, Jana G Hashash","doi":"10.20524/aog.2025.0945","DOIUrl":"10.20524/aog.2025.0945","url":null,"abstract":"Primary sclerosing cholangitis (PSC) is a progressive auto-inflammatory condition of the biliary ducts clinically characterized by painless cholestasis and jaundice. Histologically, the typical findings in PSC are periductal fibrosis with inflammation, bile duct proliferation, and ductopenia. These hallmarks eventually develop into end-stage liver disease requiring liver transplantation (LT), although the latency between diagnosis and LT is variable among patients. PSC is the leading indication for LT among patients with autoimmune liver disease. The interplay of PSC and inflammatory bowel disease (IBD) is intricate and poorly understood, as exemplified by the ongoing debate as to whether these are 2 distinct diseases or a complex 2-sided manifestation of the same disease spectrum. A true pathophysiological pathway has not been pinpointed, which explains the current lack of disease-specific therapies approved for this entity. This review summarizes our current knowledge about the epidemiology, pathophysiology, clinical presentation and management of PSC. We will also elucidate the relationship between PSC and IBD, specifically regarding the LT and pouchitis subpopulations.","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"38 2","pages":"107-120"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early versus late drainage of pancreatic necrotic fluid collections: a systematic review and meta-analysis.

IF 2.1

Annals of Gastroenterology Pub Date : 2025-03-01 Epub Date: 2025-02-28 DOI: 10.20524/aog.2025.0955

Shivanand Bomman, Andrew Canakis, Muaaz Masood, Jagpal S Klair, Rodrigo Alvarez, Arunkumar Muthusamy, Shruti Chandra, Avin Aggarwal, Hemanth Gavini, Rajesh Krishnamoorthi

{"title":"Early versus late drainage of pancreatic necrotic fluid collections: a systematic review and meta-analysis.","authors":"Shivanand Bomman, Andrew Canakis, Muaaz Masood, Jagpal S Klair, Rodrigo Alvarez, Arunkumar Muthusamy, Shruti Chandra, Avin Aggarwal, Hemanth Gavini, Rajesh Krishnamoorthi","doi":"10.20524/aog.2025.0955","DOIUrl":"10.20524/aog.2025.0955","url":null,"abstract":"Background: Necrotizing pancreatitis can be complicated by necrotic fluid collections (NFCs). International guidelines recommend waiting 4 weeks for the collection to mature before interventional management. With the advances in endoscopic drainage, the need to delay drainage by 4 weeks is unclear. We aimed to compare early drainage (ED: <4 weeks) vs. late drainage (LD: ≥4 weeks) of NFCs.Methods: Literature searches through multiple databases were performed to identify studies that investigated outcomes of ED vs. LD of NFCs. Our primary outcome was the complication rate among these groups. The secondary outcomes included the number of patients requiring subsequent necrosectomies, and mortality.Results: We identified 9 studies with 855 patients (320 ED and 535 LD). The complication rates (rate ratio 1.060, 95% confidence interval [CI] 0.79-1.42; P=0.69; I 2=51.61) and the number of patients requiring subsequent necrosectomies (odds ratio [OR] 2.15, 95% CI 0.86-5.35; P=0.099; I 2=79.81) were similar in both groups. Mortality was slightly higher in the ED group (OR 1.94, 95%CI 1.05-3.59; P=0.033; I 2=0).Conclusions: Our study suggests that ED can be performed if needed in carefully selected patients without an increase in complications or subsequent necrosectomies. However, mortality was slightly higher compared to LD. A multidisciplinary team approach is necessary for considering ED.","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"38 2","pages":"221-229"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forty-five-year trends in intra- and extrahepatic cholangiocarcinoma: sex- and race-based insights.

