{"title":"Frontispiece: Cyclochlorotine Hydroxylase CctR Reveals DUF3328 as a Family of Copper-Dependent Metalloenzymes","authors":"","doi":"10.1002/ange.202583802","DOIUrl":"https://doi.org/10.1002/ange.202583802","url":null,"abstract":"<p>The copper-dependent hydroxylase CctR from <i>Talaromyces islandicus</i> catalyzes selective C(sp<sup>3</sup>)─H hydroxylation of the fungal cyclic peptide cyclochlorotine, as reported by Jing-Ke Weng et al. in their Coomunication (e202512449). The image highlights CctR's homodimeric structure and the binuclear copper active site, which enables the oxidative formation of hydroxycyclochlorotine by this newly defined DUF3328 metalloenzyme family.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202583802","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick Lechner, Dr. Gaurab Ganguly, Dr. Michael J. Sahre, Prof. Georg Kresse, Dr. Johannes C. B. Dietschreit, Prof. Leticia González
{"title":"Spinfrustration bestimmt Stabilität und Reaktivität von metallorganischen Gerüstverbindungen mit dreieckigen Eisen(III)-Oxo-Clustern","authors":"Patrick Lechner, Dr. Gaurab Ganguly, Dr. Michael J. Sahre, Prof. Georg Kresse, Dr. Johannes C. B. Dietschreit, Prof. Leticia González","doi":"10.1002/ange.202514014","DOIUrl":"https://doi.org/10.1002/ange.202514014","url":null,"abstract":"<p>Konventionelle DFT kann den spinfrustrierten Grundzustand von MOFs mit dreieckigen Fe(III)-Knoten nicht richtig beschreiben, was zu verzerrten Geometrien und falschen Vorhersagen führt. Mittels Flip-Spin DFT identifizieren wir den echten Grundzustand von MIL-101(Fe) und zeigen, wie magnetische Frustration die temperaturabhängige Adsorption von <span></span><math></math> und CO beeinflusst.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202514014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samson B. Zacate, Juliana A. Dantas, Song Lin, Abigail G. Doyle, Matthew S. Sigman
{"title":"Considerations in Pursuing Reaction Scope Generality","authors":"Samson B. Zacate, Juliana A. Dantas, Song Lin, Abigail G. Doyle, Matthew S. Sigman","doi":"10.1002/ange.202511091","DOIUrl":"https://doi.org/10.1002/ange.202511091","url":null,"abstract":"<p>The term “generality” has recently been popularized in synthetic chemistry, owing largely to the increasing use of high-throughput technology for producing vast quantities of data and the emergence of data science tools to plan and interpret these experiments. Despite this, the term has not been clearly defined, and there is no standardized approach toward developing a method with a diverse (general) scope. This minireview will examine different emerging strategies toward achieving generality using selected examples and aims to give the reader an overview of modern workflows that have been used to expedite this pursuit.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202511091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prof. Lingyao Wang, Huirong Chen, Chengye Lou, Guangzu Xiong, Yunjia Jiang, Prof. Banglin Chen, Prof. Yuanbin Zhang
{"title":"Inside Front Cover: Cage Engineering in Anion-Pillared MOFs for Benchmark One-Step C2H4 Purification from Ternary C2H2/CO2/C2H4 Mixtures (Angew. Chem. 40/2025)","authors":"Prof. Lingyao Wang, Huirong Chen, Chengye Lou, Guangzu Xiong, Yunjia Jiang, Prof. Banglin Chen, Prof. Yuanbin Zhang","doi":"10.1002/ange.202519160","DOIUrl":"https://doi.org/10.1002/ange.202519160","url":null,"abstract":"<p>The image depicts ZNU-27, a fluorinated anion-pillared MOF (center) captures C<sub>2</sub>H<sub>2</sub> and CO<sub>2</sub> impurities (incoming meteors) in its 8.5 Å spherical cages, while pure C<sub>2</sub>H<sub>4</sub> streams out. This visual metaphor highlights ZNU-27's breakthrough capability in directly yielding polymer-grade C<sub>2</sub>H<sub>4</sub> from ternary C<sub>2</sub>H<sub>2</sub>/CO<sub>2</sub>/C<sub>2</sub>H<sub>4</sub> mixtures in a single step. Details are reported by Yuanbin Zhang et al. in their Research Article (e202514808).