{"title":"利用纳米孔技术进行单颗粒分析的最新进展。","authors":"Akihide Arima","doi":"10.1007/s44211-025-00757-1","DOIUrl":null,"url":null,"abstract":"<p><p>Nanopore sensors have been used as ultrasensitive tools for single-particle detection based on ionic current measurement. This simple, yet powerful technique allows researchers to acquire various physical properties of individual particles in a label-free manner. This mini-review describes the recent progress in nanopore technology demonstrated by our group. We first focus on the major advancements in nanopore architecture contributing to high-spatial resolution, followed by the detection strategy designed for long-term analysis. Then, we summarize the application of nanopore technology in infection diagnosis using machine learning. Following that, we discuss its potential for gene therapy, facilitated by high spatial resolution. Furthermore, we also highlighted potential applications of next-generation nanopore technology that contribute to a healthier future.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent advances in single-particle analysis with nanopore technology.\",\"authors\":\"Akihide Arima\",\"doi\":\"10.1007/s44211-025-00757-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Nanopore sensors have been used as ultrasensitive tools for single-particle detection based on ionic current measurement. This simple, yet powerful technique allows researchers to acquire various physical properties of individual particles in a label-free manner. This mini-review describes the recent progress in nanopore technology demonstrated by our group. We first focus on the major advancements in nanopore architecture contributing to high-spatial resolution, followed by the detection strategy designed for long-term analysis. Then, we summarize the application of nanopore technology in infection diagnosis using machine learning. Following that, we discuss its potential for gene therapy, facilitated by high spatial resolution. Furthermore, we also highlighted potential applications of next-generation nanopore technology that contribute to a healthier future.</p>\",\"PeriodicalId\":7802,\"journal\":{\"name\":\"Analytical Sciences\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-04-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Analytical Sciences\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s44211-025-00757-1\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Sciences","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s44211-025-00757-1","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Recent advances in single-particle analysis with nanopore technology.
Nanopore sensors have been used as ultrasensitive tools for single-particle detection based on ionic current measurement. This simple, yet powerful technique allows researchers to acquire various physical properties of individual particles in a label-free manner. This mini-review describes the recent progress in nanopore technology demonstrated by our group. We first focus on the major advancements in nanopore architecture contributing to high-spatial resolution, followed by the detection strategy designed for long-term analysis. Then, we summarize the application of nanopore technology in infection diagnosis using machine learning. Following that, we discuss its potential for gene therapy, facilitated by high spatial resolution. Furthermore, we also highlighted potential applications of next-generation nanopore technology that contribute to a healthier future.
期刊介绍:
Analytical Sciences is an international journal published monthly by The Japan Society for Analytical Chemistry. The journal publishes papers on all aspects of the theory and practice of analytical sciences, including fundamental and applied, inorganic and organic, wet chemical and instrumental methods.
This publication is supported in part by the Grant-in-Aid for Publication of Scientific Research Result of the Japanese Ministry of Education, Culture, Sports, Science and Technology.