IF 2.1

Annals of Gastroenterology Pub Date : 2025-03-01 Epub Date: 2025-02-28 DOI: 10.20524/aog.2025.0951

Rajamanuri Medha, Pannala Sai Shanmukha Sreeram, Obada Daaboul, Dar Sophia, Sundar Rahul, Johnson Adejoke, Cheema Ayesha, Tufail Muhammad Umer, Arshad Hafiz Muhammad Sharjeel

{"title":"Forty-five-year trends in intra- and extrahepatic cholangiocarcinoma: sex- and race-based insights.","authors":"Rajamanuri Medha, Pannala Sai Shanmukha Sreeram, Obada Daaboul, Dar Sophia, Sundar Rahul, Johnson Adejoke, Cheema Ayesha, Tufail Muhammad Umer, Arshad Hafiz Muhammad Sharjeel","doi":"10.20524/aog.2025.0951","DOIUrl":"10.20524/aog.2025.0951","url":null,"abstract":"Background: A comprehensive review of 45-year trends in intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) in the United States has not been published. Given their rising incidence, our study aimed to analyze trends in incidence and survival, comparing ICC and ECC.Methods: We extracted a 45-year dataset (1975-2020) from the Surveillance, Epidemiology, and End Results database. Age-adjusted incidence rates were calculated using SEERStat®. Annual Percent Change (APC) was estimated via weighted least squares. Relative survival (1- and 5-year) was calculated using the Ederer II method and compared across sexes and races.Results: A significant rise in ICC and ECC incidence was observed in both sexes (APC 3.71 for ICC vs. 6.16 for ECC; P<0.001). In females, ECC incidence increased more than ICC (APC 5.96 vs. 4.09, P<0.05), whereas males showed a fluctuating ECC trend and a steady ICC rise. Survival rates significantly improved across all races and sexes (P<0.05). ICC survival rose from 17.45% to 41.41% (1-year) and 2.83% to 10.99% (5-year), while ECC increased from 30.33% to 41.12% (1-year) and 5.96% to 10.44% (5-year). Among white and other-race females, ECC showed less improvement than ICC. Black individuals lacked statistically significant data.Conclusions: Our study highlights disparities in ICC and ECC incidence, with higher rates in males, but better survival for ECC in males and ICC in females. The underrepresentation of Black individuals warrants further study to explore contributing factors such as risk, access to care, and treatment.","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"38 2","pages":"214-220"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of intraductal ultrasound in endoscopic biliary brushing for sampling in patients with malignant biliary strictures: a bicentric retrospective study.

IF 2.1

Annals of Gastroenterology Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.20524/aog.2025.0942

Jianxiang Wang, Zhuqiong Lu, Guangwen Chen, Zhenyang Shen, Junjun Wang, Jiangfeng Hu, Xinjian Wan, Hongcheng Sun, Haiming Zheng, Xiaobo Cai

{"title":"The role of intraductal ultrasound in endoscopic biliary brushing for sampling in patients with malignant biliary strictures: a bicentric retrospective study.","authors":"Jianxiang Wang, Zhuqiong Lu, Guangwen Chen, Zhenyang Shen, Junjun Wang, Jiangfeng Hu, Xinjian Wan, Hongcheng Sun, Haiming Zheng, Xiaobo Cai","doi":"10.20524/aog.2025.0942","DOIUrl":"10.20524/aog.2025.0942","url":null,"abstract":"Background: Endoscopic biliary brushing is the first line modality for sampling in patients with indeterminate biliary stricture (BS); however, its sensitivity is limited. Endoscopic intraductal ultrasound (IDUS) is also a useful approach for the diagnosis of biliary malignancies. However, whether IDUS can guide the sampling by biliary brushing has not been reported.Methods: We retrospectively analyzed patients who underwent endoscopic retrograde cholangiopancreatography for BS in 2 tertiary care hospitals and assessed the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of IDUS and brush cytology.Results: The study involved 530 patients with BS, including 333 in the IDUS group and 197 in the non-IDUS group. Both groups exhibited similar baseline characteristics. The diagnostic ability of IDUS imaging was as follows: sensitivity 70.7%, specificity 82.4%, PPV 81.5%, NPV 72.0%, and accuracy 76.3%. Brush cytology alone demonstrated an overall sensitivity of 45.2%, with specificity 98.2%, PPV 97.2%, NPV 56.0%, and accuracy 67.2%. The sensitivity was similar in patients with or without IDUS, whereas it was significantly higher in patients with biliary mucosal invasion indicated by IDUS (55.1% vs. 30.3%, P=0.003).Conclusion: Although IDUS cannot improve the detection rate of biliary brushing for malignancy, it helps identify patients with malignant BS to be sampled more easily by brushing.","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"38 2","pages":"208-213"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early rebleeding rate following endoscopic treatment of colonic diverticular bleeding: a systematic review and meta-analysis. 内镜治疗结肠憩室出血后的早期再出血率：系统回顾和荟萃分析。

