Alchemy: Jurnal Penelitian Kimia最新文献

{"title":"Sintesis Katalis Fe/SOD Berbasis Lempung Alam Maredan Untuk Mendegradasi Zat Warna Metilen Biru","authors":"Elis Damayanti, A. Awaluddin, Muhdarina Muhdarina","doi":"10.20961/ALCHEMY.17.2.47874.%P","DOIUrl":"https://doi.org/10.20961/ALCHEMY.17.2.47874.%P","url":null,"abstract":"Zeolit merupakan material yang sangat aplikatif yang dapat disintesis dengan bahan baku yang kaya akan silika ataupun alumina. Lempung Maredan termasuk sumber daya alam Riau yang mengandung silika dan alumina dan telah diubah menjadi zeolit jenis sodalit (SOD). Namun, sodalit yang dihasilkan masih memiliki kristalinitas rendah dan belum diujiaplikasikan. Dalam penelitian ini, SOD disintesis and dilanjutkan dengan impregnasi Fe menggunakan prekursor Fe(NO3)3.9H2O dan kalsinasi pada 400 °C selama 4 jam. Padatan yang terbentuk dikarakterisasi secara XRD, EDX dan FTIR untuk menentukan struktur, kristalinitas, ukuran kristal, jumlah Fe yang terimpregnasi serta pita vibrasi Fe. Padatan ini diperankan sebagai katalis untuk degradasi zat warna metilen biru. Hasil karakterisasi menunjukkan bahwa material baru yang terbentuk adalah mineral SOD dan hematit. Kristalinitas SOD dan SOD dalam Fe/SOD berturut-turut 49,62% dan 25,49% dengan ukuran kristal masing-masing 52,50 nm dan 4,40 nm. Keberhasilan impregnasi dibuktikan oleh analisis EDX dengan meningkatnya jumlah atom Fe pada Fe/SOD dari 1,46% hingga 22,80% serta munculnya pita vibrasi FeO dan Al‒Fe‒OH masing-masing pada bilangan gelombang 430 ‒ 470 cm-1 dan 3640 ‒ 3660 cm-1 berdasarkan analisis FTIR. Katalis Fe/SOD mampu mendegradasi zat warna metilen biru sebanyak 98,80% dalam waktu 10 menit dengan dosis katalis 0,5 gL-1.Synthesis of Fe/SOD Catalyst Based on Maredan Natural Clay to Degrade Methylene Blue Dye. Zeolite is a highly applicable material that can be synthesized using silica or alumina-rich raw materials. Maredan clay is one of Riau's natural resources, which contains silica and alumina and has been converted to zeolite sodalite (SOD). However, the resulted sodalite still possesses low crystallinity and has not been tested. In this study, SOD was synthesized and was followed by the impregnation of Fe using Fe(NO3)3.9H2O as a precursor and calcination at 400 °C for 4 hours. The solid formed was characterized by XRD, EDX, and FTIR to determine the structure, crystallinity, crystal size, amount of impregnated Fe, and vibration band of Fe. The solid was then used as the catalyst for methylene blue degradation. The characterization result indicated that the newly formed materials were composed by SOD and hematite. The crystallinity of SOD and SOD in Fe/SOD were 49.62% and 25.49% respectively, with the crystal size of 52.50 nm and 4.40 nm, respectively. The impregnation result was confirmed by EDX analysis marked by the increase of the number of Fe atoms in Fe/SOD from 1.46% to 22.80%, as well as the presence FeO and Al‒Fe‒OH vibration bands at the wavenumbers of 430 ‒ 470 cm-1 and 3640 ‒ 3660 cm-1, respectively, based on FTIR analysis. The Fe/SOD catalyst was able to reduce of methylene blue dye by 98.80% for 10 minutes with the catalyst dose of 0.5 gL-1.","PeriodicalId":7926,"journal":{"name":"Alchemy: Jurnal Penelitian Kimia","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87086311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studi Transisi Fasa Polimorf Poliviniliden Fluorida Pada Membran Hibrida Poliviniliden Fluorida/Bentonit dengan Analisis Termal","authors":"M.Si Edi Pramono, R. Mustofa, Ozi Adi Saputra, Yulianto Adi Nugroho, Deana Wahyunigrum, C. Radiman, Sayekti Wahyuningsiha, Teguh Endah Saraswati, Sentot Budi Rahardjo, W. Lestari, Dian Maruto Widjonarko, Ari Handono Ramlan","doi":"10.20961/ALCHEMY.17.2.46136.