Analytical Sciences最新文献

筛选
英文 中文
A green and engineered magnetic ionic liquid system for selective extraction and trace determination of thorium in industrial and environmental samples. 用于工业和环境样品中钍的选择性提取和痕量测定的绿色工程磁性离子液体系统。
IF 1.8 4区 化学
Analytical Sciences Pub Date : 2025-07-02 DOI: 10.1007/s44211-025-00820-x
Mehdi Hosseini
{"title":"A green and engineered magnetic ionic liquid system for selective extraction and trace determination of thorium in industrial and environmental samples.","authors":"Mehdi Hosseini","doi":"10.1007/s44211-025-00820-x","DOIUrl":"https://doi.org/10.1007/s44211-025-00820-x","url":null,"abstract":"<p><p>Thorium contamination poses serious health and environmental risks, highlighting the need reliable detection methods. This study presents a green and engineered analytical system for the selective extraction and determination of thorium ions in ores and aqueous samples. A task-specific hydrazinium-based ionic liquid, 2-(4-hydroxybenzyl)hydrazinium chloride ([Hyim][Cl]), was synthesized and characterized using <sup>1</sup>HNMR, <sup>13</sup>CNMR, FTIR, VSM, and CHNO analysis. The ionic liquid demonstrated strong affinity toward thorium ions and enabled efficient magnetic separation. Experimental parameters were optimized via a design of experiments (DOE) approach. Under optimal conditions, the system achieved 98.6% extraction efficiency, a detection limit of 0.11 µg/L, a quantification limit of 0.22 µg/L, a linear dynamic range of 5.0-200.0 µg/L, intra-day relative standard deviation of 2.17%, inter-day of 2.86%, preconcentration factors of 122, enrichment factor of 100 and recovery rates between 96.4 and100.5% in real water and wastewater samples.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-throughput HPLC-SERS capable of generating a spectrum from individual eluent droplets based on a superhydrophobic SERS array. 基于超疏水SERS阵列的高通量HPLC-SERS能够从单个洗脱液液滴产生光谱。
IF 1.8 4区 化学
Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-06 DOI: 10.1007/s44211-025-00761-5
Umi Yamaguchi, Hiroaki Honda, Shusuke Kumagai, Hiroyuki Takei
{"title":"High-throughput HPLC-SERS capable of generating a spectrum from individual eluent droplets based on a superhydrophobic SERS array.","authors":"Umi Yamaguchi, Hiroaki Honda, Shusuke Kumagai, Hiroyuki Takei","doi":"10.1007/s44211-025-00761-5","DOIUrl":"10.1007/s44211-025-00761-5","url":null,"abstract":"<p><p>We have developed a protocol for a high-throughput high-performance liquid chromatography-surface enhanced Raman spectroscopy (HPLC-SERS), whereby a 15 μL eluent droplet was captured every second and a series of SERS spectra was obtained to show a time course in the chemical composition within the eluent. To accomplish this, we prepared arrays of SERS spots based on metal film on nanosphere (MFON). Fifty of these spots 3 mm in diameter were formed in a 5 by 10 array format on a special glass slide covered by a hydrophobic coating. In a second version, the SERS spot size was reduced to 1 mm, surrounded by a superhydrophobic area with a contact angle greater than 120 degrees. Here, 2 μL of the eluent droplet was placed on each spot. Heating of the array substrate allowed complete evaporation of the droplet under 3 min, without the adverse coffee ring effect. We demonstrated the utility of such a setup by injecting 1 mM adenine into a portable HPLC instrument and capturing the time course of SERS spectra. We characterize our MFON SERS spots in terms of its dependence on the concentration and incubation time as well as a two-dimensional SERS imaging showing the uniformity in the signal intensity.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"1083-1088"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of volatile organic compounds released by Trichoderma species and plant endophytic fungi using a needle-type extraction device and gas chromatography-mass spectrometry. 针式萃取-气相色谱-质谱联用法测定木霉和植物内生真菌释放的挥发性有机物。
IF 1.8 4区 化学
Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-04-30 DOI: 10.1007/s44211-025-00783-z
Ikuo Ueta, Suguru Masuda, Ryota Kataoka