IF 2.1

Annals of Gastroenterology Pub Date : 2025-01-01 Epub Date: 2024-12-23 DOI: 10.20524/aog.2025.0940

Isha Delaleeuwe, Jennifer Aoun, Hendrik Reynaert, Paraskevas Gkolfakis, Pierre Eisendrath

{"title":"Early rebleeding rate following endoscopic treatment of colonic diverticular bleeding: a systematic review and meta-analysis.","authors":"Isha Delaleeuwe, Jennifer Aoun, Hendrik Reynaert, Paraskevas Gkolfakis, Pierre Eisendrath","doi":"10.20524/aog.2025.0940","DOIUrl":"10.20524/aog.2025.0940","url":null,"abstract":"Background: Various endoscopic treatment options are available for managing colonic diverticular bleeding (CDB). We conducted a systematic review and meta-analysis to assess the effectiveness of these endoscopic interventions in achieving hemostasis in patients with CDB, focusing on early rebleeding rate (ERR) within 30 days.Methods: A systematic literature search of the PubMed and Cochrane Library databases was performed for articles published between January 2008 and December 2023. Studies evaluating endoscopic clipping, with or without epinephrine injection, endoscopic band ligation (EBL) and endoscopic snare ligation (EDSL) in the treatment of CDB were included. The primary outcome was the overall pooled ERR following successful hemostasis. Secondary outcomes addressed ERRs associated with various hemostatic endoscopic techniques, and pooled ERRs for both direct and indirect clipping methods. Results are presented as pooled rates and odds ratio (OR) with 95% confidence intervals (CI).Results: Sixteen studies were included, comprising 1435 patients with definite CDB of whom 1273 received endoscopic hemostatic treatment. Overall pooled ERR was 14.73% (95%CI 9.33-20.14%). Pooled ERRs were 9.83% (95%CI 7.41-12.26%) in the EBL/EDSL group and 22.32% (95%CI 12.48-32.16%) in the endoscopic clipping group (P=0.02). A subgroup analysis of the clipping group showed a significant difference between the pooled ERRs favoring direct clipping: 12.04% (95%CI 3.06-21.02%) vs. 27.74% (95%CI 18.34-37.14%), P=0.02. The measured effect favors direct over indirect clipping in reducing early rebleeding episodes: OR 0.45, 95%CI 0.24-0.85; P=0.01.Conclusion: In the management of patients presenting with CDB, EBL/EDSL and direct clipping showed significantly lower ERRs compared to indirect clipping.","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"38 1","pages":"41-50"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peroral endoscopic myotomy (Z-POEM) versus flexible endoscopic septotomy (FES) for treatment of Zenker's diverticulum: does either make the cut? A systematic review and meta-analysis of outcomes. 经口内窥镜肌切开术（Z-POEM）与柔性内窥镜中隔切开术（FES）治疗Zenker憩室：两者孰优孰低？对结果进行系统回顾和荟萃分析。

IF 2.1

Annals of Gastroenterology Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.20524/aog.2024.0934

Sahib Singh, Saurabh Chandan, Jay Bapaye, Himmat S Brar, Abdul Mohammed, Lena L Kassab, Ishfaq Bhat, Shailender Singh, Amol Bapaye, Dennis Yang

