Andrologia最新文献

{"title":"Ameliorating Effects of Curcumin on Testicular Cancer","authors":"Reza Arefnezhad,&nbsp;Pouya Goleij,&nbsp;Negar Heydari,&nbsp;Fatemeh Rezaei-Tazangi,&nbsp;Hossein Motedayyen","doi":"10.1155/2023/4558299","DOIUrl":"10.1155/2023/4558299","url":null,"abstract":"<div>\u0000 <p>In the young men’s population, testicular cancer (TC) is characterized as one of the main causes of morbidity and mortality around the world. This cancer is mainly divided into germ cell and nongerm cell types and manifests different signs and symptoms, like bone pain, nausea, lower back pain, and anorexia. Also, TC is associated with serious conditions, such as urogenital disorders, infertility, cardiovascular diseases, and solid tumors. Unfortunately, common remedies for TC, including chemotherapy and surgery, have not provided a promising outlook due to their adverse effects on life quality. Ergo, finding a new therapeutic candidate with high effectiveness and low detrimental impacts is indispensable. Newly, herbal remedies have attracted much interest because of their potential to improve diverse diseases, like cancer. In this context, increasing evidence indicated that curcumin, as a polyphenol compound originating from the plant <i>Curcuma longa</i>, has beneficial effects for treating TC. Hence, in this narrative review, we aimed to review documents showing the therapeutic potential of this herbal candidate against TC.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2023 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/4558299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136376472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Number of Available Embryos: A Prediction Tool for Analyzing the Effect of Sperm DNA Fragmentation on Pregnancy Outcome of Patients Undergoing IVF Cycles from Embryology","authors":"Xiaodong Liang,&nbsp;Rubing Duan,&nbsp;Qiangxiang Luo,&nbsp;Haitao Wu,&nbsp;Shasha Si,&nbsp;Ganwen Mo,&nbsp;Peng Ji,&nbsp;Yongbin Liao","doi":"10.1155/2023/1921515","DOIUrl":"10.1155/2023/1921515","url":null,"abstract":"<div>\u0000 <p>Sperm DNA fragmentation (SDF) can affect the pregnancy outcome of assisted reproduction technology. The cumulative live birth rate (CLBR), a new parameter of pregnancy outcome, attracts the attention of researchers to study the effect of SDF on CLBR. This study will focus on whether the number of available embryos (AEN) can be used as a predictor to investigate the effect of SDF on CLBR of in vitro fertilization (IVF) cycles. Our study included 1,347 couples who underwent IVF cycles and detected their SDF results by the sperm chromatin structure assay. Subsequently, CLBR and AEN on Day 3 were examined and compared between the SDF ≤ 30% and SDF &gt; 30% group. The finding by the correlation analysis showed a strong correlation in CLBR and AEN, suggesting that AEN can be used as a predictor of CLBR. When comparing the two groups, significant differences were noticed in CLBR (81.1% vs. 71.5%, <i>P</i> = 0.009) and AEN (8.10 ± 4.43 vs. 7.21 ± 4.27, <i>P</i> = 0.021), revealing that SDF has an influence on both indicators. The results of the covariance analysis suggested that the available embryo rate per maturity oocyte was higher in the SDF ≤ 30% group, and the embryologic parameters showed a significant difference in the available embryo formation rate on Day 3, but not in the fertilization and cleavage rates, suggesting that SDF reduced the quality of embryos, which did not reach the morphological standard of the available embryos, and further reduced AEN and CLBR in the IVF cycles.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2023 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/1921515","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of Hedeoma drummondii against Formaldehyde-Induced Testicular Toxicity and Genotoxicity in Wistar Rats","authors":"Nadia Denys Betancourt-Martínez,&nbsp;Pilar Carranza-Rosales,&nbsp;Ezequiel Viveros-Valdez,&nbsp;Nancy Elena Guzmán-Delgado,&nbsp;Maritza Argelia Macias-Corral,&nbsp;Irma Edith Carranza-Torres,&nbsp;Lydia Enith Nava-Rivera,&nbsp;María Soñadora Niño Castañeda,&nbsp;Javier Morán-Martínez","doi":"10.1155/2023/6631345","DOIUrl":"10.1155/2023/6631345","url":null,"abstract":"<div>\u0000 <p>Formaldehyde (FA) is an oxidative stress inducer and a known carcinogen. <i>Hedeoma drummondii</i> has been shown to have potential as a chemopreventive agent. The aim of this study was to assess