Analytical Sciences最新文献_第2页

Sensitive determination and discrimination of fluorinated ions using ion-transfer voltammetry. 用离子转移伏安法灵敏地测定和鉴别含氟离子。

IF 2 4区化学

Analytical Sciences Pub Date : 2026-04-17 DOI: 10.1007/s44211-026-00912-2

Kohei Uematsu, Kento Tamiya, Yuki Nara, Minato Tanaka, Hajime Katano

引用次数: 0

Quantification of glyphosate and glufosinate in human blood using the aqueous layer recovered from QuEChERS extraction. 利用QuEChERS提取液回收的水层定量测定人体血液中的草甘膦和草铵膦。

IF 2 4区化学

Analytical Sciences Pub Date : 2026-04-16 DOI: 10.1007/s44211-026-00913-1

Naoki Tachiiri, Kiyotaka Usui, Sohtaro Mimasaka

引用次数: 0

Dual electrochemical sensor based on graphene aerogel for quantification of ascorbic acid in pharmaceutical samples and uric acid in urine. 基于石墨烯气凝胶的双电化学传感器用于定量药物样品中的抗坏血酸和尿液中的尿酸。

IF 2 4区化学

Analytical Sciences Pub Date : 2026-04-15 DOI: 10.1007/s44211-026-00896-z

Alejandro Gutiérrez, Mario Sánchez-Suárez, Natalia Rey-Raap, Ana Arenillas, Janet Ledesma-García, Luis Gerardo Arriaga

引用次数: 0

Dual-color image analysis for quantifying fluorescence intensity in plasma membrane region of cells. 定量细胞质膜区荧光强度的双色图像分析。

IF 2 4区化学

Analytical Sciences Pub Date : 2026-04-14 DOI: 10.1007/s44211-026-00908-y

Satoshi Fujii, Keita Takaki, Shinji Sueda

引用次数: 0

Construction of a multi-label odor prediction model based on molecular structures and olfactory receptor binding profiles with a novel interpretability framework. 基于分子结构和嗅觉受体结合谱的多标签气味预测模型的构建及新的可解释性框架。

IF 2 4区化学

Analytical Sciences Pub Date : 2026-04-13 DOI: 10.1007/s44211-026-00900-6

Yuta Wakutsu, Hiromasa Kaneko

{"title":"Construction of a multi-label odor prediction model based on molecular structures and olfactory receptor binding profiles with a novel interpretability framework.","authors":"Yuta Wakutsu, Hiromasa Kaneko","doi":"10.1007/s44211-026-00900-6","DOIUrl":"https://doi.org/10.1007/s44211-026-00900-6","url":null,"abstract":"Predicting odors from molecular structures is a long-standing challenge in chemoinformatics, especially in cases where structurally similar compounds, such as optical isomers, exhibit distinct odor perceptions. To address this, we developed a multi-stage odor prediction framework that integrates both molecular structures and olfactory receptor (OR) binding information. Recognizing that human olfaction is mediated by complex receptor-ligand interactions, we divided the process into three mechanistic stages: (1) prediction of molecular binding to ORs (classification), (2) estimation of binding strength (regression), and (3) prediction of odor presence based on receptor responses (classification). We further introduced a novel interpretability metric, Positive likeness, which estimates the contribution of specific receptors to the likelihood of each odor label. Using this framework, we demonstrated the ability to distinguish odor differences between optical isomers and to identify ORs that are potentially responsible for the perception of specific odor attributes. The model also enabled extrapolative odor prediction for molecules with unknown odor annotations, leveraging receptor information and label propagation. Our results highlight the importance of receptor-level descriptors in enhancing predictive performance and biological interpretability. This study provides a foundation for receptor-guided odor modeling and supports applications in fragrance design and sensory informatics.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Mesoporous polydopamine microspheres for rapid ppb-level ultra-sensitive formaldehyde detection. 校正：用于快速ppb级超灵敏甲醛检测的介孔聚多巴胺微球。