{"title":"Determination of volatile organic compounds released by Trichoderma species and plant endophytic fungi using a needle-type extraction device and gas chromatography-mass spectrometry.","authors":"Ikuo Ueta, Suguru Masuda, Ryota Kataoka","doi":"10.1007/s44211-025-00783-z","DOIUrl":"10.1007/s44211-025-00783-z","url":null,"abstract":"<p><p>This study proposes a method for the extraction of volatile organic compounds (VOCs) generated by Trichoderma species and plant endophytic fungi. In this method, generated VOCs are extracted using a needle-type extraction device and analyzed using gas chromatography-mass spectrometry. To extract VOCs generated by a single cultured fungi species, each fungi species was cultivated in a sealed 100 mL polypropylene bottle. Before cultivation, two silicone septa were attached to the bottle and cap. After the preparation of the culture media in the bottle, the bottle was autoclaved and the fungi were inoculated. The bottle was then sealed with a cap, and the air in the bottle was replaced with clean air. The surfaces of the extraction needle and a gas supply needle were sterilized with ethanol and inserted into the bottle via the two silicone septa. A gas sampling bag filled with pure air was connected to the gas supply needle, and clean air was continuously supplied to the bottle as the purge gas during the gas sampling. As the extraction needle, a double-bed-type adsorbent, Carbopack-X and a carbon molecular sieve, was used 3-Methyl butanol and 2-methyl butanol were detected for 41 species, and 2-pentylfran and 6-pentyl-2-pyrone were detected for 2 species among the 46 considered Trichoderma species. Monoterpenes and sesquiterpenes were detected for a single plant endophytic fungus species. The limit of detection of standard 3-methyl butanol and 2-methyl butanol in the proposed method was 0.5 ng mL<sup>-1</sup>. The performance of the proposed method was compared with that of the commercial MonoTrap method.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"1097-1101"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solid-phase chromogenic method combining molecularly imprinted polymer and Simon reaction for discriminating between methamphetamine and structural analogs. 结合分子印迹聚合物和Simon反应的固相显色方法鉴别甲基苯丙胺和结构类似物。
IF 1.8 4区 化学
Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-06 DOI: 10.1007/s44211-025-00782-0
Koichi Saito, Musashi Abe, Rie Ito, Hiroshi Akiyama
{"title":"Solid-phase chromogenic method combining molecularly imprinted polymer and Simon reaction for discriminating between methamphetamine and structural analogs.","authors":"Koichi Saito, Musashi Abe, Rie Ito, Hiroshi Akiyama","doi":"10.1007/s44211-025-00782-0","DOIUrl":"10.1007/s44211-025-00782-0","url":null,"abstract":"<p><p>A systematic analytical method for discriminating methamphetamine (MA) from its structural analogs was developed by combining a solid-phase chromogenic method with the use of a molecularly imprinted polymer (MIP) and Simon reaction. L-proline (Pro), L-hydroxyproline (HYP), N-methylbenzylamine (NMe-BA), and N-isopropylbenzylamine (NIP-BA) were selected as false positives, while tert-butoxycarbonyl derivatized MA (t-Boc-MA) was selected as a false-negative substance. MA and the structural analogs were loaded into SupelMIP™ SPE-Amphetamines cartridges and Simon's reagent was added to the cartridge, then the coloration of the solid-phase gel was observed from outside the cartridge. After elution with a basic solution, Simon's reagent was added to the eluate (first-step eluate), and a change in color tone was observed. The MIP was then heated under acidic conditions, and the analytes were eluted (second-step eluate) with water, basified at pH 10, and the Simon reaction was repeated. Pro and HYP could be discriminated from MA by the color tone of the MIP solid-phase gel, whereas NMe-BA and NIP-BA could be discriminated from MA by the color tone of the first-step eluate. In addition, the color tone of the second-step eluate confirmed the presence of t-Boc-MA.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"1089-1095"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly sensitive electrochemical sensing of ascorbic acid (vitamin C) using Pd-doped MnO2 supported on carbon quantum dots (Pd-MnO2@CQD) in water and fruit juices. 在水和果汁中使用碳量子点(Pd-MnO2@CQD)负载pd掺杂MnO2对抗坏血酸(维生素C)的高灵敏度电化学传感。
