Analytical Sciences最新文献

Ratiometric electrochemical aptasensor based on functionalized graphene nanocomposites for detection of CA19-9.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-03-06 DOI: 10.1007/s44211-025-00743-7

Feifei Lin, Xiaosha Li, Jian Zhang, Hailin Zhang, Zemiao Zhang, Lijie Hou, Bingjun Shen, Lihong Jin

{"title":"Ratiometric electrochemical aptasensor based on functionalized graphene nanocomposites for detection of CA19-9.","authors":"Feifei Lin, Xiaosha Li, Jian Zhang, Hailin Zhang, Zemiao Zhang, Lijie Hou, Bingjun Shen, Lihong Jin","doi":"10.1007/s44211-025-00743-7","DOIUrl":"https://doi.org/10.1007/s44211-025-00743-7","url":null,"abstract":"A ratiometric electrochemical aptasensor was constructed based on rGO-cMWCNTs/AuNPs functionalized graphene nanocomposites for the detection of CA19-9 in serum samples. First, rGO-cMWCNTs/AuNPs nanocomposites were modified on the surface of glassy carbon electrodes. Second, the aptamer complementary chain labeled with anthraquinone-2-carboxylic acid (cDNA-AQ) was covalently linked by Au-S. Finally, the hybrid chain was formed with ferrocene (Fc)-labeled Apt-Fc by base pairing, and a sensing interface with specific target recognition and electrochemical signal amplification was constructed. In this study, the ratio of response signal to internal reference signal (IFc/IAQ) was used as the target molecular response signal to achieve the quantitative detection of CA19-9. The ratiometric electrochemical biosensor based on aptamer molecular recognition has good selectivity, reproducibility and stability. Under the optimal reaction conditions, the logarithm of CA19-9 concentration had a good linear relationship with IFc/IAQ, the linear range was 1.0-1.0 × 106 mU/mL, the detection limit was 0.65 mU/mL, and the recovery rate in CA19-9 serum was 94.12-97.83%. The results show that the sensor has potential practical application prospects, and provides a simple and feasible strategy for the rapid and accurate detection of other tumor markers.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobiodevices and quantum life science for future healthcare.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-03-04 DOI: 10.1007/s44211-025-00742-8

Taisuke Shimada, Takao Yasui, Hiroshi Yukawa, Yoshinobu Baba

引用次数: 0

Stratified quantification of targets in skin by three-dimensional Raman spectroscopic imaging.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-03-01 DOI: 10.1007/s44211-025-00738-4

Yunchi Hu, Tong Ha, Yan Kang, Yiping Du

引用次数: 0

Quantitative analysis of related substances in acetaminophen tablets using pre-column derivatization coupled with HPLC-ICP-MS.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-03-01 DOI: 10.1007/s44211-025-00739-3

Yalan Liu, Yaru Peng, Qiping Wu, Zeneng Cheng, Feifan Xie, Sanwang Li

{"title":"Quantitative analysis of related substances in acetaminophen tablets using pre-column derivatization coupled with HPLC-ICP-MS.","authors":"Yalan Liu, Yaru Peng, Qiping Wu, Zeneng Cheng, Feifan Xie, Sanwang Li","doi":"10.1007/s44211-025-00739-3","DOIUrl":"https://doi.org/10.1007/s44211-025-00739-3","url":null,"abstract":"High-performance liquid chromatography coupled with inductively coupled plasma-mass spectrometry (HPLC-ICP-MS) is a promising structure-independent technique for accurate quantification of drug-related substances in pharmaceuticals. In this study, we aimed to develop a sensitive HPLC-ICP-MS method, combined with pre-column derivatization, to quantify related substances in acetaminophen tablets. Through this method, we enhanced the sensitivity and accuracy of detecting substances that do not directly respond to ICP-MS. The key advancements include the systematic optimization of derivatization conditions and the establishment of a calibration curve with correlation coefficients greater than 0.999. The method achieved impressive limits of quantification: 0.089 µM for o-acetaminophenol, 0.097 µM for p-nitrophenol, and 0.161 µM for p-aminophenol. It demonstrated suitable accuracy and precision for the following substances: o-acetaminophenol with accuracy between 95.7-104.4% and precision ≤ 4.9%, p-nitrophenol with accuracy between 97.6-101.8% and precision ≤ 2.7%, and p-aminophenol with accuracy between 95.6-102.5% and precision ≤ 3.2%. Comparative analysis with standard HPLC-UV method revealed less than 20% difference in quantification, underscoring the effectiveness of this combined technique. Our study demonstrated the feasibility of combining chemical derivatization with HPLC-ICP-MS as a robust tool for the accurate quantification of drug-related substances, particularly those lacking elements detectable by ICP-MS alone.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The latest developments of near-infrared fluorescent probes from NIR-I to NIR-II for bioimaging.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-28 DOI: 10.1007/s44211-025-00735-7

