Jing Zhao, Yuncan Chen, Yurui Tang, Bohan Li, Qinyue Wang, Prof. Junfeng Wang, Prof. Xihui Gao, Yunle Zhang, Jing Wang, Prof. Zuhai Lei, Prof. Cong Li, Prof. Cong Wang
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Outside Back Cover: Tandem Dual-Ratiometric SERS Probe Enables Raman Imaging of Neurological pH Fluctuations in Epilepsy (Angew. Chem. 25/2025)
Dynamic monitoring of pH fluctuations within brain lesions in real time offers a promising strategy for elucidating how local acidosis contributes to neuronal hyperexcitability and the evolution of neurological disease. In their Research Article (e202504822), Cong Wang, Cong Li et al. report a precisely engineered monolayer self-assembly approach that greatly improves the signal intensity and photostability of SERS-based imaging. Leveraging this platform, they construct a tandem dual-ratiometric SERS probe capable of accurate and dynamic digital decoding of pH within diseased brain tissue, providing new insight into the microenvironmental cues that shape disease progression.
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