Analytical Sciences最新文献_第4页

Fabrication of natural enzyme-covered / amino-modified Pd-Pt bimetallic-doped zeolitic imidazolate framework for ultrasensitive detection of metabolites. 用于代谢物超灵敏检测的天然酶覆盖/氨基修饰钯铂双金属掺杂唑咪唑框架的制备。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-10-03 DOI: 10.1007/s44211-024-00670-z

Chen-Chen Bai, Jin-Ye Lang, Xin-Yu Wang, Jia-Meng Zhao, Lin-Yi Dong, Jun-Jie Liu, Xian-Hua Wang

{"title":"Fabrication of natural enzyme-covered / amino-modified Pd-Pt bimetallic-doped zeolitic imidazolate framework for ultrasensitive detection of metabolites.","authors":"Chen-Chen Bai, Jin-Ye Lang, Xin-Yu Wang, Jia-Meng Zhao, Lin-Yi Dong, Jun-Jie Liu, Xian-Hua Wang","doi":"10.1007/s44211-024-00670-z","DOIUrl":"https://doi.org/10.1007/s44211-024-00670-z","url":null,"abstract":"The present article introduced an natural enzyme-covered/amino-modified Pd-Pt bimetallic-doped zeolitic imidazolate framework (NAPPZ) for ultrasensitive and specific detection of glucose. The dodecahedral nanomaterial zeolitic imidazolate framework (ZIF-8)-loaded Pd-Pt bimetallic nanoparticles endowed the composite with peroxidase-like activity. The modification with glucose oxidase (GOx) facilitated the rapid access of H2O2 produced through glucose oxidation to the Pd-Pt nanoparticles vicinity reducing diffusion. GOx specifically catalyzes the transformation of glucose into H2O2, which then H2O2 rapidly migrates to the Pd-Pt nanoparticles, catalyzing the oxidation of colorless o-phenylenediamine into the orange-yellow product 2,3-diaminophenazine. Based on the aforementioned cascade reaction, the NAPPZ and NAPPZ based on ChOx were utilized for detecting glucose in human urine samples and cholesterol in milk, respectively. The NAPPZ strategy presented a broad detection range (20-1100 μmol L-1) and a low detection limit (15.9 μmol L-1) for glucose, and the NAPPZ based on ChOx strategy approach offered a broad detection range (10-500 μmol L-1) and low detection limit (6.4 μmol L-1) for cholesterol. Therefore, this novel method holds significant potential in the areas of clinical diagnostics and food safety.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic extraction of residual solvents from pharmaceutical formulations using a needle-type extraction device. 使用针式萃取装置动态萃取药物制剂中的残留溶剂。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-09-28 DOI: 10.1007/s44211-024-00674-9

Ikuo Ueta, Daisuke Kondo, Suguru Masuda, Yuki Ariizumi, Ryosuke Kikuchi, Koki Nakagami, Yoshihiro Saito

{"title":"Dynamic extraction of residual solvents from pharmaceutical formulations using a needle-type extraction device.","authors":"Ikuo Ueta, Daisuke Kondo, Suguru Masuda, Yuki Ariizumi, Ryosuke Kikuchi, Koki Nakagami, Yoshihiro Saito","doi":"10.1007/s44211-024-00674-9","DOIUrl":"https://doi.org/10.1007/s44211-024-00674-9","url":null,"abstract":"This study developed a rapid screening method to determine residual solvents contained in a tablet formulation using a needle-type extraction device. For this, the tablet formulation was pulverized and the powdered sample was rapidly inserted into a pipette tip. After fixing the sample with quartz wool, the pipette tip was capped with a silicon septum. A needle-type extraction device packed with Carbopack X and a carbon molecular sieve was inserted into the pipette tip through the septum, and the gas sample was collected. During this gas sampling, pure N2 gas was introduced into the pipette tip. The extraction time for collecting 100 mL of the sample was approximately 10 min. After gas sampling, the extraction needle was connected to a gas-tight syringe and 0.5 mL of pure N2 gas (desorption gas) was collected. The extraction needle was then inserted into a heated gas chromatographic injection port. The extracted residual solvents were then thermally desorbed and determined using a gas chromatograph-flame ionization detector. The detector response is very low for carbon tetrachloride, although the proposed method showed sufficient sensitivity for five Class 1 compounds. Additionally, this study clearly indicated that the purge efficiency of residual solves with dynamic extraction is different between powdered pharmaceutical formulations.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of methamphetamine in urine by GC/MS coupled with solid-phase dispersive extraction and solid-phase derivatization. 利用气相色谱/质谱结合固相分散萃取和固相衍生化技术分析尿液中的甲基苯丙胺。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-09-27 DOI: 10.1007/s44211-024-00675-8

