Angewandte Chemie最新文献

{"title":"A Highly Dispersed Heterogeneous Cobalt Catalyst for Efficient Domino Hydroformylation Reductive Amination of Olefins","authors":"Dr. Kangkang Sun,&nbsp;Tianyue Su,&nbsp;Prof. Guo-Ping Lu,&nbsp;Prof. Robert Franke,&nbsp;Dr. Helfried Neumann,&nbsp;Prof. Matthias Beller","doi":"10.1002/ange.202419370","DOIUrl":"https://doi.org/10.1002/ange.202419370","url":null,"abstract":"<p>The hydroaminomethylation of alkenes using CO and H₂ proceeds efficiently in the presence of a heterogeneous Co−N/C catalyst with highly dispersed metal centers. Various secondary and tertiary amines can be effectively synthesized from cyclic and linear aliphatic alkenes using this specific material. The active sites of the optimal catalyst result from the synergistic effect of atomically dispersed Co sites with their surrounding N atoms, and the high surface area as well as structural defects of the NC support. The broad applicability (&gt;54 examples), including pharmaceutically relevant molecules, together with the high activity and reusability, underline the general applicability of this catalytic system.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202419370","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontispiz: Microfluidic Precision Manufacture of High Performance Liquid Chromatographic Microspheres","authors":"Dr. Kaiyue Sun,&nbsp;Dr. Juxing Zeng,&nbsp;Dr. Ya Liu,&nbsp;Dr. Zhuoheng Zhou,&nbsp;Jikai Chen,&nbsp;Jiawei Chen,&nbsp;Xiangyu Huang,&nbsp;Dr. Fan Gao,&nbsp;Dr. Xin Wang,&nbsp;Dr. Xin Zhang,&nbsp;Dr. Xiaofei Wang,&nbsp;Prof. Dr. Sebastiaan Eeltink,&nbsp;Prof. Dr. Bo Zhang","doi":"10.1002/ange.202580562","DOIUrl":"https://doi.org/10.1002/ange.202580562","url":null,"abstract":"<p>Chromatography material is precisely manufactured in a high-throughput manner, based on a droplet microfluidic strategy developed by Kaiyue Sun, Juxing Zeng, Ya Liu, Zhuoheng Zhou and co-workers in their Communication (e202418642). The universal high-resolution separation is achievable for a wide range of molecules, due to the well-controlled particle size distribution, freely-tunable pore structure and versatile material chemistry.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202580562","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontispiz: Orientational Compatibility Modulation of Ligands in Low-Symmetry Multi-Cavity Discrete Coordination Cages by Neighbouring Cage Participation","authors":"Ashish Kumar,&nbsp;Dr. Shobhana Krishnaswamy,&nbsp;Prof. Dr. Dillip Kumar Chand","doi":"10.1002/ange.202580561","DOIUrl":"https://doi.org/10.1002/ange.202580561","url":null,"abstract":"<p>The Molecular Architecture Laboratory of IIT Madras demonstrates the role of “Neighbouring Cage Participation” (NCP) in the construction of a family of pear-shaped low-symmetry double-cavity coordination cages. Combination of Pd(II) with a pair of isomeric ligands resulted in a low-hanging fruit i.e. a mixed-ligated <i>syn</i>-Pd₃L^a₂L^b₂ type cage duly supported by orientational compatibility of the ligands. However, use of one type of the ligands resulted in loss of compatibility, yet forming stable though not low-hanging fruits due to NCP. In their Research Article (e202416332), Dillip K Chand et al. systematically investigate the aforementioned low-symmetry conjoined-cages.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202580561","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Die Elektrochemische Iodierung von Elektronenarmen Aromaten","authors":"Sara Torabi,&nbsp;Dr. Mahdi Jamshidi,&nbsp;Prof. Dr. Gerhard Hilt","doi":"10.1002/ange.202422442","DOIUrl":"https://doi.org/10.1002/ange.202422442","url":null,"abstract":"&lt;p&gt;Halogenierte Aromaten sind sehr wichtige Edukte in nahezu allen Sektoren der chemischen Industrie und als wichtige Bausteine bedeutend u. a. für die Synthese von Polymeren, pharmazeutischen Produkten und Naturstoffen. Außerdem sind bromierte und iodierte (Hetero)Aromaten wichtige Startmaterialien in Palladium- und Nickel-katalysierten-Kreuzkupplungsreaktionen.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Zudem finden diese Edukte seit Kurzem auch zunehmend in (elektrochemischen) Kreuz-Elektrophilen-Kupplungsreaktionen Verwendung.