Analytical Sciences最新文献_第9页

Assessment of the X-ray-induced damage to sulfur in glass by laboratory X-ray fluorescence and wet chemical analysis 用实验室x射线荧光和湿化学分析评价x射线对玻璃中硫的损伤。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-29 DOI: 10.1007/s44211-025-00777-x

Yoshitaka Saijo, Hiroyuki Hijiya

{"title":"Assessment of the X-ray-induced damage to sulfur in glass by laboratory X-ray fluorescence and wet chemical analysis","authors":"Yoshitaka Saijo, Hiroyuki Hijiya","doi":"10.1007/s44211-025-00777-x","DOIUrl":"10.1007/s44211-025-00777-x","url":null,"abstract":"<div><p>Accurate valence state analysis of sulfur in glass is crucial because sulfur, a multivalent element, plays a pivotal role in regulating glass properties. X-ray analysis is a key technique for determining the valence state of sulfur; however, high-brightness synchrotron X-ray analysis can induce damage to sulfur in glass, reducing result reliability. Laboratory wavelength-dispersive X-ray fluorescence with a single crystal (single-crystal WD-XRF) is useful for routine analysis of average sulfur valence in glass samples; however, potential damage has not been reported. In this study, the stability of sulfur valence states in glass samples subjected to X-ray irradiation was investigated. WD-XRF measurements were conducted for up to 50 h, allowing in situ observation of sulfur damage. Wet chemical analysis was subsequently performed to verify the average sulfur valence in the irradiated areas. Two types of standard soda-lime silicate glasses, SRM 1831 (clear glass, high sulfur valence) and SGT10 (amber glass, low sulfur valence), were analyzed. Average sulfur valence remained stable in SRM 1831 but was gradually oxidized in SGT10 by X-ray irradiation. Wet chemical analyses confirmed these results, indicating that the sulfur valence change in SGT10 was actual. These analyses suggest that the oxidized layer of SGT10 was limited to the surface layer of the glass. This study highlights the importance of the conditions of WD-XRF analysis for the accurate determination of sulfur valence in glass, and the need for cross-validation with wet chemical analysis.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 7","pages":"1007 - 1013"},"PeriodicalIF":2.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Fabrication of ultra-thin glass sheets and their application to MEMS devices 超薄玻璃片的制备及其在MEMS器件中的应用。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-26 DOI: 10.1007/s44211-025-00774-0

Yo Tanaka

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Advancement of microchip electrophoresis coupled with capacitively coupled contactless conductivity detection—from design to application (2018–2024) 微芯片电泳耦合电容耦合非接触电导率检测的进展-从设计到应用（2018-2024）。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-25 DOI: 10.1007/s44211-025-00771-3

Mingpeng Yang, Chaofan Wang, Jun Cai, Xiaochen Lai, Mingyi Cao, Xingqiang Zhao

{"title":"Advancement of microchip electrophoresis coupled with capacitively coupled contactless conductivity detection—from design to application (2018–2024)","authors":"Mingpeng Yang, Chaofan Wang, Jun Cai, Xiaochen Lai, Mingyi Cao, Xingqiang Zhao","doi":"10.1007/s44211-025-00771-3","DOIUrl":"10.1007/s44211-025-00771-3","url":null,"abstract":"<div><p>Over the past three decades, microchip electrophoresis coupled with capacitively coupled contactless conductivity detection (ME-C<sup>4</sup>D) has garnered considerable interest due to its various merits, including minimal sample consumption, compact structure, immediate detection, and high analytical precision. Continuous technological innovation and improvement have significantly advanced ME-C<sup>4</sup>D in structural design, fabrication processes, and experimental methodologies. As a result, the application of this technology has expanded into a wider range of electrochemical analysis fields, including disease diagnosis, food safety assessment, environmental pollutant detection, and soil nutrient analysis. This review meticulously examines the forefront of ME-C<sup>4</sup>D over the last five years. It methodically categorizes and scrutinizes advancements from various dimensions, including newly emerged ME microchips, C<sup>4</sup>D electrodes, experimental protocols, and pioneering applications. Moreover, this paper critically summarizes these developments, identifying the prevailing limitations and challenges within ME-C<sup>4</sup>D. Ultimately, it projects potential future trajectories for innovation in the field of ME-C<sup>4</sup>D, suggesting pathways to overcome existing hurdles and hinting at the untapped possibilities that lie ahead. </p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 7","pages":"903 - 921"},"PeriodicalIF":2.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of rust due to freshwater on the provenance determination of unearthed iron artifacts using nondestructive X-ray fluorescence spectrometry 淡水生锈对出土铁器物源测定的影响——无损x射线荧光光谱法