{"title":"Peroral endoscopic myotomy (Z-POEM) versus flexible endoscopic septotomy (FES) for treatment of Zenker's diverticulum: does either make the cut? A systematic review and meta-analysis of outcomes.","authors":"Sahib Singh, Saurabh Chandan, Jay Bapaye, Himmat S Brar, Abdul Mohammed, Lena L Kassab, Ishfaq Bhat, Shailender Singh, Amol Bapaye, Dennis Yang","doi":"10.20524/aog.2024.0934","DOIUrl":"10.20524/aog.2024.0934","url":null,"abstract":"Background: Endoscopic treatments of symptomatic Zenker's diverticulum (ZD) include flexible endoscopic septotomy (FES) and, more recently, peroral endoscopic myotomy (Z-POEM). Data comparing these techniques are limited. We conducted a meta-analysis evaluating FES vs. Z-POEM for symptomatic ZD.Methods: Multiple databases were searched from inception to September 2024. Our primary outcomes were clinical and technical success. Secondary outcomes included adverse events, length of hospital stay (LOS), procedure time, and recurrence. A random-effects model was used, and outcomes were represented as pooled rates, relative risk (RR) and standardized mean difference (SMD), along with 95% confidence intervals (CI).Results: Seven studies with 580 patients (Z-POEM=274, FES=306) were included. Mean age ranged from 68.9-74.9 years. The diverticulum size was not statistically different between the 2 groups: SMD -3.78 (-11.68 to 4.12), P=0.35. The pooled technical success was similar for Z-POEM and FES: RR 0.99 (95%CI 0.96-1.02; I 2=0%); P=0.4. Clinical success rate was significantly higher for Z-POEM compared to FES: RR 1.11 (95%CI 1.04-1.18; I 2=16%); P=0.001. There were no statistically significant differences between the 2 treatment modalities in pooled rate of recurrence, adverse events, LOS or procedural time.Conclusions: Our analysis shows that Z-POEM and FES in the treatment of symptomatic ZD are both associated with high technical success and a good safety profile, and have comparable procedural times and rates of recurrence. Z-POEM may offer higher rates of clinical success at follow up.","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"38 1","pages":"20-27"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diverticulosis and neoplastic lesions in screening colonoscopy: a large, multicenter study. 结肠镜筛查中的憩室病和肿瘤病变：一项大型多中心研究。

IF 2.1

Annals of Gastroenterology Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.20524/aog.2024.0928

Paolo Fedeli, Monica Masotti, Chiara Marzano, Angelo Dezi, Giuseppe Scaccianone, Elisabetta Martinelli, Lucia Montenegro, Maurizio Giovannone, Alessandra Zannella, Alessandro Gigliozzi, Alessandro Azzarone, Roberto Bringiotti, Costantino Zampaletta, Maria Carlotta Sacchi, Lorenzo Ridola, Alessandra Spagnoli, Sabrina Berardi, Angelo Zullo

{"title":"Diverticulosis and neoplastic lesions in screening colonoscopy: a large, multicenter study.","authors":"Paolo Fedeli, Monica Masotti, Chiara Marzano, Angelo Dezi, Giuseppe Scaccianone, Elisabetta Martinelli, Lucia Montenegro, Maurizio Giovannone, Alessandra Zannella, Alessandro Gigliozzi, Alessandro Azzarone, Roberto Bringiotti, Costantino Zampaletta, Maria Carlotta Sacchi, Lorenzo Ridola, Alessandra Spagnoli, Sabrina Berardi, Angelo Zullo","doi":"10.20524/aog.2024.0928","DOIUrl":"10.20524/aog.2024.0928","url":null,"abstract":"Background: Data on the potential association between diverticulosis and colonic neoplastic lesions are still controversial. We investigated this issue in subjects who underwent screening colonoscopy.Methods: We reviewed the data of subjects with a positive fecal immunological test who underwent a first colonoscopy in the national colorectal screening program. Endoscopic and histological reports were evaluated, using both univariate and multivariate analyses to search for an association between diverticulosis and colonic neoplastic lesions.Results: Data from 5050 subjects (males: 52.2%; mean age: 61.7±6.5 years) observed in the 7 participating centers were considered. Diverticula were found in 2176 (43.1%) cases; at least 1 adenoma was detected in 2277 (45.1%) patients, at least 1 advanced adenoma in 842 (16.7%); and cancer was diagnosed in 159 (3.1%) cases. By univariate analysis, the prevalence of adenomas in patients with diverticula (46.7%, 95% confidence interval [CI] 44.6-48.8%) was significantly higher than in controls (43.8%, 95%CI 42.1-45.7%; P=0.041), while prevalences of both advanced adenomas (13.8%, 95%CI 16.3-19.5%) and cancers (2.4%, 95%CI 1.7-3.1% vs. 3.7%, 95%CI 3.1-4.4%) were lower. By multivariate analysis, only male sex (odds ratio [OR] range: 1.54-2.05) and age (OR range: 1.03-1.05) were found to be independent variables associated with different neoplastic lesions in the colon, whilst diverticulosis was not.Conclusion: This large, multicenter study found no significant association between diverticulosis and neoplastic lesions in subjects who underwent screening colonoscopy.","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"38 1","pages":"68-71"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The treatment interventions and targets of cancer cachexia research during the past decade: a systematic review of the literature. 近十年来癌症恶病质研究的治疗干预和目标：文献系统综述。

