Analytical Sciences最新文献

{"title":"Enhancing refinery heavy oil fractions analytical performance through real-time predicative modeling","authors":"Emad Al-Shafei,&nbsp;Ali Aljishi,&nbsp;Mohammed Albahar,&nbsp;Ali Alnasir,&nbsp;Mohammad Aljishi","doi":"10.1007/s44211-024-00625-4","DOIUrl":"10.1007/s44211-024-00625-4","url":null,"abstract":"<div><p>This study introduces a suite of robust models aimed to advance the determination of physiochemical properties in heavy oil refinery fractions. By integrating real-time analytical technique inside the refinery analysis, we have developed a single analyzer capable of employing six partial least square regression equations. These designed models enable to provide real-time prediction of critical petroleum properties, such as sulfur content, micro carbon residues (MCR), asphaltene content, heating value, and the concentrations of nickel and vanadium metals. Specifically tailored for heavy oil in refinery feeds with an American petroleum institute (API) gravity range of 3° to 32° and sulfur content of 2.8 to 5.5 wt%, the models streamline the analysis process within refinery operations, bridging the gap between catalytic and non-catalytic processes across refinery units. The accuracy of our physiochemical prediction models has been validated against American Society for Testing and Materials (ASTM) standards, demonstrating their capability to deliver precise real-time property values. This approach not only enhances the efficiency of refinery analysis but also sets a new standard for the monitoring and optimization of heavy oil processing in real-time approach.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1899 - 1906"},"PeriodicalIF":1.8,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing X-ray diffraction in conjunction with competitive adaptive reweighted sampling (CARS) and principal component analysis for the discrimination of medicinal pearl powder and nacre powder","authors":"Chaogang Xing,&nbsp;Jingqun Yuan,&nbsp;Chenyang Shi,&nbsp;Xuancheng Chen,&nbsp;Shimin Li","doi":"10.1007/s44211-024-00624-5","DOIUrl":"10.1007/s44211-024-00624-5","url":null,"abstract":"<div><p>Nacre powder, often utilized to counterfeit medicinal pearl powder due to their similar chemical composition and appearance, poses a challenge in product authentication. This study introduces a rapid and efficient method for distinguishing between medicinal pearl powder and nacre powder using X-ray diffraction in conjunction with principal component analysis (PCA). The X-ray diffraction pattern underwent preprocessing techniques including smoothing denoising (Savitzky-Golay filter, 5-point) and second-order derivative analysis. Subsequently, PCA was employed for dimensionality reduction modeling. The CARS method was applied to select optimal variables for model refinement, determining the data preprocessing approach and key modeling variables. This method demonstrates the capability to accurately differentiate between pearl powder, nacre powder, and even counterfeit samples containing up to 90% pearl powder. With a high accuracy rate, swift operational speed, and potential for automation, this approach shows promise for practical implementation in the realm of pearl powder quality control.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1889 - 1897"},"PeriodicalIF":1.8,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical analysis of human hair","authors":"Hiroki Hotta","doi":"10.1007/s44211-024-00595-7","DOIUrl":"10.1007/s44211-024-00595-7","url":null,"abstract":"","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 7","pages":"1217 - 1218"},"PeriodicalIF":1.8,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a simultaneous LC–MS/MS analytical method for plasma: 16 antipsychotics approved in Japan and 4 drug metabolites","authors":"Masamitsu Maekawa,&nbsp;Maki Yokota,&nbsp;Toshihiro Sato,&nbsp;Yu Sato,&nbsp;Masaki Kumondai,&nbsp;Yuji Sato,&nbsp;Masato Suzuka,&nbsp;Daisuke Kobayashi,&nbsp;Kotaro Sakamoto,&nbsp;Masaki Matsuura,&nbsp;Masafumi Kikuchi,&nbsp;Hiroshi Komatsu,&nbsp;Kumiko Fujii,&nbsp;Yuji Ozeki,&nbsp;Hiroaki Tomita,&nbsp;Nariyasu Mano","doi":"10.1007/s44211-024-00619-2","DOIUrl":"10.1007/s44211-024-00619-2","url":null,"abstract":"<div><p>The increased risk of adverse drug reactions due to the concomitant use of antipsychotics is problematic in the treatment of schizophrenia. Therefore, the simultaneous analysis of their plasma concentrations is required. In