Analytical Sciences最新文献_第10页

Elemental and isotopic analyses of individual nanoparticles using single particle inductively coupled plasma mass spectrometry 使用单粒子电感耦合等离子体质谱分析单个纳米粒子的元素和同位素。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-19 DOI: 10.1007/s44211-025-00766-0

Masaki Nakazato, Takafumi Hirata

{"title":"Elemental and isotopic analyses of individual nanoparticles using single particle inductively coupled plasma mass spectrometry","authors":"Masaki Nakazato, Takafumi Hirata","doi":"10.1007/s44211-025-00766-0","DOIUrl":"10.1007/s44211-025-00766-0","url":null,"abstract":"<div><p>Sensitive and rapid technique for elemental analysis of individual nanoparticles is increasingly desired in various research fields such as geochemical, environmental, clinical, and biochemical sciences. Among the techniques, single particle inductively coupled plasma mass spectrometry (spICP-MS) becomes one of the principal choices for the analytical method because of both the simple sample preparation and high analytical throughput, realizing the statistical treatments of the resulting data obtained from large numbers of particles. The analytical capability of the spICP-MS is further improved by the combination of ICP ion source with various types of mass spectrometers including quadrupole-type instrument, multiple collector system setup equipped on magnetic sector, or superfast mass scanning data acquisition utilizing time of flight-type mass spectrometers. In this article, both the principles and applications of size, elemental, and isotopic analysis of nanoparticles using spICP-MS are critically reviewed.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1185 - 1201"},"PeriodicalIF":2.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovations in paper-based analytical devices and portable absorption photometers for onsite analysis 创新的纸质分析设备和便携式吸收光度计的现场分析。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-18 DOI: 10.1007/s44211-025-00764-2

Sasikarn Seetasang, Mika I. Umeda, Jianchao Ren, Takashi Kaneta

{"title":"Innovations in paper-based analytical devices and portable absorption photometers for onsite analysis","authors":"Sasikarn Seetasang, Mika I. Umeda, Jianchao Ren, Takashi Kaneta","doi":"10.1007/s44211-025-00764-2","DOIUrl":"10.1007/s44211-025-00764-2","url":null,"abstract":"<div><p>Two types of analytical instruments and devices—one sophisticated high-performance instrument and another portable device—have been the focus of recent trends in analytical science. The necessity of point-of-care testing and onsite analysis has accelerated the advancement of high-performance, user-friendly portable analytical devices such as paper-based analytical devices (PADs) and light-emitting diode-based portable photometers. In this review, we summarize our achievements in the study of PADs and portable photometers. Several types of PADs are capable of performing titrations, metal ion analysis, and food analysis, while photometers, which consist of paired emitter–detector light-emitting diode (PEDD) photometers, are used for thiocyanate and herbicide analysis. These PADs and photometers permit the onsite determination of real environmental, body fluid, and food samples when an equipped laboratory is unavailable.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1169 - 1184"},"PeriodicalIF":2.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breath biomarkers for esophageal cancer: identification, quantification, and diagnostic modeling 食管癌的呼吸生物标志物：鉴定、量化和诊断模型。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-15 DOI: 10.1007/s44211-025-00769-x

Yuke Ren, Fei Wang, Ziyi Zhu, Raojun Luo, Guojun Lv, Haibin Cui

{"title":"Breath biomarkers for esophageal cancer: identification, quantification, and diagnostic modeling","authors":"Yuke Ren, Fei Wang, Ziyi Zhu, Raojun Luo, Guojun Lv, Haibin Cui","doi":"10.1007/s44211-025-00769-x","DOIUrl":"10.1007/s44211-025-00769-x","url":null,"abstract":"<div><p>Esophageal cancer is a major global health issue with a high mortality rate. Early diagnosis is crucial for improving patient outcomes, but traditional diagnostic methods are often invasive and costly. This study explores the potential of exhaled volatile organic compounds (VOCs) as a non-invasive diagnostic tool for esophageal cancer. Using gas chromatography-mass spectrometry (GC–MS), we analyzed the breath samples of 80 esophageal cancer patients and 60 healthy controls, identifying and quantifying over 100 VOCs. The results revealed significant differences in the concentrations of VOCs such as acetone, ethanol, and isoprene between the two groups. A multi-parameter regression diagnostic model based on a neural network algorithm achieved an accuracy of 90.3% in distinguishing esophageal cancer patients from healthy individuals. Further optimization incorporating physiological factors, including smoking, drinking, and dietary habits, improved the model’s accuracy to 92.4%, with a specificity of 93.1%, representing a significant improvement over previous studies. These results suggest that VOCs analysis in exhaled breath holds great promise as a non-invasive, cost-effective, and accurate method for early detection of esophageal cancer.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 7","pages":"965 - 976"},"PeriodicalIF":2.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Confocal micro-X-ray fluorescence and total reflection X-ray fluorescence analyses of Ryugu sample in a laboratory environment 琉球样品的共聚焦微x射线荧光和全反射x射线荧光分析。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-14 DOI: 10.1007/s44211-025-00753-5