the protective effect of <i>H. drummondii</i> on FA-induced genotoxic damage, sperm quality parameters, and histological changes of the testis. The male Wistar rats used were divided into the following groups: (G1) 100 mg/kg <i>H. drummondii</i>; (G2) 10 mg/kg FA; (G3) 100 mg/kg <i>H. drummondii</i> + 10 mg/kg FA; (G4) phosphate-buffered saline; (G5) 100 mg/kg <i>α</i>-tocopherol; (G6) 100 mg/kg <i>α</i>-tocopherol + 10 mg/kg FA; and (G7) soybean oil. The results showed a sperm concentration of 23.66 ± 1.52 versus 33.67 cells/mL (<i>p</i> = 0.02), and a percentage of motility of 29.66 ± 1.51 versus 33.33 (<i>p</i> = 0.620), for groups G3 and G6, respectively. Histopathological (H&amp;E) and immunohistochemical analysis of superoxide dismutase showed damage in the germinal epithelium (GE) in G2. While in groups G3 and G6, the histological structure was preserved. A protective effect on sperm DNA fragmentation was also observed for treated groups (G3 and G6, <i>p</i> &lt; 0.0001 vs. G2). While in groups G3 and G6 the histological structure was preserved. A protective effect on sperm DNA fragmentation was also observed for treated groups (G3 and G6). In conclusion, FA exposure significantly reduces sperm quality parameters, causes sperm DNA damage, and alters GE in the testis, while <i>H. drummondii</i> has a protective effect against FA-induced sperm genotoxic damage, similar to <i>α</i>-tocopherol.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2023 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/6631345","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135729249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of SARS-CoV-2 and Other Upper Respiratory Tract Viral Infections on Reproductive Parameters in Young Healthy Men with Mild Symptoms of Disease","authors":"Angel Elenkov,&nbsp;Anna Nilsson,&nbsp;Alexandra Kondic,&nbsp;Blenda Bottiger,&nbsp;Marcus Broden,&nbsp;Ebba Bergman,&nbsp;Annie Dahl,&nbsp;Aleksander Giwercman","doi":"10.1155/2023/8895384","DOIUrl":"10.1155/2023/8895384","url":null,"abstract":"<div>\u0000 <p>Data regarding excretion of SARS-CoV-2 in semen are inconclusive and counseling regarding risk of sexual transmission is still challenging. Our knowledge on the effect of upper respiratory tract infections (URTI) on male reproductive system is also scarce. Apart from negative effect of fever on spermatogenesis virtually no study has been able to compare reproductive parameters in men with COVID-19 or other URTI with predisease data. Eleven men who developed symptoms of URTI during the first and second wave of COVID-19 pandemic and who had preexistent fertility and hormonal data, participated in the study leaving sperm and blood samples. Three additional subjects were recruited among proven SARS-CoV-2 positive male hospital workers (without previous data). SARS-CoV-2 RNA was present in the ejaculate from 2 of 5 (40%) young men with mild COVID-19. In one of them viral particles could be detected in the semen sample 2 weeks after the first sampling. Men with any URTI showed higher LH (<i>p</i> = 0.02), lower sperm concentration (<i>p</i> = 0.047), and free testosterone (<i>p</i> = 0.008) when compared to their samples delivered 10 years earlier. When SARS-CoV-2 positive subjects were compared to subjects with other URTIs, no difference in levels of reproductive parameters or inflammatory markers was seen. In conclusion, SARS-CoV-2 RNA can be present in the ejaculate but does not seem to affect reproductive parameters any more than other viruses. However, mild URTI was shown to affect the sperm concentration, LH, and free testosterone negatively.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2023 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/8895384","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135729353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-DNA Stainability Is Not Related to Embryonic Development and Clinical Outcomes on In Vitro Fertilization Cycles: A Retrospective Study Using a Propensity Score-Matching Analysis","authors":"Mingzhe Song,&nbsp;Wensi Huang,&nbsp;Lijun Ye,&nbsp;Zhiqiang Liu,&nbsp;Weiqiang Xiao,&nbsp;Feng Xiong,&nbsp;Yueqin Peng,&nbsp;Jing Cai,&nbsp;Yong Zeng","doi":"10.1155/2023/1751627","DOIUrl":"10.1155/2023/1751627","url":null,"abstract":"<div>\u0000 <p>The high-DNA stainability (HDS) might be an indicator for the detection of sperm chromatin decondensation structure resulting from the incomplete