Animal Biotechnology最新文献_第4页

IF 1.7 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-07-03 DOI: 10.1080/10495398.2025.2528007

引用次数: 0

Quercetin alleviates metabolic-associated fatty liver disease by tuning hepatic lipid metabolism, oxidative stress and inflammation. 槲皮素通过调节肝脏脂质代谢、氧化应激和炎症来缓解代谢相关的脂肪肝疾病。

IF 1.7 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2024-12-24 DOI: 10.1080/10495398.2024.2442351

Ling Jiang, Rong Yi, Huan Chen, Shuwu Wu

{"title":"Quercetin alleviates metabolic-associated fatty liver disease by tuning hepatic lipid metabolism, oxidative stress and inflammation.","authors":"Ling Jiang, Rong Yi, Huan Chen, Shuwu Wu","doi":"10.1080/10495398.2024.2442351","DOIUrl":"https://doi.org/10.1080/10495398.2024.2442351","url":null,"abstract":"The natural flavonoid quercetin, which exhibits a range of biological activities, has been implicated in liver disease resistance in recent research. In vivo study attesting to quercetin's protective effect against metabolic-associated fatty liver disease (MAFLD) is inadequate, however. Here, our investigation explored the potential benefits of quercetin in preventing MAFLD in C57BL/6 mice fed a high-fat diet (HFD). The results revealed that quercetin ameliorated the aberrant enhancement of body and liver weight. The hepatic histological anomalie induced by MAFLD were also mitigated by quercetin. HFD-induced imbalance in serum LDL, HDL, AST, ALT, TG, and LDH was mitigated by quercetin. Mechanically, we found that quercetin improved lipid metabolism by reducing lipogenesis proteins including ACC, FASN, and SREBP-1c and enhancing β-oxidation proteins including PPARα and CPT1A. In vitro study demonstrated that quercetin regulated hepatic lipid metabolism by targeting SREBP-1c and PPARα. Additionally, quercetin enhanced the antioxidant capacity in HFD-treated mice by downregulating Nrf2 and HO-1 expressions and upregulating SOD and GPX1 expressions. The hyper-activation of inflammation was also restored by quercetin via eliminating the phosphorylation of IκBα and NF-κB p65. Collectively, our observations highlight that quercetin exerts hepatoprotective properties in MAFLD mice by regulating hepatic lipid metabolism, oxidative stress and inflammatory response.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"36 1","pages":"2442351"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional and microbiological effects of a microencapsulated probiotic consortium on the ruminal microbiota in vivo and in vitro systems. 微囊化益生菌联合体对体内和体外瘤胃微生物群的功能和微生物学影响。

IF 1.8 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-08-22 DOI: 10.1080/10495398.2025.2547345

Johanna Marcela Urán Velásquez, Mauricio Agudelo Rendón, Mariana Zapata, Wilyer García Arboleda, Sara Echeverri, Juan Camilo Arroyave Manco, Koen Venema, Juan Vasquez

{"title":"Functional and microbiological effects of a microencapsulated probiotic consortium on the ruminal microbiota in vivo and in vitro systems.","authors":"Johanna Marcela Urán Velásquez, Mauricio Agudelo Rendón, Mariana Zapata, Wilyer García Arboleda, Sara Echeverri, Juan Camilo Arroyave Manco, Koen Venema, Juan Vasquez","doi":"10.1080/10495398.2025.2547345","DOIUrl":"https://doi.org/10.1080/10495398.2025.2547345","url":null,"abstract":"Fistulated animals and rumen simulation systems are essential for evaluating the effects of ingredients like probiotics, proposed as sustainable alternatives to growth-promoting antibiotics in ruminant nutrition. This study assessed the impact of microencapsulated probiotics on the structure and functionality of an initial ruminal microbial community using in vivo (IVV) and in vitro (IVT) systems. The IVT system was inoculated with rumen fluid obtained from the cattle animal used as IVV system. Over time, both systems were analysed for short-chain fatty acid (SCFA) production, microbial composition and functionality using next-generation sequencing. Physicochemical parameters were consistent across both systems and the inoculum, with an increase in propionate concentration observed. Although the microbial composition of IVV and IVT systems was highly similar (Pearson correlation of 0.869), significant differences in B-diversity were noted (p value = 0.023). The systems also exhibited high similarity in enzymatic profiles (correlation: 0.971) and metabolic pathways (correlation: 0.938), despite differences in functional B-diversity. Both systems showed increased production of fibrolytic enzymes, enhancing feed efficiency. The use of microencapsulated probiotics induced both taxonomic and functional changes in the initial microbial community of the IVT and IVV systems, which can be linked to the zootechnical effects of using probiotics as additives in ruminal animal nutrition.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"36 1","pages":"2547345"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perilipin1 mediates milk fat synthesis in bovine mammary epithelial cells through SREBP1 phosphorylation. Perilipin1通过SREBP1磷酸化介导牛乳腺上皮细胞的乳脂合成。

