Analytical Sciences最新文献

{"title":"Femtosecond Raman-induced Kerr effect spectroscopic study of the intermolecular dynamics in aqueous solutions of imidazolium hydrochloride, imidazole, sodium triazolide, and triazole: concentration dependence.","authors":"Masako Shimizu, Hideaki Shirota","doi":"10.1007/s44211-024-00692-7","DOIUrl":"https://doi.org/10.1007/s44211-024-00692-7","url":null,"abstract":"<p><p>In this study, we employed femtosecond Raman-induced Kerr effect spectroscopy to analyze the concentration-dependent intermolecular dynamics in positively or negatively charged aromatics and their neutral analogous aromatics (imidazolium hydrochloride (ImHCl), imidazole (Im), sodium triazolide (NaTr), and triazole (Tr)) in aqueous solutions at 293 K. We also measured their liquid properties, such as density, viscosity, and surface tension, at 293 K, and compared them with their dynamic properties. Furthermore, we performed the quantum chemistry calculations of the target aromatics and some clusters to elucidate their optimized structures, interaction energies, charge populations, and Raman-active normal modes. We characterized the Kerr transients over 2 ps using a triexponential function. The results revealed that the aqueous solutions' intermediate and slow relaxation time constants were linearly proportional to the viscosities. The slopes of the time constants to the viscosity of the aqueous ImHCl solutions were steeper than those of the aqueous Im solutions, whereas the slopes of the aqueous NaTr solutions were milder than those of the aqueous Tr solutions. These findings indicated that the charge of the aromatics in the aqueous solutions affected the coupling parameter between the solute and solvent in the orientational dynamics with different ways. The first moment (M₁) of the low-frequency band (< 200 cm^-1), coming from the intermolecular vibrations, in the difference spectra between the aqueous aromatic solutions and neat water shifted to the high-frequency region as the concentration increased. The M₁ slope to the concentration for the aqueous ImHCl solutions was steeper than that for the aqueous Im solutions. Conversely, the concentration dependence of M₁ for the aqueous NaTr solutions was similar to that for the aqueous Tr solutions. We used the local structures of the target aromatics based on the quantum chemistry calculations to rationally clarify their concentration-dependent intermolecular dynamics in the aqueous solutions.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorimetric quantification of vancomycin by highly active nitroxyl radical compounds.","authors":"Kyoko Sugiyama, Fumiya Sato, Kentaro Yoshida, Sachiko Komatsu, Tetsuya Ono, Yusuke Sasano, Yoshiharu Iwabuchi, Tsutomu Fujimura, Yoshitomo Kashiwagi, Katsuhiko Sato","doi":"10.1007/s44211-024-00686-5","DOIUrl":"10.1007/s44211-024-00686-5","url":null,"abstract":"<p><p>Nitroxyl radicals, represented by 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO), are highly stable organic free radicals with unique properties and are used as functional molecules in various fields. However, TEMPO had low reactivity and sometimes did not provide enough response. Therefore, highly active nitroxyl radical compounds have been developed in which bicyclo and tricyclo structures stabilize the radicals. In this study, we found that nortropine N-oxyl (NNO), a type of highly active nitroxyl radical, can oxidize the 2,2'-dihydroxybiphenyl structure under physiological conditions, and succeeded in the colorimetric quantification of vancomycin containing 2,2'-dihydroxybiphenyl moieties in the molecular structure. The reaction took only a few minutes to complete and could be confirmed with the naked eye, with a quantitative range of 10-100 μM. High-performance analytical probes are expected to be developed that use highly active nitroxyl radical derivatives to replace TEMPO derivatives.