Angewandte Chemie最新文献

Metal-Phenolic Networks: Emerging Nanoarchitectures for Cancer Therapy 金属-酚网络：用于癌症治疗的新兴纳米结构

Angewandte Chemie Pub Date : 2026-10-19 Epub Date: 2026-08-20 DOI: 10.1002/ange.8987221

Kecheng Huang, Ran Meng, Bei Li, Yunlu Dai

{"title":"Metal-Phenolic Networks: Emerging Nanoarchitectures for Cancer Therapy","authors":"Kecheng Huang, Ran Meng, Bei Li, Yunlu Dai","doi":"10.1002/ange.8987221","DOIUrl":"https://doi.org/10.1002/ange.8987221","url":null,"abstract":"<div>\u0000 \u0000 <p>Cancer is a complicated disease driven by multiple etiologies, necessitating urgent, multimodal, and integrated therapeutic strategies. Coined just over a decade ago, metal-phenolic networks (MPNs) have emerged as broad and powerful platforms, demonstrating great potential in cancer therapy, with broad success achieved in animal models. MPNs are characterized by the network's formation via phenolic ligands and metal ion coordination and serve as versatile drug delivery platforms. Moreover, MPNs not only inherit the inherent pharmacological properties of the building blocks but also acquire new functions during their assembly, including pH responsiveness, photothermal conversion, and redox activity. This review explores the latest advancements and design principles of MPNs in cancer therapy. First, we introduce the building blocks and formation of MPNs and analyze their unique properties and functions. Second, we comprehensively describe various strategies of MPNs in tumor treatment and discuss their potential as a multifunctional treatment platform. Finally, we outline our perspective on the key challenges in translating MPNs to the clinic, with the intention of stimulating the initiation of MPNs-based anti-cancer trials.</p>\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SO2-Mediated 2e−, 4e−, and 6e− Reductions: Facile Access to Aryl Amines 二氧化硫介导的2e -， 4e -和6e -还原：对芳基胺的快速获取

Angewandte Chemie Pub Date : 2026-10-19 Epub Date: 2026-08-27 DOI: 10.1002/ange.3181079

Partha Protim Dey, Paramita Datta, Pallabi Mandal, Anex Jose, Swadhin K. Mandal

{"title":"SO2-Mediated 2e−, 4e−, and 6e− Reductions: Facile Access to Aryl Amines","authors":"Partha Protim Dey, Paramita Datta, Pallabi Mandal, Anex Jose, Swadhin K. Mandal","doi":"10.1002/ange.3181079","DOIUrl":"https://doi.org/10.1002/ange.3181079","url":null,"abstract":"<div>\u0000 \u0000 <p>Traditional electron-transfer catalysis frequently requires complex procedures to separate the catalyst from the reaction mixture. In contrast, a concept of a gas-mediated redox process may offer unique advantages, including its facile removal from the reaction medium. However, such a concept has remained unknown. Addressing this gap, we report the use of the SO<sub>2</sub> gas molecule as an electron-transfer mediator by generating the sulfur dioxide radical anion (SO<sub>2</sub><sup>•−</sup>) under ambient and chemical conditions. Such SO<sub>2</sub><sup>•−</sup> enabled chemoselective, controlled, and scalable multi-electron reductions (2e<sup>−</sup>/2H<sup>+</sup>, 4e<sup>−</sup>/4H<sup>+</sup>, 6e<sup>−</sup>/6H<sup>+</sup>) of diverse nitrogen-containing substrates. Furthermore, the method was successfully applied to the synthesis of clinically active drugs on a multi-gram scale. Therefore, this work establishes a new paradigm in redox chemistry, demonstrating that a gas molecule can act as an electron-transfer catalyst, capable of performing reactions that typically require transition metals.</p>\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible, Biocompatible Supercapacitors Weaved From Layered Phyllosilicates and Zwitterions via Ionicity 柔性的、生物相容性的超级电容器，由层状硅酸盐和两性离子通过离子性编织而成

