{"title":"Optical lateral flow assays in early diagnosis of SARS-CoV-2 infection","authors":"Rushi Liang, Aiping Fan, Feiqian Wang, Yajing Niu","doi":"10.1007/s44211-024-00596-6","DOIUrl":"10.1007/s44211-024-00596-6","url":null,"abstract":"<div><p>So far, the 2019 novel coronavirus (COVID-19) is spreading widely worldwide. The early diagnosis of infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is essential to provide timely treatment and prevent its further spread. Lateral flow assays (LFAs) have the advantages of rapid detection, simple operation, low cost, ease of mass production, and no need for special devices and professional operators, which make them suitable for self-testing at home. This review focuses on the early diagnosis of SARS-CoV-2 infection based on optical LFAs including colorimetric, fluorescent (FL), chemiluminescent (CL), and surface-enhanced Raman scattering (SERS) LFAs for the detection of SARS-CoV-2 antigens and nucleic acids. The types of recognition components, detection modes used for antigen detection, labels employed in different optical LFAs, and strategies to improve the detection sensitivity of LFAs were reviewed. Meanwhile, LFAs coupled with different nucleic acid amplification techniques and CRISPR–Cas systems for the detection of SARS-CoV-2 nucleic acids were summarized. We hope this review provides research mentalities for developing highly sensitive LFAs that can be used in home self-testing for the early diagnosis of SARS-CoV-2 infection.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comprehensive extraction study using N,N-dioctylthiodiglycolamic acid: effect of S donor on metal extraction","authors":"Kojiro Shimojo, Iori Fujiwara, Takumi Saito, Tatsuya Oshima","doi":"10.1007/s44211-024-00577-9","DOIUrl":"10.1007/s44211-024-00577-9","url":null,"abstract":"<div><p>Extraction ability of <i>N,N</i>-dioctylthiodiglycolamic acid (T-DODGAA), a soft-base sulfur donor ligand with an amide group and a carboxylic acid connected by a thioether chain, for 56 metal ions have been comprehensively investigated and compared with that of <i>N,N</i>-dioctyldiglycolamic acid (DODGAA) with an etheric oxygen atom, a hard-base donor. The acid dissociation constant (p<i>K</i><sub>a</sub>) of the thiodiglycolamic acid framework was determined to be 3.71 ± 0.06 in water (0.1 M LiCl, 25 °C) by potentiometric titration, indicating that T-DODGAA is a slightly weaker acid than DODGAA (p<i>K</i><sub>a</sub> = 3.54 ± 0.03). T-DODGAA can quantitatively extract various metal ions from the 56 metal ions into the organic phase (isooctane) through a proton-exchange reaction. T-DODGAA provided higher extraction performance than DODGAA for Hf(IV), Cr(III), Fe(III), Ni(II), Cu(II), Pd(II), Ag(I), Au(III), Hg(II), Al(III), and Ga(III), especially for soft metal ions. Furthermore, to demonstrate the practical feasibility of T-DODGAA for hydrometallurgy and metal recycling, we performed selective separation tests of rare metal ions such as Sc(III), Ni(II), Co(II), Pd(II), Au(III), In(III), and Ga(III) in metal-mixed extraction systems.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of on-line sample preconcentration by large-volume dual preconcentration by isotachophoresis and stacking (LDIS) on straight-channel microchips","authors":"Fumihiko Kitagawa, Kazuki Takahashi, Reina Osanai, Ryota Sasaki, Takayuki Kawai","doi":"10.1007/s44211-024-00597-5","DOIUrl":"10.1007/s44211-024-00597-5","url":null,"abstract":"<div><p>In this study, large-volume dual preconcentration by isotachophoresis and stacking (LDIS) which is an on-line sample preconcentration technique coupling large-volume sample stacking with an electroosmotic flow pump (LVSEP) with transient isotachophoresis (tITP) was applied to microchip electrophoresis (MCE) for improving both detection sensitivities and peak shapes. To realize LDIS in MCE, we investigated experimental procedures for injecting a short plug of a leading electrolyte (LE) solution into a straight microchannel without any sophisticated injector apparatus. We found that a short LE plug could be injected into a sample-filled straight-channel only by making the liquid level of the LE solution in an outlet reservoir higher than that in an inlet one. By applying a reversed-polarity voltage to the microchip, anionic analytes injected throughout the microchannel were first enriched by LVSEP, followed by tITP. Through the second preconcentration effect by tITP in LDIS, sensitivity enhancement factor (SEF) and asymmetry factor for a standard dye were improved from 878 and 0.62 to 1330 and 1.14, respectively, relative to those in conventional LVSEP. It should be noted that more viscous running buffer containing sieving polymers could be employed to the LDIS analysis, which was effective for improving the SEF and the separation efficiencies, especially for bio-polymeric compounds. Finally, LDIS was applied to the oligosaccharide and protein analyses in MCE, resulting in the SEFs of 1410 and <i>ca</i>. 