Angewandte Chemie最新文献_第4页

Von In-Silico bis In-Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus 从硅内到脑内：食欲素受体拮抗剂“光orexant”在体外和小鼠大脑中的光调节的发展

Angewandte Chemie Pub Date : 2026-10-10 Epub Date: 2026-08-05 DOI: 10.1002/ange.9938411

Marcus Angermann, Marie H. Deventer, Vicente Ledesma-Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker

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Macrocycle-Based Charge-Transfer Cocrystals: From Host–Guest Recognition to Multifunctional Solid-State Materials 基于大循环的电荷转移共晶：从主客识别到多功能固态材料

Angewandte Chemie Pub Date : 2026-10-10 Epub Date: 2026-08-13 DOI: 10.1002/ange.5451795

Gengxin Wu, Haitao Wang, Susu Ren, Jia-Rui Wu

{"title":"Macrocycle-Based Charge-Transfer Cocrystals: From Host–Guest Recognition to Multifunctional Solid-State Materials","authors":"Gengxin Wu, Haitao Wang, Susu Ren, Jia-Rui Wu","doi":"10.1002/ange.5451795","DOIUrl":"https://doi.org/10.1002/ange.5451795","url":null,"abstract":"<div>\u0000 \u0000 Macrocycle-based charge-transfer (CT) cocrystals have recently emerged as a distinctive class of adaptive supramolecular solids that bridge molecular recognition and solid-state functional materials. Unlike conventional CT assemblies, these systems combine host–guest chemistry with intermolecular donor–acceptor interactions, enabling simultaneous regulation of molecular packing, electronic coupling, and excited-state processes. The coexistence of cavity-confined complexation and exo-wall CT assembly, together with the dynamic nature of host–guest interactions, provides unique opportunities for constructing stimuli-responsive materials whose structures and functions can be continuously modulated by external inputs. In this Review, we discuss the fundamental principles underlying the design and construction of macrocycle-based CT cocrystals and highlight how adaptive host–guest recognition governs CT interactions and emergent solid-state properties. Recent advances in vapochromic sensing, molecular separation, photothermal conversion, luminescence modulation, and multifunctional integrated systems are systematically summarized, with particular emphasis on competitive and cooperative structural regulation mechanisms. Finally, we outline current challenges and future directions toward programmable, multicomponent, and application-oriented CT materials. By establishing connections between supramolecular structure, CT behavior, and functional output, this Review aims to provide a conceptual framework for the development of next-generation adaptive molecular solids.\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistische Diversität in der photoangeregten Radikal-Redoxchemie: Eine kritische Evaluierung 光激发自由基氧化还原化学的机械多样性：一个关键的评估

Angewandte Chemie Pub Date : 2026-10-10 Epub Date: 2026-08-11 DOI: 10.1002/ange.3889857

Samuel J. Horsewill, Ryan Phelps, Joshua P. Barham, Daniel J. Scott

引用次数: 0

Visualizing Labor Division in Oxygen Electrocatalysis: Fully Exposed Ni Clusters Enabling Dual-Site Catalysis via Asymmetric Atomic Bridging 可视化氧电催化中的劳动分工：完全暴露的Ni簇通过不对称原子桥接实现双位点催化

Angewandte Chemie Pub Date : 2026-10-10 Epub Date: 2026-08-19 DOI: 10.1002/ange.8680687

Mingyang Liu, Jiao Li, Qi Li, Xudong Xiao, Shan Hu, Panzhe Qiao, Kun Lang, Baojian Jing, Zhangxin Xu, Shuting Zhang, Jinlong Zou, Baojiang Jiang, Zhenbo Wang