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Die Halogenierung von Aromaten mit den Elementen Cl&lt;sub&gt;2&lt;/sub&gt;, Br&lt;sub&gt;2&lt;/sub&gt; und I&lt;sub&gt;2&lt;/sub&gt; ist eine der fundamentalen Reaktionen und ist Bestandteil jedes Lehrbuchs zur Organischen Chemie. Diese Reaktionen sind seit mehr als einem Jahrhundert bekannt und die Beschränkungen dieser Reaktionen sind wohl publiziert und auch immer noch schwer bis unmöglich zu überwinden. Die Reaktivität der elementaren Halogenide nimmt vom Cl&lt;sub&gt;2&lt;/sub&gt; über Br&lt;sub&gt;2&lt;/sub&gt; zum I&lt;sub&gt;2&lt;/sub&gt; hin stetig ab, so dass die direkte Iodierung eines Aromaten nur erfolgreich abläuft, wenn es sich um einen elektronenreichen Aromaten wie ein Phenol-, Anisol- oder Anilin-Derivat handelt. Zur weiteren Aktivierung von I&lt;sub&gt;2&lt;/sub&gt; wurden Additive, wie etwa Ag(I)- oder Hg(II)-Verbindungen verwendet oder Lewis-Säuren zur Aktivierung von Interhalogeniden, wie etwa I−Cl oder I−Br, können zugesetzt werden, um das Gleichgewicht in Richtung der gewünschten iodierten Aromaten zu verschieben, sodass auch weniger aktivierte Aromaten iodiert werden können (Schema 1).&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Die Iodierung von deaktivierten, elektronenarmen Aromaten ist in der chemischen Literatur nur sporadisch beschrieben.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Erst in den letzten Jahren wurden einige Reagenzien für solche Umsetzungen entwickelt, wie etwa ein System bestehend aus FeCl&lt;sub&gt;3&lt;/sub&gt; und &lt;i&gt;N&lt;/i&gt;-Iodsuccinimid (NIS), das von Sutherland entwickelt wurde,&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; ein &lt;i&gt;m&lt;/i&gt;-NBSA/NIS-System, das von Song und Jiao beschrieben wurde&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; und ein 1,3-Diiod-5,5-dimethylhydantoin (DIH)/S&lt;sub&gt;8&lt;/sub&gt;-System von Maegawa,&lt;span&gt;&lt;sup&gt;7&lt;/sup&gt;&lt;/span&gt; neben einigen anderen Systemen mit sulfidischen Additiven.&lt;span&gt;&lt;sup&gt;8&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Mit diesen neuen Reagenzien konnten nicht weiter substituierte elektronenarme Aromaten, wie etwa Trifluorbenzol in guten Ausbeuten iodiert werden. In vielen Beispielen wird die elektronenabstrahierende Funktionalität jedoch durch eine elektronenabgebende Gruppe begleitet und nur in wenigen Ausnahmefällen werden die Grundkörper der elektronenarmen Aromaten, wie Nitrobenzol, Benzoesäureester oder Pyridin,&lt;span&gt;&lt;sup&gt;9&lt;/sup&gt;&lt;/span&gt; in guten Ausbeuten direkt iodiert.&lt;/p&gt;&lt;p&gt;Eine elektrochemische Methode zur direkten Iodierung von elektronenreichen und elektronenneutralen Aromaten wurde durch die Kationen-Pool Elektrolyse beschrieben, die auf Miller zurückgeht und die von Yoshida für die Generierung von I&lt;sup&gt;+","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202422442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer Ligands with Multi-Nitrogen Heterocyclic Carbenes for Enhanced Stability and Reactivity in Nanoparticle Surface Functionalization","authors":"Jing Tao,&nbsp;Di Zheng,&nbsp;Yutian Tang,&nbsp;Dr. Huibin He,&nbsp;Dr. Yan Zhang,&nbsp;Dr. Yanqiong Yang,&nbsp;Dr. Liwei Dai,&nbsp;Huaining Zha,&nbsp;Prof. Yutao Sang,&nbsp;Prof. Zhihong Nie","doi":"10.1002/ange.202419640","DOIUrl":"https://doi.org/10.1002/ange.202419640","url":null,"abstract":"<p>Nitrogen heterocyclic carbenes (NHCs) are emerging as effective substitutes for conventional thiol ligands in surface functionalization of nanoparticles (NPs), offering exceptional stability to NPs under harsh conditions. However, the highly reactive feature of NHCs limits their use in introducing chemically active groups onto the NP surface. Herein, we develop a general yet robust strategy for the efficient surface functionalization of NPs with copolymer ligands bearing various functional groups. The polymer ligands consist of a multiple NHCs block, utilized for surface binding on NPs, alongside a poly(reactive ester) block intended for incorporating functional groups. The multiple NHCs block enables NPs with excellent colloidal stability across a broader range of pH values (0–14), temperature variations (–78 °C-100 °C), and electrolyte concentrations (0–1000 mM). Through the in situ ammonolysis of the poly(reactive ester) block, various active functional groups can be individually or together introduced on the NP surface. We further demonstrate the chemical reactivity of these functionalized NPs, including addition polymerization, Diels–Alder and Schiff base reactions. This method is applicable to various types of NPs, including metal NPs, metal oxide NPs, and even upconversion NPs, thereby paving new pathways for the design and creation of nanoparticle-based functional materials.