IF 1.8 4区 化学
Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-08 DOI: 10.1007/s44211-025-00787-9
Deepak Kumar, Daraksha Bano, Subhash Chandra, Bharat Kumar, Vivek Kumar, Pradeep Kumar Yadav, Syed Hadi Hasan
{"title":"Highly sensitive electrochemical sensing of ascorbic acid (vitamin C) using Pd-doped MnO<sub>2</sub> supported on carbon quantum dots (Pd-MnO<sub>2</sub>@CQD) in water and fruit juices.","authors":"Deepak Kumar, Daraksha Bano, Subhash Chandra, Bharat Kumar, Vivek Kumar, Pradeep Kumar Yadav, Syed Hadi Hasan","doi":"10.1007/s44211-025-00787-9","DOIUrl":"10.1007/s44211-025-00787-9","url":null,"abstract":"<p><p>The Pd-MnO<sub>2</sub> nanoparticles attached to carbon quantum dots nanocomposite were synthesized using the green synthesis and hydrothermal process. Characterization of the as-prepared nanocomposite was intensively performed by FT-IR, powder XRD, XPS, and HR-TEM analysis. The synthesized nanomaterial was further examined for its selective and sensitive ascorbic acid (ASA) sensing using a Pd-MnO<sub>2</sub>@CQD modified glassy carbon electrode (GCE). The Pd-MnO<sub>2</sub>@CQD nanocomposite exhibits a distinct and improved peak current of ASA when compared to electrodes treated with Pd-MnO<sub>2</sub> and bare GCE. The designed sensor has excellent performance, with a linear range of 10-1500 μM, a low detection limit of 0.14 μM (S/N = 3), a high sensitivity of 1.9671 μAµM<sup>-1</sup> cm<sup>-2</sup>. Furthermore, the constructed sensor demonstrates good sensitivity for detecting ASA in a variety of real samples.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"1029-1040"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancement of microchip electrophoresis coupled with capacitively coupled contactless conductivity detection-from design to application (2018-2024). 微芯片电泳耦合电容耦合非接触电导率检测的进展-从设计到应用(2018-2024)。
IF 1.8 4区 化学
Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI: 10.1007/s44211-025-00771-3
Mingpeng Yang, Chaofan Wang, Jun Cai, Xiaochen Lai, Mingyi Cao, Xingqiang Zhao
{"title":"Advancement of microchip electrophoresis coupled with capacitively coupled contactless conductivity detection-from design to application (2018-2024).","authors":"Mingpeng Yang, Chaofan Wang, Jun Cai, Xiaochen Lai, Mingyi Cao, Xingqiang Zhao","doi":"10.1007/s44211-025-00771-3","DOIUrl":"10.1007/s44211-025-00771-3","url":null,"abstract":"<p><p>Over the past three decades, microchip electrophoresis coupled with capacitively coupled contactless conductivity detection (ME-C<sup>4</sup>D) has garnered considerable interest due to its various merits, including minimal sample consumption, compact structure, immediate detection, and high analytical precision. Continuous technological innovation and improvement have significantly advanced ME-C<sup>4</sup>D in structural design, fabrication processes, and experimental methodologies. As a result, the application of this technology has expanded into a wider range of electrochemical analysis fields, including disease diagnosis, food safety assessment, environmental pollutant detection, and soil nutrient analysis. This review meticulously examines the forefront of ME-C<sup>4</sup>D over the last five years. It methodically categorizes and scrutinizes advancements from various dimensions, including newly emerged ME microchips, C<sup>4</sup>D electrodes, experimental protocols, and pioneering applications. Moreover, this paper critically summarizes these developments, identifying the prevailing limitations and challenges within ME-C<sup>4</sup>D. Ultimately, it projects potential future trajectories for innovation in the field of ME-C<sup>4</sup>D, suggesting pathways to overcome existing hurdles and hinting at the untapped possibilities that lie ahead.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"903-921"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cobalt oxide modified screen-printed carbon electrode for electrochemical detection of high blood pressure treating drug: reserpine. 氧化钴修饰网印碳电极电化学检测高血压治疗药物利血平。