IF 2.1

Annals of Gastroenterology Pub Date : 2025-01-01 Epub Date: 2024-10-20 DOI: 10.20524/aog.2024.0918

Panagiotis Filis, Dimitrios Peschos, Yannis V Simos, Nikolaos Filis, Christianna Zachariou, Dimitrios Stagikas, Konstantinos I Tsamis

{"title":"The treatment interventions and targets of cancer cachexia research during the past decade: a systematic review of the literature.","authors":"Panagiotis Filis, Dimitrios Peschos, Yannis V Simos, Nikolaos Filis, Christianna Zachariou, Dimitrios Stagikas, Konstantinos I Tsamis","doi":"10.20524/aog.2024.0918","DOIUrl":"10.20524/aog.2024.0918","url":null,"abstract":"Background: Cachexia is a detrimental multifactorial syndrome that has been strongly associated with cancer. A growing body of data concerning its management is being generated from the ongoing advances of experimental cancer cachexia research. This study aimed to delineate the broad landscape of cancer cachexia research, by comprehensively presenting the treatment interventions and targets of cancer cachexia during the past decade.Methods: A systematic literature search was performed in Medline and Scopus databases from January to April 2023. Articles were considered eligible if they described any type of intervention in tumor-bearing rodents to study the effect on prevention or treatment of cancer cachexia. The corresponding signaling and metabolic pathways that were targeted by these interventions were documented.Results: A total of 271 articles were considered eligible for our study. Of these, 176 studies pertained to pharmaceutical interventions with 100 corresponding targets, 58 studies pertained to nutritional interventions with 60 corresponding targets, and 37 studies pertained to exercise interventions with 60 corresponding targets.Conclusions: The continuous evolution of cancer cachexia research has provided a plethora of disease targets and corresponding treatment interventions. Moving forward, the available management strategies should be refined and clinical research should efficiently capitalize on the robust experimental evidence.","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"38 1","pages":"85-92"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simethicone with or without N-acetylcysteine as premedication in esophagogastroduodenoscopy: a systematic review and meta-analysis. 加或不加n -乙酰半胱氨酸的西甲硅氧烷作为食管胃十二指肠镜检查前用药：一项系统回顾和荟萃分析。

IF 2.1

Annals of Gastroenterology Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.20524/aog.2024.0930

Caroline Tanadi, Fegita Beatrix Pajala, Yehuda Tri Nugroho Supranoto, Kevin Tandarto, Maureen Miracle Stella, Randy Adiwinata, Paulus Simadibrata, Marcellus Simadibrata