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Guided Modulation of Li+ Solvation Structures towards Optimal Electrolyte Systems for High-Performance Li−O2 Battery","authors":"Prof. Dapeng Liu,&nbsp;Zerui Fu,&nbsp;Shu Wang,&nbsp;Xiangrui Gong,&nbsp;Prof. Tingting You,&nbsp;Haohan Yu,&nbsp;Prof. Ying Jiang,&nbsp;Prof. Yu Zhang","doi":"10.1002/ange.202425277","DOIUrl":"https://doi.org/10.1002/ange.202425277","url":null,"abstract":"<p>As the “blood” of Li−O₂ batteries (LOBs), electrolytes with various solvation structures of Li⁺ can greatly influence the composition of solid electrolyte interphase (SEI) on anode and the growth kinetics of Li₂O₂ on cathode, and further the battery performance. However, achieving delicate modulation of the multi-composition electrolytes remains significantly challenging to simultaneously give consideration to both the anode and cathode reactions. In this work, we employed Bayesian optimization to develop advanced electrolytes for LOBs, enabling the formation of a stable inorganic-rich SEI, and modulation of Li₂O₂ morphologies. Thus obtained LOBs using the optimized dual-solvent electrolyte could deliver a discharge capacity of 14,063 mAh g⁻¹ at a current density of 500 mA g⁻¹, which is far higher than those using the single-solvent electrolytes. This study not only highlights the critical role of the solvation structure for improving the battery performance, but also provides new insights and important theoretical guidance for delicate modulation of electrolyte compositions.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precise Identification of Native Peptides with Posttranslational Proline Hydroxylation by Nanopore","authors":"Jing-Wen Chang,&nbsp;Yan Gao,&nbsp;Prof. Ai-Hua Zou,&nbsp;Meng-Yin Li,&nbsp;Prof. Yi-Tao Long,&nbsp;Jie Jiang","doi":"10.1002/ange.202422692","DOIUrl":"https://doi.org/10.1002/ange.202422692","url":null,"abstract":"<p>Hydroxylation, an extensive post-translational modification on proline, is critical for the modulation of native protein structures, further dominating their functions in life systems. However, current mass spectrometry (MS)-based identification, could hardly distinguish hydroxylation with the neighboring oxidation due to the same mass shifts, as well as challenges posed by low abundance and exogenous oxidation during sample preparation. To address this, an engineered nanopore was designed, capable of discriminating single hydroxyl group on proline, to achieve the identification of proline hydroxylation on individual native peptides directly in mixture. By modeling the interaction between hydroxylated proline and its specific recognition protein, we introduced a hydrophobic region in aerolysin lumen with A224Y/T274W mutations to enhance the sensitivity for proline residue. The results showed that the proline hydroxylation on native HIF-1α fragments could be unambiguously identified without purification, which could be maintained even in the presence of neighboring oxidation. The voltage-dependent experiments further demonstrated the more relaxed peptide structure induced by hydroxylation that supported the great impact of hydroxylation on chemical properties of proline and the molecular mechanism of the specific recognition for hydroxylated proline in nature. These findings highlight the potential of nanopore for precise hydroxylation detection, offering a reliable platform for further uncovering the related functions in biological systems.