IF 1.8 4区 化学
Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-06 DOI: 10.1007/s44211-025-00781-1
Chenxi Wu, Shengzhou Qiu, Sima Akter, Shaoli Hong, Huihong Liu, Sakil Mahmud
{"title":"Cobalt oxide modified screen-printed carbon electrode for electrochemical detection of high blood pressure treating drug: reserpine.","authors":"Chenxi Wu, Shengzhou Qiu, Sima Akter, Shaoli Hong, Huihong Liu, Sakil Mahmud","doi":"10.1007/s44211-025-00781-1","DOIUrl":"10.1007/s44211-025-00781-1","url":null,"abstract":"<p><p>This study presents the development of a cobalt oxide-modified screen-printed carbon electrode (CoO/SPCE) for the electrochemical detection of reserpine (RES), a drug used to treat high blood pressure. The CoO/SPCE was fabricated using an optimized electrodeposition method, resulting in a sensitive and reproducible platform for RES detection. Electrochemical characterization demonstrated that the CoO/SPCE exhibited superior electrocatalytic activity, as evidenced by a notable increase in oxidation peak current compared to bare and activated SPCEs. The electrode showed a linear response to RES concentrations ranging from 2 to 100 μM with a detection limit of 1.08 μM. Additionally, the sensor demonstrated good stability and reproducibility with relative standard deviations (RSDs) of 5.11% and 2.72%, respectively. This work highlights the CoO/SPCE's potential for practical pharmaceutical analysis, offering a novel approach to enhancing the sensitivity and reliability of electrochemical sensors for drug monitoring.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"953-964"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a frontal analysis capillary electrophoresis coupled with time-of-flight mass spectrometry for determining the equilibrium dissociation constant between cyclophilin A and cyclosporin A. 毛细管电泳-飞行时间质谱联用测定亲环素a和环孢素a平衡解离常数的研究进展。
IF 1.8 4区 化学
Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-19 DOI: 10.1007/s44211-025-00790-0
Jia Tang, Fan Shui, Li Deng, Yujie Zhang, Qibing Mei, Min Wang, Jing Zeng
{"title":"Development of a frontal analysis capillary electrophoresis coupled with time-of-flight mass spectrometry for determining the equilibrium dissociation constant between cyclophilin A and cyclosporin A.","authors":"Jia Tang, Fan Shui, Li Deng, Yujie Zhang, Qibing Mei, Min Wang, Jing Zeng","doi":"10.1007/s44211-025-00790-0","DOIUrl":"10.1007/s44211-025-00790-0","url":null,"abstract":"<p><p>Exploring the interactions between ligands and proteins in vitro and in vivo is of irreplaceable significance for disease prevention, diagnosis, therapeutic development, and drug discovery. Herein, we have developed a novel method for determining the equilibrium dissociation constant (Kd) using frontal analysis capillary electrophoresis coupled with time-of-flight mass spectrometry (FACE-TOF-MS). This method enables the rapid determination of the Kd value for the interaction between cyclophilin A and cyclosporin A. Furthermore, the reliability of this method was validated by comparing it with bio-layer interferometry (BLI). The Kd values determined by FACE-TOF-MS and BLI were 3.32 μM and 0.60 μM, respectively, which fall within an acceptable range when considering previous reports using various methods. This study introduces a novel approach for analyzing molecular interactions, offering potential specificity for simultaneously determining the Kd values of multiple ligands in complex samples, particularly in the areas of biomarker discovery, high-throughput lead compound screening, and therapeutic target validation.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"1061-1072"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breath biomarkers for esophageal cancer: identification, quantification, and diagnostic modeling. 食管癌的呼吸生物标志物:鉴定、量化和诊断模型。
IF 1.8 4区 化学
Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-04-15 DOI: 10.1007/s44211-025-00769-x
Yuke Ren, Fei Wang, Ziyi Zhu, Raojun Luo, Guojun Lv, Haibin Cui
{"title":"Breath biomarkers for esophageal cancer: identification, quantification, and diagnostic modeling.","authors":"Yuke Ren, Fei Wang, Ziyi Zhu, Raojun Luo, Guojun Lv, Haibin Cui","doi":"10.1007/s44211-025-00769-x","DOIUrl":"10.1007/s44211-025-00769-x","url":null,"abstract":"<p><p>Esophageal cancer is a major global health issue with a high mortality rate. Early diagnosis is crucial for improving patient outcomes, but traditional diagnostic methods are often invasive and costly. This study explores the potential of exhaled volatile organic compounds (VOCs) as a non-invasive diagnostic tool for esophageal cancer. Using gas chromatography-mass spectrometry (GC-MS), we analyzed the breath samples of 80 esophageal cancer patients and 60 healthy controls, identifying and quantifying over 100 VOCs. The results revealed significant differences in the concentrations of VOCs such as acetone, ethanol, and isoprene between the two groups. A multi-parameter regression diagnostic model based on a neural network algorithm achieved an accuracy of 90.3% in distinguishing esophageal cancer patients from healthy individuals. Further optimization incorporating physiological factors, including smoking, drinking, and dietary habits, improved the model's accuracy to 92.4%, with a specificity of 93.1%, representing a significant improvement over previous studies. These results suggest that VOCs analysis in exhaled breath holds great promise as a non-invasive, cost-effective, and accurate method for early detection of esophageal cancer.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"965-976"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial regulation effects of Taohong Siwu decoction on disordered lipids in a rat model of ischemic stroke assessed using mass spectrometry imaging. 桃红四物汤对缺血性脑卒中大鼠血脂紊乱的空间调节作用。
IF 1.8 4区 化学
Analytical Sciences Pub Date : 2025-07-01 DOI: 10.1007/s44211-025-00813-w
Xueting Zhang, Qingqing Xie, Zhuqing Liu, Daiyin Peng, Lan Han, Xiaoqun Wang
{"title":"Spatial regulation effects of Taohong Siwu decoction on disordered lipids in a rat model of ischemic stroke assessed using mass spectrometry imaging.","authors":"Xueting Zhang, Qingqing Xie, Zhuqing Liu, Daiyin Peng, Lan Han, Xiaoqun Wang","doi":"10.1007/s44211-025-00813-w","DOIUrl":"https://doi.org/10.1007/s44211-025-00813-w","url":null,"abstract":"<p><p>Ischemic stroke serves as a disease closely related to cerebral blood vessels, with high mortality, disability, and recurrence rates. Growing studies have confirmed that lipid disturbances have a strong correlation with ischemic stroke damage. Taohong Siwu decoction (THSWD) as a classical remedy in Chinese pharmacopeia medicinal formula could promote blood circulation and eliminate stagnation of blood. THSWD has attracted extensive attention in its research on treating cerebral ischemia-reperfusion injury. However, the spatial effects about THSWD on lipids in ischemic stroke have not been adequately studied. Here, we comprehensively determined the spatial effects of THSWD on lipid dysregulation about the rodent cerebral tissue with middle cerebral artery occlusion-reperfusion (MCAO/R) using desorption electrospray ionization mass spectrometry imaging (DESI-MSI). Our findings suggest that the spatial distributions of 40 lipids were observed in normal rat brain tissue slices and significant dysregulation was observed in 37 lipids after ischemia-reperfusion injury, primarily in the cortex and striatum. DESI-MSI revealed that THSWD improved the abnormal expression of most lipids. DESI-MSI is an effective and intuitive method about studying the changes in lipid levels within spatial brain tissue after ischemic stroke, particularly following treatment with THSWD. This approach provides a unique perspective in exploring the potential mechanism underlying the therapeutic impacts of THSWD on ischemic stroke.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信