{"title":"Visualizing Labor Division in Oxygen Electrocatalysis: Fully Exposed Ni Clusters Enabling Dual-Site Catalysis via Asymmetric Atomic Bridging","authors":"Mingyang Liu, Jiao Li, Qi Li, Xudong Xiao, Shan Hu, Panzhe Qiao, Kun Lang, Baojian Jing, Zhangxin Xu, Shuting Zhang, Jinlong Zou, Baojiang Jiang, Zhenbo Wang","doi":"10.1002/ange.8680687","DOIUrl":"https://doi.org/10.1002/ange.8680687","url":null,"abstract":"<div>\u0000 \u0000 Fully exposed metal cluster catalysts combine the atomic precision of single-atom catalysts with the multi-site reactivity of nanomaterials; however, achieving both structural stability and site-specific bifunctionality remains challenging. Herein, we report a Janus-type bifunctional catalyst comprising fully exposed atomic-layered nickel clusters anchored on Co2P nanocrystals (NiAC-Co2P), demonstrating excellent oxygen reduction/evolution reaction (ORR/OER) performance. Leveraging an electronic metal-support interaction, interfacial charge redistribution fine-tunes the d-band centers, optimizes intermediate adsorption and promotes dual-site catalysis. Theoretical calculations show the Ni-P-Co bridge lowers the *OOH formation barrier in ORR (half-wave potential of 0.90 V), while Ni clusters facilitate *O to *OOH conversion in OER (overpotential of 260 mV), enabling efficient four-electron kinetics via spatially decoupled dual-site cooperation. Operando x-ray absorption spectroscopy further confirms this mechanism, revealing Ni sites at the Ni-P-Co bridge undergo reversible Ni-P coordination modulation and transient Ni-O bond formation during ORR, whereas Ni-Ni clusters transform into NiOOH-like species to drive OER. Importantly, NiAC-Co2P-assembled Zn-air battery delivers a peak power density of 199.8 mW cm−2 and stable cycling performance exceeding 1400 h (approximately 4200 cycles). This work introduces a dual-site catalysis paradigm in transition metal phosphide-supported, fully exposed cluster catalysts, providing a robust strategy for designing multifunctional catalysts for energy conversion.\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iridium Artificial Metalloenzymes Enabled Photo-Enzymatic Radical Indolone Synthesis 铱人工金属酶催化光酶自由基吲哚酮合成

Angewandte Chemie Pub Date : 2026-10-10 Epub Date: 2026-08-19 DOI: 10.1002/ange.5014162

Nandita Ahalyan, Hirak Jyoti Deka, Subal Mondal, Argha Saha, Jhilik Mondal, Nikhil Ranjan Panigrahi, Abhishek Dubey, Ekta Pandey, Kaushal S., Debabrata Maiti

{"title":"Iridium Artificial Metalloenzymes Enabled Photo-Enzymatic Radical Indolone Synthesis","authors":"Nandita Ahalyan, Hirak Jyoti Deka, Subal Mondal, Argha Saha, Jhilik Mondal, Nikhil Ranjan Panigrahi, Abhishek Dubey, Ekta Pandey, Kaushal S., Debabrata Maiti","doi":"10.1002/ange.5014162","DOIUrl":"https://doi.org/10.1002/ange.5014162","url":null,"abstract":"<div>\u0000 \u0000 Biotin–streptavidin artificial metalloenzymes (ArMs) provide a platform to integrate transition-metal catalysis within a protein-defined microenvironment. Traditional indolone syntheses often rely on transition metal catalysts, high temperatures, and strong oxidants, limiting functional-group tolerance, and sustainability. In this study, we report a visible-light-driven radical cyclization of acrylamides and diazo-esters to indolones mediated by a biotinylated iridium-photocatalyst. Incorporation into engineered streptavidin generates highly active photo-ArMs, enabling reactions under mild aqueous conditions at 0.01 mol% Ir loading, broad substrate scope, and TONs up to 6300. Confinement of the iridium center within the protein binding pocket enhances turnover efficiency, establishing indolone formation as a new transformation accessible via biotin–streptavidin ArMs and highlighting their potential as sustainable platforms for bioactive motif synthesis.\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outside Front Cover: Directional Second Sphere Effect on CO2 Activation and Reduction by Iron Porphyrin in Aprotic and Protic Media (Angew. Chem. 42/2026) 外封面：非质子和质子介质中铁卟啉对CO2活化和还原的定向第二球效应（新）。化学42/2026)

Angewandte Chemie Pub Date : 2026-10-10 Epub Date: 2026-09-21 DOI: 10.1002/ange.2026-m1709014400

Ashutosh Vishwakarma, Sami Essid, Sarah Bouery, Régis Guillot, Bernard Boitrel, Philipp Gotico, Marie Sircoglou, Zakaria Halime

引用次数: 0

Outside Back Cover: Positional Effects of Single-Atom Active Sites in 1D Porphyrinic COFs on Photocatalytic CO2 Reduction (Angew. Chem. 42/2026) 外封底：一维卟啉COFs中单原子活性位点对光催化CO2还原的位置影响（新）。化学42/2026)

Angewandte Chemie Pub Date : 2026-10-10 Epub Date: 2026-09-21 DOI: 10.1002/ange.2026-m1709012800

Yu Zhao, Xiuli Ye, Shangqing Liu, Li Fang, Guolong Xing, Bo Song, Teng Ben

引用次数: 0

Positional Effects of Single-Atom Active Sites in 1D Porphyrinic COFs on Photocatalytic CO2 Reduction 一维卟啉COFs中单原子活性位对光催化CO2还原的影响