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Room temperature quantitative liquid concentration device and application to interleukins analysis in a B-cell culture medium.","authors":"Ruriko Kawanabe, Hidekatsu Tazawa, Kazuma Mawatari, Ayumi Yoshizaki","doi":"10.1007/s44211-024-00688-3","DOIUrl":"https://doi.org/10.1007/s44211-024-00688-3","url":null,"abstract":"<p><p>In biological analysis and medical diagnosis, there is an increasing demand for improving the lower detection limit without deteriorating the quantitativity; however, it is usually challenging. In this study, we utilized a cyclone flow device and established a liquid concentration method. An air cyclone flow induced a liquid cyclone flow in the concentration devices and enhanced the air/liquid interface area, which allowed an effective concentration of liquid from mL to mL at room temperature. The heating temperature and actual temperature inside the liquid were investigated to know the cooling effect of evaporation. The collection efficiency of larger than 98% was confirmed with a standard solution. Finally, the analytical procedure to realize a quantitative concentration was established, and the concentration and quantification of interleukins (IL-8, IL-17, and IL-23) from the supernatant of the B-cell culture medium was demonstrated. The B-cell was stimulated with CD40L, and the supernatant was concentrated 27 times at maximum.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple-template surface imprinted magnetic polymers for wide-coverage extraction of steroid hormones from human serum.","authors":"Li Wang, Hongyu Wu, Caihong Wang, Yunfei Ma, Zheng Xiang","doi":"10.1007/s44211-024-00690-9","DOIUrl":"https://doi.org/10.1007/s44211-024-00690-9","url":null,"abstract":"<p><p>In this study, novel triple-template magnetic nanospheres by surface imprinting, called triple-template magnetic molecularly imprinted polymers (tri-MMIPs), were prepared for the detection of steroid hormones in human serum. The polymers were constructed by Fe₃O₄ as support, estrone (E1), progesterone (PROG), and estradiol (E2) as triple templates, acrylic acid (AA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker. The resulting tri-MMIPs were further characterized and applied as sorbents in human serum pretreatment. Coupled with ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometry (UHPLC-MS/MS) profiling after derivatization, 15 steroids (E1, 6-ketoE1, 4-OHE1, 16α-OHE1, DHEA, 4-MeOE1, PROG, PREG, 17-OHPROG, 7-DHE2, E2, 2-OHE2, 16-epiE3, E3, 2-MeOE2) were successfully quantified. The developed method exhibited a good recovery (78.9-114%) and low limit of quantitation (LLOQ, 5-10 pg/mL), which indicates a great potential for application in the analysis of multiple steroid hormones in complex biological samples.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of calcite for evaluation of spectral resolution of Raman spectrometers.","authors":"Nobuyasu Itoh","doi":"10.1007/s44211-024-00684-7","DOIUrl":"https://doi.org/10.1007/s44211-024-00684-7","url":null,"abstract":"<p><p>Raman microscopes are widely used in various fields and their spectral resolutions differ greatly depending on the system and optical components. Thus, it is important to evaluate the spectral resolution of Raman systems under measurement conditions. Although both atomic emission lines and calcites have been used for the evaluation of spectral resolution and described in some guidelines, calcite is preferable because it contains information on laser width. Calcite is a crystal with a trigonal structure and the peak width of Raman spectra is sensitive to crystallinity, so the peak width of calcite may change depending on its quality. In this study, we examined differences in the peak width of atomic emission lines and calcites as well as laser line. The peak width of calcite at ~ 1086 cm^-1 was wider than that of laser and atomic emission lines due to contribution of laser width and calcite itself. Among various calcite samples, calcite blocks for optical prisms showed the narrowest peak width (< 1.3 cm^-1) followed by high-grade reagent calcites (1.35-1.43 cm^-1) and usual-grade reagent calcites (2.23-2.53 cm^-1). Although the peak width of calcite slightly changed with temperature (~ 0.2 cm^-1 between 5 °C and 45 °C), it was comparable to the differences among high-grade reagent calcites. Thus, calcite is preferable for evaluating spectral resolution of Raman systems but its quality requires attention.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resonance-enhanced multiphoton ionization time-of-flight mass spectrometry for direct analysis of liposome-encapsulated compounds.","authors":"Keishi Yamashita, Kento Sakakibara, Yuta Kouyama, Hitomi Sugiyama, Tomohiro Ueyama, Koji Nishijima, Tomohiro Uchimura","doi":"10.1007/s44211-024-00683-8","DOIUrl":"https://doi.org/10.1007/s44211-024-00683-8","url":null,"abstract":"<p><p>The direct measurement of compounds encapsulated into liposomes without pretreatment allows verification of both the encapsulation efficiency and the release rate of liposomes in their original state. In the present study, the direct analysis of liposomes was conducted via