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-25 DOI: 10.1007/s44211-025-00773-1

Shintaro Ichikawa, Kanon Sato, Yusuke Momosaki, Tsutomu Kurisaki

{"title":"Effect of rust due to freshwater on the provenance determination of unearthed iron artifacts using nondestructive X-ray fluorescence spectrometry","authors":"Shintaro Ichikawa, Kanon Sato, Yusuke Momosaki, Tsutomu Kurisaki","doi":"10.1007/s44211-025-00773-1","DOIUrl":"10.1007/s44211-025-00773-1","url":null,"abstract":"<div><p>We examined the effect of rust due to freshwater on the provenance determination of iron artifacts, which is typically conducted based on elemental concentrations determined using nondestructive X-ray fluorescence (XRF) spectrometry. This was achieved by comparing a rusted iron sickle collected from farmland in Fukuoka, Japan before and after rust removal. The data were collected at 30 positions on the surface of the sample using nondestructive XRF spectrometry before and after rust removal. The concentration distributions of all elements in the sample before and after rust removal were considerably different. The escape depths of the fluorescent X-rays were calculated based on the median chemical composition of the rusted sample and then compared, and the rust thickness was estimated based on the sample thickness before and after rust removal. The fluorescent X-rays emitted from the sample, except Ba Kα, reflected only information from the rusted part not the uncorroded metal part. The As/Sb scatter plots, which are often used in provenance determination of iron artifacts, were created to compare the sample before and after rust removal. The As/Sb values measured at 30 positions after rust removal were normally distributed, whereas those measured before rust removal were not. Similarly, the scatter plots obtained in both cases exhibited different distributions. Therefore, the provenance determination of ironware using nondestructive XRF spectrometry would be affected by its rusting due to freshwater.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 7","pages":"977 - 988"},"PeriodicalIF":2.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergent mutual separation strategy for rare-earth elements based on crystallization of coordination compounds 基于配位化合物结晶的稀土元素紧急互分离策略。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-23 DOI: 10.1007/s44211-025-00768-y

Atsuko Masuya-Suzuki

{"title":"Emergent mutual separation strategy for rare-earth elements based on crystallization of coordination compounds","authors":"Atsuko Masuya-Suzuki","doi":"10.1007/s44211-025-00768-y","DOIUrl":"10.1007/s44211-025-00768-y","url":null,"abstract":"<div><p>Over the past several decades, rare-earth (RE) elements have been widely used in industrial products due to their exceptional physical, chemical, and mechanical properties. The discovery and industrial applications of RE elements have largely been driven by advances in their mutual separation, as RE ions exhibit highly similar chemical properties. In recent years, the growing production of RE-based products has highlighted concerns over supply risks. Recovering RE ions from end-of-life industrial products, often referred to as “urban mines,” offers a sustainable solution and supports a circular RE economy. To promote RE recycling, there is a pressing need to develop separation methods with higher selectivity and lower environmental impact. This mini-review focuses on a novel strategy for RE separation based on the crystallization of coordination compounds, as reported over the past decade. First, separation systems utilizing the crystallization of coordination polymers constructed with RE ions and organic bridging ligands are summarized. Then, separation through the crystallization of discrete RE complexes with organic ligands is described, with particular emphasis on ligand structure, separation factors, and crystallization conditions.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1121 - 1127"},"PeriodicalIF":2.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Surface plasmon resonance (SPR) sensing utilizing far- and deep-ultraviolet light 利用远紫外光和深紫外光的表面等离子体共振（SPR）传感。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-22 DOI: 10.1007/s44211-025-00772-2

