Analytical Sciences最新文献_第10页

Automated infrared ashing with palladium nitrate as an ashing aid for the determination of selenium in plant foods by inductively coupled plasma mass spectrometry. 用硝酸钯作为灰化辅助剂进行自动红外灰化，以电感耦合等离子体质谱法测定植物性食品中的硒。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-07-01 Epub Date: 2024-04-29 DOI: 10.1007/s44211-024-00570-2

Ni Zhang, Tuankun Zhou, Man Ye, Xiaoming Yang, Zhiying Ding, Hang Gao

{"title":"Automated infrared ashing with palladium nitrate as an ashing aid for the determination of selenium in plant foods by inductively coupled plasma mass spectrometry.","authors":"Ni Zhang, Tuankun Zhou, Man Ye, Xiaoming Yang, Zhiying Ding, Hang Gao","doi":"10.1007/s44211-024-00570-2","DOIUrl":"10.1007/s44211-024-00570-2","url":null,"abstract":"Based on the automatic light wave ashing instrument, palladium nitrate was used as an ashing aid for the first time to collect selenium in the process of food ashing pre-treatment, and a method for the determination of selenium in food by ashing method was established with inductively coupled plasma mass spectrometry. At the same time, the effects of magnesium nitrate, rhodium nitrate, and nickel nitrate as ashing aids on selenium collection were investigated using certified plant standard materials. The capture of selenium by magnesium nitrate, rhodium nitrate, and nickel nitrate as ashing aids did not exceed 50%. Using palladium nitrate as an ashing aid, six food standard materials were measured, with selenium recovery rates ranging from 97 to 106%. A complete analysis cycle can be completed within an hour. The method detection limit of selenium was 0.021 μg g-1, and the relative standard deviation of five measurements was less than 7%. The experimental results show that palladium nitrate is an excellent ashing aid for capturing selenium, and it is far superior to the other three aids. In addition, the mechanism of palladium nitrate as an ashing aid for capturing selenium was discussed.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperature imaging inside fluid devices using a ratiometric near infrared (NIR-II/III) fluorescent Y₂O₃: Nd³⁺, Yb³⁺, Er³⁺ nanothermometer. 使用比率测量法近红外（NIR-II/III）荧光 Y2O3 对流体设备内部进行温度成像：Nd3+、Yb3+、Er3+ 纳米温度计。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-07-01 Epub Date: 2024-04-15 DOI: 10.1007/s44211-024-00564-0

Masakazu Umezawa, Hikaru Haraguchi, Gaku Sugawara, Konosuke Sato, Hiroyuki Kurahashi, Teiji Oda, Kyohei Okubo, Kohei Soga

{"title":"Temperature imaging inside fluid devices using a ratiometric near infrared (NIR-II/III) fluorescent Y2O3: Nd3+, Yb3+, Er3+ nanothermometer.","authors":"Masakazu Umezawa, Hikaru Haraguchi, Gaku Sugawara, Konosuke Sato, Hiroyuki Kurahashi, Teiji Oda, Kyohei Okubo, Kohei Soga","doi":"10.1007/s44211-024-00564-0","DOIUrl":"10.1007/s44211-024-00564-0","url":null,"abstract":"Luminescence thermometry is a non-contact method that can measure surface temperatures and the temperature of the area where the fluorescent probe is located, allowing temperature distribution visualizations with a camera. Ratiometric fluorescence thermometry, which uses the intensity ratio of fluorescence peaks at two wavelengths with different fluorescence intensity dependencies, is an excellent method for visualizing temperature distributions independent of the fluorophore spatial concentration, excitation light intensity and absolute fluorescence intensity. Herein, Nd3+/Yb3+/Er3+-doped Y2O3 nanomaterials with a diameter of 200 nm were prepared as phosphors for temperature distribution measurement of fluids at different temperatures. The advantages of this designed fluorescent material include non-aggregation in water and the fact that its near-infrared (NIR) fluorescence excitation (808 nm) is not absorbed by water, thereby minimizing sample heating upon irradiation. Under optical excitation at 808 nm, the ratio of the fluorescence intensities of Yb3+ (IYb; 975 nm) and Er3+ (IEr; 1550 nm), which exhibited different temperature responses, indicated the temperature distribution inside the fluid device. Thus, this technique using Nd3+/Yb3+/Er3+-doped Y2O3 is expected to be applied for temperature distribution mapping analysis inside fluidic devices as a ratiometric NIR fluorescence thermometer, which is unaffected by laser-induced heating.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of lard adulteration in 3 kinds of vegetable oils by liquid chromatography-mass spectrometry with porous graphite carbon column. 多孔石墨碳柱液相色谱-质谱法检测 3 种植物油中的猪油掺假。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-07-01 Epub Date: 2024-04-06 DOI: 10.1007/s44211-024-00560-4