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202519160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145171930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuzhe Chen, Yunchuan Huang, Shisheng Wang, Xinyuan Wang, Hongyu Lu, Jie Chen, Jing Li, Zhuo Chen, Zhao Li, Tianshan She, Youmei Jin, Yuanping Gao, Jie Zhang, Lijun Wang, Wenjuan Zeng, Hong Zhu, Ze Tao, Prof. Xiaofeng Lu, Prof. Hao Yang
{"title":"Inside Back Cover: A Self-Assembled Protein Platform for Plug-and-Play Customization of Multivalent Artificial Antibodies and Antibody-Drug Conjugates (Angew. Chem. 40/2025)","authors":"Yuzhe Chen, Yunchuan Huang, Shisheng Wang, Xinyuan Wang, Hongyu Lu, Jie Chen, Jing Li, Zhuo Chen, Zhao Li, Tianshan She, Youmei Jin, Yuanping Gao, Jie Zhang, Lijun Wang, Wenjuan Zeng, Hong Zhu, Ze Tao, Prof. Xiaofeng Lu, Prof. Hao Yang","doi":"10.1002/ange.202519343","DOIUrl":"https://doi.org/10.1002/ange.202519343","url":null,"abstract":"<p>Inspired by the interlocking wisdom of mortise-and-tenon Chinese craftsmanship, Hao Yang's team from West China Hospital, Sichuan University developed a modular protein platform ATPlug, turning age-old structural ingenuity into therapeutic innovation (Research Article e202506426). ATPlug enables plug-and-play customization of artificial antibodies and antibody-drug conjugates. This fusion of ancient craftsmanship and modern bioengineering helps overcome multivalent protein synthesis bottlenecks, offering a versatile toolkit for modular drug design.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202519343","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145171931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Frontispiece: Dual Co Sites in n─n Type Heterojunction Enable Selective Electrochemical Co-Valorization of HMF and CO2","authors":"","doi":"10.1002/ange.202583702","DOIUrl":"https://doi.org/10.1002/ange.202583702","url":null,"abstract":"<p>Dual cobalt sites and a built-in electric field in CoS/Co─N─C were designed for selective electrochemical co-valorization of HMF and CO<sub>2</sub>, as reported by Li Shuai et al. in their Communication (e202511448). The optimized catalyst achieved exceptional performance metrics, with 99.0% HMF-to-FDCA selectivity and 98.6% CO<sub>2</sub>─to─CO selectivity.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202583702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Frontispiece: Stable Yet Strongly Lewis-Acidic Anions Enabling Cooperative Catalysis with Cationic Transition-Metal Complexes","authors":"","doi":"10.1002/ange.202583701","DOIUrl":"https://doi.org/10.1002/ange.202583701","url":null,"abstract":"<p>In their Research Article (e202503322), Takanori Iwasaki, Kyoko Nozaki, and Ryo Mandai realized a stable tetraarylborate anion, <b>BBcat</b>, which exhibits strong Lewis acidity. Its Ir complex exhibited high efficiency in the hydrogen isotope exchange of 1,2-disubstituted arenes by cooperative catalysis of the Ir complex and the Lewis-acidic sites on <b>BBcat</b>. <b>BBcat</b> and the Ir complex are symbolically associated with mythological Genbu and Suzaku. Genbu, a tortoise entwined with a snake, reflects <b>BBcat</b>'s dual nature.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202583701","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Atsuya Yaguchi, Prof. Noriyuki Uchida, Daiki Miura, Prof. Go Watanabe, Prof. Hirotsugu Hiramatsu, Prof. Itsuki Ajioka, Prof. Teruhiko Matsubara, Prof. Toshinori Sato, Chinbat Enkhzaya, Shunto Itani, Tomokazu Saito, Prof. Takahiro Muraoka
