Dr. Niklas Wallstein, Dr. Andrea Capucciati, Prof. Dr. Andreas Pöppl, Prof. Dr. Claudia S. Schnohr, Prof. Dr. Michela Sturini, Dr. André Pampel, Dr. Carsten Jäger, Prof. Dr. Luigi Zecca, Dr. Fabio A. Zucca, Prof. Dr. Enrico Monzani, Prof. Dr. Luigi Casella, Dr. Prof. Harald E. Möller
{"title":"内页后盖：模拟中脑和脑干神经黑色素，表征帕金森病和阿尔茨海默病的金属结合和相关MRI对比。化学41/2025)","authors":"Dr. Niklas Wallstein, Dr. Andrea Capucciati, Prof. Dr. Andreas Pöppl, Prof. Dr. Claudia S. Schnohr, Prof. Dr. Michela Sturini, Dr. André Pampel, Dr. Carsten Jäger, Prof. Dr. Luigi Zecca, Dr. Fabio A. Zucca, Prof. Dr. Enrico Monzani, Prof. Dr. Luigi Casella, Dr. Prof. Harald E. Möller","doi":"10.1002/ange.202519533","DOIUrl":null,"url":null,"abstract":"<p>Neuromelanin is a pigment in the brain and an effective metal chelator. It is likely a crucial factor in the viability of neurons, which has sparked interest in MRI biomarkers for neurodegenerative diseases. In their Research Article (e202509102), Harald E. Möller and co-workers demonstrate remarkable complexity of the binding of Fe and Cu to synthetic neuromelanin analogues, with different binding sites, competition, and intricate magnetic properties, all of which affect the proton relaxation of surrounding water, the main contrast mechanism in MRI.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 41","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202519533","citationCount":"0","resultStr":"{\"title\":\"Inside Back Cover: Modeling Midbrain and Brainstem Neuromelanins to Characterize Metal Binding and Associated MRI Contrast in Parkinson's and Alzheimer's Diseases (Angew. Chem. 41/2025)\",\"authors\":\"Dr. Niklas Wallstein, Dr. Andrea Capucciati, Prof. Dr. Andreas Pöppl, Prof. Dr. Claudia S. Schnohr, Prof. Dr. Michela Sturini, Dr. André Pampel, Dr. Carsten Jäger, Prof. Dr. Luigi Zecca, Dr. Fabio A. Zucca, Prof. Dr. Enrico Monzani, Prof. Dr. Luigi Casella, Dr. Prof. Harald E. Möller\",\"doi\":\"10.1002/ange.202519533\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Neuromelanin is a pigment in the brain and an effective metal chelator. It is likely a crucial factor in the viability of neurons, which has sparked interest in MRI biomarkers for neurodegenerative diseases. In their Research Article (e202509102), Harald E. Möller and co-workers demonstrate remarkable complexity of the binding of Fe and Cu to synthetic neuromelanin analogues, with different binding sites, competition, and intricate magnetic properties, all of which affect the proton relaxation of surrounding water, the main contrast mechanism in MRI.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":7803,\"journal\":{\"name\":\"Angewandte Chemie\",\"volume\":\"137 41\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202519533\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Angewandte Chemie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ange.202519533\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angewandte Chemie","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ange.202519533","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
神经黑色素是大脑中的一种色素，也是一种有效的金属螯合剂。它可能是神经元活力的关键因素，这引发了人们对神经退行性疾病的MRI生物标志物的兴趣。在他们的研究文章（e202509102）中，Harald E. Möller及其同事展示了Fe和Cu与合成神经黑色素类似物结合的显着复杂性，具有不同的结合位点，竞争和复杂的磁性，所有这些都会影响周围水的质子弛豫，这是MRI的主要对比机制。
Inside Back Cover: Modeling Midbrain and Brainstem Neuromelanins to Characterize Metal Binding and Associated MRI Contrast in Parkinson's and Alzheimer's Diseases (Angew. Chem. 41/2025)
Neuromelanin is a pigment in the brain and an effective metal chelator. It is likely a crucial factor in the viability of neurons, which has sparked interest in MRI biomarkers for neurodegenerative diseases. In their Research Article (e202509102), Harald E. Möller and co-workers demonstrate remarkable complexity of the binding of Fe and Cu to synthetic neuromelanin analogues, with different binding sites, competition, and intricate magnetic properties, all of which affect the proton relaxation of surrounding water, the main contrast mechanism in MRI.
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