Angewandte Chemie最新文献

{"title":"Inside Front Cover: Chemical Proteomics Identifies Ketogenesis-Mediated Cysteine Modifications Regulating Redox Function (Angew. Chem. 14/2026)","authors":"Dr. Yuan-Fei Zhou,&nbsp;Dr. Ling Zhang,&nbsp;Zhuoyi L. Niu,&nbsp;Prof. Dr. Xin Wang,&nbsp;Alejandro Storper,&nbsp;Ryan Hunt,&nbsp;Prof. Dr. Yingming Zhao,&nbsp;Prof. Dr. Nima Sharifi,&nbsp;Prof. Dr. Zhipeng A. Wang","doi":"10.1002/ange.2026-m2702055600","DOIUrl":"10.1002/ange.2026-m2702055600","url":null,"abstract":"<p>Ketone body metabolism induces a previously unrecognized cysteine crotonation (Ccr) in mitochondrial proteins via a crotonyl intermediate. In the Research Article (e19830), Zhipeng A. Wang and co-workers reveal that Ccr at PRDX3 C229 disrupts redox regulation, leading to elevated reactive oxygen species. By integrating metabolic labeling with chemical proteomics, the work uncovers a new mechanism linking ketogenesis to mitochondrial redox signaling.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.2026-m2702055600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Der Nicht-Adiabatische Charakter von Substituenteneffekten in Azobenzol","authors":"Jacob Jan van der Wal,&nbsp;Roman Yu. Peshkov,&nbsp;Jorn D. Steen,&nbsp;Nadja A. Simeth,&nbsp;Stefano Crespi","doi":"10.1002/ange.202523613","DOIUrl":"10.1002/ange.202523613","url":null,"abstract":"<p><b>Vereinheitlichung Nicht-Adiabatischen Schaltens</b>: die thermische <i>Z</i>→<i>E</i> Isomerisierung von <i>para</i>-substitutierten Azobenzolen verläuft über einen einzelnen Reaktionsweg mit nicht-adiabatischem Charakter. Anstatt eines mechanistischen Wechsels spiegelt der bekannte V-förmige Hammett Graph ein Artefakt des σ_p Parameters, zeigt so die Grenzen von DFT auf und verweist auf die Aktivierungsentropie als des Pudels Kern im Photoschaltdesign.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202523613","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Proteomics Identifies Ketogenesis-Mediated Cysteine Modifications Regulating Redox Function","authors":"Dr. Yuan-Fei Zhou,&nbsp;Dr. Ling Zhang,&nbsp;Zhuoyi L. Niu,&nbsp;Prof. Dr. Xin Wang,&nbsp;Alejandro Storper,&nbsp;Ryan Hunt,&nbsp;Prof. Dr. Yingming Zhao,&nbsp;Prof. Dr. Nima Sharifi,&nbsp;Prof. Dr. Zhipeng A. Wang","doi":"10.1002/ange.202519830","DOIUrl":"https://doi.org/10.1002/ange.202519830","url":null,"abstract":"<p>All the studies of ketogenesis-dependent post-translational modifications (PTMs), notably those mediated by ketone bodies, β-hydroxybutyrate (Bhb) and acetoacetate (Acac), have focused on lysine acylations. However, given the chemically diverse and reactive nature of metabolites generated, it remains unclear whether non-lysine modifications can also happen. Here, we develop an acetoacetate-alkyne (Acac-alkyne) chemical probe that enables efficient metabolic labeling, robust fluorescent visualization, and site-specific identification of Acac-modified proteins. By combining chemical proteomics with open-search strategy, we showed that Acac induces previously uncharacterized cysteine modifications in mammalian cells. Notably, cysteine crotonation (Ccr) is validated by employing both probe-based and standard peptide-based co-elution assays. Metabolic pathway tracing further identifies BDH1 and ECHS1 as key enzymes that generate Ccr formation. We further demonstrate that Ccr at PRDX3 C229 site impairs dimerization and redox activity, linking this newly discovered modification to the regulation of cellular reactive oxygen species. Together, these findings establish ketone metabolism as a novel source of cysteine modifications and provide an alternative mechanistic pathway to explain the profound biological effects of ketone bodies.