%P","DOIUrl":"https://doi.org/10.20961/ALCHEMY.17.2.46136.%P","url":null,"abstract":"Preparasi membran hibrida PVDF/lempung bentonit (BNT) dan trasnformasi struktur fasa polimofnya telah dikaji secara komprehensif.  Membran hibrida dengan variasi konsentrasi BNT dipreparasi menggunakan metode inversi fasa. Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR), X-Ray Diffraction (XRD), dan Differential Scanning Calorimetry (DSC) digunakan untuk mengkarakterisasi membran hibrida. Data menunjukkan bahwa membran hibrida tersusun atas fasa α dan β dari struktur polimof PVDF yang terkonfirmasi oleh analisis ATR-FTIR dan XRD. Penambahan BNT mempengaruhi sifat termal, seperti temperatur leleh dan kristalisasi, dari membran hibrida. Temperatur leleh sedikit menurun dengan meningkatnya konsentrasi BNT, akan tetapi bertolak belakang untuk temperature kristalisasi. Selain itu, keberadaan BNT mereorientasi struktur fasa PVDF lebih homogen, dibandingkan PVDF yang memiliki fasa heterogen (fasa α dan β), yang dikaji secara mendalam  menggunakan DSC. Oleh karena itu, analisis DSC merupakan instrument yang bermanfaat untuk menentukan lebih lanjut struktur fasa polimof dari PVDF, yang secara langsung berdampak terhadap studi performa membran.","PeriodicalId":7926,"journal":{"name":"Alchemy: Jurnal Penelitian Kimia","volume":"42 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72630169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifikasi Aktivitas Inhibitor Enzim Tirosinase Senyawa Turunan Flavonoid pada Kulit Buah Cokelat (Theobroma cacao L) secara In Silico","authors":"Sani Ega Priani, T. M. Fakih","doi":"10.20961/ALCHEMY.17.2.45317.%P","DOIUrl":"https://doi.org/10.20961/ALCHEMY.17.2.45317.%P","url":null,"abstract":"<p id=\"docs-internal-guid-fa145b0a-7fff-0af1-a074-1cbfd7cb8daf\" style=\"line-height: 1.2; margin-left: 0.35pt; margin-right: -0.1pt; text-align: justify; margin-top: 6pt; margin-bottom: 6pt;\" dir=\"ltr\"><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Limbah kulit buah cokelat diketahui mengandung berbagai senyawa aktif, termasuk di antaranya adalah golongan flavonoid. Senyawa flavonoid diketahui berpotensi memiliki aktivitas inhibitor enzim tirosinase, suatu enzim yang menstimulasi proses pembentukan melanin. Penelitian ini bertujuan untuk mengevaluasi interaksi antara senyawa flavonoid dari kulit buah cokelat dengan enzim tirosinase menggunakan metode penambatan molekuler secara </span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">in silico</span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">. Pengujian dilakukan dengan beberapa tahapan yakni preparasi makromolekul enzim, pemodelan molekul senyawa uji, identifikasi sisi aktif molekul enzim, identifikasi dan evaluasi penambatan molekuler, serta simulasi dinamika molekuler senyawa uji dengan molekul enzim. Hasil simulasi penambatan molekuler antara molekul enzim dengan ligan alaminya yakni tirosin memberikan energi ikatan sebesar -4,91 kkal/mol. Senyawa flavonoid dari kulit buah cokelat yakni apigenin, epikatekin, katekin, kaemferol, kuersetin, dan kuersitrin  diketahui memiliki afinitas pada sisi aktif enzim tirosinase dengan energi ikatan berturut turut -6,14; -6,17; -6,01; -5,89; -6,13; -6,81 kkal/mol. Hasil simulasi dinamika molekuler menunjukkan kuersitrin memiliki stabilitas yang baik dengan nilai RMSD rata-rata dan nilai energi bebas ikatan MM/PBSA masing-masing sebesar ±1,73 Å dan -80,12 kJ/mol. Hasil penelitian menunjukkan bahwa senyawa turunan flavonoid tersebut mampu berikatan dengan sisi aktif enzim tirosinase dengan afinitas yang lebih baik dibandingkan dengan ligan alaminya diamati dari nilai energi ikatannya. Senyawa turunan flavonoid yang terkandung dalam kulit buah cokelat berpotensi menjadi inhibitor kompetitif dari enzim tirosinase.