Koichi Saito, Noriko Segawa, Rie Ito

{"title":"Analysis of methamphetamine in urine by GC/MS coupled with solid-phase dispersive extraction and solid-phase derivatization.","authors":"Koichi Saito, Noriko Segawa, Rie Ito","doi":"10.1007/s44211-024-00675-8","DOIUrl":"https://doi.org/10.1007/s44211-024-00675-8","url":null,"abstract":"In this study, we investigated a solid-phase dispersive extraction (SPDE) method and solid-phase derivatization method using the same solid-phase gel to extract methamphetamine (MA) from urine samples more efficiently and perform trifluoroacetic acid (TFA) derivatization for MA analysis by gas chromatography/mass spectrometry (GC/MS). N-Methylbenzylamine (NMe-BA) was added to the urine sample as a surrogate, and MA was extracted by SPDE using Oasis® HLB gel as a solid-phase agent. After drying the solid-phase gel of the SPDE, anhydrous TFA was added to the MA-absorbed HLB gel in order to derivatize MA with TFA on the solid-phase, followed by elution of the TFA derivative from this gel using ethyl acetate. As a validation of the analytical method, the limit of detection (S/N = 3) and the limit of quantification (S/N > 10) of MA were 0.002 µg/mL and 0.01 µg/mL, respectively. And the average recovery rate was 97.6-100.1%, repeatability was 5.6-10.7%, and intermediate precision was 10.1-11.4% for low (0.02 µg/mL), intermediate (0.1 µg/mL), and high (1 µg/mL) concentrations of MA added in urine. The developed pretreatment method enabled continuous extraction, cleanup, and TFA derivatization of urinary MA on the same solid-phase. Thus, urinary MA can be analyzed easily, rapidly, and with high sensitivity and accuracy.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the sensitivity of immunoassays toward single-cell secretion analysis 提高单细胞分泌分析免疫测定的灵敏度。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-09-24 DOI: 10.1007/s44211-024-00651-2

Masato Suzuki

引用次数: 0

Preparation of a covalent organic framework-modified silica-gel composite for the effective adsorption of Pd(II), Zr(IV) and Mo(VI) from nitric acid solution 制备共价有机框架修饰的二氧化硅凝胶复合材料，用于有效吸附硝酸溶液中的钯（II）、锆（IV）和钼（VI）。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-09-20 DOI: 10.1007/s44211-024-00666-9

Hao Wu, Naoki Osawa, Masahiko Kubota, Seong-Yun Kim

引用次数: 0

Ultrahigh-sensitivity vinyl-COF fluorescent sensor for trace organic arsenic detection. 用于痕量有机砷检测的超高灵敏度乙烯基-COF 荧光传感器。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-09-19 DOI: 10.1007/s44211-024-00671-y

Wenyang Li, Qiangrong Xie

{"title":"Ultrahigh-sensitivity vinyl-COF fluorescent sensor for trace organic arsenic detection.","authors":"Wenyang Li, Qiangrong Xie","doi":"10.1007/s44211-024-00671-y","DOIUrl":"https://doi.org/10.1007/s44211-024-00671-y","url":null,"abstract":"Recently, the misuse of organic arsenic feed additives, such as roxarsone (ROX), has increasingly jeopardized both human health and the environment. In response, a unique electron-rich pyrazine-cored fluorescent covalent organic framework (COF) nanosheet, named as COF-TMP, was synthesized using an alkali-catalyzed reaction between 2, 3, 5, 6-tetramethylpyrazine (TMP) and terephthalaldehyde (TPA). Characterization demonstrated that COF-TMP boasted high porosity, pronounced fluorescence, and an abundance of (E)-2-styrylpyrazine (SPA) groups. These attributes render it an exceptional fluorescent sensor for the ultrahigh sensitivity detection of electron-deficient ROX molecules. The limit of detection (LOD) for COF-TMP in detecting ROX was found to be 0.015 ppb through fluorescence-quenching titration experiments-surpassing all previously reported fluorescent sensors. A combination of experimental results and theoretical calculations suggests that the extraordinary detection capability of COF-TMP for ROX arises from a static quenching mechanism. This study paves the way not only for a novel pyrazine-based fluorescent COF nanosheet with high porosity, exceptional fluorescent capabilities, and abundant SPA groups suitable for highly sensitive and selective ROX detection but also hints at its potential application as a fluorescent sensor for environmental pollution management and related domains.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemiluminescence detection of kanamycin by DNA aptamer regulating peroxidase-like activity of Co3O4 nanoparticles. 通过 DNA 配体调节 Co3O4 纳米粒子的过氧化物酶样活性对卡那霉素进行化学发光检测。