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202519830","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient Electrochemical Urea Synthesis From CO2 and N2 in Moderate Pressure","authors":"Xiangyu Chen,&nbsp;Tongcai Yue,&nbsp;Yue Liu,&nbsp;Yong Zhao,&nbsp;Hanke Cui,&nbsp;Hongfei Gu,&nbsp;Xiaoyi Sun,&nbsp;Qi Hu,&nbsp;Mingke Sun,&nbsp;Haolin Li,&nbsp;Yuhan Ma,&nbsp;Weifeng Huang,&nbsp;Jianxin Kang,&nbsp;Li-Min Liu,&nbsp;Lin Guo","doi":"10.1002/ange.8253479","DOIUrl":"https://doi.org/10.1002/ange.8253479","url":null,"abstract":"<div>\u0000 \u0000 <p>Although electrochemical nitrogen fixation emerges as a sustainable pathway to revolutionize the nitrogen cycle using renewable electricity, the overwhelming dominance of the hydrogen evolution reaction over N₂ activation in aqueous systems imposes fundamental limitations on simultaneously achieving high production rates and Faradaic efficiency. Inspired by Le Chatelier's principle, in this work, an appropriate pressure field was innovatively coupled with electrochemical reduction into the N₂-CO₂ co-fed urea synthesis system, achieving concurrently suppression of gaseous byproducts of CO/H₂ and enhancement of C–N coupling. Atomically dispersed amorphous Bi<i>_x</i>Ni_1-<i>_x</i>O<i>_y</i> clusters were engineered as tandem catalyst, the pressure-driven in situ electronic modulation of the liquid-immersed catalyst—originating from increased surface coverage—is for the first time confirmed: Bi sites exhibit a progressive increase in oxidation state, while Ni centers undergo gradual reduction. The rational atomic-scale integration of multimetallic active centers and system engineering principles for interfacial microenvironment modulation via moderate pressurization achieved breakthrough performance with a high urea production rate of 8.71 mmol h⁻¹ g⁻¹_cat, coupled with remarkable 50% nitrogen fixation efficiency, pointing to one of the best catalysts in aqueous systems among those reported so far. By integrating pressure engineering with atomic-scale catalyst design, this work provides a guiding paradigm for gas-involved electrochemical reactions.</p>\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Self-Assembled Single-Ion Membrane via In Situ Neutralization Enables Triple Stability in Ultrahigh-Nickel Cathodes","authors":"Chen Mao,&nbsp;Xu Zhang,&nbsp;Zili Cui,&nbsp;Qian Zhou,&nbsp;Chenglong Lu,&nbsp;Chaojie Chen,&nbsp;Linyan Yao,&nbsp;Hong Xu,&nbsp;Jun Ma,&nbsp;Zhaolin Lv,&nbsp;Shanmu Dong,&nbsp;Xinhong Zhou,&nbsp;Guanglei Cui","doi":"10.1002/ange.202524314","DOIUrl":"https://doi.org/10.1002/ange.202524314","url":null,"abstract":"<div>\u0000 \u0000 <p>Ultrahigh-nickel layered oxides (Ni ≥ 90%) offer exceptional specific capacity but suffer from severe air sensitivity, poor thermal stability, and rapid capacity decay. To date, it is still a significant challenge to address all three bottlenecks simultaneously with a single and integrated strategy, which have severely hindered the large-scale commercial deployment of ultrahigh-nickel layered oxide cathodes. Herein, a novel self-assembling single-ion conductor membrane, featuring exceptional hydrophobicity, outstanding thermal stability (&gt;445°C), and strong Donnan exclusion against PF₆⁻ anions, is rationally engineered to holistically enhance the air stability, heat resistance, and electrochemical performance of ultrahigh-nickel layered oxide cathodes. The N-cyano-sulfonamide group on membrane undergoes an in-situ neutralization reaction with residual LiOH/Li₂CO₃ on the LiNi_0.9Co_0.05Mn_0.05O₂ (NCM9055), which drives it migration toward the cathode surface and form a self-assembled protective coating with pronounced hydrophobicity and strong Donnan exclusion. As a result, 3.5 Ah NCM9055/Gr pouch battery demonstrates a commendable capacity retention of 94.97% after 500 cycles. meanwhile the onset temperature of thermal runaway was significantly elevated from 124.2°C to 158.2°C. This work establishes a unified interfacial engineering paradigm that simultaneously addresses the long-standing triad of bottlenecks plaguing ultrahigh-nickel layered oxide cathodes, offering a scalable and industrially viable pathway toward safe, long-life, high-energy-density lithium-ion batteries (LIBs).