</span></p><p style=\"line-height: 1.2; margin-left: 0.35pt; margin-right: -0.1pt; text-align: justify; margin-top: 6pt; margin-bottom: 6pt;\" dir=\"ltr\"><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-sp","PeriodicalId":7926,"journal":{"name":"Alchemy: Jurnal Penelitian Kimia","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89650916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Limonoid from the Seeds of Chisocheton lasiocarpus (Meliaceae)","authors":"Ronauli Fitriana, N. Nurlelasari, Darwati Darwati, D. Harneti, R. Maharani, T. Mayanti, U. Supratman","doi":"10.20961/ALCHEMY.17.2.44782.%P","DOIUrl":"https://doi.org/10.20961/ALCHEMY.17.2.44782.%P","url":null,"abstract":"<p> <strong>A</strong><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> New Limonoid from the Seeds of </span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: bold; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Chisocheton lasiocarpus</span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> (Meliaceae). </span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Chisocheton</span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> is one of Meliaceae genus, which has about 53 species spreading in subtropical and tropical regions. One of the species is </span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Chisocheton lasiocarpus</span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">. </span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Chisocheton</span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> is rich in limonoids that have various biological activities such as anticancer, antimalarial, anti-inflammatory, antifeedant, antiviral, neuroprotective, and antimicrobial properties. This study aims to isolate limonoids from the seeds </span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">of C","PeriodicalId":7926,"journal":{"name":"Alchemy: Jurnal Penelitian Kimia","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76724278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Molecular Docking Study of 4-(3-(2-Chlorophenyl)-5-(2-Methoxyphenyl)-4,5-Dihydro-1H-Pyrazol-1-yl) Benzenesulfonamide as Antibreast Cancer Agent","authors":"Eka Marisa Putri, Noval Herfindo, G. Guntur, N. Frimayanti, A. Zamri","doi":"10.20961/ALCHEMY.17.2.48298.%P","DOIUrl":"https://doi.org/10.20961/ALCHEMY.17.2.48298.%P","url":null,"abstract":"Breast cancer is a disease in which cells in the breast tissue change and divide in an uncontrolled way. Pyrazoline is a promising agent reported against cancer. In this work, we have synthesized pyrazoline 4-(3-(2-chlorophenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide (EMP-1). The reaction was successfully carried out in one-pot three components from 2-chloroacetophenone, 2-methoxybenzaldehyde, and 4-hydrazinylbenzenesulfonamide as starting materials. The reaction was conducted by assisting the irradiation of Monowave 50 (Anton-Paar) with a high yield of 91%. Its potential anti-breast cancer was investigated by molecular docking and dynamic studies. The molecular docking study showed that EMP-1 had binding energy of -7.17 kcal/mol. The spatial arrangement of EMP-1 was similar to the positive control of doxorubicin. These results indicate that EMP-1 compound potentially developed as anti-breast cancer.","PeriodicalId":7926,"journal":{"name":"Alchemy: Jurnal Penelitian Kimia","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79404704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Produksi Bioetanol sebagai Energi Terbarukan dari Rumput Laut Ulva reticulata Asal Pulau Timor","authors":"Sefrinus Maria Dolfi Kolo","doi":"10.20961/ALCHEMY.17.2.45476.%P","DOIUrl":"https://doi.org/10.20961/ALCHEMY.17.2.45476.