Can Gong, Xiang-Ting Lu, Shi-Ding Zhang, Kun Xiao, Xu Xu

{"title":"Detection of lard adulteration in 3 kinds of vegetable oils by liquid chromatography-mass spectrometry with porous graphite carbon column.","authors":"Can Gong, Xiang-Ting Lu, Shi-Ding Zhang, Kun Xiao, Xu Xu","doi":"10.1007/s44211-024-00560-4","DOIUrl":"10.1007/s44211-024-00560-4","url":null,"abstract":"Liquid chromatography‒mass spectrometry employing porous graphite carbon columns and an n-octane-isopropanol mobile phase was utilized for the separation of triacylglycerols (TAGs) in various edible oils, aiming to identify lard adulteration in soybean, corn, and sunflower seed oils. Experiments were conducted using a Hypercarb column (2.1 mm × 100 mm, 5 µm) and an n-octane-isopropanol (70:30, V/V) mobile phase at a flow rate of 0.25 mL· min-1 and a column temperature of 60 °C. Detection was achieved through atmospheric pressure chemical ionization-mass spectrometry. Analysis of diverse edible oil samples revealed that oils of the same type shared similar TAG compositions, while different types exhibited distinct TAG profiles. Distinct variations in triglyceride composition were observed across different edible oils. Based on liquid chromatography‒mass spectrometry analysis, the characteristic component 1-stearic acid-2-palmitic acid-3-oleic acid glyceride (SPO), which may also include PSO, was identified in lard through principal component analysis and orthogonal partial least squares discriminant analysis. This component served as a marker for detecting as low as 0.1% lard adulteration in soybean, corn, and sunflower seed oils. The technique offers a precise and effective approach for the identification of lard adulteration in these edible oils.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A high-throughput sequence determination for one cyclic peptide immobilized on a single bead by the one-pot cyanidation followed by MALDI-TOF-MS/MS for discovery of interacting peptides. 通过一锅氰化法和 MALDI-TOF-MS/MS，对固定在单个珠子上的环肽进行高通量序列测定，以发现相互作用的肽。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-07-01 Epub Date: 2024-05-22 DOI: 10.1007/s44211-024-00594-8

Takeshi Kasama, Kiyoshi Nokihara

引用次数: 0

Utilizing X-ray diffraction in conjunction with competitive adaptive reweighted sampling (CARS) and principal component analysis for the discrimination of medicinal pearl powder and nacre powder. 将 X 射线衍射与竞争性自适应再加权采样（CARS）和主成分分析相结合，用于鉴别药用珍珠粉和珍珠母粉。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-06-28 DOI: 10.1007/s44211-024-00624-5

