利用纳米孔技术进行单颗粒分析的最新进展。

IF 1.8 4区 化学 Q3 CHEMISTRY, ANALYTICAL
Akihide Arima
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引用次数: 0

摘要

纳米孔传感器已被用作基于离子电流测量的单颗粒超灵敏检测工具。这种简单而强大的技术允许研究人员以无标记的方式获取单个粒子的各种物理特性。这篇微型综述介绍了我们小组在纳米孔技术方面取得的最新进展。我们首先重点介绍了纳米孔结构在实现高空间分辨率方面取得的重大进展,然后介绍了为长期分析而设计的检测策略。然后,我们总结了纳米孔技术在利用机器学习进行感染诊断方面的应用。随后,我们讨论了高空间分辨率在基因治疗中的应用潜力。此外,我们还强调了下一代纳米孔技术的潜在应用,这些应用有助于创造更健康的未来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent advances in single-particle analysis with nanopore technology.

Nanopore sensors have been used as ultrasensitive tools for single-particle detection based on ionic current measurement. This simple, yet powerful technique allows researchers to acquire various physical properties of individual particles in a label-free manner. This mini-review describes the recent progress in nanopore technology demonstrated by our group. We first focus on the major advancements in nanopore architecture contributing to high-spatial resolution, followed by the detection strategy designed for long-term analysis. Then, we summarize the application of nanopore technology in infection diagnosis using machine learning. Following that, we discuss its potential for gene therapy, facilitated by high spatial resolution. Furthermore, we also highlighted potential applications of next-generation nanopore technology that contribute to a healthier future.

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来源期刊
Analytical Sciences
Analytical Sciences 化学-分析化学
CiteScore
2.90
自引率
18.80%
发文量
232
审稿时长
1 months
期刊介绍: Analytical Sciences is an international journal published monthly by The Japan Society for Analytical Chemistry. The journal publishes papers on all aspects of the theory and practice of analytical sciences, including fundamental and applied, inorganic and organic, wet chemical and instrumental methods. This publication is supported in part by the Grant-in-Aid for Publication of Scientific Research Result of the Japanese Ministry of Education, Culture, Sports, Science and Technology.
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