Angewandte Chemie Pub Date : 2026-10-19 Epub Date: 2026-07-20 DOI: 10.1002/ange.3295676

Md Roxy Islam, Pritha Sarkar, Tanmay Sarkar Akash, Amanda Gabriela Bernard, Siddhartha Das, Josh Marsh, Neil Cunningham, Gernot Rother, Kausik Mukhopadhyay

{"title":"Flexible, Biocompatible Supercapacitors Weaved From Layered Phyllosilicates and Zwitterions via Ionicity","authors":"Md Roxy Islam, Pritha Sarkar, Tanmay Sarkar Akash, Amanda Gabriela Bernard, Siddhartha Das, Josh Marsh, Neil Cunningham, Gernot Rother, Kausik Mukhopadhyay","doi":"10.1002/ange.3295676","DOIUrl":"https://doi.org/10.1002/ange.3295676","url":null,"abstract":"<div>\u0000 \u0000 <p>Phyllosilicates, for example, bentonite clay, are among the most abundant natural minerals, yet their brittleness and poor conductivity have limited their use in energy storage applications, typically requiring harmful solvents and synthetic binders to form functional membranes. Here, we report a polymer-free, aqueous-based approach in which betaine, a naturally occurring zwitterion, is intercalated into bentonite clay galleries through ionic interactions between its cationic trimethylammonium group and the negatively charged clay surface. This intercalation bridges the clay galleries, creating ion-conductive pathways within free-standing, mechanically robust membranes, as confirmed by molecular dynamics simulations, rheo-impedance, and electrochemical impedance spectroscopy. Incorporation of transition-metal ions (Fe<sup>3</sup><sup>+</sup>, Mn<sup>2</sup><sup>+</sup>) introduces redox-active sites that contribute to pseudocapacitive charge storage. The resulting membranes function as both electrodes (113 mAh/g vs. NMC811) and separators in all-clay supercapacitor devices, delivering an energy density of 158 mWh/cm<sup>3</sup> and a power density of 5688 mW/cm<sup>3</sup>, with ∼75% capacitance retention after 30000 cycles. The devices are biocompatible and can power LEDs up to 2.2 V after brief charging. We show, for the first time, that zwitterions and clay provide a simple, scalable, and sustainable route to biocompatible, flexible supercapacitors for low-power applications requiring mechanical flexibility and material sustainability.</p>\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulating What We Cannot Yet Measure? A Scientific Perspective on Polymeric PFASs, Total Fluorine, and the PFAS Fluorine Gap 监管我们还无法衡量的东西？聚合物全氟化合物、全氟化合物和全氟化合物氟差距的科学观点

Angewandte Chemie Pub Date : 2026-10-19 Epub Date: 2026-09-14 DOI: 10.1002/ange.6774558

Jörg Feldmann, Raquel Gonzalez de Vega, Viktoria Müller

{"title":"Regulating What We Cannot Yet Measure? A Scientific Perspective on Polymeric PFASs, Total Fluorine, and the PFAS Fluorine Gap","authors":"Jörg Feldmann, Raquel Gonzalez de Vega, Viktoria Müller","doi":"10.1002/ange.6774558","DOIUrl":"https://doi.org/10.1002/ange.6774558","url":null,"abstract":"<div>\u0000 \u0000 <p>Class-based regulation of per- and polyfluoroalkyl substances (PFASs) requires analytical metrics that are both scientifically meaningful and operationally enforceable. The proposed EU REACH restriction uses total fluorine (TF), extractable or adsorbable organic fluorine (EOF/AOF), targeted PFAS analysis, and non-target analysis as complementary lines of evidence. We argue that these approaches are valuable, but they do not measure the same chemical quantity. While TF is a useful conservative gatekeeper for fluorinated materials, it cannot distinguish between polymeric PFASs, inorganic fluorine, volatile precursors, or fluorinated substances that may or may not fall within broad PFAS definitions. This limitation is especially important for polymeric PFASs, including both backbone fluoropolymers and side-chain fluorinated polymers, which can be non-extractable, particulate, or transformable into mobile precursors such as fluorotelomer alcohols. We propose an analytical decision tree that separates bulk fluorine screening, extractable fractions, volatile and semi-volatile PFASs, polymeric and particulate PFASs, and structurally confirmed molecular PFASs. Such an operational framework would preserve the regulatory value of fluorine screening while avoiding overinterpretation of any single metric as “PFAS content”. PFAS content should be assessed by what is there not by what can easily be measured.</p>\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outside Front Cover: Flexible, Biocompatible Supercapacitors Weaved From Layered Phyllosilicates and Zwitterions via Ionicity (Angew. Chem. Int. Ed. 43/2026) 外封面：柔性的、生物相容性的超级电容器，由层状硅酸盐和两性离子通过离子性编织而成。化学。Int。艾德。43/2026)