{"title":"Inside Front Cover: A Photoresponsive Hybrid of Viruses and Supramolecular Peptide Fibers for Multidimensional Control of Patterning and Infection (Angew. Chem. 41/2025)","authors":"Dr. Atsuya Yaguchi, Prof. Noriyuki Uchida, Daiki Miura, Prof. Go Watanabe, Prof. Hirotsugu Hiramatsu, Prof. Itsuki Ajioka, Prof. Teruhiko Matsubara, Prof. Toshinori Sato, Chinbat Enkhzaya, Shunto Itani, Tomokazu Saito, Prof. Takahiro Muraoka","doi":"10.1002/ange.202519532","DOIUrl":"https://doi.org/10.1002/ange.202519532","url":null,"abstract":"<p>In their Research Article (e202508528), Noriyuki Uchida, Takahiro Muraoka, and co-workers develop a nanofiber-forming peptide (A2Az) enabling photo-control of adhesion and dispersion of M13 bacteriophage virus and successfully demonstrated patterning of localization and infection of the virus. The cover image illustrates adhesion of the virus onto the A2Az supramolecular nanofibers and its dispersion to trigger infection with Escherichia coli.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202519532","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Niklas Wallstein, Dr. Andrea Capucciati, Prof. Dr. Andreas Pöppl, Prof. Dr. Claudia S. Schnohr, Prof. Dr. Michela Sturini, Dr. André Pampel, Dr. Carsten Jäger, Prof. Dr. Luigi Zecca, Dr. Fabio A. Zucca, Prof. Dr. Enrico Monzani, Prof. Dr. Luigi Casella, Dr. Prof. Harald E. Möller
{"title":"Inside Back Cover: Modeling Midbrain and Brainstem Neuromelanins to Characterize Metal Binding and Associated MRI Contrast in Parkinson's and Alzheimer's Diseases (Angew. Chem. 41/2025)","authors":"Dr. Niklas Wallstein, Dr. Andrea Capucciati, Prof. Dr. Andreas Pöppl, Prof. Dr. Claudia S. Schnohr, Prof. Dr. Michela Sturini, Dr. André Pampel, Dr. Carsten Jäger, Prof. Dr. Luigi Zecca, Dr. Fabio A. Zucca, Prof. Dr. Enrico Monzani, Prof. Dr. Luigi Casella, Dr. Prof. Harald E. Möller","doi":"10.1002/ange.202519533","DOIUrl":"https://doi.org/10.1002/ange.202519533","url":null,"abstract":"<p>Neuromelanin is a pigment in the brain and an effective metal chelator. It is likely a crucial factor in the viability of neurons, which has sparked interest in MRI biomarkers for neurodegenerative diseases. In their Research Article (e202509102), Harald E. Möller and co-workers demonstrate remarkable complexity of the binding of Fe and Cu to synthetic neuromelanin analogues, with different binding sites, competition, and intricate magnetic properties, all of which affect the proton relaxation of surrounding water, the main contrast mechanism in MRI.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202519533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to “A Hybrid Supramolecular Polymeric Nanomedicine for Cascade-Amplified Synergetic Cancer Therapy”","authors":"","doi":"10.1002/ange.202518045","DOIUrl":"https://doi.org/10.1002/ange.202518045","url":null,"abstract":"<p><i>Angew. Chem. Int. Ed</i>. <b>2022</b>, <i>61</i>, e202203786, https://doi.org/10.1002/ange.202203786.</p><p>In Figure S52, the H&E image of the liver in group b was misplaced by an image of the kidney. After carefully re-examining the data, we found the correct liver image was accidently covered by the kidney image during figure assembly. The correct version is provided below. This correction does not affect any conclusions of the study.</p><p>We apologize for any inconvenience caused.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202518045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}