resonance-enhanced multiphoton ionization time-of-flight mass spectrometry (REMPI-TOFMS). When analyte species (2-phenoxyethanol) encapsulated in liposomes were measured online, spike signals appeared in a time profile of the peak area for 2-phenoxyethanol, which suggested a dispersion of the compound in this sample. In addition, the spikes disappeared when the liposomes collapsed following the addition of a Triton X-100 aqueous solution. These results strongly suggest that the appearance of spikes arises from the compound encapsulated into the dispersed liposomes. REMPI-TOFMS has an inherent characteristic of superior selectivity, which suggests that this process would be useful for achieving a precise evaluation of the release properties of target compounds even in a liposome sample containing a large variety of components.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial neural network in optimization of bioactive compound extraction: recent trends and performance comparison with response surface methodology.","authors":"Vigneshwaran Subramani, Vidisha Tomer, Gunji Balamurali, Paul Mansingh","doi":"10.1007/s44211-024-00681-w","DOIUrl":"https://doi.org/10.1007/s44211-024-00681-w","url":null,"abstract":"<p><p>Plant products and its by-products are rich source of bioactive compounds like antioxidants, flavonoids, phenolics, pigments and phytochemicals. Bioactive compound's health-promoting properties are well studied. However, optimal extraction of bioactive compounds is a complex, labour- and time-intensive process. It is also highly sensitive to experimental variables. Predicting output variables can reduce the experimental work and has positive environmental impact. Various tools such as Response Surface Methodology (RSM), Mathematical modelling have been commonly used for optimization and predictive modelling of the extraction process. Although mathematical modelling and RSM are efficient, recent studies have used Artificial Neural Network (ANN) which is more efficient and accurate and can perform extensive predictions with high accuracy. The manuscript focuses on current trends of ANN application in optimizing the extraction of bioactive compounds. In this study, ANN and RSM have been compared in terms of their performances in optimizing and modelling the extraction of bioactive compounds from herbs, medicinal plants, fruit, vegetables, and their by-products. The findings from the literature indicate that efficiency of ANN was superior to RSM. Future researches can focus on use of ANN in industrial optimization experiments.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pH monitoring in high ionic concentration environments: performance study of graphene-based sensors.","authors":"Xin Qi, Wei Jin, Cao Tang, Xue Xiao, Rui Li, Yanqing Ma, Lei Ma","doi":"10.1007/s44211-024-00682-9","DOIUrl":"https://doi.org/10.1007/s44211-024-00682-9","url":null,"abstract":"<p><p>Graphene-based pH sensors, acclaimed for their exceptional sensitivity to environmental variations, have garnered significant interest in scientific research. However, the sensor performance in high ionic concentration environments is limited, due to the Debye length ion screening effect. In this study, an innovative graphene channel pH sensing device was developed and modified by cross-linked poly(methyl methacrylate) (PMMA). Furthermore, even in high ionic concentrations, the pH value can be precisely measured by this sensor. The sensor has remarkable sensitivity, and high response rate of - 70.49 mV/pH within the pH range from 7 to 10. Notably, the sensors retain uniform response direction and sensitivity under different ionic concentrations environmental and maintain consistent reversibility and stability. This advancement in sensor technology paves the way for broader applications in complex ionic environments.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ionic liquid applications in analytical chemistry","authors":"Kenta Fujii","doi":"10.1007/s44211-024-00668-7","DOIUrl":"10.1007/s44211-024-00668-7","url":null,"abstract":"","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 11","pages":"1931 - 1932"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Effect of the alkyl chain length of α,ω‑dichloroalkane on the Gibbs energy of transfer for functional groups.","authors":"Kohei Uematsu, Erina Tanaka, Takanari Tanaka, Hajime Katano","doi":"10.1007/s44211-024-00669-6","DOIUrl":"https://doi.org/10.1007/s44211-024-00669-6","url":null,"abstract":"","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}