Tsugufumi Matsuyama, Sora Yasuda, Koen Janssens, Lee Wah Lim, Yoshio Takahashi, Kouichi Tsuji

{"title":"Confocal micro-X-ray fluorescence and total reflection X-ray fluorescence analyses of Ryugu sample in a laboratory environment","authors":"Tsugufumi Matsuyama, Sora Yasuda, Koen Janssens, Lee Wah Lim, Yoshio Takahashi, Kouichi Tsuji","doi":"10.1007/s44211-025-00753-5","DOIUrl":"10.1007/s44211-025-00753-5","url":null,"abstract":"<div><p>This study analyzed Ryugu samples utilizing confocal micro-X-ray fluorescence (CM-XRF) and total reflection X-ray fluorescence (TXRF), in which information of elemental mapping as well as the content of trace elements could be obtained separately, and respectively. In CM-XRF, polycapillary lenses are placed in front of the X-ray tube and detector, and elemental information in the overlapping region of both focus points was obtained. Three-dimensional elemental distributions could be obtained by scanning a sample; the Ryugu sample was placed on an Al plate with one center, and the images of Fe, Ni, Cr, and Ca were obtained. The outlines of these elements were almost equivalent; however, as the energy of Ca Kα was low, its intensity in the elemental mapping was weak. Non-destructive TXRF measurements were performed to measure the trace elements in the Ryugu sample. We then performed quantitative analysis and determined the concentrations of trace elements such as Ga, Ge, and Se. The concentrations of these elements are higher than those in the CI chondrites. Therefore, we verified that the 3D elemental distributions and quantitative measurements in the Ryugu sample were performed without destruction.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 6","pages":"847 - 855"},"PeriodicalIF":2.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid determination of total colony counts and prediction of shelf life of dried tofu using LF-NMR 用LF-NMR快速测定干豆腐菌落总数及预测保质期。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-13 DOI: 10.1007/s44211-025-00759-z

Jian Xiao, Alin Xia, Taidong Hou

{"title":"Rapid determination of total colony counts and prediction of shelf life of dried tofu using LF-NMR","authors":"Jian Xiao, Alin Xia, Taidong Hou","doi":"10.1007/s44211-025-00759-z","DOIUrl":"10.1007/s44211-025-00759-z","url":null,"abstract":"<div><p>Dried tofu is a type of bean food that is popular among Chinese people. However, because dried tofu is usually exposed to air during storage or shelf life, this may lead to a rapid increase in colony counts and spoilage, resulting in shortened shelf life. The traditional method for measuring total colony counts is the plate counting method, which is complex and time consuming. Therefore, it is particularly important to explore a method that can quickly, accurately, and non-destructively determine the total colony counts of dried tofu and predict its shelf life. In this study, the samples were measured by low-field nuclear magnetic resonance (LF-NMR) to obtain transverse relaxation data. Then, the total colony counts in dried tofu was determined by plate counting method, and it was used as a reference value. The backpropagation artificial neural network (BP-ANN) was used to analyze the transverse relaxation data. The results show that the BP-ANN model could quickly and accurately predict total colony counts. In addition, the total colony counts predicted by BP-ANN were used to predict the shelf life. Comparing the predicted shelf life with the actual shelf life of dried tofu. The results show that the relative error between them is less than 10%. Thus, the shelf life model established by the BP-ANN predicted value has a certain reliability. This study provides some references for rapid and nondestructive determination of total colony counts and shelf life prediction of dried tofu.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 7","pages":"945 - 952"},"PeriodicalIF":2.0,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermal radiometric image identification of microplastics through near-infrared excitation 基于近红外激发的微塑料光热辐射图像识别。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-10 DOI: 10.1007/s44211-025-00756-2