</p>\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facet-Selective Nucleation Control for Constructing Multi-Dimensional MOFs Heterostructures","authors":"Ru Lin,&nbsp;Hongkang Zhang,&nbsp;Yuyu Xu,&nbsp;Kai Wang,&nbsp;Hongrui Liu,&nbsp;Dr. Shunwei Chen,&nbsp;Dr. Zifei Wang,&nbsp;Prof. Kang Wang,&nbsp;Prof. Yong Sheng Zhao,&nbsp;Prof. Zhenhua Gao","doi":"10.1002/ange.202525577","DOIUrl":"10.1002/ange.202525577","url":null,"abstract":"<p>Metal–organic framework (MOF) heterostructures featuring tunable morphologies and compositions have shown great promise for applications in high-throughput sensing, anti-counterfeiting, and information encryption. Nevertheless, the precise engineering of heterogeneous architectures with multi-dimensional building units remains challenging, primarily hindered by an insufficient understanding of the growth dynamics between modules of different dimensionality. Here, we demonstrate a facet-selective epitaxial growth approach for architecting spatially defined dimensional heterostructures via crystalline plane-selective reactivity control. The intrinsically higher surface energy at the tips of 1D microrods facilitates the nucleation of 2D modules on the terminal facets, thereby yielding dumbbell-like heterostructures. Conversely, by selectively enhancing the reaction activity on the body regions of the 1D templates, preferential nucleation and growth at the central areas over the tips were effectively achieved, which enables the controlled formation of periodic modular architectures through systematic regulation of surface energies. The facet-selective epitaxial growth paradigm establishes a pathway for synthesizing hierarchical dimensional heterostructures with tailored architectures, which show great promise for applications in advanced optoelectronics, anti-counterfeiting systems, and information encryption technologies.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Back Cover: Neo-Cysteine Molecular Glues for Targeting Mutated SMAD4 Protein (Angew. Chem. 14/2026)","authors":"Pooja Kumari,&nbsp;Yoon Hyeun Oum,&nbsp;Eric J. Miller,&nbsp;Min Qui,&nbsp;Yuhong Du,&nbsp;Hongmei Mou,&nbsp;Rakesh Singh,&nbsp;Haian Fu,&nbsp;Xiulei Mo","doi":"10.1002/ange.2026-m2302040700","DOIUrl":"10.1002/ange.2026-m2302040700","url":null,"abstract":"<p>Disease-causing mutations frequently disrupt regulatory protein–protein interactions. In the Research Article (e12791), Xiulei Mo and co-workers exploit a mutation-generated neo-cysteine as a covalent handle to repair such defects. In this case study, a neo-cysteine targeted molecular glue (neoCMG) restores the mutant SMAD4–SMAD3 interface and reactivates tumor-suppressive signaling. This proof-of-concept establishes a generalizable strategy for targeted protein restoration in cancer and other diseases.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.2026-m2302040700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outside Back Cover: Tellurophene-Induced Triplet–Singlet Spin–Flip Acceleration: An Advanced Design for Narrowband Organoboron Emitters with Fast Reverse Intersystem Crossing (Angew. Chem. 14/2026)","authors":"Peiyuan Yang,&nbsp;Jun Hyeon Lee,&nbsp;Kotone Urano,&nbsp;Prof. Dr. Takuma Yasuda","doi":"10.1002/ange.2026-m2702061600","DOIUrl":"10.1002/ange.2026-m2702061600","url":null,"abstract":"<p>The first multi-resonance thermally activated delayed fluorescence (MR-TADF) emitters incorporating tellurium—the heaviest stable chalcogen—have been developed by Takuma Yasuda and co-workers in the Research Article (e24098). Simply linking a dibenzo[<i>b</i>,<i>d</i>]tellurophene unit dramatically accelerates excitonic spin conversion between triplets and singlets. This design concept is applicable to various MR-TADF and other functional π-conjugated frameworks, enabling advanced optoelectronic applications.