Angewandte Chemie Pub Date : 2026-10-19 Epub Date: 2026-09-28 DOI: 10.1002/ange.2026-m2509042700

Md Roxy Islam, Pritha Sarkar, Tanmay Sarkar Akash, Amanda Gabriela Bernard, Siddhartha Das, Josh Marsh, Neil Cunningham, Gernot Rother, Kausik Mukhopadhyay

引用次数: 0

Yuwei Gu

Angewandte Chemie Pub Date : 2026-10-19 Epub Date: 2026-09-10 DOI: 10.1002/ange.3221634

Yuwei Gu

引用次数: 0

Inside Back Cover: Supramolecular Self-Assembly Enables Controlled Lithium Replenishment Toward High-Performance and Sustainable Regeneration of Spent LiFePO4 Batteries (Angew. Chem. Int. Ed. 43/2026) 内页后盖：超分子自组装使可控锂补充朝着高性能和可持续再生的废LiFePO4电池（新）。化学。Int。艾德。43/2026)

Angewandte Chemie Pub Date : 2026-10-19 Epub Date: 2026-09-28 DOI: 10.1002/ange.2026-m2509022200

Yixin Lin, Tiansheng Wang, Chaochao Gao, Jie Xu, Jiawen Chen, Zixi Lin, Guanghao Mao, Weihao Gao, Yixuan Tang, Jiaheng Zhang

引用次数: 0

Outside Back Cover: A Programmable and Printable Microbial Bioelectronic Sensor for Real-Time and Targeted Pollutant Monitoring in Water (Angew. Chem. Int. Ed. 43/2026) 外封底：一个可编程和可打印的微生物生物电子传感器，用于实时和有针对性的污染物监测在水中。化学。Int。艾德。43/2026)

Angewandte Chemie Pub Date : 2026-10-19 Epub Date: 2026-09-30 DOI: 10.1002/ange.2026-m2809065900

Xing-Yu Wang, Yi-Xuan Wang, Jun Ding, Xiao-Li Liu, Meng-Jie Luo, Meng Liu, Dong-Feng Liu, Zhi-Xiang She, Yang Mu

引用次数: 0

CRISPR RNA Engineering Enables Single Nucleotide Polymorphism Discrimination in Nucleic Acid Detection CRISPR RNA工程使核酸检测中的单核苷酸多态性判别成为可能

Angewandte Chemie Pub Date : 2026-10-19 Epub Date: 2026-08-14 DOI: 10.1002/ange.202600004

