Analytical Sciences最新文献_第3页

Determination of circulating tumor cells by surface-enhanced Raman scattering based on molecularly imprinted polymers doped with silver nanoparticles

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-25 DOI: 10.1007/s44211-025-00719-7

JunJie Wei, Yong Shen, GangFeng Ouyang

{"title":"Determination of circulating tumor cells by surface-enhanced Raman scattering based on molecularly imprinted polymers doped with silver nanoparticles","authors":"JunJie Wei, Yong Shen, GangFeng Ouyang","doi":"10.1007/s44211-025-00719-7","DOIUrl":"10.1007/s44211-025-00719-7","url":null,"abstract":"<div><p>The rapid and simple detection of circulating tumor cells (CTCs) can help with early diagnosis of tumor diseases and assist clinical judgment of tumor disease development status and prognosis. An important alteration in cancer progression is a significant increase in sialic acid (SA) levels, making sialic acid one of an interesting biomarker for cancer type diversity. Here, novel SERS nano-biosensors were fabricated employing molecularly imprinted polymers (MIPs) particles loaded with Ag nanoparticles (AgNPs) to form high affinity toward sialic acid on CTCs. In this work, the glycol-specific MIPs are produced using precipitation polymerization. The nanocomposite was characterized by Fourier transform infrared spectroscopy (FTIR), zeta potential, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Consequently, CTC can be rapidly detected in mouse blood in a specific and sensitive manner, as low as 1 cells/ml. In addition, a good linear relationship was observed between CTC concentration and signal intensity (<i>R</i><sup>2</sup> = 0.9881). Moreover, the SERS nano-biosensors was used to detect CTC with excellent precision (relative standard deviation, RSD = 3.9%) and good repeatability (RSD = 6.8%). Therefore, this inexpensive, highly sensitive, and rapid method using SERS nano-biosensors can quickly detect CTCs and may prove to be a new platform to be an early diagnostic tool for cancer patient detection.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 4","pages":"447 - 455"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of electrogenerated chemiluminescence mechanism on the emission spectra and intensities.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-25 DOI: 10.1007/s44211-025-00736-6

Ryoichi Ishimatsu

引用次数: 0

Raman spectroscopic analysis of carbonates on a CY-type carbonaceous chondrite Yamato 980115: unexpectedly abundant terrestrial weathering products.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-24 DOI: 10.1007/s44211-025-00731-x

Shu-Hei Urashima, Hayato Tsuchiya, Naoya Imae, Akira Yamaguchi, Hiroharu Yui

{"title":"Raman spectroscopic analysis of carbonates on a CY-type carbonaceous chondrite Yamato 980115: unexpectedly abundant terrestrial weathering products.","authors":"Shu-Hei Urashima, Hayato Tsuchiya, Naoya Imae, Akira Yamaguchi, Hiroharu Yui","doi":"10.1007/s44211-025-00731-x","DOIUrl":"https://doi.org/10.1007/s44211-025-00731-x","url":null,"abstract":"<p><p>This study presents Raman spectra of carbonates on a carbonaceous chondrite, Yamato (Y) 980115. Y 980115 is an Antarctic meteorite and is originally classified as CI1-type. Since CI1-type meteorites are expected to record information of aqueous alteration of carbonaceous matters in the primitive solar photosphere or planetesimals, extensive studies have been performed. Among a variety of minerals on meteorites, carbonates are one of environment indicators because its cation composition depends on thermochemical properties of the aqueous solution when they were precipitated. Although the minerals on meteorites are usually identified by elemental composition analysis techniques such as backscattered electron imaging, these techniques have a drawback that they lack information of crystal structures so that it is difficult to distinguish some minerals such as ordered or disordered dolomite (CaMg(CO<sub>3</sub>)<sub>2</sub>) and a mixture of calcite (CaCO<sub>3</sub>) and magnesite (MgCO<sub>3</sub>). The present study employed Raman spectroscopy as a complementary technique to the elemental composition analysis. As a result, surprisingly, while the Mg-bearing carbonates on Y 980115 were expected mainly to be dolomite, the Raman spectra revealed that they are indeed nesquehonite (Mg(HCO<sub>3</sub>)(OH)·2H<sub>2</sub>O), which is a typical terrestrial weathering product for Antarctic meteorites. Among 63 carbonate grains found on Y 980115, 60 and 3 grains were assigned to nesquehonite and calcite, respectively, and no dolomite was found. This result indicates that there are unexpectedly abundant terrestrial weathering products for carbonates found on Y 980115.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of iodide in concentrated chloride springs by reversed-phase high-performance liquid chromatography with ultraviolet detection.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-23 DOI: 10.1007/s44211-025-00732-w