Ichiro Tanabe

{"title":"Surface plasmon resonance (SPR) sensing utilizing far- and deep-ultraviolet light","authors":"Ichiro Tanabe","doi":"10.1007/s44211-025-00772-2","DOIUrl":"10.1007/s44211-025-00772-2","url":null,"abstract":"<div><p>This study explores the development and applications of surface plasmon resonance (SPR) sensors operating in the far-ultraviolet (FUV) and deep-ultraviolet (DUV) regions. Aluminum (Al) is utilized as the plasmonic material. The experimental setup leverages an attenuated total reflectance (ATR) spectrometer with Al thin films deposited on prisms, enabling measurements under atmospheric conditions. These results highlight the potential for tuning SPR wavelengths through material and configuration adjustments. Enhanced performance compared to visible-region SPR sensors is demonstrated, with promising selectivity and detection capabilities. Furthermore, a flow measurement system designed for real-time monitoring underscores the practical utility of UV-SPR sensors. By fixing the measurement wavelength, rapid changes in environmental conditions can be observed with a time resolution of 0.1 s. This study establishes the foundation for advanced UV plasmonic sensors with broad implications for medical diagnostics, environmental monitoring, and biochemical analysis.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1213 - 1220"},"PeriodicalIF":2.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Microfluidic technologies for protein crystallography: advances and applications 蛋白质晶体学的微流控技术：进展与应用。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-21 DOI: 10.1007/s44211-025-00767-z

Masatoshi Maeki, Akihiko Ishida, Manabu Tokeshi

{"title":"Microfluidic technologies for protein crystallography: advances and applications","authors":"Masatoshi Maeki, Akihiko Ishida, Manabu Tokeshi","doi":"10.1007/s44211-025-00767-z","DOIUrl":"10.1007/s44211-025-00767-z","url":null,"abstract":"<div><p>Three-dimensional protein structure determination by X-ray crystallography is essential for understanding biological function and accelerating drug discovery. However, obtaining high-quality protein crystals remains a significant bottleneck. The conventional crystallization methods are often labor-intensive, require large sample volumes, and offer limited control over the crystallization environment. This review summarizes the application of microfluidic technologies to protein crystallography with a focus on their advantages over the conventional crystallization methods. Microfluidic devices enable nanoliter-scale sample handling, precise control over crystallization conditions, and high-throughput screening, addressing major limitations of the conventional approaches. This review introduces various microfluidic platforms, including droplet-based and microwell-based systems, for protein crystallization, crystal growth control, and on-chip X-ray diffraction analysis. The review also covers the use of microfluidics for creating diffusion-controlled crystal growth environments, real-time crystal growth measurement, on-chip X-ray diffraction measurement, and room-temperature X-ray crystallography with automated data processing.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1203 - 1211"},"PeriodicalIF":2.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultra-sensitive biosensor detection of microRNA based on the CRISPR/Cas12a system and exonuclease-assisted target recycling signal amplification 基于CRISPR/Cas12a系统和外切酶辅助靶标循环信号放大的microRNA超灵敏生物传感器检测。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-21 DOI: 10.1007/s44211-025-00755-3