%P","url":null,"abstract":"Rumput laut dengan kandungan karbohidrat dan lipid yang tinggi dianggap menjadi sumber energi terbarukan generasi ketiga. Penelitian ini bertujuan menentukan kadar gula pereduksi optimum, mengetahui tekstur permukaan serbuk sebelum dan sesudah hidrolisis serta menentukan kadar etanol hasil fermentasi. Kandungan karbohidrat rumput laut Ulva reticulata dapat dikonversi menjadi gula heksosa dan pentosa (glukosa, arabinosa, ramnosa, dan xilosa) melalui hidrolisis asam. Campuran gula optimum hasil proses hidrolisis kemudian dikonversi menjadi etanol menggunakan ragi Saccharomyces cerevisiae. Fermentasi dilakukan dengan konsentrasi inokulum 10% (v/v) selama 5 hari pada temperatur 30 °C dan pH 4,5. Analisis tekstur permukaan sampel dilakukan dengan Scanning Electron Microscopy (SEM). Analisis gula pereduksi dilakukan dengan metode DNS (Dinitro salisilat). Analisis etanol dilakukan dengan uji kualitatif dan kuantitatif menggunakan metode berat jenis dan kromatografi gas. Hasil penelitian menunjukkan bahwa kadar gula pereduksi meningkat seiring meningkatnya suhu hidrolisis pada suhu      75 °C ke 150 °C (2,3 – 23,7 g/L) dan mengalami penurunan kadar pada suhu 175 °C menjadi 17,1 g/L. Hasil analisis dengan variasi konsentrasi terhadap waktu 30, 40, 50, dan 60 menit terlihat bahwa kadar gula pereduksi meningkat seiring meningkatnya waktu hidrolisis dari 30 menit sampai 50 menit yakni 23,7 – 33,4 g/L dan mengalami penurunan pada waktu 60 menit yakni 19,2 g/L. Kadar gula pereduksi optimum sebesar 33,4 g/L  pada suhu 150 °C dengan konsentrasi asam 2 % pada waktu hidrolisis 50 menit. Tekstur permukaan serbuk sebelum dan sesudah hidrolisis mengalami perubahan yang signifikan. Hasil uji kualitatif etanol hasil fermentasi dibuktikan dengan adanya perubahan warna dari jingga menjadi biru. Hasil uji kadar etanol dengan metode berat jenis yakni sebesar 1% dan metode kromatografi gas sebesar 5,02%. Bioethanol Production as Renewable Energy from Ulva Reticulata Seaweed from Timor Island. Seaweed with carbohydrate and lipid content is considered to be the third generation of renewable energy sources. The carbohydrate content of Ulva reticulata seaweed can be converted into hexose and pentose sugars (glucose, arabinose, ramnose, and xylose) through acid hydrolysis. The optimum sugar mixture resulting from the hydrolysis process is then converted to ethanol using Saccharomyces cerevisiae yeast. Fermentation was carried out with an inoculum concentration of 10% (v/v) for five days at a temperature of 30 °C and a pH of 4.5. Analysis of the surface texture of the sample was carried out by Scanning Electron Microscopy (SEM). Reducing sugar analysis was performed using the DNS (Dinitrosalicylate) method. Ethanol analysis was carried out by qualitative and quantitative tests using specific gravity and gas chromatography methods. The results showed that the reducing sugar content increased with increasing hydrolysis temperature at 75 °C to 150 °C (2.3 – 23.7 g/L) and decreased l","PeriodicalId":7926,"journal":{"name":"Alchemy: Jurnal Penelitian Kimia","volume":"219 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79786134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradasi Pewarna Tekstil Rhodamin B oleh Bakteri Pembentuk Biofilm","authors":"Nurlela Yanti, Sitti Wirdhana Ahmad, Fatimah Alwi Albakar","doi":"10.20961/ALCHEMY.17.2.49010.151-158","DOIUrl":"https://doi.org/10.20961/ALCHEMY.17.2.49010.151-158","url":null,"abstract":"<p id=\"docs-internal-guid-91ba8b82-7fff-b26e-92e4-41a17a9eec57\" style=\"line-height: 1.2; margin-left: 0.35pt; margin-right: -0.1pt; text-align: justify; margin-top: 6pt; margin-bottom: 6pt;\" dir=\"ltr\"><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Rhodamin