histone-to-protamine exchange. The aim of our study was to investigate the association of HDS with embryonic development and clinical outcomes after <i>in vitro</i> fertilization (IVF) treatment. Couples underwent IVF cycles from January 2016 to December 2020 were retrospectively studied, including a total of 2,604 target couples undergoing IVF treatment and 628 couples undergoing fresh IVF-embryo transplantation (IVF-ET) treatment. Couples were divided into HDS &gt; 15% group and HDS ≤ 15% group according to HDS levels. After controlling the bias between groups using the propensity score-matching method, data of embryonic development, and clinical outcomes were analyzed. No significant differences were observed between HDS &gt; 15% group and HDS ≤ 15% group regarding fertilization rate (83.33% vs. 84.62%, <i>P</i> = 0.349), two pronuclei rate (81.82% vs. 83.33%, <i>P</i> = 0.613), cleavage rate (100.00% vs. 100.00%, <i>P</i> = 0.172), and high-quality embryo rate (60.00% vs. 60.00%, <i>P</i> = 0.961). Linear regression analysis showed that HDS was negatively associated with fertilization rate (<i>B</i> value = −0.094, 95% CI: −0.184 to −0.005, <i>P</i> = 0.039), whereas no correlation (adjusted <i>B</i> value = −0.081, 95% CI: −0.170 to 0.008, <i>P</i> = 0.074) was observed after adjusting potential confounding factors. The clinical pregnancy rate (62.11% vs. 60.39%, <i>P</i> = 0.699), ongoing pregnancy rate (52.17% vs. 53.10%, <i>P</i> = 0.838), early miscarriage rate (9.94% vs. 7.28%, <i>P</i> = 0.283), late miscarriage rate (0.62% vs. 2.14%, <i>P</i> = 0.305), and live birth rate (51.55% vs. 50.96%, <i>P</i> = 0.838) were not significantly different between groups. Binary logistic regression analysis showed that HDS levels did not affect clinical outcomes after fresh IVF-ET treatments. HDS was not significantly associated with embryonic development and clinical outcomes of IVF. Our findings suggested that HDS evaluation before IVF treatment might be with limited potential to predict embryo development and clinical outcomes.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2023 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/1751627","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136078717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yangjing Capsule Increases Testosterone Production through SET/PI3K/Akt Pathway in Leydig Cell","authors":"Dong Xing,&nbsp;Yuanyuan Liu,&nbsp;Dalin Sun,&nbsp;Dandan Wang,&nbsp;Yihan Jin,&nbsp;Bin Cai,&nbsp;Baofang Jin","doi":"10.1155/2023/4144490","DOIUrl":"10.1155/2023/4144490","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Our previous works revealed Yangjing capsule (YC) could inhibit cell apoptosis and promote testosterone production in Leydig cells. SET protein has been reported to be important in regulating testosterone synthesis and apoptosis. The purpose of this study was to investigate whether the steroidogenic and antiapoptotic effects of YC are mediated in part by the SET/PI3K/Akt pathway in Leydig cells. <i>Methods</i>. MLTC-1 cells were treated with YC-medicated serum. si-RNA was used to knockdown SET expression in MLTC-1 cells. The elderly BALB/c mice were treated with different doses of YC extract. Flow cytometry and TUNEL staining were used to assess apoptosis in MLTC-1 cells and mouse testes. HE staining was conducted to detect the morphological changes in mouse testes. Testosterone levels in cell culture medium and serum were measured by ELISA kit. Quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR) and Western blot were used to detect the expression levels of key molecules. <i>Results</i>. YC-medicated serum could significantly increase the expression of SET and StAR, P450scc, HSD17B, and testosterone production in MLTC-1 cells. YC-medicated serum could increase Akt phosphorylation and Bcl-2/Bax ratio to suppress apoptosis in MLTC-1 cells. SET knockdown significantly inhibited YC-medicated serum-induced steroidogenic and antiapoptotic effects in MLTC-1 cells. In vivo experiments revealed the YC extract could enhance SET expression, trigger Akt phosphorylation, and suppress apoptosis in mouse testis to raise serum testosterone levels. <i>Conclusions</i>. A possible mechanism of promoting testosterone production induced by YC in Leydig cell was by triggering SET/PI3K/Akt pathway.