Chaogang Xing, Jingqun Yuan, Chenyang Shi, Xuancheng Chen, Shimin Li

{"title":"Utilizing X-ray diffraction in conjunction with competitive adaptive reweighted sampling (CARS) and principal component analysis for the discrimination of medicinal pearl powder and nacre powder.","authors":"Chaogang Xing, Jingqun Yuan, Chenyang Shi, Xuancheng Chen, Shimin Li","doi":"10.1007/s44211-024-00624-5","DOIUrl":"https://doi.org/10.1007/s44211-024-00624-5","url":null,"abstract":"Nacre powder, often utilized to counterfeit medicinal pearl powder due to their similar chemical composition and appearance, poses a challenge in product authentication. This study introduces a rapid and efficient method for distinguishing between medicinal pearl powder and nacre powder using X-ray diffraction in conjunction with principal component analysis (PCA). The X-ray diffraction pattern underwent preprocessing techniques including smoothing denoising (Savitzky-Golay filter, 5-point) and second-order derivative analysis. Subsequently, PCA was employed for dimensionality reduction modeling. The CARS method was applied to select optimal variables for model refinement, determining the data preprocessing approach and key modeling variables. This method demonstrates the capability to accurately differentiate between pearl powder, nacre powder, and even counterfeit samples containing up to 90% pearl powder. With a high accuracy rate, swift operational speed, and potential for automation, this approach shows promise for practical implementation in the realm of pearl powder quality control.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Density and porosity analyses of porous hybrid microparticles containing gas in closed pores using centrifugal liquid sedimentation-dynamic light scattering combined analytical method. 利用离心液相沉降-动态光散射联合分析法分析封闭孔隙中含有气体的多孔混合微粒的密度和孔隙率。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-06-24 DOI: 10.1007/s44211-024-00623-6

Tetsuji Yamaguchi, Tetsuya Yamamoto

{"title":"Density and porosity analyses of porous hybrid microparticles containing gas in closed pores using centrifugal liquid sedimentation-dynamic light scattering combined analytical method.","authors":"Tetsuji Yamaguchi, Tetsuya Yamamoto","doi":"10.1007/s44211-024-00623-6","DOIUrl":"https://doi.org/10.1007/s44211-024-00623-6","url":null,"abstract":"Porous hybrid microparticles are characterized by their densities and porosities. Consequently, the evaluation for density and porosity of porous hybrid microparticles in liquids is crucial for predicting the transport of particles in the atmosphere, human body, and industrial processes. However, direct measurement of the density and porosity of porous hybrid microparticles in liquids remains a challenge. In this study, we investigated the centrifugal sedimentation of polystyrene-silica hybrid microparticles with and without gas-containing closed pores. A centrifugal liquid sedimentation-dynamic light scattering combined analytical method was employed to determine the apparent densities of hybrid microparticles with and without gas-containing closed pores. The porosity of the hybrid microparticles with gas-containing closed pores was elucidated based on the inner buoyancy, which is a centrifugal force generated by the presence of low-density gas inside numerous closed pores. Further, the inner gas buoyancy was analyzed to estimate the particle porosity in liquids. The results obtained in this study confirmed the feasibility of utilizing the proposed method to determine the apparent density and porosity of porous hybrid microparticles in liquids.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring and warning for ammonia nitrogen pollution of urban river based on neural network algorithms. 基于神经网络算法的城市河流氨氮污染监测与预警。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-06-23 DOI: 10.1007/s44211-024-00622-7

Yang Zhang, Liang Liu, Shenghong Zhang, Xiaolin Zou, Jinlong Liu, Jian Guo, Ying Teng, Yu Zhang, Hengpan Duan

