Impact of SARS-CoV-2 and Other Upper Respiratory Tract Viral Infections on Reproductive Parameters in Young Healthy Men with Mild Symptoms of Disease

IF 2.1 4区医学 Q3 ANDROLOGY

Andrologia Pub Date : 2023-10-19 DOI:10.1155/2023/8895384

Angel Elenkov, Anna Nilsson, Alexandra Kondic, Blenda Bottiger, Marcus Broden, Ebba Bergman, Annie Dahl, Aleksander Giwercman

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引用次数: 0

Abstract

Data regarding excretion of SARS-CoV-2 in semen are inconclusive and counseling regarding risk of sexual transmission is still challenging. Our knowledge on the effect of upper respiratory tract infections (URTI) on male reproductive system is also scarce. Apart from negative effect of fever on spermatogenesis virtually no study has been able to compare reproductive parameters in men with COVID-19 or other URTI with predisease data. Eleven men who developed symptoms of URTI during the first and second wave of COVID-19 pandemic and who had preexistent fertility and hormonal data, participated in the study leaving sperm and blood samples. Three additional subjects were recruited among proven SARS-CoV-2 positive male hospital workers (without previous data). SARS-CoV-2 RNA was present in the ejaculate from 2 of 5 (40%) young men with mild COVID-19. In one of them viral particles could be detected in the semen sample 2 weeks after the first sampling. Men with any URTI showed higher LH (p = 0.02), lower sperm concentration (p = 0.047), and free testosterone (p = 0.008) when compared to their samples delivered 10 years earlier. When SARS-CoV-2 positive subjects were compared to subjects with other URTIs, no difference in levels of reproductive parameters or inflammatory markers was seen. In conclusion, SARS-CoV-2 RNA can be present in the ejaculate but does not seem to affect reproductive parameters any more than other viruses. However, mild URTI was shown to affect the sperm concentration, LH, and free testosterone negatively.

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SARS-CoV-2及其他上呼吸道病毒感染对轻症健康青年男性生殖参数的影响

关于SARS-CoV-2在精液中排泄的数据尚无定论，关于性传播风险的咨询仍然具有挑战性。我们对上呼吸道感染（URTI）对男性生殖系统的影响也知之甚少。除了发烧对精子发生的负面影响外，几乎没有研究能够将患有COVID-19或其他尿道感染的男性的生殖参数与病前数据进行比较。11名在第一波和第二波COVID-19大流行期间出现尿路感染症状的男性参加了这项研究，他们之前有生育和激素数据，留下了精子和血液样本。在已证实的SARS-CoV-2阳性男性医院工作人员（无既往数据）中招募了另外三名受试者。5名患有轻度COVID-19的年轻男性中有2名（40%）的射精中存在SARS-CoV-2 RNA。其中1例在第一次取样2周后精液中检出病毒颗粒。与10年前提供的样本相比，患有任何尿路感染的男性显示出更高的LH (p = 0.02)，更低的精子浓度（p = 0.047）和游离睾酮（p = 0.008）。当将SARS-CoV-2阳性受试者与其他URTIs受试者进行比较时，未发现生殖参数或炎症标志物水平的差异。总之，SARS-CoV-2 RNA可以存在于射精中，但似乎不会比其他病毒更多地影响生殖参数。然而，轻度尿路感染对精子浓度、LH和游离睾酮均有负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Andrologia 医学-男科学

CiteScore

5.60

自引率

8.30%

发文量

292

审稿时长

6 months

期刊介绍： Andrologia provides an international forum for original papers on the current clinical, morphological, biochemical, and experimental status of organic male infertility and sexual disorders in men. The articles inform on the whole process of advances in andrology (including the aging male), from fundamental research to therapeutic developments worldwide. First published in 1969 and the first international journal of andrology, it is a well established journal in this expanding area of reproductive medicine.