IF 1.7 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-05-08 DOI: 10.1080/10495398.2025.2497915

Benshun Yang, Meng Wang, Zhangqing Wu, Jianbing Tan, Yanhong Meng, Taoping Zhang, Linsen Zan, Wucai Yang

{"title":"Perilipin1 mediates milk fat synthesis in bovine mammary epithelial cells through SREBP1 phosphorylation.","authors":"Benshun Yang, Meng Wang, Zhangqing Wu, Jianbing Tan, Yanhong Meng, Taoping Zhang, Linsen Zan, Wucai Yang","doi":"10.1080/10495398.2025.2497915","DOIUrl":"https://doi.org/10.1080/10495398.2025.2497915","url":null,"abstract":"This study investigates the role of Perilipin1 (PLIN1) in milk fat synthesis in bovine mammary epithelial cells (BMECs) and its regulatory mechanisms, aiming to provide a foundation for improving milk fat content through molecular breeding. BMECs were used as a model to analyze the effects of PLIN1 overexpression (OE-PLIN1) and interference (si-PLIN1) on milk fat synthesis and lipid-related gene expression using RT-qPCR, Western blot, and Oil Red O staining. Results show that OE-PLIN1 significantly enhances triglyceride (TAG) accumulation in BMECs (P < 0.01), upregulates lipid synthesis-related genes (such as PPARγ, C/EBPα, C/EBPβ, FABP4, FASN) (P < 0.05), and downregulates the mRNA expression of lipid breakdown-related genes (HSL, ATGL) (P < 0.05). Conversely, si-PLIN1 significantly reduces TAG accumulation (P < 0.05) and lowers the expression of lipid synthesis and breakdown genes (P < 0.05). Additionally, OE-PLIN1 combined with SREBP1 siRNA interference (si-SREBP1) did not have a significant impact on the mRNA and protein levels of SREBP1, but it significantly altered SREBP1's phosphorylation, indicating that SREBP1 interference inhibits PLIN1's effect on milk fat synthesis. This study suggests that PLIN1 promotes milk fat synthesis in BMECs via regulating SREBP1 activity, offering a new strategy for enhancing milk fat content in dairy cattle.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"36 1","pages":"2497915"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Composition and diversity of rumen mycobiota in Jiani yaks (Bos grunniens jiani): insights into microbial ecology and functions. 贾尼牦牛瘤胃菌群的组成和多样性：微生物生态学和功能研究

IF 1.7 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-03-12 DOI: 10.1080/10495398.2025.2476539

Yangji Cidan, Jia Wang, Hongzhuang Wang, Chang Xu, Yanbin Zhu, Muhammad Kasib Khan, Wangdui Basang, Kun Li