{"title":"Monitoring and warning for ammonia nitrogen pollution of urban river based on neural network algorithms.","authors":"Yang Zhang, Liang Liu, Shenghong Zhang, Xiaolin Zou, Jinlong Liu, Jian Guo, Ying Teng, Yu Zhang, Hengpan Duan","doi":"10.1007/s44211-024-00622-7","DOIUrl":"https://doi.org/10.1007/s44211-024-00622-7","url":null,"abstract":"Ammonia nitrogen (AN) pollution frequently occurs in urban rivers with the continuous acceleration of industrialization. Monitoring AN pollution levels and tracing its complex sources often require large-scale testing, which are time-consuming and costly. Due to the lack of reliable data samples, there were few studies investigating the feasibility of water quality prediction of AN concentration with a high fluctuation and non-stationary change through data-driven models. In this study, four deep-learning models based on neural network algorithms including artificial neural network (ANN), recurrent neural network (RNN), long short-term memory (LSTM), and gated recurrent unit (GRU) were employed to predict AN concentration through some easily monitored indicators such as pH, dissolved oxygen, and conductivity, in a real AN-polluted river. The results showed that the GRU model achieved optimal prediction performance with a mean absolute error (MAE) of 0.349 and coefficient of determination (R2) of 0.792. Furthermore, it was found that data preprocessing by the VMD technique improved the prediction accuracy of the GRU model, resulting in an R2 value of 0.822. The prediction model effectively detected and warned against abnormal AN pollution (> 2 mg/L), with a Recall rate of 93.6% and Precision rate of 72.4%. This data-driven method enables reliable monitoring of AN concentration with high-frequency fluctuations and has potential applications for urban river pollution management.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of methodology for the visual identification of Tributyltin (TBT) in antifouling paint matrices. 开发目视识别防污漆基质中三丁基锡（TBT）的方法。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-06-22 DOI: 10.1007/s44211-024-00620-9

Fabricio Araújo Gonçalves Cruz, Cid Pereira, Marcos Antônio Dos Santos Fernandez, Aricelso Maia Limaverde Filho, Tiago Lima da Silva

{"title":"Development of methodology for the visual identification of Tributyltin (TBT) in antifouling paint matrices.","authors":"Fabricio Araújo Gonçalves Cruz, Cid Pereira, Marcos Antônio Dos Santos Fernandez, Aricelso Maia Limaverde Filho, Tiago Lima da Silva","doi":"10.1007/s44211-024-00620-9","DOIUrl":"https://doi.org/10.1007/s44211-024-00620-9","url":null,"abstract":"Organotin compounds (OTC), mainly tributyltin (TBT), have been used since the 1970s as biocides in the composition of antifouling paints. Due to its physical-chemical characteristics, TBT has high toxicity to the marine environment affecting non-target organisms. The present study aims to develop a method of direct visual identification of TBT in antifouling paints using the cyclopalladate complex, 4- (2-thiazolylazo) resorcinol (TAR-Pd), synthesized in our laboratory. Tests were performed in blank and in the paint matrix with the following OTC: TBT-O; TBT-Cl; TPT-Cl; DBT-Cl (tributyltin oxide, tributyltin chloride, triphenyltin chloride, dibutyltin chloride), in addition to the SnCl4 and SnCl2 compounds (tin IV chloride and tin II chloride), all at a concentration of approximately 20 g/ kg of dry paint). The test was performed by applying paint samples to test bodies and scraping a few tens of milligrams of the dry paint film. The scraped paint samples were submitted to the test, showing a different staining reaction for the TBT-Cl and SnCl4 samples concerning blank and other samples (TBT-O, TPT, DBT-Cl, and SnCl2). Solution tests were performed to characterize reaction products by spectroscopy in the visible band. The method developed has potential for application in real samples, being selective for TBT-Cl and SnCl4 in an acid medium, obtaining a limit of detection, in the range of 1-10 mg/kg dry paint.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on cellular uptake of a hydrophobic near-infrared-absorbing diradical-platinum(II) complex solubilized by albumin using hyperspectral imaging, spectrophotometry, and spectrofluorimetry. 利用高光谱成像、分光光度法和分光荧光测定法研究白蛋白溶解的疏水性近红外吸收二拉德铂(II)复合物的细胞吸收。