{"title":"Simethicone with or without N-acetylcysteine as premedication in esophagogastroduodenoscopy: a systematic review and meta-analysis.","authors":"Caroline Tanadi, Fegita Beatrix Pajala, Yehuda Tri Nugroho Supranoto, Kevin Tandarto, Maureen Miracle Stella, Randy Adiwinata, Paulus Simadibrata, Marcellus Simadibrata","doi":"10.20524/aog.2024.0930","DOIUrl":"10.20524/aog.2024.0930","url":null,"abstract":"Background: The impairment of gastrointestinal mucosa visibility during esophagogastroduodenoscopy (EGD), due to the presence of foam and bubbles, may lead to reduced quality in the EGD results. The combination of simethicone, a defoaming agent, along with N-acetylcysteine (NAC), which has mucolytic properties, has been proposed to improve the visibility of the mucosa. This study aimed to evaluate the effectiveness of pre-procedural administration of simethicone and N-acetylcysteine in improving mucosal visibility, procedure time and mucosal cleansing volume needed during EGD.Methods: We conducted a comprehensive literature search from inception to November 23, 2023, in PubMed, CENTRAL, ProQuest, SAGE, and JSTOR. We included randomized clinical trials that investigated the effects of simethicone with or without NAC as premedication in EGD. For the quantitative analysis, standardized mean difference (SMD) was used to assess continuous outcomes and risk ratio for dichotomous outcomes. The Cochrane risk of bias 2 tool was used to evaluate the risk of bias.Results: This meta-analysis comprised a total of 20 studies and found that simethicone with or without NAC improved mucosal visibility compared with control (SMD -1.27, 95% confidence interval [CI] -1.74 to -0.81, P<0.001). The combination of simethicone and NAC was significantly better than simethicone alone (SMD -0.68, 95%CI -1.08 to -0.28, P=0.001). Simethicone with or without NAC also shortened the procedure time compared to control (MD -1.40, 95%CI -2.67 to -0.12, P=0.03). The risk of bias was low with a moderate grade of certainty.Conclusion: The administration of simethicone with or without NAC may improve EGD quality.","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"38 1","pages":"28-40"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal cancer incidence after lung transplantation in sarcoidosis patients. 结节病患者肺移植后胃肠道肿瘤的发病率。

IF 2.1

Annals of Gastroenterology Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.20524/aog.2024.0932

Graham Saeed, Tierra Sanders, Dmitry Tumin, Ogugua N Obi, Stanley Oghoghorie, Hassam Ali, Douglas G Adler

{"title":"Gastrointestinal cancer incidence after lung transplantation in sarcoidosis patients.","authors":"Graham Saeed, Tierra Sanders, Dmitry Tumin, Ogugua N Obi, Stanley Oghoghorie, Hassam Ali, Douglas G Adler","doi":"10.20524/aog.2024.0932","DOIUrl":"10.20524/aog.2024.0932","url":null,"abstract":"Background: The risk of gastrointestinal (GI) cancer after lung transplantation (LTx) in sarcoidosis patients is not well defined. Given the cancer risks linked to sarcoidosis and organ transplantation, this study investigated the incidence of GI de novo malignancies (DNM), comparing LTx recipients with sarcoidosis or idiopathic pulmonary fibrosis (IPF).Methods: We analyzed data from the United Network for Organ Sharing registry, including adults with sarcoidosis or IPF who underwent LTx between May 2005 and December 2018. The primary outcome was the incidence of GI DNM by March 2023.Results: Of 7996 lung transplant recipients, 108 (1.35%) developed GI malignancies post-transplantation. Among these, 662 patients (9%) had sarcoidosis and 7334 (91%) had IPF. Sarcoidosis patients showed a non-significant trend toward a higher risk of GI malignancies compared to those with IPF (subhazard ratio 1.72, 95% confidence interval 0.90-3.29; P=0.099), with no observed difference in the risk of non-GI cancers.Conclusions: The overall incidence of GI DNM following LTx is low, and sarcoidosis does not appear to increase the risk of GI cancers compared to IPF. This finding suggests that enhanced GI cancer screening beyond standard guidelines may not be warranted in this population, allowing for targeted surveillance of more prevalent malignancies in sarcoidosis patients post-LTx.","PeriodicalId":7978,"journal":{"name":"Annals of Gastroenterology","volume":"38 1","pages":"80-84"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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