{"title":"Composition and diversity of rumen mycobiota in Jiani yaks (Bos grunniens jiani): insights into microbial ecology and functions.","authors":"Yangji Cidan, Jia Wang, Hongzhuang Wang, Chang Xu, Yanbin Zhu, Muhammad Kasib Khan, Wangdui Basang, Kun Li","doi":"10.1080/10495398.2025.2476539","DOIUrl":"10.1080/10495398.2025.2476539","url":null,"abstract":"This study aimed to explore the diversity and functions of rumen mycobiota in 14‑ (PLf) and 15‑rib (DLf) Jiani yaks using ITS sequencing. A total of 1,079,105 and 1,086,799 filtered sequences were obtained for the PLf and DLf groups, respectively, with 491 ASVs common to both. No significant difference regarding the α‑diversity of mycobiota within the two groups was observed. While β‑diversity analysis indicated that the abundance of fifteen (15) genera in the PLf group and two (2) genera in the DLf group was found to be significantly different (p < 0.05). 16S rRNA sequencing results indicated that at the phylum level, in 14 ribs yaks Ascomycota, Basidiomycota, and Olpidiomycota, while in 15 rib yaks, Neocallimastigomycota, Mortierellomycota, and Rozellomycota were found to be significantly different (p < 0.05). At the genus level, Rhodotorula, Kluyveromyces, Comoclathris, Arthrinium, Cladophialophora, Seimatosporium, Lambertella, and Sphacelotheca in 14 rib yaks, and Orpinomyces, Ustilago, Fusarium, Aspergillus, Caecomyces, Alternaria, Trichoderma and Acremonium in 15 rib yaks were found to be significantly (p < 0.05) different. Predictive functional analysis based on ruminal fungal DNA sequences from 15‑rib yaks (DLf) demonstrated that genes involved in energy metabolism were upregulated. This study sheds novel insights into how genetic variations influence gut mycobiota in Jiani yak.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"36 1","pages":"2476539"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cefoxitin inhibits the formation of biofilm involved in antimicrobial resistance MDR Escherichia coli. 头孢西丁抑制生物膜的形成参与抗微生物药耐多药大肠杆菌。

IF 1.7 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-03-23 DOI: 10.1080/10495398.2025.2480176

Hailan Ma, Dacheng Liu, Chen Song, Hongliang Fan, Weiguang Zhou, Hongxia Zhao

{"title":"Cefoxitin inhibits the formation of biofilm involved in antimicrobial resistance MDR Escherichia coli.","authors":"Hailan Ma, Dacheng Liu, Chen Song, Hongliang Fan, Weiguang Zhou, Hongxia Zhao","doi":"10.1080/10495398.2025.2480176","DOIUrl":"10.1080/10495398.2025.2480176","url":null,"abstract":"The study investigates the relationship between biofilm formation and antibiotic resistance in Escherichia coli (E. coli) isolated from calves. Using biochemical and molecular methods, we identified the isolates and assessed their biofilm-forming ability through an improved crystal violet staining method. The minimum inhibitory concentrations (MICs) of 18 antibiotics against the isolates were determined using the broth microdilution method. The impact of cefoxitin on biofilm formation was analyzed using laser scanning confocal microscopy (LSCM). Additionally, qRT-PCR was employed to evaluate the expression levels of biofilm-related genes (luxS, motA, fliA, pfs, and csgD) in response to varying cefoxitin concentrations. Results indicated a significant correlation between antimicrobial resistance (AMR) and biofilm formation ability. Cefoxitin effectively reduced biofilm formation of multidrug-resistant E. coli isolates at 1/2 and 1 MIC, with enhanced inhibition at higher concentrations. The QS-related genes luxS, pfs, motA, and fliA were downregulated, leading to decreased csgD expression. At 1/2 MIC, csgD expression was significantly reduced. In conclusion, cefoxitin inhibits biofilm formation in multidrug-resistant E. coli by down-regulating key genes, offering a potential strategy to mitigate resistance and control infections in calves caused by biofilm-positive E. coli isolates.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"36 1","pages":"2480176"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic analysis for cattle breeding improvement, progress and future perspectives in Peru: a review. 秘鲁牛种改良、进展和未来展望的基因组分析综述。

IF 1.8 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-08-31 DOI: 10.1080/10495398.2025.2547344

Deyanira Figueroa, Yolanda Romero, Lizeth A Heredia-Vilchez, Carlos Poemape, Wigoberto Alvarado, Carlos Quilcate