B merupakan salah satu pewarna yang paling sering digunakan pada industri tekstil. Limbah pewarna tekstil ini dapat mencemari lingkungan jika masuk ke lingkungan melebihi ambang batas normal. Penggunaan bakteri pembentuk biofilm sebagai agensia pendegradasi Rhodamin B sangat memungkinkan karena mampu meningkatkan degradasi senyawa melalui interaksi antar bakteri sehingga mampu melengkapi proses metabolik. Tujuan penelitian ini adalah untuk mengetahui kemampuan isolat bakteri lokal pembentuk biofilm dalam mendegradasi pewarna tekstil Rhodamin B. Penelitian ini menggunakan 3 isolat bakteri pembentuk biofilm yang diperoleh dari perairan Tanjung Tiram, Kabupaten Konawe Selatan, Sulawesi Tenggara, yaitu isolat bakteri </span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Chromohalobacter</span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">sp.</span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> BfTT2.1.5, </span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Bacillus</span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">sp. </span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">BfTT2.11 dan </span><span style=\"font-size: 8.5pt; font-family: 'Times New Roman'; color: #000000; background-color: transparent; font-weight: 400; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Vibrio</span><span","PeriodicalId":7926,"journal":{"name":"Alchemy: Jurnal Penelitian Kimia","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90833658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolasi Senyawa Metabolit Sekunder dari Ekstrak Metanol Kulit Batang Bauhinia semibifida Roxb. dan Uji Aktivitas Antioksidan","authors":"Haiyul Fadhli, Nuril Rohmatul Ummah, Noveri Rahmawati","doi":"10.20961/ALCHEMY.17.1.42268.132-139","DOIUrl":"https://doi.org/10.20961/ALCHEMY.17.1.42268.132-139","url":null,"abstract":"Kulit batang Bauhinia semibifida Roxb. telah lama digunakan sebagai obat tradisional oleh masyarakat Melayu Lingga, Kepulauan Riau. Penelitian ini bertujuan untuk mengisolasi dan menguji aktivitas antioksidan senyawa metabolit sekunder dari ekstrak metanol kulit batang B. semibifida Roxb. Tiga isolat murni berupa satu senyawa alkaloid (BR1) dan dua senyawa flavonoid (BR2 dan BR3) telah berhasil diisolasi dengan cara ekstraksi menggunakan metode maserasi dan dilanjutkan fraksinasi dengan metode kromatografi kolom. Uji aktivitas antioksidan dilakukan terhadap isolat dengan metode 2,2 difenil-1-pikrilhidrazil (DPPH). Senyawa isolat BR1 menunjukan IC 50 >1000 µg/mL dikategorikan tidak aktif sebagai antioksidan, sedangkan senyawa isolat BR2 dan BR3 menunjukan IC 50 2,92 µg/mL dan 4,39 µg/mL dikategorikan sangat kuat sebagai antioksidan jika dibandingkan dengan vitamin C sebagai kontrol. Berdasarkan evaluasi aktivitas antioksidan senyawa BR2 adalah senyawa pilihan yang dilanjutkan identifikasi dengan spektroskopi Fourier-Transform Infrared Spectroscopy ( FTIR ) dan Proton Nuclear Magnetic Resonance ( 1 H-NMR) sehingga diduga senyawa isolat memiliki struktur dasar senyawa flavonoid. Isolation of Secondary Metabolite Compounds of Methanolic Extract of Steam Bark Bauhinia semibifida Roxb. and Their Antioxidant Activites . Stem bark of Bauhinia semibifida Roxb. has been long consumed as a medicinal herb by Lingga Malaya Ethnic. Therefore, this research aimed to isolate and examines the antioxidant activity of secondary metabolites from methanol extract of stembark of Bauhinia semibifida Roxb. Three pure compounds which are an alkaloid (BR1) and two flavonoids (BR2 and BR3) have been isolated by extraction using maceration method followed by fractionation using column chromatography method. Antioxidant activity assay was carried out by 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method. Compound