Tomoko Kemmei, Azusa Yudo, Shuji Kodama, Atsushi Yamamoto, Yoshinori Inoue, Shigehiro Kagaya, Kazuichi Hayakawa

引用次数: 0

The usage of color coordinates preserved in microscopic image for elucidation on chemical behavior in confined micro-/nano-spaces.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-22 DOI: 10.1007/s44211-025-00733-9

Arinori Inagawa

{"title":"The usage of color coordinates preserved in microscopic image for elucidation on chemical behavior in confined micro-/nano-spaces.","authors":"Arinori Inagawa","doi":"10.1007/s44211-025-00733-9","DOIUrl":"https://doi.org/10.1007/s44211-025-00733-9","url":null,"abstract":"<p><p>Characterizing the properties of micro-/nanomaterials and micro-/nanospaces is crucial due to their widespread use in diverse applications, including analytical methods. While microspectroscopy offers a powerful characterization technique, limitations in acquisition speed and instrument accessibility persist. This study comprehensively explores the use of color coordinates to elucidate the chemical phenomena within confined micro-/nanospaces. Encoding spectral information directly as color coordinates within digital images enables rapid data acquisition. In addition, simple instrumentation that requires only a camera as a detector expands the versatility of solving tasks that occur in microspectroscopy. This work details the fundamental principles of color coordinates and presents illustrative research examples demonstrating their utility in characterizing chemical reactions and physicochemical properties within confined spaces. Herein, the evaluation of the chemical reactions occurring in the confined microspace is explained, including the steel corrosion occurring in the freeze concentration of the salt solutions (FCS) formed in the frozen salt solutions, proton-involved reactions in the FCS, liquid/liquid and solid/gel interface. This work aims to promote the adoption of image processing for colorimetric analysis as a complementary or alternative approach to conventional microspectroscopy.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemiluminescence immunoassay using ionic-liquid submicron particles for prostate-specific antigen determination.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-21 DOI: 10.1007/s44211-025-00734-8

Aki Tanaka, Yuki Kiguchi, Shigehiko Takegami

{"title":"Electrochemiluminescence immunoassay using ionic-liquid submicron particles for prostate-specific antigen determination.","authors":"Aki Tanaka, Yuki Kiguchi, Shigehiko Takegami","doi":"10.1007/s44211-025-00734-8","DOIUrl":"https://doi.org/10.1007/s44211-025-00734-8","url":null,"abstract":"<p><p>In this study, ionic-liquid submicron particles (ILSPs) encapsulating the luminophore tris(2',2-bipyridyl)ruthenium (II) ([Ru(bpy)<sub>3</sub>]<sup>2+</sup>) were developed as a carrier for an electrochemiluminescence immunoassay (ECLIA). The ILSPs were applied to quantitative determination of the model analyte prostate-specific antigen (PSA). The electrochemiluminescence of [Ru(bpy)<sub>3</sub>]<sup>2+</sup> was measured with 2-(dibutylamino)ethanol as a co-reactant in nine ionic liquids (ILs). The electrochemiluminescence intensity was higher in 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([BMIM][TFSA]) and N-(2-methoxyethyl)-N-methyl pyrrolidinium bis(trifluoromethanesulfonyl)imide ([MEMP][TFSA]) than the other ILs. ILSPs were prepared using polyoxyethylene sorbitan monolaurate and sorbitan monooleate as surfactants and either [BMIM][TFSA] or [MEMP][TFSA]. The [BMIM][TFSA] ILSPs had a mean particle size of 244 nm and zeta potential of - 21.0 mV, and the [MEMP][TFSA] ILSPs had a mean particle size of 293 nm and zeta potential of - 17.9 mV. Microscope images showed that ILSPs were IL-in-water emulsions that completely encapsulated [Ru(bpy)<sub>3</sub>]<sup>2+</sup>. The ILSPs with [BMIM][TFSA] were more stable than those with [MEMP][TFSA], and [BMIM][TFSA] ILSPs was selected as a carrier in ECLIA for PSA determination. The calibration curve of PSA for ECLIA using the [BMIM][TFSA] ILSPs showed a good linear relationship (y = 0.29x + 4.02, r = 0.95) for the PSA concentration range of 100 pg/mL-100 μg/mL. The limit of detection and limit of quantification were 544 pg/mL and 35 ng/mL, respectively. Our results demonstrate that ECLIA using ILSPs can be used to easily determine the PSA concentration even with ILSPs in the particle state.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon black imprinted o-diaminobenzene sensing platform for sensitive electrochemical detection of interleukin 6