{"title":"Genomic analysis for cattle breeding improvement, progress and future perspectives in Peru: a review.","authors":"Deyanira Figueroa, Yolanda Romero, Lizeth A Heredia-Vilchez, Carlos Poemape, Wigoberto Alvarado, Carlos Quilcate","doi":"10.1080/10495398.2025.2547344","DOIUrl":"https://doi.org/10.1080/10495398.2025.2547344","url":null,"abstract":"Genomics offers a promising solution by enabling precise cattle selection and breeding to boost productivity and sustainability. In Peru, livestock plays a crucial role in the economy and food security. Despite its importance, the sector faces significant challenges, including poor pasture quality, limited conservation practices, a shortage of trained professionals, minimal use of genomic tools, and an incomplete understanding of the genetic potential of both native and introduced breeds. Since the 1940s, Peru has advanced in genetic improvement through artificial insemination, improved semen preservation, the establishment of a National Semen Bank, and the introduction of new breeds. Key developments have included embryo transfer, in vitro fertilization, and pioneering cloning efforts. Future perspectives for livestock genomics in Peru involve expanding bioinformatics capacity, improving genomic infrastructure, and integrating genomic selection into national breeding strategies. This review discusses the history, current status, challenges, and future perspectives of livestock genomics in Peru.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"36 1","pages":"2547344"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to Imidacloprid under variable conditions disturbs the muscle fatty acid profile of a fresh water non target fish: Labeo rohita. 在不同条件下接触吡虫啉会扰乱淡水非目标鱼类的肌肉脂肪酸谱：Labeo rohita。

IF 3.7 3区农林科学

Animal Biotechnology Pub Date : 2024-11-01 Epub Date: 2024-01-23 DOI: 10.1080/10495398.2024.2307020

Shazia Qadir, Muhammad Latif, Wen-Feng Wu, Fengqin Feng, Wadi B Alonazi, Arwah Amjad, Chien-Chin Chen, Zia Ur Rehman, Adil Khan, Furhan Iqbal

{"title":"Exposure to Imidacloprid under variable conditions disturbs the muscle fatty acid profile of a fresh water non target fish: Labeo rohita.","authors":"Shazia Qadir, Muhammad Latif, Wen-Feng Wu, Fengqin Feng, Wadi B Alonazi, Arwah Amjad, Chien-Chin Chen, Zia Ur Rehman, Adil Khan, Furhan Iqbal","doi":"10.1080/10495398.2024.2307020","DOIUrl":"10.1080/10495398.2024.2307020","url":null,"abstract":"Economy of Pakistan is heavily dependent upon agriculture and extensive use of pesticide is quiet common to enhance the crop yield. Imidacloprid is among the first choice pesticides in Pakistan and it has been reported that through run off along with water it ends up in water bodies affecting non target aquatic fauna. Through the present investigation, we are reporting the effects of Imidacloprid on the fatty acids composition of a non-target, commercially important carp: Labeo rohita. Fish were exposed to sub lethal concentration of Imidacloprid (120 mgL1) for 2, 4 and 8 days (short term) as well as for 16, 32 and 64 days (long term experimental conditions). Pesticide untreated controls were also maintained for each treatment. Following the specific Imidacloprid exposure, fatty acid composition (%) was determined in the muscle of all experimental groups by using gas chromatography. Fish exposed to Imidacloprid for 8 days had reduced Palmitic acid (p = 0.02) and elevated muscle Arachidic acid (p < 0.001) than control group. Labeo rohita exposed to the pesticide for 32 days had elevated muscle Oleic (p = 0.02) and Linoleic acid (p = 0.02) while fish exposed to Imidacloprid to 64 days had reduced muscle Palmitic (p = 0.04) and Oleic acid (p = 0.03). In conclusion, we are reporting that the exposure to sub lethal concentration of Imidacloprid disturb the muscle fatty acid composition of Labeo rohita that may affect its food quality. The effects were more pronounced under long term experimental conditions and were probably due to potentiating lipid peroxidation and disturbed fish metabolism upon Imidacloprid exposure.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":" ","pages":"2307020"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139519254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diversity assessment of a lesser known buffalo population from Central India and its comparative evaluation reveals presence of sufficient genetic variation and absence of selection. 对印度中部一个鲜为人知的水牛种群进行的多样性评估及其比较评价显示，该种群存在足够的遗传变异，而且没有经过选择。

IF 3.7 3区农林科学

Animal Biotechnology Pub Date : 2024-11-01 Epub Date: 2024-01-25 DOI: 10.1080/10495398.2024.2305550