BR1 showed IC 50 >1000 µg/mL categorized as inactive as an antioxidant, while compounds BR2 and BR3 showed IC 50 2.92 µg/mL and 4.394 µg/mL, respectively, categorized as very strong as an antioxidant when compared to vitamin C as a control. Based on the evaluation of the antioxidant activity, the BR2 was selected compound and continued to identification by Fourier-Transform Infrared Spectroscopy ( FTIR ) and Proton Nuclear Magnetic Resonance ( 1 H-NMR) spectroscopy so that the isolate has the basic structure of flavonoid compound.","PeriodicalId":7926,"journal":{"name":"Alchemy: Jurnal Penelitian Kimia","volume":"648 1","pages":"132-139"},"PeriodicalIF":0.0,"publicationDate":"2021-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77537361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membran Alginat Padina sp. - Polietilen Glikol (AP-PEG): Preparasi, Karakterisasi dan Aplikasinya sebagai Enkapsulan","authors":"H. Herlina, Aswin Falahudin, Irfan Gustian, A. Putranto, Morina Adfa, S SalprimaYudha","doi":"10.20961/ALCHEMY.17.1.41713.63-73","DOIUrl":"https://doi.org/10.20961/ALCHEMY.17.1.41713.63-73","url":null,"abstract":"Pengembangan penelitian tentang material berbasiskan sumber daya alam lokal dan dapat diperbaharui terus dikembangkan akhir-akhir ini. Hal tersebut didasari adanya kebutuhan material baru dengan karakteristik yang lebih menguntungkan dan dapat digunakan pada aplikasi yang spesifik. Penelitian ini bertujuan untuk mempelajari preparasi membran alginat-polietilen glikol (AP-PEG) dan aplikasinya sebagai enkapsulan. Alginat yang digunakan adalah hasil ekstraksi dari rumput laut cokelat Padina sp. Dengan metode maserasi jalur asam alginat. Preparasi membrane alginat Padina sp. -polietilen glikol (AP-PEG) dilakukan dengan perbandingan PEG-AP = 1:5; 1:10; 1:15; 0:1 (b/b). Analisis gugus fungsi terhadap seluruh membran yang dihasilkan, menunjukkan bahwa membran AP-PEG yang dihasilkan diprediksi sebagai hasil blending secara fisika karena tidak ada gugus fungsi baru yang terbentuk. Membran dengan perbandingan berat PEG-AP=1:15 memiliki karakteristik terbaik dengan persentase swelling sebesar 1465,5%, stress sebesar 14,588 MPa, strain 0,07 dan Modulus Young sebesar 193,13 MPa. Hasil analisis morfologi menunjukkan bahwa banyak rongga ditemukan pada membrane tersebut. Hasil uji disolusi terhadap membrane tersebut menunjukkan bahwa, pada pH 1,2 membran tersebut dapat melepaskan vitamin C sebesar 78,12% selama 60 menit dan tidak mengalami cracking . Di sisi lain, pada pH 7,2 membran tersebut dapat melepaskan vitamin C sebesar 83,54% dan cracking terjadi dalam waktu 12 menit. Hasil penelitian ini menunjukkan bahwa komposit AP-PEG dapat dibuat dari rumput laut coklat dan memiliki kemampuan sebagai enkapsulan.   Alginate Padina sp. - Polyethylene Glycol (AP - PEG) Membranes: Preparation, Characterization and Their Application as Encapsulant . The development of research on materials based on local and renewable natural resources has been continuously being developed recently. This is based on the need for new materials with more favorable characteristics and can be used in specific applications. This research aims to study the synthesis of alginate-polyethylene glycol (AP-PEG) membranes and their application as an encapsulant. The alginate was extracted from the brown seaweed Padina sp . by maceration method using alginic acid pathway. Alginate Padina sp. -polyethylene glycol (AP-PEG) alginate membrane was prepared with a ratio of PEG:AP = 1: 5, 1:10, 1:15 and 0:1 (w/w). The functional group analysis showed that the resulting AP-PEG membranes were predicted as a result of physical blending due to no new functional groups are formed. The membrane with a weight ratio