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-21 DOI: 10.1007/s44211-024-00709-1

Xu Cui, Zhiqiang Chen, Longyao Xu, Changwei Wu, Bin Qiu, Chaoming Zhou

{"title":"Carbon black imprinted o-diaminobenzene sensing platform for sensitive electrochemical detection of interleukin 6","authors":"Xu Cui, Zhiqiang Chen, Longyao Xu, Changwei Wu, Bin Qiu, Chaoming Zhou","doi":"10.1007/s44211-024-00709-1","DOIUrl":"10.1007/s44211-024-00709-1","url":null,"abstract":"<div><p>As a typical proinflammatory cytokine, interleukin 6 (IL-6) exhibits great influence on treating diseases (e.g., urocystitis) and adjusting immune. Normally, the IL-6 degree keeps a low content (< 40.0 pg mL<sup>−1</sup>) in bodies, but when its degree becomes higher, several serious conditions (e.g., urocystitis and infections) may occur. Hence, it is very essential to design a highly effective technology for monitoring IL-6 as a biomarker. In the present work, through adopting carbon black (CB) as substrate substance, o-diaminobenzene as electropolymerized monomer and [Fe(CN)<sub>6</sub>]<sup>4−/3−</sup> as the signal probe, a low-cost, sensitive and simple molecularly imprinted polymer (MIP) electrochemical sensing platform was designed to detect the IL-6 degree. The experiments revealed that the current of [Fe(CN)<sub>6</sub>]<sup>4−/3−</sup> probe at the MIP sensor would decrease along with the increase of IL-6 degree. Owing to the prominent properties of CB (e.g., high conductivity and surface area as well as stability) and high target-recognition capability of MIP, the as-proposed MIP sensor offers wide linearity (0.1–800 pg mL<sup>−1</sup>) and low analytical limit (0.03 pg mL<sup>−1</sup>); meanwhile, it possesses good repeatability, stability, and practical applications. It is, thus, expected this simple MIP sensor has some application value for IL-6 detection.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 4","pages":"487 - 494"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochar-based electrochemical sensors: a tailored approach to environmental monitoring.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-18 DOI: 10.1007/s44211-025-00726-8

Alvin Lim Teik Zheng, Ellie Teo Yi Lih, Yiu Pang Hung, Supakorn Boonyuen, Syeed SaifulAzry Osman Al Edrus, Eric Lim Teik Chung, Yoshito Andou

{"title":"Biochar-based electrochemical sensors: a tailored approach to environmental monitoring.","authors":"Alvin Lim Teik Zheng, Ellie Teo Yi Lih, Yiu Pang Hung, Supakorn Boonyuen, Syeed SaifulAzry Osman Al Edrus, Eric Lim Teik Chung, Yoshito Andou","doi":"10.1007/s44211-025-00726-8","DOIUrl":"https://doi.org/10.1007/s44211-025-00726-8","url":null,"abstract":"<p><p>Biochar (BC), often obtained via thermochemical conversion methods of biomass, has emerged as a versatile material with significant potential in electrochemical sensing applications. This review critically examines the recent advancements in the development of BC-based sensors for the electrochemical determination of pharmaceuticals, pesticides, heavy metals, phenolic compounds, and microplastics. BC-based electrochemical sensors have emerged as a promising alternative due to their sustainability, cost-effectiveness, and excellent electrochemical properties. The unique physicochemical properties of BC, including its high surface area, porosity, and functional groups, contribute to its effectiveness as a sensor material. The review begins with an overview of the synthesis methods for BC, highlighting the activation strategies on its structural and electrochemical properties. Next, the functionalization of BC and its integration into electrochemical sensor platforms are explored. The performance of BC-based sensors is evaluated using electrochemical focusing on their sensitivity, selectivity, detection limits, and stability. Future directions for research are proposed, emphasizing the need for further optimization, miniaturization, and integration of BC-based sensors into portable and on-site analytical devices.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Luciferase complementation for cellular assays beyond protein-protein interactions.

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-18 DOI: 10.1007/s44211-025-00730-y

Genki Kawamura, Takeaki Ozawa

引用次数: 0

Mechanical phenotype of cancer cells and its measurement methodology

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-02-17 DOI: 10.1007/s44211-025-00714-y

Noritada Kaji

引用次数: 0