Inside Back Cover: A Self-Assembled Protein Platform for Plug-and-Play Customization of Multivalent Artificial Antibodies and Antibody-Drug Conjugates (Angew. Chem. 40/2025)
Yuzhe Chen, Yunchuan Huang, Shisheng Wang, Xinyuan Wang, Hongyu Lu, Jie Chen, Jing Li, Zhuo Chen, Zhao Li, Tianshan She, Youmei Jin, Yuanping Gao, Jie Zhang, Lijun Wang, Wenjuan Zeng, Hong Zhu, Ze Tao, Prof. Xiaofeng Lu, Prof. Hao Yang
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引用次数: 0
Abstract
Inspired by the interlocking wisdom of mortise-and-tenon Chinese craftsmanship, Hao Yang's team from West China Hospital, Sichuan University developed a modular protein platform ATPlug, turning age-old structural ingenuity into therapeutic innovation (Research Article e202506426). ATPlug enables plug-and-play customization of artificial antibodies and antibody-drug conjugates. This fusion of ancient craftsmanship and modern bioengineering helps overcome multivalent protein synthesis bottlenecks, offering a versatile toolkit for modular drug design.
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