Takumi Aramaki, Miki Isoda, Akira Harata

引用次数: 0

Correction: Recent advances in the development of 225Ac- and 211At-labeled radioligands for radiotheranostics 更正：用于放射治疗的225Ac-和211at标记放射配体的最新进展。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-09 DOI: 10.1007/s44211-025-00763-3

Masayuki Munekane, Takeshi Fuchigami, Kazuma Ogawa

引用次数: 0

Detection of a large antigen through the masking and exposure of a fragment of split luciferase 通过掩蔽和暴露一个分裂的荧光素酶片段来检测一个大抗原。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-04-08 DOI: 10.1007/s44211-025-00754-4

Cheng Qian, Ayumu Ninomiya, Natsuki Shibukawa, Hiroshi Ueda, Takanobu Yasuda, Bo Zhu, Tetsuya Kitaguchi

{"title":"Detection of a large antigen through the masking and exposure of a fragment of split luciferase","authors":"Cheng Qian, Ayumu Ninomiya, Natsuki Shibukawa, Hiroshi Ueda, Takanobu Yasuda, Bo Zhu, Tetsuya Kitaguchi","doi":"10.1007/s44211-025-00754-4","DOIUrl":"10.1007/s44211-025-00754-4","url":null,"abstract":"<div><p>We developed PMBiT, an antibody-binding Protein M (PM)-based bioluminescent probe that detects large antigens via luciferase reconstitution by exposing a luciferase fragment. Detection is achieved by exploiting the principle that the antibody, large antigen, and PM cannot form a complex simultaneously. PMBiT was prepared by conjugating PM with a HiBiT-based peptide from split NanoLuc luciferase through an Azide-DBCO click reaction. It retained its binding activity to the antibody and showed bioluminescence upon reconstitution of the luciferase with LgBiT, the other fragment of the split NanoLuc. Mixing PMBiT with various IgG antibodies resulted in decreased bioluminescence. In contrast, when PMBiT was mixed with IgG bound to its large antigen, such as human C-reactive protein, a dose-dependent increase in bioluminescence was obtained. Molecular dynamics simulations of PM showed that two regions in the C-terminus contribute to steric clashes with antigens owing to their relatively rigid structures. Furthermore, in silico analysis of the structure suggested that the antigen size was the primary factor blocking the binding of PMBiT to IgG for antigen detection. An immunoassay utilizing PMBiT does not require genetic manipulation of antibodies, allowing for seamless and scalable antibody replacement, and will advance the future of on-site detection and rapid diagnostics.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 6","pages":"857 - 865"},"PeriodicalIF":2.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosensing approaches in body fluids using extended-gate-type organic field-effect transistor enzymatic sensors 使用扩展门型有机场效应晶体管酶传感器的体液生物传感方法。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-04-05 DOI: 10.1007/s44211-025-00750-8

Yui Sasaki, Tsuyoshi Minami

{"title":"Biosensing approaches in body fluids using extended-gate-type organic field-effect transistor enzymatic sensors","authors":"Yui Sasaki, Tsuyoshi Minami","doi":"10.1007/s44211-025-00750-8","DOIUrl":"10.1007/s44211-025-00750-8","url":null,"abstract":"<div><p>Biomarkers in body fluids provide essential chemical information for examining health conditions; however, unlike conventional instrumental approaches, easy-to-use analytical methods have not yet been fully established. This review introduces extended-gate-type organic field-effect transistors (OFETs) as biosensor platforms for real-sample analysis. OFETs are electronic devices that show switching profiles when gate voltages are applied. Therefore, the gate electrode of OFET functions as a sensing unit combined with appropriate molecular recognition materials. Owing to their signal amplification properties, OFETs enable sensitive biosensing. The extended-gate surfaces are easily functionalized with enzymatic layers using chemical modification, and these surfaces provide a high discrimination ability for specific biomarkers from their analogs. This review presents the designs of the extended-gate structures (i.e., integrated and separated styles) and their enzymatic layers and includes their actual sensing performance.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 5","pages":"523 - 530"},"PeriodicalIF":1.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44211-025-00750-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in single-particle analysis with nanopore technology 利用纳米孔技术进行单颗粒分析的最新进展。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-04-05 DOI: 10.1007/s44211-025-00757-1

Akihide Arima

引用次数: 0