IF 1.6 4区化学

Analytical Sciences Pub Date : 2024-06-19 DOI: 10.1007/s44211-024-00621-8

Ryota Sawamura, Atsuko Masuya-Suzuki, Nobuhiko Iki

{"title":"Study on cellular uptake of a hydrophobic near-infrared-absorbing diradical-platinum(II) complex solubilized by albumin using hyperspectral imaging, spectrophotometry, and spectrofluorimetry.","authors":"Ryota Sawamura, Atsuko Masuya-Suzuki, Nobuhiko Iki","doi":"10.1007/s44211-024-00621-8","DOIUrl":"https://doi.org/10.1007/s44211-024-00621-8","url":null,"abstract":"Owing to its biopenetrability and minimal invasiveness, near-infrared (NIR) light in the region between 700-1100 nm has attracted attention in cancer diagnosis and therapy. Our group previously reported that the hydrophobic diradical-platinum(II) complex PtL2 is a promising agent for cancer photothermal therapy (L = 3,5-dibromo-1,2-diiminobenzosemiquinonate radical). Because PtL2 does not fluoresce, its intercellular uptake of PtL2 cannot be observed with a fluorescence microscope. In this study, we clarified the uptake and intracellular behavior of PtL2 solubilized by bovine serum albumin (BSA) using hyperspectral imaging enabling spectrophotometric analysis of the image. The spectral changes in the obtained images indicated that the internalization of PtL2 was followed by crystallization of the complex during the long incubation period (> 4 h). Additionally, the binding constant Kb = 5.91 × 104 M-1 could be estimated upon fluorescence quenching analysis of BSA upon binding of PtL2; Kb is two orders of magnitude smaller than that of albumin-common drugs. Considering the small Kb and low solubility of PtL2 in water, we ultimately proposed the internalization path and fate of PtL2 in the cell: release of PtL2 from BSA near cellular membranes and subsequent cellular uptake via membrane permeation followed by saturation, resulting in crystallization.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of quantitative detection methods for four Alzheimer's disease specific biomarker panels using electrochemical immunosensors based on enzyme immunoassay. 利用基于酶免疫测定的电化学免疫传感器，开发四种阿尔茨海默病特异性生物标记物的定量检测方法。

IF 1.6 4区化学

Analytical Sciences Pub Date : 2024-06-17 DOI: 10.1007/s44211-024-00614-7

Il Kyu Park, Young Sun Choi, Seo Yun Jo

{"title":"Development of quantitative detection methods for four Alzheimer's disease specific biomarker panels using electrochemical immunosensors based on enzyme immunoassay.","authors":"Il Kyu Park, Young Sun Choi, Seo Yun Jo","doi":"10.1007/s44211-024-00614-7","DOIUrl":"https://doi.org/10.1007/s44211-024-00614-7","url":null,"abstract":"Accurate and timely diagnosis of Alzheimer's disease (AD) is necessary to maximize the effectiveness of treatment and using biomarkers for diagnosis is attracting attention as a minimally invasive method with few side effects. Electrochemical immunosensor (EI) is a method that is in the spotlight in the medical and bioanalytical fields due to its portability and field usability. Here, we quantified four AD specific biomarkers using EIs based on enzyme immunoassay. We selected and developed quantitative methods for the biomarkers using screen-printed gold electrodes. For three biomarkers, quantification was performed using competition immunoassays in which antigen-antibody premix mixtures were applied to antigen-immobilized electrodes and the limit of detection (LOD) values were secured, 1.20 ng/ml, 1.30 ng/ml, and 1.74 ng/ml, respectively. For the other, a sandwich immunoassay using antibody pair was selected for quantification and LOD was also achieved as 0.077 ng/ml. All four biomarkers in buffer samples were successfully quantified and reliable R2 values were obtained, and reliable calibration curves were secured for three biomarkers in spiked human serum samples. The immunosensors developed and will be optimized are expected to be used in various fields, including detection of biomarkers for not only AD but also related diseases.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0