this study, we developed a simultaneous liquid chromatography/tandem mass spectrometry (LC–MS/MS) method for analyzing plasma antipsychotics approved in Japan for therapeutic drug monitoring (TDM) applications. First, we counted the prescriptions for 16 antipsychotics and concomitant drugs used at the Tohoku University Hospital. LC–MS/MS was used for the simultaneous analysis of 16 antipsychotics and four drug metabolites. This analysis was conducted using a combination of selected reaction monitoring mode and reversed-phase chromatography. Following the examination of the MS/MS and LC conditions, an analytical method validation test was conducted. The developed method was used to analyze plasma antipsychotic levels in patients with schizophrenia. One-third of the patients received treatment with multiple antipsychotics. Under LC–MS/MS conditions, LC separation was performed using a combination of a C18 column and ammonium formate-based mobile phases with a gradient flow. The calibration curves were optimized by adjusting the ion abundance, and 11 compounds met the criteria for intra- and inter-day reproducibility tests. Some stability test results did not meet these criteria; therefore, further investigation is required. The developed method permitted the measurement of all the plasma parameters, including concentrations above the therapeutic range. Therefore, this method may be useful in the daily TDM practice of antipsychotics.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 9","pages":"1749 - 1763"},"PeriodicalIF":1.8,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11358186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Density and porosity analyses of porous hybrid microparticles containing gas in closed pores using centrifugal liquid sedimentation–dynamic light scattering combined analytical method","authors":"Tetsuji Yamaguchi,&nbsp;Tetsuya Yamamoto","doi":"10.1007/s44211-024-00623-6","DOIUrl":"10.1007/s44211-024-00623-6","url":null,"abstract":"<div><p>Porous hybrid microparticles are characterized by their densities and porosities. Consequently, the evaluation for density and porosity of porous hybrid microparticles in liquids is crucial for predicting the transport of particles in the atmosphere, human body, and industrial processes. However, direct measurement of the density and porosity of porous hybrid microparticles in liquids remains a challenge. In this study, we investigated the centrifugal sedimentation of polystyrene–silica hybrid microparticles with and without gas-containing closed pores. A centrifugal liquid sedimentation–dynamic light scattering combined analytical method was employed to determine the apparent densities of hybrid microparticles with and without gas-containing closed pores. The porosity of the hybrid microparticles with gas-containing closed pores was elucidated based on the inner buoyancy, which is a centrifugal force generated by the presence of low-density gas inside numerous closed pores. Further, the inner gas buoyancy was analyzed to estimate the particle porosity in liquids. The results obtained in this study confirmed the feasibility of utilizing the proposed method to determine the apparent density and porosity of porous hybrid microparticles in liquids.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1881 - 1888"},"PeriodicalIF":1.8,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring and warning for ammonia nitrogen pollution of urban river based on neural network algorithms","authors":"Yang Zhang,&nbsp;Liang Liu,&nbsp;Shenghong Zhang,&nbsp;Xiaolin Zou,&nbsp;Jinlong Liu,&nbsp;Jian Guo,&nbsp;Ying Teng,&nbsp;Yu Zhang,&nbsp;Hengpan Duan","doi":"10.1007/s44211-024-00622-7","DOIUrl":"10.1007/s44211-024-00622-7","url":null,"abstract":"<div><p>Ammonia nitrogen (AN) pollution frequently occurs in urban rivers with the continuous acceleration of industrialization. Monitoring AN pollution levels and tracing its complex sources often require large-scale testing, which are time-consuming and costly. Due to the lack of reliable data samples, there were few studies investigating the feasibility of water quality prediction of AN concentration with a high fluctuation and non-stationary change through data-driven models. In this study, four deep-learning models based on neural network algorithms including artificial neural network (ANN), recurrent neural network (RNN), long short-term memory (LSTM), and gated recurrent unit (GRU) were employed to