IF 1.6 4区化学

Analytical Sciences Pub Date : 2024-09-17 DOI: 10.1007/s44211-024-00672-x

Xuxin Zhang,Yihao Li,Shaojie Xia,Zhenyuan Yang,Baiyun Zhang,Yonghong Wang

{"title":"Chemiluminescence detection of kanamycin by DNA aptamer regulating peroxidase-like activity of Co3O4 nanoparticles.","authors":"Xuxin Zhang,Yihao Li,Shaojie Xia,Zhenyuan Yang,Baiyun Zhang,Yonghong Wang","doi":"10.1007/s44211-024-00672-x","DOIUrl":"https://doi.org/10.1007/s44211-024-00672-x","url":null,"abstract":"Kanamycin (KAN) is widely used as a growth hormone analog and an antibacterial agent. However, abuse of this substance has resulted in the accumulation of excessive residue levels in foods of animal origin, which presents a significant risk to human health. A chemiluminescent aptasensor was constructed for the rapid quantitative detection of KAN by combining the properties of Co3O4 nanoparticles (Co3O4 NPs) nanozyme activity and DNA aptamer with high specificity. The DNA aptamer/Co3O4 NPs nanozyme regulated the chemiluminescence signal by exploiting the chemiluminescent properties of luminol oxidation by H2O2. Specific binding of KAN to the aptamer led to the formation of a steric hindrance block in the solution, which inhibited the activity of nanozyme and reduced signal intensity. The degree of signal reduction is related to the concentration of KAN. Under optimal conditions, there was good linearity between KAN concentration and chemiluminescence signal intensity in the range of 0.5-8.0 μΜ, with a detection limit of 0.26 μΜ. The detection system performed well in the presence of competing antibiotics and was virtually unaffected. The method was also suitable for the detection of KAN in milk samples with sample recoveries of 97.8%-99.1%. The chemiluminescence sensor has the advantages of low cost, specificity, and sensitivity, and does not require an external light source or modification of the nucleic acid aptamer which makes it a promising candidate for applications in the field of food detection.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"53 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lateral flow immunoassay device to detect staphylococcal enterotoxin B (SEB) in durian candy. 检测榴莲糖中的葡萄球菌肠毒素 B (SEB) 的侧流免疫测定装置。

IF 1.6 4区化学

Analytical Sciences Pub Date : 2024-09-13 DOI: 10.1007/s44211-024-00665-w

Paquito E Relox,Katherine Ann C Israel,Yuki Hiruta,Daniel Citterio

{"title":"Lateral flow immunoassay device to detect staphylococcal enterotoxin B (SEB) in durian candy.","authors":"Paquito E Relox,Katherine Ann C Israel,Yuki Hiruta,Daniel Citterio","doi":"10.1007/s44211-024-00665-w","DOIUrl":"https://doi.org/10.1007/s44211-024-00665-w","url":null,"abstract":"Staphylococcal enterotoxin B (SEB), a potent enterotoxin produced by Staphylococcus aureus, has been implicated in incidences of Staphylococcal food poisoning in the Philippines. The use of lateral flow immunoassay devices to detect this toxin in solid food samples, like durian candy, at the point of sampling is constrained by the requirement for sample purification (e.g. centrifugation). This problem is also true with the other applications of LFIA devices on food samples. To overcome this challenge, a lateral flow immunoassay (LFIA) device capable of detecting SEB in unpurified durian candy sample was developed in this study. A modified LFIA device was assembled with three layers of glass fiber pads functioning as sample pads instead of a conventional cellulose fiber pad. Unlike with the cellulose fiber pad, the glass fiber sample pads acted as filter and allowed the flow of a 1:5 dilution of durian candy. The LFIA device applied to spiked 1:5 diluted durian candy samples achieved a visual limit of detection of 5 ng/mL for SEB, which is twofold lower than reported for previous LFIA devices designed to detect SEB in food samples.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"15 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-tech innovation: biomimetic solid-contact potentiometric sensor for nanomolar-level atrazine detection 低技术创新：用于检测纳摩尔级莠去津的仿生物固体接触电位传感器。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2024-09-12 DOI: 10.1007/s44211-024-00664-x