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lanthanide-Controlled Protein Switches: Development and In Vitro and In Vivo Applications","authors":"Zhong Guo,&nbsp;Oleh Smutok,&nbsp;Chantal Ronacher,&nbsp;Raquel Aguiar Rocha,&nbsp;Patricia Walden,&nbsp;Sergey Mureev,&nbsp;Zhenling Cui,&nbsp;Evgeny Katz,&nbsp;Colin Scott,&nbsp;Kirill Alexandrov","doi":"10.1002/ange.202411584","DOIUrl":"https://doi.org/10.1002/ange.202411584","url":null,"abstract":"<p>Lanthanides, which are part of the rare earth elements group have numerous applications in electronics, medicine and energy storage. However, our ability to extract them is not meeting the rapidly increasing demand. The discovery of the bacterial periplasmic lanthanide-binding protein lanmodulin spurred significant interest in developing biotechnological routes for lanthanide detection and extraction. Here we report the construction of β-lactamase-lanmodulin chimeras that function as lanthanide-controlled enzymatic switches. Optimized switches demonstrated dynamic ranges approaching 3000-fold and could accurately quantify lanthanide ions in simple colorimetric or electrochemical assays. <i>E.coli</i> cells expressing such chimeras grow on β-lactam antibiotics only in the presence of lanthanide ions. The developed lanthanide-controlled protein switches represent a novel platform for engineering metal-binding proteins for biosensing and microbial engineering.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202411584","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical Cyclopropanation of Unactivated Alkenes with Methylene Compounds","authors":"Min Liu,&nbsp;Yanwei Wang,&nbsp;Chao Gao,&nbsp;Jingpei Jia,&nbsp;Zile Zhu,&nbsp;Prof. Dr. Youai Qiu","doi":"10.1002/ange.202425634","DOIUrl":"https://doi.org/10.1002/ange.202425634","url":null,"abstract":"<p>Cyclopropanes are prevalent in natural products, pharmaceuticals, and bioactive compounds, functioning as a significant structural motif. Although a series of methods have been developed for the construction of the cyclopropane skeleton, the development of a direct and efficient strategy for the rapid synthesis of cyclopropanes from bench-stable starting materials with a broad substrate scope and functional group tolerance remains challenging and highly desirable. Herein, we present an electrochemical method for the direct cyclopropanation of unactivated alkenes using active methylene compounds. The strategy shows a broad substrate scope with a high level of functional group compatibility, as well as potential application as demonstrated by late-stage cyclopropanation of complex molecules and drug derivatives. Further mechanistic investigations suggest that Cp₂Fe (Fc) plays an essential role as an oxidative mediator in generating radicals from active methylene compounds.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Oligosaccharide Isomers Using Electrostatically Asymmetric OmpF Nanopore","authors":"Fan Gao,&nbsp;Jia-Hong Wang,&nbsp;Hui Ma,&nbsp;Prof. Bingqing Xia,&nbsp;Prof. Liuqing Wen,&nbsp;Prof. Yi-Tao Long,&nbsp;Prof. Yi-Lun Ying","doi":"10.1002/ange.202422118","DOIUrl":"https://doi.org/10.1002/ange.202422118","url":null,"abstract":"<p>Glycans, unlike uniformly charged DNA and compositionally diverse peptides, are typically uncharged and possess rich stereoisomeric diversity in the glycosidic bonds between two monosaccharide units. These unique features, including charge heterogeneity and structural complexity, pose significant challenges for accurate analysis. Herein, we developed a novel single-molecule oligosaccharide sensor, OmpF nanopore. The natural electroosmotic flow within OmpF generates a robust driving force for unlabeled neutral oligosaccharides, enabling detection at a concentration as low as 6.4 <i>μ</i>M. Furthermore, the asymmetric constriction zone of OmpF was employed to construct a stereoselective recognition site, enabling sensitive identification of glycosidic bond differences in cell lysate samples. With the assistance of machine learning algorithms, the OmpF nanopore achieved a recognition accuracy of 99.9 % for tetrasaccharides differing in only one glycosidic bond was achieved. This nanopore sensor provides a highly sensitive analytical tool with a broad dynamic range. It enables chiral recognition of oligosaccharides at low concentrations and is suitable for analysing both low-abundance and practical samples.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}