50 for maltotriose and bovine milk casein, respectively.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Teruki Nii, Shoichi Hijii, Ryosuke Kaneko, Kenta Tanito, Kota Yamanaka, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama
{"title":"In vitro evaluation of novel SN-38 prodrug activated by α-rhamnosidase of exogenous enzyme","authors":"Teruki Nii, Shoichi Hijii, Ryosuke Kaneko, Kenta Tanito, Kota Yamanaka, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama","doi":"10.1007/s44211-024-00593-9","DOIUrl":"10.1007/s44211-024-00593-9","url":null,"abstract":"<div><p>This study introduces the α-rhamnose (Rham)-conjugated prodrug of SN-38 (Rham-SN-38) as a promising alternative to irinotecan. α-rhamnosidase, responsible for SN-38 release from Rham-SN-38, does not express in human cells, minimizing individual variability and side effects. The injection of the α-rhamnosidase into the tumor tissues makes it possible, for the first time, to activate the Rham-SN-38. Furthermore, α-rhamnosidase demonstrates significantly higher activity than carboxylesterase, the specific enzyme activating irinotecan. SN-38 release mediated by α-rhamnosidase completes within 2 h, with a <i>k</i><sub><i>cat</i></sub>/K<sub>m</sub> value approximately 5.0 × 10<sup>4</sup>-fold higher than that of irinotecan. The 50% inhibition concentration (IC<sub>50</sub>) of Rham-SN-38 against three types of cancer cells and one normal cell exceeds 4.5 × 10<sup>3</sup> nM. The addition of α-rhamnosidase significantly increases cytotoxicity, with IC<sub>50</sub> comparable to free SN-38. The QIC<sub>50</sub>, an index reflecting the difference in cytotoxicity with and without α-rhamnosidase, exceeds approximately 1.0 × 10<sup>2</sup>-fold. Rham-SN-38, synthesized in this study, demonstrates significant potential as a prodrug for cancer therapy.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salah M. El-Bahy, Abdullah A. A. Sari, Alaa S. Amin, Mohamed A. Ali
{"title":"Revolutionizing scandium detection in real samples: Unleashing the power of sol–gel-based optical sensor","authors":"Salah M. El-Bahy, Abdullah A. A. Sari, Alaa S. Amin, Mohamed A. Ali","doi":"10.1007/s44211-024-00589-5","DOIUrl":"10.1007/s44211-024-00589-5","url":null,"abstract":"<div><p>The development of a highly selective and ultra-sensitive optical sensor for detecting scandium (Sc<sup>3+</sup>) ions involves incorporating the reagent 2,3-dichloro-6-(3-carboxy-2-hydroxy-1-naphthylazo)quinoxaline (DCHNAQ) into a silica sol–gel thin film on a glass substrate. This innovative approach utilizes tetraethoxy-silane (TEOS) as the precursor, maintaining a sol–gel pH level of 4.5, a water-to-alkoxide ratio of 5:1, and a DCHNAQ concentration of 5.0 × 10<sup>−4</sup> M. A detailed exploration of the impact of sol–gel parameters on the sensing capabilities of the developed sensor has been meticulously undertaken. This innovative sensor demonstrates remarkable selectivity in evaluating Sc<sup>3+</sup> ions over a dynamic range of 7.5–170 ng/mL, with limits of quantification and detection recorded at 7.3 and 2.20 ng/mL, respectively. Consistent results are achieved with a minimal RSD of 1.47 and 0.94% for Sc<sup>3+</sup> ions at 50 and 100 ng/mL, respectively, coupled with a swift response time of three min. Assessments of interference demonstrate a noteworthy preference for Sc<sup>3+</sup>ions, accomplished by enclosing DCHNAQ within the sol–gel framework and making optimal structural modifications to the doped sol–gel. The sensor offers straightforward regeneration using a 0.25 M EDTA solution, exhibiting complete reversibility. Comparative analysis with other methodologies underscores the efficacy in determining Sc<sup>3+</sup>ions in various reference materials, including plant leaves, fish, water, alloys, ores, and monazite samples.