Angewandte Chemie Pub Date : 2026-10-10 Epub Date: 2026-07-30 DOI: 10.1002/ange.2029789

Yu Zhao, Xiuli Ye, Shangqing Liu, Li Fang, Guolong Xing, Bo Song, Teng Ben

{"title":"Positional Effects of Single-Atom Active Sites in 1D Porphyrinic COFs on Photocatalytic CO2 Reduction","authors":"Yu Zhao, Xiuli Ye, Shangqing Liu, Li Fang, Guolong Xing, Bo Song, Teng Ben","doi":"10.1002/ange.2029789","DOIUrl":"https://doi.org/10.1002/ange.2029789","url":null,"abstract":"<div>\u0000 \u0000 The selective photocatalytic reduction of carbon dioxide (CO2) to methane (CH4) remains a formidable challenge due to the demanding eight-electron/proton-coupled reduction process. Here, we report a positional engineering strategy for tailoring the spatial distribution of single-atom active sites within 1D porphyrinic covalent organic frameworks (CPOF-13-M1-M2, where M1 = H/Cu and M2 = H/Cu), enabling tunable catalytic selectivity. By selectively positioning Cu atoms at either edge- or central-positioned porphyrin sites of the framework, or both, we elucidate how active-site location governs charge-carrier dynamics and reaction pathways. Central Cu sites favor CO formation via *CO desorption, whereas edge-positioned Cu sites promote sequential hydrogenation of *CO toward CH4 through multielectron transfer, achieving a CH4 production rate of 31.6 µmol g−1 h−1 with 92.9% electron selectivity. Dual-site configurations exhibited intermediate selectivity, reflecting the competing catalytic preferences of the two differently positioned active sites. These findings establish active-site positional engineering as a versatile design principle for tailoring photocatalytic pathways in COF-based catalysts, opening new avenues for the rational design of reticular materials for solar fuel generation.\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mimicking Enzymatic Proton Channeling Enables Near-Unity Selective Ammonia Electrosynthesis Beyond Neutral Limits 模拟酶的质子通道使接近统一的选择性氨电合成超越中性限制

Angewandte Chemie Pub Date : 2026-10-10 Epub Date: 2026-08-19 DOI: 10.1002/ange.2808377

Zhihao Wang, Jiaxin Yu, Lin He, Xu Zhang, Tong Shen, Bianli Luo, Xue Li, Ying Xie, Zhiyu Ren, Zhimin Chen

{"title":"Mimicking Enzymatic Proton Channeling Enables Near-Unity Selective Ammonia Electrosynthesis Beyond Neutral Limits","authors":"Zhihao Wang, Jiaxin Yu, Lin He, Xu Zhang, Tong Shen, Bianli Luo, Xue Li, Ying Xie, Zhiyu Ren, Zhimin Chen","doi":"10.1002/ange.2808377","DOIUrl":"https://doi.org/10.1002/ange.2808377","url":null,"abstract":"<div>\u0000 \u0000 Fragmented hydrogen-bond networks relegate proton transport to sluggish diffusion, leading to mismatched proton supply that compromises catalytic efficiency and selectivity, thereby necessitating strategies to enhance water-network ordering. Inspired by the proton channel mechanism in enzymatic catalysis, this work anchors silicotungstate (SiW12) onto Co3O4 to construct a SiW12/Co3O4 catalyst. The domain electrostatic field of SiW12 induces the ordered arrangement of interfacial water molecules, establishing an ordered water channel for proton migration. The results demonstrate that SiW12 promotes interfacial water activation and alleviates proton-transfer limitations, enabling rapid and directional proton delivery to nitrogen-containing intermediates. Leveraging this unique proton channel, SiW12/Co3O4 achieves near 100% selectivity over a wide potential window (−0.3 to −0.9 V vs. RHE) and a broad nitrate concentration range (0.01–1 M), achieving 99.3% NH3 FE and 15.1 mg h−1 cm−2 yield at −0.8 V versus RHE. Furthermore, the assembled Zn–NO3− battery delivers the highest reported power density (26.1 mW cm−2) under neutral conditions. This work establishes interfacial solvation-structure engineering as a general strategy for regulating proton delivery and developing highly selective electrocatalysts for sustainable ammonia electrosynthesis.\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Philipp Dabringhaus Philipp Dabringhaus

Angewandte Chemie Pub Date : 2026-10-10 Epub Date: 2026-08-27 DOI: 10.1002/ange.2399100

Philipp Dabringhaus

引用次数: 0