IF 2 4区化学

Analytical Sciences Pub Date : 2026-04-10 DOI: 10.1007/s44211-026-00909-x

Luyu Wang, Jia Song, Chunyang Yu

引用次数: 0

Design of a green ammonia production process by machine learning. 基于机器学习的绿色氨生产工艺设计。

IF 2 4区化学

Analytical Sciences Pub Date : 2026-04-06 DOI: 10.1007/s44211-026-00903-3

Sho Takaoka, Hiromasa Kaneko

引用次数: 0

Deep autoencoder for low dimensionality for high dimensional data in regression models and direct inverse analysis of models. 深度自编码器用于低维数据的高维回归模型和直接逆分析模型。

IF 2 4区化学

Analytical Sciences Pub Date : 2026-04-06 DOI: 10.1007/s44211-026-00904-2

Hiromasa Kaneko

引用次数: 0

Simultaneous detection of SARS-CoV-2 proteins and nucleic acids by coupling PNIPAM with circle-to-circle amplification. PNIPAM与圈对圈扩增耦合同时检测SARS-CoV-2蛋白和核酸

IF 2 4区化学

Analytical Sciences Pub Date : 2026-04-06 DOI: 10.1007/s44211-026-00905-1

Yu Feng, Jiaxin Liu, Kebing Yi, Ziwen Tang, Feng Gong, Yimiao He, Xiaoyun Shan, Hui Xu, Fuxiang Zhou, Xinghu Ji, Zhike He

{"title":"Simultaneous detection of SARS-CoV-2 proteins and nucleic acids by coupling PNIPAM with circle-to-circle amplification.","authors":"Yu Feng, Jiaxin Liu, Kebing Yi, Ziwen Tang, Feng Gong, Yimiao He, Xiaoyun Shan, Hui Xu, Fuxiang Zhou, Xinghu Ji, Zhike He","doi":"10.1007/s44211-026-00905-1","DOIUrl":"https://doi.org/10.1007/s44211-026-00905-1","url":null,"abstract":"In the past few years, the global uncontrollable spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has underscored the need for rapid, sensitive, and accurate detection methods. Given the continuous mutation characteristics of viruses, single-target detection carries the risk of false-positive or false-negative results, whereas dual-target detection can effectively mitigate such risks. Therefore, thermosensitive polymer poly(N-isopropylacrylamide) (PNIPAM) was integrated with an isothermal amplification method-circle-to-circle amplification (C2CA) in this study, enabling individual and simultaneous detection of the SARS-CoV-2 S1 protein and N gene, respectively. PNIPAM-capture probe conjugates enabled specific target recognition and thermal separation from complex matrices, while C2CA achieved exponential signal amplification by leveraging two cascaded rolling circle amplification (RCA) reactions. During single-target detection, the method exhibited linear ranges of 0.1-1000 pg/mL for S1 protein detection and 0.1-1000 pM for Ng detection, with the limit of detection (LOD) of 55 fg/mL and 11.2 fM, respectively. The spiked recovery experiment demonstrated that this method possesses high specificity and robust anti-interference capability. Furthermore, in order to improve the accuracy and efficiency, simultaneous detection was achieved by integrating S1 protein and Ng detection into a single reaction system and labeling differential fluorophores. The LOD was 68.3 fg/mL for S1 protein and 33.1 fM for Ng, respectively. This method combines the advantages of homogeneous reaction and isothermal amplification, eliminating the need for complex instruments and cumbersome procedures, thereby making it suitable for resource-limited settings.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a micro separation and analysis system for uranyl ions composed of microplug extraction and liquid scintillation detection. 由微塞萃取和液体闪烁检测组成的铀酰离子微分离分析系统的研制。

IF 2 4区化学

Analytical Sciences Pub Date : 2026-04-06 DOI: 10.1007/s44211-026-00887-0

Xinyi Qian, Naoki Shitara, Naokazu Idota, Takehiko Tsukahara

引用次数: 0