predict AN concentration through some easily monitored indicators such as pH, dissolved oxygen, and conductivity, in a real AN-polluted river. The results showed that the GRU model achieved optimal prediction performance with a mean absolute error (MAE) of 0.349 and coefficient of determination (<i>R</i>²) of 0.792. Furthermore, it was found that data preprocessing by the VMD technique improved the prediction accuracy of the GRU model, resulting in an <i>R</i>² value of 0.822. The prediction model effectively detected and warned against abnormal AN pollution (&gt; 2 mg/L), with a Recall rate of 93.6% and Precision rate of 72.4%. This data-driven method enables reliable monitoring of AN concentration with high-frequency fluctuations and has potential applications for urban river pollution management.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1867 - 1879"},"PeriodicalIF":1.8,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of methodology for the visual identification of Tributyltin (TBT) in antifouling paint matrices","authors":"Fabricio Araújo Gonçalves Cruz,&nbsp;Cid Pereira,&nbsp;Marcos Antônio dos Santos Fernandez,&nbsp;Aricelso Maia Limaverde Filho,&nbsp;Tiago Lima da Silva","doi":"10.1007/s44211-024-00620-9","DOIUrl":"10.1007/s44211-024-00620-9","url":null,"abstract":"<div><p>Organotin compounds (OTC), mainly tributyltin (TBT), have been used since the 1970s as biocides in the composition of antifouling paints. Due to its physical–chemical characteristics, TBT has high toxicity to the marine environment affecting non-target organisms. The present study aims to develop a method of direct visual identification of TBT in antifouling paints using the cyclopalladate complex, 4- (2-thiazolylazo) resorcinol (TAR-Pd), synthesized in our laboratory. Tests were performed in blank and in the paint matrix with the following OTC: TBT-O; TBT-Cl; TPT-Cl; DBT-Cl (tributyltin oxide, tributyltin chloride, triphenyltin chloride, dibutyltin chloride), in addition to the SnCl₄ and SnCl₂ compounds (tin IV chloride and tin II chloride), all at a concentration of approximately 20 g/ kg of dry paint). The test was performed by applying paint samples to test bodies and scraping a few tens of milligrams of the dry paint film. The scraped paint samples were submitted to the test, showing a different staining reaction for the TBT-Cl and SnCl₄ samples concerning blank and other samples (TBT-O, TPT, DBT-Cl, and SnCl₂). Solution tests were performed to characterize reaction products by spectroscopy in the visible band. The method developed has potential for application in real samples, being selective for TBT-Cl and SnCl₄ in an acid medium, obtaining a limit of detection, in the range of 1–10 mg/kg dry paint.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1843 - 1855"},"PeriodicalIF":1.8,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual dual-mode aptasensor for non-small cell lung cancer exosome detection via HRP self-coupling enhanced oxidized iridium nanoparticle aggregation","authors":"Xin Xu,&nbsp;Ze Zhang,&nbsp;Tong Shen,&nbsp;Hongzhi Pan,&nbsp;Dong Chang","doi":"10.1007/s44211-024-00582-y","DOIUrl":"10.1007/s44211-024-00582-y","url":null,"abstract":"<div><p>The main reason for the high mortality rate of non-small cell lung cancer is that patients are usually diagnosed at an advanced stage of the disease. Exosomes, small membrane vesicles secreted by normal cells or tumor cells, play a significant role in the progression of NSCLC. This study successfully optimized the preparation of artificial nanoenzymes self-coupling with horseradish peroxidase (IrO₂NPs@HRP-AptCD63), without adding any ligand, demonstrating remarkable catalytic activity suitable for detecting the EGFR protein on the surface of NSCLC exosomes. When fused with the CD63 aptamer for identifying NSCLC exosomes, IrO₂NPs@HRP showed enhanced catalytic activity in the 3,3′,5,5′-tetramethylbenzidine-H₂O₂ oxidation–reduction system, thereby enhancing the colorimetric signal. This phenomenon can be distinguished by the naked eye and quantified using a UV–Vis spectrophotometer. Meanwhile, as the redox reaction occurs, the current signal of 3,3′,5,5′-tetramethylbenzidine-H₂O₂, acting as an electrolyte, changes. The developed aptasensor generates dual-mode signal outputs, firstly, to visually assess the samples for their positive or negative status, and subsequently employ more in-depth electrochemical or colorimetric analysis methods for a detailed quantitative analysis of suspected positive samples. The detection limits of electrochemical analysis and colorimetric analysis were 0.9 × 10³particles/mL and 0.14 × 10³particles/mL, respectively. Compared with traditional biomarkers such as CA125, this method exhibits exceptional specificity, capable of simultaneously distinguishing serum exosomes of healthy volunteers, COPD patients, and NSCLC patients, promoting exosome detection in mouse models for tumor monitoring. Additionally, it elucidates the changes in EGFR protein expression on the surface of serum exosomes throughout the developmental trajectory.