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2023 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/4144490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136097279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Heat Exposure, Obesity, and Physical Activity on Sperm Quality: An Observational Study","authors":"Eriana Melinawati,&nbsp;Teguh Prakosa,&nbsp;Uki Retno Budihastuti,&nbsp;Mulyoto Pangestu,&nbsp;Affi Angelia Ratnasari,&nbsp;Puji Aris Rismawan","doi":"10.1155/2023/9142450","DOIUrl":"10.1155/2023/9142450","url":null,"abstract":"<div>\u0000 <p>In Indonesia, 12% or 3 million married couples suffer from infertility, with 36% of cases caused by male factors. Heat exposure, obesity, and lack of physical activity can decrease sperm quality by inducing oxidative stress and inflammation and altering the hypothalamic–pituitary–gonadal axis mechanisms. This study investigated the impact of heat exposure, obesity, and physical activity on sperm quality. This study employed an analytical observational design with a cross-sectional approach, conducted at the Sekar Fertility Clinic, Dr. Moewardi General Hospital. Sixty samples were analyzed using bivariate, multivariate, and <i>χ</i>2 tests or Fisher exact test with a 95% confidence interval and <i>p</i> &lt; 0.05. Exposure to heat was found to increase the risk of low-sperm concentration by 74.09 times (<i>p</i> = 0.001), obesity increased the risk of low-sperm concentration by 16.74 times (<i>p</i> = 0.013), and low-sperm motility by 6.12 times (<i>p</i> = 0.014), and lack of physical activity increased the risk of low-sperm concentration by 27.23 times (<i>p</i> = 0.033). Heat exposure, obesity, and physical inactivity are associated with low-sperm concentration, and obesity is also associated with low-sperm motility.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2023 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/9142450","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135596085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin Supplementation to the Freezing Extender Improves the Quality of Canine Epididymal Spermatozoa","authors":"Eman Fayez,&nbsp;Haney Samir,&nbsp;Mohamed A. I. El Sayed,&nbsp;Zaher M. Rawash,&nbsp;Ali Salama","doi":"10.1155/2023/7873399","DOIUrl":"10.1155/2023/7873399","url":null,"abstract":"<div>\u0000 <p>The present study aimed to determine the cryoprotective effect of melatonin supplements on the extender on the quality of canine epididymal spermatozoa. Epididymis from 20 castrated dogs were minced and incubated in Tris buffer. Spermatozoa were diluted in tris-citric acid-fructose (TCF) extender with two doses of melatonin (0.002 and 0.0035 mol) as well as a control (0.0 mol). The samples were packed in 0.25 ml straws after 2 hr of equilibration at 5°C and kept in liquid nitrogen (−196°C). Sperm parameters such as viability, motility, integrity of acrosome, sperm membrane functioning, and DNA integrity were assessed after thawing (37°C for 30 s). In addition, lipid peroxidation was assessed using the determination of malondialdehyde (MDA) levels. Results revealed that adding 0.0035 mol melatonin to the cryopreservation medium enhanced (<i>P</i> &lt; 0.05) the measured parameters of spermatozoa compared to the control and 0.002 mol melatonin. Levels of MDA were obviously (<i>P</i> &lt; 0.05) lower when 0.0035 mol melatonin was added in comparison to 0.002 mol melatonin and the control. Eventually, adding 0.0035 mol melatonin to the TCF extender significantly improved the percentage of motility, viability, and integrity of both plasma membrane and acrosome integrity of dog epididymal spermatozoa. In addition, melatonin supplementation improved DNA integrity and reduced membrane lipid peroxidation.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2023 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/7873399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135739460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Thyme Honey on the Histopathological Changes of the Testis in Relation to the Side Effects of Valproic Acid in Adult Male Wistar Rats","authors":"Nasrin Safarian,&nbsp;Pegah Shakib,&nbsp;Asghar Rajabzadeh,&nbsp;Leila Zarei","doi":"10.1155/2023/9913454","DOIUrl":"10.1155/2023/9913454","url":null,"abstract":"<div>\u0000 <p><i>Introduction</i>. Valproic acid (VPA) is a widely used drug in the treatment of emotional and nervous depression, mental imbalances, epilepsy, and control of bipolar disorders. Despite its therapeutic effects, VPA has toxic effects on male reproduction. The testis