Anjana Kolarveetil Rajagopalan, Saumya Varghese, Aneesh Padmanabhan, Theertha Thayyullathil

{"title":"Low-tech innovation: biomimetic solid-contact potentiometric sensor for nanomolar-level atrazine detection","authors":"Anjana Kolarveetil Rajagopalan, Saumya Varghese, Aneesh Padmanabhan, Theertha Thayyullathil","doi":"10.1007/s44211-024-00664-x","DOIUrl":"10.1007/s44211-024-00664-x","url":null,"abstract":"<div>Despite the fact that there are already a number of solid-contact-based ion-selective electrodes designed for atrazine detection, our ground-breaking contribution lies in introducing the first-ever atrazine potentioselectrode, enabling the ultra-sensitive detection of atrazine at nanomolar levels. Solid-contact ion-selective electrodes can offer advantages, such as improved stability, reproducibility, sensitivity, and selectivity compared to their liquid-contact counterparts. Here, a biomimetic potentiometric sensor for Atrazine was developed using economic, light weight, and flexible carbon cloth as solid-contact material. Our methodology entails the synthesis of a molecularly imprinted polymer (MIP) through straightforward precipitation polymerization, showcasing a streamlined and efficient method for creating highly specific molecular recognition elements. The validation of template removal is confirmed via meticulous analysis employing EDX and FTIR techniques, ensuring the efficacy of our methodology. The resulting sensing membrane are casted by dispersing the MIP in 2-nitrophenyl octyl ether plasticizer and embedding it within a PVC matrix containing sodium tetraphenyl borate as a lipophilic additive. The developed sensor responds to atrazine in the pH range of 2.8–3.3 over a wide concentration range of 1 × 10–8 M to 1 × 10–5 M & 1 × 10–5 M to 1 × 10–1 M with respective slopes of 29.2 mv & 58.7 mV and a limit of detection of 1 × 10–9 M. An impressive feature of this sensor lies in its swift response time, registering a rapid reaction within a mere 10 s. Emphasize the sensor’s commendable attributes of reproducibility, selectivity, and sensitivity underscoring its successful application in field monitoring.<h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 12","pages":"2199 - 2212"},"PeriodicalIF":1.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A QuEChERS method based on octadecyl-bonded hectorite for the determination of ten mycotoxins in yak ghee. 基于十八烷基键合蛭石的 QuEChERS 方法测定牦牛酥油中的十种霉菌毒素。

IF 1.6 4区化学

Analytical Sciences Pub Date : 2024-09-11 DOI: 10.1007/s44211-024-00667-8

Jun Wang,Hai-Yan Yang,Jia-Jia Fan,Zi-Han Xu,Zai-Hui Pang,Yuan Feng,Na Wei

{"title":"A QuEChERS method based on octadecyl-bonded hectorite for the determination of ten mycotoxins in yak ghee.","authors":"Jun Wang,Hai-Yan Yang,Jia-Jia Fan,Zi-Han Xu,Zai-Hui Pang,Yuan Feng,Na Wei","doi":"10.1007/s44211-024-00667-8","DOIUrl":"https://doi.org/10.1007/s44211-024-00667-8","url":null,"abstract":"To develop a clean-up material suitable for high-fat food matrices for detecting mycotoxins in yak ghee, an octadecyl-bonded hectorite (Hectorite@NHCO(CH2)17CH3) was synthesized through multi-step chemical reactions. A modified QuEChERS-HPLC-MS/MS method for detecting ten mycotoxins in sesame oil in yak ghee was established using Hectorite@NHCO(CH2)17CH3 as clean-up agent. It involved extracting mycotoxin contaminants using acidified acetonitrile and employing the Hectorite@NHCO(CH2)17CH3 to remove interfering substances from the extract. The purified samples were then analyzed using HPLC-MS/MS. Within a linear range of 1.0-500 μg/kg, there was a good linear relationship between the quantification ion peak area of the target analytes and the corresponding concentrations (R2 ≥ 0.9991). The limit of detection (LOD) ranged from 0.10 μg/kg to 18.62 μg/kg and the limit of quantitation (LOQ) ranged 0.32-62.07 μg/kg. The recoveries at low, medium and high concentrations (25, 100 and 500 μg/kg) ranged from 72.2% to 113.9%, with relative standard deviations (RSD) between 3.2% and 17.5%. The intra-day and inter-day precision met experimental requirements. The proposed method was characterized by a high accuracy and precision, and it could cater to the current demand for detecting ten mycotoxins in yak ghee.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"72 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0