of PEG:AP = 1:15 had the best characteristics, with a percentage of swelling of 1465.5%, stress of 14.588 MPa, 0.07 strain, and Young Modulus of 193.13 MPa. Morphological analysis showed that the membrane obtained had many cavities. The dissolution test showed that the AP-PEG membrane was able to release vitamin C of 78.12% for 60 minutes at pH 1.2 and no cracking was observed, while at pH 7.2 the membr","PeriodicalId":7926,"journal":{"name":"Alchemy: Jurnal Penelitian Kimia","volume":"43 1","pages":"63-73"},"PeriodicalIF":0.0,"publicationDate":"2021-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84846581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aktivitas Antioksidan dan Screening Fitokimia Kulit Bligo (Benincasa hispida)","authors":"Dini Nur Hakiki, Athiefah Fauziyyah, Sri Wijanarti","doi":"10.20961/ALCHEMY.17.1.38675.27-36","DOIUrl":"https://doi.org/10.20961/ALCHEMY.17.1.38675.27-36","url":null,"abstract":"Bligo ( Benincasa hispida ) merupakan tanaman yang tumbuh di daerah tropis dan subtropis. Buah bligo mengandung senyawa-senyawa aktif antara lain flavonoid, glikosida, karoten, vitamin, mineral, dan asam uronat. Penelitian di bidang farmakologi telah mengungkapkan bahwa buah bligo memberikan efek kesehatan, antara lain antidepressant , ansiolitik, antioksidan, antiinflamatori, diuretik, antidiabetik, dan antimikrobia. Namun penelitian di Indonesia mengenai kulit bligo masih sangat terbatas. Penelitian ini bertujuan untuk melakukan aktivitas antioksidan dan screening fitokimia pada kulit bligo. Kulit bligo dikeringkan kemudian digiling menjadi bubuk ukuran 100 mesh. Pengujian yang dilakukan adalah uji aktivitas antioksidan menggunakan DPPH, dan uji screening fitokimia kualitatif menggunakan LC-MS/MS QTOF. Aktivitas antioksidan pada kulit bligo adalah kelas medium dengan nilai IC 50 6,91 mg/mL. Dari hasil analisis LC-MS/MS QTOF diketahui bahwa kulit bligo mengandung 36 senyawa, dengan 5 senyawa dominannya adalah adenosin; polidatin; 7-(4-hidroksi-3-metoksifenil)-l-(4-hidroksifenil)-4E,6E-heptadien-3-on; morasin C; dan kushenol S. Hasil karakterisasi yang diperoleh menunjukkan bahwa kulit bligo berpotensi sebagai senyawa aktif. Antioxidant Activity and Phytochemical Screening of Peel Bligo ( Benincasa hispida ). Bligo ( Benincasa hispida ) is a plant that grows in tropical and subtropical regions. Bligo fruit contains active compounds such as flavonoids, glycosides, carotene, vitamins, minerals, and uronic acid. Research in the field of pharmacology has revealed that bligo fruit has health effects, including antidepressants, anxiolytics, antioxidants, anti-inflammatory, diuretics, antidiabetic, and antimicrobials. However, research on bligo peel is very limited. This study aims were to carry out antioxidant activity and phytochemical screening of bligo peel characteristics. Bligo’s peel was dried and ground into 100 mesh powder. Then antioxidant activity test using DPPH, and qualitative phytochemical screening test using LC-MS/MS QTOF were conducted. The bligo peel is medium class of antioxidant activity with IC 50 value was 6.91 mg/mL. From the results of LC-MS/MS QTOF analysis it was known that bligo skin contained 36 compounds, with 5 dominant compounds, namely adenosine; polydatin; 7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-4E, 6E-heptadien-3-one; moracin C; and kushenol S. The results of the characterization showed that bligo skin has the potential as a source of active compounds for further utilization.","PeriodicalId":7926,"journal":{"name":"Alchemy: Jurnal Penelitian Kimia","volume":"3 1","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"2021-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88568083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}