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 8","pages":"1459 - 1473"},"PeriodicalIF":1.8,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on cellular uptake of a hydrophobic near-infrared-absorbing diradical-platinum(II) complex solubilized by albumin using hyperspectral imaging, spectrophotometry, and spectrofluorimetry","authors":"Ryota Sawamura,&nbsp;Atsuko Masuya-Suzuki,&nbsp;Nobuhiko Iki","doi":"10.1007/s44211-024-00621-8","DOIUrl":"10.1007/s44211-024-00621-8","url":null,"abstract":"<div><p>Owing to its biopenetrability and minimal invasiveness, near-infrared (NIR) light in the region between 700–1100 nm has attracted attention in cancer diagnosis and therapy. Our group previously reported that the hydrophobic diradical-platinum(II) complex PtL₂ is a promising agent for cancer photothermal therapy (L = 3,5-dibromo-1,2-diiminobenzosemiquinonate radical). Because PtL₂ does not fluoresce, its intercellular uptake of PtL₂ cannot be observed with a fluorescence microscope. In this study, we clarified the uptake and intracellular behavior of PtL₂ solubilized by bovine serum albumin (BSA) using hyperspectral imaging enabling spectrophotometric analysis of the image. The spectral changes in the obtained images indicated that the internalization of PtL₂ was followed by crystallization of the complex during the long incubation period (&gt; 4 h). Additionally, the binding constant <i>K</i>_b = 5.91 × 10⁴ M^–1 could be estimated upon fluorescence quenching analysis of BSA upon binding of PtL₂; <i>K</i>_b is two orders of magnitude smaller than that of albumin–common drugs. Considering the small <i>K</i>_b and low solubility of PtL₂ in water, we ultimately proposed the internalization path and fate of PtL₂ in the cell: release of PtL₂ from BSA near cellular membranes and subsequent cellular uptake via membrane permeation followed by saturation, resulting in crystallization.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1857 - 1865"},"PeriodicalIF":1.8,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of quantitative detection methods for four Alzheimer’s disease specific biomarker panels using electrochemical immunosensors based on enzyme immunoassay","authors":"Il Kyu Park,&nbsp;Young Sun Choi,&nbsp;Seo Yun Jo","doi":"10.1007/s44211-024-00614-7","DOIUrl":"10.1007/s44211-024-00614-7","url":null,"abstract":"<div><p>Accurate and timely diagnosis of Alzheimer's disease (AD) is necessary to maximize the effectiveness of treatment and using biomarkers for diagnosis is attracting attention as a minimally invasive method with few side effects. Electrochemical immunosensor (EI) is a method that is in the spotlight in the medical and bioanalytical fields due to its portability and field usability. Here, we quantified four AD specific biomarkers using EIs based on enzyme immunoassay. We selected and developed quantitative methods for the biomarkers using screen-printed gold electrodes. For three biomarkers, quantification was performed using competition immunoassays in which antigen–antibody premix mixtures were applied to antigen-immobilized electrodes and the limit of detection (LOD) values were secured, 1.20 ng/ml, 1.30 ng/ml, and 1.74 ng/ml, respectively. For the other, a sandwich immunoassay using antibody pair was selected for quantification and LOD was also achieved as 0.077 ng/ml. All four biomarkers in buffer samples were successfully quantified and reliable R² values were obtained, and reliable calibration curves were secured for three biomarkers in spiked human serum samples. The immunosensors developed and will be optimized are expected to be used in various fields, including detection of biomarkers for not only AD but also related diseases.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1809 - 1821"},"PeriodicalIF":1.8,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}