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><img></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thiol-based chemically modified carbon screen-printed electrode for simultaneous quantification of trace level Pb(II) and Cd(II)","authors":"Mritunjay S. Tiwari, Arun K. Kadu","doi":"10.1007/s44211-024-00581-z","DOIUrl":"10.1007/s44211-024-00581-z","url":null,"abstract":"<div><p>Present work reports, the development of a novel electrochemical sensor based on a diazonium-coupling reaction and covalent attachment of the –NH<sub>2</sub> group of cysteamine (Cyst) on screen-printed carbon electrode (SPCE), for simultaneous determination of Pb(II) and Cd(II). Initially, the in-situ generated 4-carboxyphenyl (4-CP) diazonium salt was electro-grafted to generate 4-CP/SPCE, followed by covalent bonding of terminal carboxylic group of 4-CP with –NH<sub>2</sub> group of Cyst to give Cyst/4-CP/SPCE. The modified electrode showed an enhanced selectivity and sensitivity toward the quantification of Pb(II) and Cd(II) using square wave anodic stripping voltammetry (SWASV) without mutual interference. Under optimal experimental conditions, the newly designed sensor showed a wide linear range of 0.01 µM to 0.7 µM. The limit of detection (LOD) obtained was 0.882 nM (0.09 ppb) and 0.65 nM (0.134 ppb) for Cd(II) and Pb(II), respectively. The modified SPCE exhibited good stability, selectivity, and reproducibility. Furthermore, the sensor was successfully applied for the determination of Pb(II) and Cd(II) ions in water samples which illustrated excellent recoveries in different spiked samples and the results were in line with the standard ICP-AES analysis.</p><h3>Graphical abstract</h3><p>A thiol-based disposable electrochemical sensor was developed via electro grafting of diazonium salt on SPCE followed by covalent immobilization of cysteamine for quantification of Pb(II) and Cd(II) in water samples.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Highly sensitive and novel dual-emission fluorescence nanosensor utilizing hybrid carbon dots–quantum dots for ratiometric determination of chlorpromazine","authors":"Saeedeh Narimani, Naser Samadi, Elnaz Delnavaz","doi":"10.1007/s44211-024-00591-x","DOIUrl":"10.1007/s44211-024-00591-x","url":null,"abstract":"<div><p>Herein, a ratiometric fluorimetric nanosensor is introduced for the sensitive and selective analysis of chlorpromazine (CPZ) via employing blue-emitting B-doped carbon dots (B-CDs) as the reference fluorophore and green-emitting CdTe capped thioglycolic acid (TGA) quantum dots (TGA-CdTe-QDs) as the specific recognition probe. The sensor exhibits dual emission centered at 440 and 560 nm, under a single excitation wavelength of 340 nm. Upon the addition of ultra-trace amount of CPZ, the fluorescence signal of TGA-CdTe-QDs declines due to electron transfer process from excited TGA-CdTe-QDs to CPZ molecules, whereas the fluorescence peak of B-CDs is unaffected. Therefore, a new fluorimetric platform was prepared for the assay of CPZ in the range of 2.2 × 10<sup>–10</sup> to 5.0 × 10<sup>–9</sup> M with a detection limit of 1.3 × 10<sup>–10</sup> M. Moreover, the practicability of the designed strategy was investigated for the detection of CPZ in biological samples and the results demonstrate that it possesses considerable potential to be utilized in practical applications.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Removal and detoxification of iprodione in water using didodecyldimethylammonium bromide-montmorillonite organoclay and manganese dioxide","authors":"Ngo Thi Thu Thao, Mako Oiwa, Hideo Hayashi, Tohru Saitoh","doi":"10.1007/s44211-024-00576-w","DOIUrl":"10.1007/s44211-024-00576-w","url":null,"abstract":"<div><p>Combination of organoclay sorption with manganese(IV) oxide (MnO<sub>2</sub>) catalyzed catechol oxidation was studied for the removal of a dicarboximide fungicide, iprodione, from water. Iprodion in water was sorbed on didodecyldimethylammonium bromide (DDAB)-modified montmorillonite (MT) organoclay and converted into the degraded product, 3,5-dichloroaniline (DCA). The degree of sorption increased by the modification with DDAB, because of the formation of a hydrophobic region for the incorporation of iprodione and negligibly interfered by coexisting MnO<sub>2</sub>. The half-life for the degradation of irodione in water at 25 °C was 7 days, whreas it reduced to 15 min in the organoclay. The activation energy, 65.4 ± 4.8 kJ mol<sup>−1</sup>, for the first-order reaction in the aqueous solution (pH 7.0) decreased to 43.9 ± 1.8 kJ mol<sup>−1</sup> in the organoclay, indicating the catalytic activity of the organoclay that accelerates the hydrolysis reaction of iprodione. In the coexistence of appropriate amounts of MnO<sub>2</sub> and catechol, the degraded product, DCA, reacted with oxidized products of catechol to form a water-insoluble precipitate and was successfully eliminated from water. The results obtained in the present study strongly suggest the applicability of the combined method of organoclay sorption method and MnO<sub>2</sub>-catalyzed oxidation for the diffusion control of toxic agrochemicals.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suhan P. Panditharatne, D. Yureka Imali, E. Chavin J. Perera, L. Hasini R. Perera, G. H. Chamari M. Hettiarachchi, M. N. Kaumal