Tianrui Sun, Aijiao Yuan, Wenjing Xie, Guibin Jiang, Hanyong Peng

{"title":"CRISPR RNA Engineering Enables Single Nucleotide Polymorphism Discrimination in Nucleic Acid Detection","authors":"Tianrui Sun, Aijiao Yuan, Wenjing Xie, Guibin Jiang, Hanyong Peng","doi":"10.1002/ange.202600004","DOIUrl":"https://doi.org/10.1002/ange.202600004","url":null,"abstract":"<div>\u0000 \u0000 <p>Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based diagnostic systems have emerged as powerful platforms for sensitive nucleic acid detection, yet their clinical reliability is frequently constrained by off-target activation and insufficient discrimination of closely related sequences. This review synthesizes current advances aimed at enhancing the specificity of CRISPR diagnostics, with particular emphasis on the pivotal role of CRISPR RNA (crRNA) engineering. We detail how structural determinants of crRNA, including spacer length optimization, intentional mismatch design, secondary-structure modulation, chemical modification, strand-displacement gating, and synergistic design frameworks, govern CRISPR-mediated target recognition and define the energetic and kinetic thresholds for accurate cleavage. Key engineering strategies encompassing computational prediction and modeling, high-throughput screening, and hybrid guide architectures are systematically examined for their capacity to elevate single-nucleotide discrimination, stabilize reaction performance, and enable robust multiplexed detection for pathogen profiling and mutation identification. Despite rapid progress, outstanding challenges persist, including interference from complex clinical matrices, lack of unified evaluation standards, and scalability barriers that hinder clinical translation. Addressing these limitations through integrated crRNA design, system-level optimization, and standardized benchmarking will be essential for realizing the promise of CRISPR diagnostics. Ultimately, these advances are poised to support ultrasensitive, highly specific, and portable point-of-care testing, thereby accelerating precision medicine and strengthening infectious disease surveillance and management.</p>\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electric/Thermal Coupling Field Promotes Phonon Delocalization to Accelerate Defect-Repair Kinetics in Spent LiFePO4 电/热耦合场促进声子离域加速废LiFePO4缺陷修复动力学

Angewandte Chemie Pub Date : 2026-10-19 Epub Date: 2026-09-02 DOI: 10.1002/ange.1597082

Sen Dang, Zhijie Zhang, Menghang Sun, Kai Jia, Xiyao Dong, Bo Wen, Shen Wang, Xiaolong Lyu, Yaxin Chen, Lili Li, Kai Xi, Shujiang Ding, Guorui Yang

{"title":"Electric/Thermal Coupling Field Promotes Phonon Delocalization to Accelerate Defect-Repair Kinetics in Spent LiFePO4","authors":"Sen Dang, Zhijie Zhang, Menghang Sun, Kai Jia, Xiyao Dong, Bo Wen, Shen Wang, Xiaolong Lyu, Yaxin Chen, Lili Li, Kai Xi, Shujiang Ding, Guorui Yang","doi":"10.1002/ange.1597082","DOIUrl":"https://doi.org/10.1002/ange.1597082","url":null,"abstract":"<div>\u0000 \u0000 <p>Solid-phase regeneration is widely considered as the most promising scalable approach for recycling spent LiFePO<sub>4</sub> (S-LFP) cathode. However, the sluggish defect-repair kinetics in traditional solid-phase routes remains mechanistically unclear, limiting the practical deployment of this technology. Here, theoretical calculations reveal that the phonon localization in defect-rich S-LFP is the essential factor responsible for the sluggish defect-repair kinetics. Localized phonons retard thermal diffusion, hindering the energy available to overcome defect repair barriers, and concurrently intensify electron-phonon coupling that suppresses the electron migration necessary for the reduction of Fe(III). Guided by this insight, we employ electric/thermal coupling field strategy to repair the S-LFP cathode. Carriers driven by the electric field transfer energy to phonons through electron-phonon scattering, which promotes energy redistribution across disparate phonon modes, collectively enhancing phonon delocalization. As a result, Li-Fe antisites (Fe<sub>Li</sub>) were repaired within 5 s at 700°C, and the complete structural repair and lithiation are achieved within 60 s. Experimental results indicate that the regenerated cathode delivers a discharge specific capacity of 151.2 mAh g<sup>−1</sup> at 0.1C, and exhibits a capacity retention of 84.3% after 1100 cycles at 1 C. This theoretical breakthrough establishes a solid theoretical foundation for developing advanced S-LFP restoration technologies.</p>\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0