Angewandte Chemie最新文献_第2页

Innentitelbild: Multiple Structural and Phase Transformations of MOF and Selective Hydrocarbon Gas Separation in its Amorphous, Glass Phase States (Angew. Chem. 9/2025)

Angewandte Chemie Pub Date : 2025-02-10 DOI: 10.1002/ange.202502039

Dr. Jian Li, Jia-Xin Wu, Tao Liu, Jian Yang, Mei-Ling Wei, Chuang Yang, Dr. Qiubing Dong, Prof. Dr. Zheng Yin, Prof. Dr. Mohamedally Kurmoo, Prof. Dr. Ming-Hua Zeng

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Anna Wuttig

Angewandte Chemie Pub Date : 2025-02-05 DOI: 10.1002/ange.202501445

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Marcus W. Drover

Angewandte Chemie Pub Date : 2025-02-05 DOI: 10.1002/ange.202501753

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Frontispiz: Total Syntheses of β- and γ-Naphthocyclinones

Angewandte Chemie Pub Date : 2025-02-05 DOI: 10.1002/ange.202580662

Prof. Dr. Yoshio Ando, Taiju Hoshino, Nozomi Tanaka, Dr. Mark M. Maturi, Yusuke Nakazawa, Dr. Takumi Fukazawa, Prof. Dr. Ken Ohmori, Prof. Dr. Keisuke Suzuki

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Frontispiz: Schwere Pentaisopropylcyclopentadienyltriylene und deren heterobimetallische Komplexe

Angewandte Chemie Pub Date : 2025-02-05 DOI: 10.1002/ange.202580661

Inga-Alexandra Bischoff, Bernd Morgenstern, Michael Zimmer, Dr. André Schäfer

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BERICHTIGUNG: Correction to “Chiral Isochalcogenourea-Catalysed Enantioselective (4+2) Cycloadditions of Allenoates”

Angewandte Chemie Pub Date : 2025-02-03 DOI: 10.1002/ange.202501948

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Photoacids and Photobases: Applications in Functional Dynamic Systems

Angewandte Chemie Pub Date : 2025-01-31 DOI: 10.1002/ange.202422963

Dr. Anna Yucknovsky, Prof. Nadav Amdursky

{"title":"Photoacids and Photobases: Applications in Functional Dynamic Systems","authors":"Dr. Anna Yucknovsky, Prof. Nadav Amdursky","doi":"10.1002/ange.202422963","DOIUrl":"https://doi.org/10.1002/ange.202422963","url":null,"abstract":"Brønsted photoacids and photobases are a unique class of molecules that undergo a major change in their pKa values between their ground and excited states, resulting in donating or accepting a proton, respectively, but only after light excitation. This property of photoacids/photobases makes them an attractive tool for light-gating various dynamic processes. Here, we review the use of this property to manipulate functional dynamic systems with light. We discuss how a proton transfer event that can happen upon light excitation from a photoacid to a chemical moiety of a certain system or, vice versa, from the system to a photobase, can result in a shift in the equilibrium of the system, resulting in some dynamicity. We detail various systems, including self-assembly processes of nanostructures, self-propulsion of droplets, catalysis for hydrogen evolution or CO2 capturing, nanotechnological devices based on enzymatic processes, and changes in proton-conducting ionophores and materials. We detail the basic guidelines for using Brønsted photoacids and photobases in a desired system and conclude with the current technological gaps in further using these molecules.","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202422963","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Stefano Crespi

Angewandte Chemie Pub Date : 2025-01-31 DOI: 10.1002/ange.202500414

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Nanocrystals with Aggregate Anionic Structure Enable Ion Transport Decoupling of Chain Segment Movement in Poly(ethylene oxide) Electrolytes

Angewandte Chemie Pub Date : 2025-01-30 DOI: 10.1002/ange.202418783

Jinze Hou, Dr. Weiwei Xie, Long Shang, Shuang Wu, Yuewei Cui, Dr. Yixin Li, Prof. Zhenhua Yan, Prof. Kai Zhang, Prof. Yong Lu, Prof. Jun Chen