is an organ sensitive to oxidative stress. On the other hand, thyme honey contains antioxidant compounds. The aim of this study was to investigate the effect of thyme honey on the histopathological changes of the testis in relation to the side effects of VPA in adult male Wistar rats. <i>Methods</i>. In this study, 48 Wistar rats were used, which were randomly divided into equal eight groups and received their desired substances. Including the control group, Th1, Th2, and Th3 groups receiving 1, 2, and 3 g/kg of thyme honey, respectively, VPA (500 mg/kg), VPA + Th1 (500 mg/kg of VPA + 1 g/kg of thyme honey), VPA + Th2 (500 mg/kg of VPA + 2 g/kg of thyme honey), and VPA + Th3 (500 mg/kg of VPA + 3 g/kg of thyme honey). After 60 days, evaluation of malondialdehyde (MDA), total antioxidant capacity (TAC), and histological studies of hematoxylin-eosin and Masson’s trichrome staining were performed. <i>Results</i>. The use of thyme honey significantly improved some parameters related to spermatogenesis, and in addition, it increased sperm production in the honey groups. In addition, the changes in MDA levels in the groups have shown a decrease in the amount of lipid peroxidation in the VPA + Th2 group. The amount of TAC also increased after increasing the dose of thyme honey. <i>Conclusion</i>. Based on the results of this study, it seems that thyme honey has been able to reduce the side effects of VPA to some extent due to its high percentage of antioxidants.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2023 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/9913454","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135535076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seminal TEX101 May Predict Seminal Sperm Recovery after Varicocelectomy in Nonobstructive Azoospermic Patients with Varicocele","authors":"Mohamed Wael Ragab,&nbsp;Mina Saad,&nbsp;Zeinab Nour,&nbsp;Hamed Abdallah Hamed,&nbsp;Taymour Mostafa,&nbsp;Ahmed M. El-Guindi","doi":"10.1155/2023/5652572","DOIUrl":"10.1155/2023/5652572","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Infertile men with nonobstructive azoospermia (NOA) associated with varicocele may benefit from varicocele repair with recovered sperms in semen. Currently, there is no clinically applied method to predict the success of seminal sperm recovery in this subset of azoospermic men. <i>Objective</i>. We aimed to evaluate the predictive role of the seminal testis expressed protein (TEX101) in sperm recovery in the semen of NOA men with palpable bilateral varicocele after microsurgical varicocelectomy. <i>Patients and Methods</i>. This prospective cross-sectional cohort study included 40 patients with NOA and bilateral varicocele. Seminal TEX101 levels were measured followed by subinguinal microsurgical varicocele repair. Two seminal analyses were carried out at 3- and 6-month follow-up periods to evaluate seminal sperm recovery. <i>Results</i>. After varicocele repair, sperms were recovered in the semen of 10/40 patients (25%) along the follow-up periods (seven patients after 3 months and additional three patients after 6 months). The preoperative median seminal TEX101 level was significantly higher in NOA men with seminal sperm recovery compared with NOA patients without seminal sperm recovery (13.5 vs. 9.8 ng/ml, <i>p</i> = 0.014). Besides, the serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) median levels were significantly higher in NOA men without seminal sperm recovery compared with NOA men with seminal sperm recovery (<i>p</i> = 0.001, <i>p</i> = 0.01). There were nonsignificant differences comparing the preoperative testicular volume or serum testosterone levels between the two investigated groups (<i>p</i> = 0.072, <i>p</i> = 0.272). A cutoff value of 9.9 ng/ml was demonstrated to have preoperative TEX101 prediction of seminal sperm recovery (sensitivity of 90% and specificity of 57%). <i>Conclusion</i>. Preoperative seminal TEX101 could be considered as a biomarker for sperm recovery for seminal sperm recovery in NOA cases associated with varicocele after its surgical repair. Further work at this point with larger number of cases should be carried out to verify its potential importance.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2023 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/5652572","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136017132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}