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.2026-m2702061600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147579759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring Electronic Properties of Precision Graphene Nanoribbons via Nanopore Engineering","authors":"Kun Liu,&nbsp;Guanzhao Wen,&nbsp;Gianluca Serra,&nbsp;Nicolás Arisnabarreta,&nbsp;Hongde Yu,&nbsp;Andrea Lucotti,&nbsp;Yarden Peleg Walg,&nbsp;Hartmut Komber,&nbsp;Zhen-Lin Qiu,&nbsp;Qing-Song Deng,&nbsp;Ran He,&nbsp;Wenhui Niu,&nbsp;Thomas Heine,&nbsp;Eike Brunner,&nbsp;Mischa Bonn,&nbsp;Steven De Feyter,&nbsp;Matteo Tommasini,&nbsp;Hai I. Wang,&nbsp;Ji Ma,&nbsp;Xinliang Feng","doi":"10.1002/ange.202524299","DOIUrl":"10.1002/ange.202524299","url":null,"abstract":"<p>The precise incorporation of nanopores into graphene nanoribbons (GNRs) offers a complementary strategy for modulating their opto-electronic properties beyond conventional width and edge engineering. However, a systematic understanding of the relationship between the structure and electronic properties of porous GNRs (<b>pGNRs</b>) remains experimentally unexplored due to the lack of rational synthetic strategies. Herein, we report two novel porous GNRs (<b>pGNR 1</b> and <b>pGNR 2</b>) synthesized via solution-phase methods, featuring periodically arranged [18]annulene nanopores and gulf-edged architectures, along with a nonporous GNR (<b>npGNR</b>) as a counterpart. Utilizing efficient Diels-Alder polymerization and Scholl-type cyclization, these GNRs attain average lengths of up to 60 nm. The chemical identities of the synthesized GNRs were comprehensively characterized by IR, Raman, and solid-state NMR spectroscopy, complemented by theoretical calculations. To further elucidate the structural features underlying the observed properties, three representative model compounds (<b>1</b>, <b>2</b>, and <b>3</b>) corresponding to segments of the respective GNRs were synthesized and analyzed. UV–vis and THz spectroscopic analyses demonstrate that <b>npGNR</b> exhibits a relatively narrow optical bandgap of 1.63 eV and a high intrinsic charge carrier mobility of ∼40 cm² V⁻¹ s⁻¹, whereas <b>pGNR 2</b> displays a wider bandgap of 1.91 eV with a reduced mobility of ∼27 cm² V⁻¹ s⁻¹. This study systematically elucidates the effects of nanopore incorporation on the electronic structure and charge transport properties of GNRs, offering a rational design framework for the design of nanopore-engineered carbon-based electronic materials.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202524299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Proteomics Identifies Ketogenesis-Mediated Cysteine Modifications Regulating Redox Function","authors":"Dr. Yuan-Fei Zhou,&nbsp;Dr. Ling Zhang,&nbsp;Zhuoyi L. Niu,&nbsp;Prof. Dr. Xin Wang,&nbsp;Alejandro Storper,&nbsp;Ryan Hunt,&nbsp;Prof. Dr. Yingming Zhao,&nbsp;Prof. Dr. Nima Sharifi,&nbsp;Prof. Dr. Zhipeng A. Wang","doi":"10.1002/ange.202519830","DOIUrl":"https://doi.org/10.1002/ange.202519830","url":null,"abstract":"<p>All the studies of ketogenesis-dependent post-translational modifications (PTMs), notably those mediated by ketone bodies, β-hydroxybutyrate (Bhb) and acetoacetate (Acac), have focused on lysine acylations. However, given the chemically diverse and reactive nature of metabolites generated, it remains unclear whether non-lysine modifications can also happen. Here, we develop an acetoacetate-alkyne (Acac-alkyne) chemical probe that enables efficient metabolic labeling, robust fluorescent visualization, and site-specific identification of Acac-modified proteins. By combining chemical proteomics with open-search strategy, we showed that Acac induces previously uncharacterized cysteine modifications in mammalian cells. Notably, cysteine crotonation (Ccr) is validated by employing both probe-based and standard peptide-based co-elution assays. Metabolic pathway tracing further identifies BDH1 and ECHS1 as key enzymes that generate Ccr formation. We further demonstrate that Ccr at PRDX3 C229 site impairs dimerization and redox activity, linking this newly discovered modification to the regulation of cellular reactive oxygen species. Together, these findings establish ketone metabolism as a novel source of cysteine modifications and provide an alternative mechanistic pathway to explain the profound biological effects of ketone bodies.</p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202519830","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}