{"title":"Nanocrystals with Aggregate Anionic Structure Enable Ion Transport Decoupling of Chain Segment Movement in Poly(ethylene oxide) Electrolytes","authors":"Jinze Hou, Dr. Weiwei Xie, Long Shang, Shuang Wu, Yuewei Cui, Dr. Yixin Li, Prof. Zhenhua Yan, Prof. Kai Zhang, Prof. Yong Lu, Prof. Jun Chen","doi":"10.1002/ange.202418783","DOIUrl":"https://doi.org/10.1002/ange.202418783","url":null,"abstract":"All-solid-state polymer electrolytes are promising for lithium batteries, but Li+ transport in these electrolytes relies on amorphous chain segment movement, leading to low Li+ mobility and poor mechanical strength. Here we propose a novel Li+ transport mechanism mediated by PEO3:LiBF4 nanocrystals (NCPB) with the aggregate (AGG) anionic structure, which enables a change from amorphous to crystalline phase dominated ion transport in all-solid-state PEO/LiBF4 electrolyte. Experiments and simulations reveal that the interaction between Li+ and F in NCPB with AGG anionic structure simultaneously restricts anion transport and reorients anions within the free volume of NCPB, resulting in a three-coordination intermediate to facilitate Li+ transport. The unique Li+ transport mechanism through NCPB makes the PEO/LiBF4 electrolyte with a high Li+ transference number (0.73) and remarkably increased mechanical strength (storage modulus >100 MPa) at 45 °C. As a result, the Li|LiFePO4 batteries with the ultrathin self-supported PEO/LiBF4 electrolyte (10 μm) exhibit significantly improved cycle life (97 % @ 468 cycles) compared to those with PEO/LiTFSI electrolyte (failed @ 68 cycles). This work demonstrates a novel ion transport mechanism for achieving selective and rapid Li+ transport.","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Optimization of Structure-Guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS-CoV-2

Angewandte Chemie Pub Date : 2025-01-29 DOI: 10.1002/ange.202417961

Betül Ceylan, Jennifer Adam, Sabrina Toews, Frank Kaiser, Jonas Dörr, Daniel Scheppa, Dr. Jan-Niklas Tants, Alexandria Smart, Julian Schoth, Susanne Philipp, Elke Stirnal, Dr. Jan Ferner, Dr. Christian Richter, Dr. Sridhar Sreeramulu, Prof. Dr. Neva Caliskan, Prof. Dr. Andreas Schlundt, Prof. Dr. Julia E. Weigand, Prof. Dr. Michael Göbel, Dr. Anna Wacker, Prof. Dr. Harald Schwalbe

{"title":"Optimization of Structure-Guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS-CoV-2","authors":"Betül Ceylan, Jennifer Adam, Sabrina Toews, Frank Kaiser, Jonas Dörr, Daniel Scheppa, Dr. Jan-Niklas Tants, Alexandria Smart, Julian Schoth, Susanne Philipp, Elke Stirnal, Dr. Jan Ferner, Dr. Christian Richter, Dr. Sridhar Sreeramulu, Prof. Dr. Neva Caliskan, Prof. Dr. Andreas Schlundt, Prof. Dr. Julia E. Weigand, Prof. Dr. Michael Göbel, Dr. Anna Wacker, Prof. Dr. Harald Schwalbe","doi":"10.1002/ange.202417961","DOIUrl":"https://doi.org/10.1002/ange.202417961","url":null,"abstract":"Targeting the RNA genome of SARS-CoV-2 is a viable option for antiviral drug development. We explored three ligand binding sites of the core pseudoknot RNA of the SARS-CoV-2 frameshift element. We iteratively optimized ligands, based on improved affinities, targeting these binding sites and report on structural and dynamic properties of the three identified binding sites. Available experimental 3D structures of the pseudoknot element were compared to SAXS and NMR data to validate its dominant folding state in solution. In order to experimentally map in silico predicted binding sites, NMR assignments of the majority of nucleobases were achieved by segmental labeling of the pseudoknot RNA and isotope-filtered NMR experiments at 1.2 GHz, demonstrating the value of NMR spectroscopy to supplement modelling and docking data. Optimized ligands with enhanced affinity were shown to specifically inhibit frameshifting without affecting 0-frame translation in cell-free translation assays, establishing the frameshift element as target for drug-like ligands of low molecular weight.","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202417961","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0