Xing Yang, Yu Luo, Chunhua Su, Zhimei Huang, Yafang Tang, Liwen Zhang

{"title":"Ultra-sensitive biosensor detection of microRNA based on the CRISPR/Cas12a system and exonuclease-assisted target recycling signal amplification","authors":"Xing Yang, Yu Luo, Chunhua Su, Zhimei Huang, Yafang Tang, Liwen Zhang","doi":"10.1007/s44211-025-00755-3","DOIUrl":"10.1007/s44211-025-00755-3","url":null,"abstract":"<div><p>MicroRNAs (miRNAs) are essential regulators of gene expression and are significantly involved in both preventing and treating a range of diseases. To that end, we developed an ultra-sensitive detection method for miRNA-141 by integrating exonuclease-assisted target recycling signal amplification with the CRISPR/Cas12a system. This method employs a variable hairpin probe (HP) designed to hybridize with miRNA, which, under the action of exonuclease III (ExoIII), cleaves the hairpin probe and triggers target recycling signal amplification. This results in the formation of output DNAs (ODs) containing multiple repeat sequences. The CRISPR/Cas12a system identifies these repeated sequences in ODs through its crRNA component, which in turn triggers the trans-cleavage function of the Cas12a/crRNA complex. It leads to the cleavage of a fluorescently quenched reporter probe. Consequently, this process restores fluorescence, producing a significantly enhanced fluorescent signal that facilitates the detection of miRNA-141, achieving a detection threshold down to 62 fM. This detection approach can specifically differentiate miRNA-141 from other confounding substances and has effectively identified low concentrations of miRNA-141 in actual sample human serum and diverse cancer cell lysates, showcasing its capability for tracing various nucleic acid biomarkers at minimal levels.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 6","pages":"867 - 876"},"PeriodicalIF":2.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Raman spectroscopy for the quantitative and qualitative analyses of solid drug formulations of salbutamol 固体剂型沙丁胺醇的拉曼光谱定量和定性分析。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-20 DOI: 10.1007/s44211-025-00760-6

Syeda Takmeel Zahra, Noor Ul Sabah, Muhammad Irfan Majeed, Haq Nawaz, Nosheen Rashid, Abdulrahman Alshammari, Norah A. Albekairi, Arslan Ali, Sadia Arshad, Ammara Rehman, Aleena Shahzadi, Sonia Yaseen, Muhammad Kashif, Saira Dastgir, Maria Ghafoor

{"title":"Raman spectroscopy for the quantitative and qualitative analyses of solid drug formulations of salbutamol","authors":"Syeda Takmeel Zahra, Noor Ul Sabah, Muhammad Irfan Majeed, Haq Nawaz, Nosheen Rashid, Abdulrahman Alshammari, Norah A. Albekairi, Arslan Ali, Sadia Arshad, Ammara Rehman, Aleena Shahzadi, Sonia Yaseen, Muhammad Kashif, Saira Dastgir, Maria Ghafoor","doi":"10.1007/s44211-025-00760-6","DOIUrl":"10.1007/s44211-025-00760-6","url":null,"abstract":"<div><p>Inhalable drugs are commonly used to treat different kinds of respiratory disorders, such as asthma, coughing, wheezing, and breathing difficulties. Salbutamol is an inhalable drug which is used to treat symptoms of acute obstructive lungs disease and asthma. In this research, Raman spectroscopy technique has been utilized to determine the quality and quantity of solid dosage forms of salbutamol drug. Eight formulations of solid drug Salbutamol, combination of excipients and API, were prepared and analyzed. The Raman spectral features showed significant change in their intensities as directly related to variation in the concentration of formulation. Raman spectral results were further assessed by principal component analysis (PCA) and partial least squares regression analysis (PLSR) which are very potent chemometric tools for the quantitative and qualitative analyses of the pharmaceutical drugs. PCA was found to be useful in discriminating the acquired Raman spectra of various salbutamol drug formulations in solid forms of dosage. Furthermore, PLSR model developed for analyzing the quantitative relationship between different formulated solid dosages of salbutamol drug. The prediction of model and the prediction of an unknown drug formulation’s concentration is performed by PLSR model. A value of 0.9079 mg was found to be for the root mean square error of cross-validation (RMSECV) and good fit regression <i>R</i><sup>2</sup> was found to be 0.998. Moreover, API concentration (w/w) of unknown formulation of the drug was found to be 8.90 mg (w/w) having actual concentration of 8 mg (w/w).</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 6","pages":"705 - 713"},"PeriodicalIF":2.0,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Microfluidic paper-based analytical devices: proven applications and future prospects in therapeutic drug monitoring, homeland security, and chemical education 微流控纸基分析装置：在治疗药物监测、国土安全和化学教育方面的成熟应用和未来前景。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-19 DOI: 10.1007/s44211-025-00758-0

Manabu Tokeshi

引用次数: 0