{"title":"Anodized CuO-based reusable non-enzymatic glucose sensor as an alternative method for the analysis of pharmaceutical glucose infusions: a cyclic voltammetric approach","authors":"Suhan P. Panditharatne, D. Yureka Imali, E. Chavin J. Perera, L. Hasini R. Perera, G. H. Chamari M. Hettiarachchi, M. N. Kaumal","doi":"10.1007/s44211-024-00585-9","DOIUrl":"10.1007/s44211-024-00585-9","url":null,"abstract":"<div><p>Analyzing pharmaceutical products is a quality control requirement in a production facility. This study presents a CuO electrode-based reusable non-enzymatic sensor as an alternative method for rapid analysis of glucose levels in glucose infusions. CuO is extensively employed as an electrode material in non-enzymatic glucose sensors. Conventionally, these electrodes are fabricated using chemical synthesis of CuO followed by immobilization to the electrode substrate. In contrast, here, Cu metal was mechanically modified to create a grooved surface, followed by electrochemical anodization and subsequent annealing process to grow a seamless CuO layer in situ with enhanced catalytic activity. The morphology of the electrodes was characterized using scanning electron microscopy (SEM) and X-ray diffractometry (XRD). The direct electrocatalytic activity of the developed CuO-modified electrode towards glucose oxidation in alkaline media was investigated by cyclic voltammetry in detail. The CuO-modified electrode commenced the oxidation process around 0.10 V vs. Ag pseudo-reference electrode, demonstrating a significant reduction in the overvoltage for glucose oxidation compared to the bare Cu electrode. The sensor is capable of detecting glucose at low oxidation potentials such as 0.2 V with a sensitivity value of 0.37 µA ppm<sup>−1</sup>, a wide linear range (80–2300 ppm), limit of quantification (LOQ) of 1 ppm, greater repeatability, 1% precision, 3% bias, a short response time (80 s), good reproducibility and excellent reusability (196 consecutive attempts). The enhanced performance and cost-effectiveness make this sensor a promising alternative method for product analysis in glucose injection solutions.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diffusion behavior of rhodamine 6G in single octadecylsilyl-functionalized silica particle revealed by fluorescence correlation spectroscopy","authors":"Akihisa Miyagawa, Terumasa Nohira, Shigenori Nagatomo, Kiyoharu Nakatani","doi":"10.1007/s44211-024-00583-x","DOIUrl":"10.1007/s44211-024-00583-x","url":null,"abstract":"<div><p>We investigated the diffusion behavior of rhodamine 6G (Rh6G) within single octadecylsilyl-functionalized (ODS) silica particle in an acetonitrile (ACN)/water system using fluorescence correlation spectroscopy (FCS). FCS measurements were conducted at the center of the particle to exclusively determine the intraparticle diffusion coefficient (<i>D</i>). The obtained <i>D</i> values were analyzed based on a pore and surface diffusion model, the results of which indicate that surface diffusion primarily governs the intraparticle diffusion of Rh6G. Furthermore, an increase in the concentration of ACN (<i>C</i><sub>ACN</sub>) resulted in a corresponding increase in the surface diffusion coefficient (<i>D</i><sub>s</sub>), whereas the addition of NaCl did not significantly affect the <i>D</i><sub>s</sub> values. We attributed this dependence of <i>D</i><sub>s</sub> to the dielectric constant change in the interfacial liquid phase formed on the ODS layer. Specially, <i>D</i><sub>s</sub> values of (4.0 ± 0.5) × 10<sup>–7</sup>, (7.7 ± 1.1) × 10<sup>–7</sup>, (1.0 ± 0.3) × 10<sup>–6</sup>, and (1.1 ± 0.2) × 10<sup>–6</sup> cm<sup>2</sup> s<sup>−1</sup> were obtained for <i>C</i><sub>ACN</sub> = 20, 30, 40, and 50 vol%, respectively. We anticipate that this approach will contribute to advancing research on intraparticle mass transfer mechanisms.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}