Yuzuka Kuronuma, Ryuji Watanabe, Yuki Hiruta

引用次数: 0

Solid-phase-extraction device for extracting volatile organic compounds from gaseous samples.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-26 DOI: 10.1007/s44211-025-00729-5

Ikuo Ueta, Koki Nakagami, Yoshihiro Saito

引用次数: 0

Determination of circulating tumor cells by surface-enhanced Raman scattering based on molecularly imprinted polymers doped with silver nanoparticles.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-25 DOI: 10.1007/s44211-025-00719-7

JunJie Wei, Yong Shen, GangFeng Ouyang

{"title":"Determination of circulating tumor cells by surface-enhanced Raman scattering based on molecularly imprinted polymers doped with silver nanoparticles.","authors":"JunJie Wei, Yong Shen, GangFeng Ouyang","doi":"10.1007/s44211-025-00719-7","DOIUrl":"https://doi.org/10.1007/s44211-025-00719-7","url":null,"abstract":"The rapid and simple detection of circulating tumor cells (CTCs) can help with early diagnosis of tumor diseases and assist clinical judgment of tumor disease development status and prognosis. An important alteration in cancer progression is a significant increase in sialic acid (SA) levels, making sialic acid one of an interesting biomarker for cancer type diversity. Here, novel SERS nano-biosensors were fabricated employing molecularly imprinted polymers (MIPs) particles loaded with Ag nanoparticles (AgNPs) to form high affinity toward sialic acid on CTCs. In this work, the glycol-specific MIPs are produced using precipitation polymerization. The nanocomposite was characterized by Fourier transform infrared spectroscopy (FTIR), zeta potential, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Consequently, CTC can be rapidly detected in mouse blood in a specific and sensitive manner, as low as 1 cells/ml. In addition, a good linear relationship was observed between CTC concentration and signal intensity (R2 = 0.9881). Moreover, the SERS nano-biosensors was used to detect CTC with excellent precision (relative standard deviation, RSD = 3.9%) and good repeatability (RSD = 6.8%). Therefore, this inexpensive, highly sensitive, and rapid method using SERS nano-biosensors can quickly detect CTCs and may prove to be a new platform to be an early diagnostic tool for cancer patient detection.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of electrogenerated chemiluminescence mechanism on the emission spectra and intensities.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-25 DOI: 10.1007/s44211-025-00736-6

Ryoichi Ishimatsu

引用次数: 0

Raman spectroscopic analysis of carbonates on a CY-type carbonaceous chondrite Yamato 980115: unexpectedly abundant terrestrial weathering products.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-24 DOI: 10.1007/s44211-025-00731-x

Shu-Hei Urashima, Hayato Tsuchiya, Naoya Imae, Akira Yamaguchi, Hiroharu Yui

{"title":"Raman spectroscopic analysis of carbonates on a CY-type carbonaceous chondrite Yamato 980115: unexpectedly abundant terrestrial weathering products.","authors":"Shu-Hei Urashima, Hayato Tsuchiya, Naoya Imae, Akira Yamaguchi, Hiroharu Yui","doi":"10.1007/s44211-025-00731-x","DOIUrl":"https://doi.org/10.1007/s44211-025-00731-x","url":null,"abstract":"This study presents Raman spectra of carbonates on a carbonaceous chondrite, Yamato (Y) 980115. Y 980115 is an Antarctic meteorite and is originally classified as CI1-type. Since CI1-type meteorites are expected to record information of aqueous alteration of carbonaceous matters in the primitive solar photosphere or planetesimals, extensive studies have been performed. Among a variety of minerals on meteorites, carbonates are one of environment indicators because its cation composition depends on thermochemical properties of the aqueous solution when they were precipitated. Although the minerals on meteorites are usually identified by elemental composition analysis techniques such as backscattered electron imaging, these techniques have a drawback that they lack information of crystal structures so that it is difficult to distinguish some minerals such as ordered or disordered dolomite (CaMg(CO3)2) and a mixture of calcite (CaCO3) and magnesite (MgCO3). The present study employed Raman spectroscopy as a complementary technique to the elemental composition analysis. As a result, surprisingly, while the Mg-bearing carbonates on Y 980115 were expected mainly to be dolomite, the Raman spectra revealed that they are indeed nesquehonite (Mg(HCO3)(OH)·2H2O), which is a typical terrestrial weathering product for Antarctic meteorites. Among 63 carbonate grains found on Y 980115, 60 and 3 grains were assigned to nesquehonite and calcite, respectively, and no dolomite was found. This result indicates that there are unexpectedly abundant terrestrial weathering products for carbonates found on Y 980115.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of iodide in concentrated chloride springs by reversed-phase high-performance liquid chromatography with ultraviolet detection.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-23 DOI: 10.1007/s44211-025-00732-w

Tomoko Kemmei, Azusa Yudo, Shuji Kodama, Atsushi Yamamoto, Yoshinori Inoue, Shigehiro Kagaya, Kazuichi Hayakawa

引用次数: 0