Rajesh Kumar Gahlyan, Vikas Vohra, Supriya Chhotaray, R S Kataria

{"title":"Diversity assessment of a lesser known buffalo population from Central India and its comparative evaluation reveals presence of sufficient genetic variation and absence of selection.","authors":"Rajesh Kumar Gahlyan, Vikas Vohra, Supriya Chhotaray, R S Kataria","doi":"10.1080/10495398.2024.2305550","DOIUrl":"10.1080/10495398.2024.2305550","url":null,"abstract":"Planned breeding and conservation strategies for a lesser-known population require an assessment of complete genetic diversity and population structure analysis in addition to its morphometric characteristics. In the present study, a comparative analysis of the genetic structure of a rare buffalo population, namely Chhattisgarhi, was extensively studied using a panel of FAO-recommended microsatellite markers along with well-established breeds namely Murrah, Nili-Ravi, Gojri, Kalahandi, and Nagpuri. Mode shift analysis indicated the absence of genetic bottleneck in the recent past. Assessment of genetic diversity indices across all loci indicated the presence of sufficient genetic variation within and between populations. Analysis of molecular variance between the six different buffalo populations attributed 19.05% of the variations to between-population differentiation. Cluster analyses using DAPC and Bayesian approach along with the phylogenetic tree based on UPGMA grouped six populations into three groups. The Chhattisgarhi population was revealed to be genetically closer to Nagpuri and Kalahandi populations. The study reveals the presence of sufficient genetic diversity within the Chhattisgarhi population and indicates the absence of a systematic selection program. We suggest improvement and conservation programs should be planned for this breed in the near future through short-term selection.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":" ","pages":"2305550"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postbiotic, anti-inflammatory, and immunomodulatory effects of aqueous microbial lysozyme in broiler chickens. 水溶液微生物溶菌酶对肉鸡的益生菌后作用、抗炎作用和免疫调节作用。

IF 3.7 3区农林科学

Animal Biotechnology Pub Date : 2024-11-01 Epub Date: 2024-02-07 DOI: 10.1080/10495398.2024.2309955

Mustafa Bastamy, Ismail Raheel, Ahmed Elbestawy, Mohamed Diab, Enas Hammad, Lamiaa Elebeedy, Amal M El-Barbary, Ghadeer M Albadrani, Mohamed M Abdel-Daim, Mervat A Abdel-Latif, Ahmed Orabi

{"title":"Postbiotic, anti-inflammatory, and immunomodulatory effects of aqueous microbial lysozyme in broiler chickens.","authors":"Mustafa Bastamy, Ismail Raheel, Ahmed Elbestawy, Mohamed Diab, Enas Hammad, Lamiaa Elebeedy, Amal M El-Barbary, Ghadeer M Albadrani, Mohamed M Abdel-Daim, Mervat A Abdel-Latif, Ahmed Orabi","doi":"10.1080/10495398.2024.2309955","DOIUrl":"10.1080/10495398.2024.2309955","url":null,"abstract":"Lysozymes, efficient alternative supplements to antibiotics, have several benefits in poultry production. In the present study, 120, one-day-old, Ross 308 broiler chickens of mixed sex, were allocated into 2 equal groups, lysozyme treated group (LTG) and lysozyme free group (LFG), to evaluate the efficacy of lysozyme (Lysonir®) usage via both drinking water (thrice) and spray (once). LTG had better (p = 0.042) FCR, and higher European production efficiency factor compared to LFG (p = 0.042). The intestinal integrity score of LTG was decreased (p = 0.242) compared to that of LFG; 0.2 vs. 0.7. Higher (p ≤ 0.001) intestinal Lactobacillus counts were detected in chickens of LTG. Decreased (p ≤ 0.001) IL-1β and CXCL8 values were reported in LTG. The cellular immune modulation showed higher (p ≤ 0.001) opsonic activity (MΦ and phagocytic index) in LTG vs. LFG at 25 and 35 days. Also, higher (p ≤ 0.001) local, IgA, and humoral, HI titers, for both Newcastle, and avian influenza H5 viruses were found in LTG compared to LFG. In conclusion, microbial lysozyme could improve feed efficiency, intestinal integrity, Lactobacillus counts, anti-inflammatory, and immune responses in broiler chickens.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":" ","pages":"2309955"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139696820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0