Analytical Sciences最新文献_第5页

Highly sensitive electrochemical sensing of ascorbic acid (vitamin C) using Pd-doped MnO₂ supported on carbon quantum dots (Pd-MnO₂@CQD) in water and fruit juices. 在水和果汁中使用碳量子点（Pd-MnO2@CQD）负载pd掺杂MnO2对抗坏血酸（维生素C）的高灵敏度电化学传感。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-08 DOI: 10.1007/s44211-025-00787-9

Deepak Kumar, Daraksha Bano, Subhash Chandra, Bharat Kumar, Vivek Kumar, Pradeep Kumar Yadav, Syed Hadi Hasan

引用次数: 0

Advancement of microchip electrophoresis coupled with capacitively coupled contactless conductivity detection-from design to application (2018-2024). 微芯片电泳耦合电容耦合非接触电导率检测的进展-从设计到应用（2018-2024）。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI: 10.1007/s44211-025-00771-3

Mingpeng Yang, Chaofan Wang, Jun Cai, Xiaochen Lai, Mingyi Cao, Xingqiang Zhao

{"title":"Advancement of microchip electrophoresis coupled with capacitively coupled contactless conductivity detection-from design to application (2018-2024).","authors":"Mingpeng Yang, Chaofan Wang, Jun Cai, Xiaochen Lai, Mingyi Cao, Xingqiang Zhao","doi":"10.1007/s44211-025-00771-3","DOIUrl":"10.1007/s44211-025-00771-3","url":null,"abstract":"Over the past three decades, microchip electrophoresis coupled with capacitively coupled contactless conductivity detection (ME-C4D) has garnered considerable interest due to its various merits, including minimal sample consumption, compact structure, immediate detection, and high analytical precision. Continuous technological innovation and improvement have significantly advanced ME-C4D in structural design, fabrication processes, and experimental methodologies. As a result, the application of this technology has expanded into a wider range of electrochemical analysis fields, including disease diagnosis, food safety assessment, environmental pollutant detection, and soil nutrient analysis. This review meticulously examines the forefront of ME-C4D over the last five years. It methodically categorizes and scrutinizes advancements from various dimensions, including newly emerged ME microchips, C4D electrodes, experimental protocols, and pioneering applications. Moreover, this paper critically summarizes these developments, identifying the prevailing limitations and challenges within ME-C4D. Ultimately, it projects potential future trajectories for innovation in the field of ME-C4D, suggesting pathways to overcome existing hurdles and hinting at the untapped possibilities that lie ahead.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"903-921"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cobalt oxide modified screen-printed carbon electrode for electrochemical detection of high blood pressure treating drug: reserpine. 氧化钴修饰网印碳电极电化学检测高血压治疗药物利血平。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-06 DOI: 10.1007/s44211-025-00781-1

Chenxi Wu, Shengzhou Qiu, Sima Akter, Shaoli Hong, Huihong Liu, Sakil Mahmud

引用次数: 0

Development of a frontal analysis capillary electrophoresis coupled with time-of-flight mass spectrometry for determining the equilibrium dissociation constant between cyclophilin A and cyclosporin A. 毛细管电泳-飞行时间质谱联用测定亲环素a和环孢素a平衡解离常数的研究进展。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-19 DOI: 10.1007/s44211-025-00790-0

Jia Tang, Fan Shui, Li Deng, Yujie Zhang, Qibing Mei, Min Wang, Jing Zeng

{"title":"Development of a frontal analysis capillary electrophoresis coupled with time-of-flight mass spectrometry for determining the equilibrium dissociation constant between cyclophilin A and cyclosporin A.","authors":"Jia Tang, Fan Shui, Li Deng, Yujie Zhang, Qibing Mei, Min Wang, Jing Zeng","doi":"10.1007/s44211-025-00790-0","DOIUrl":"10.1007/s44211-025-00790-0","url":null,"abstract":"Exploring the interactions between ligands and proteins in vitro and in vivo is of irreplaceable significance for disease prevention, diagnosis, therapeutic development, and drug discovery. Herein, we have developed a novel method for determining the equilibrium dissociation constant (Kd) using frontal analysis capillary electrophoresis coupled with time-of-flight mass spectrometry (FACE-TOF-MS). This method enables the rapid determination of the Kd value for the interaction between cyclophilin A and cyclosporin A. Furthermore, the reliability of this method was validated by comparing it with bio-layer interferometry (BLI). The Kd values determined by FACE-TOF-MS and BLI were 3.32 μM and 0.60 μM, respectively, which fall within an acceptable range when considering previous reports using various methods. This study introduces a novel approach for analyzing molecular interactions, offering potential specificity for simultaneously determining the Kd values of multiple ligands in complex samples, particularly in the areas of biomarker discovery, high-throughput lead compound screening, and therapeutic target validation.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"1061-1072"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial regulation effects of Taohong Siwu decoction on disordered lipids in a rat model of ischemic stroke assessed using mass spectrometry imaging 桃红四物汤对缺血性脑卒中大鼠血脂紊乱的空间调节作用。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-07-01 DOI: 10.1007/s44211-025-00813-w

Xueting Zhang, Qingqing Xie, Zhuqing Liu, Daiyin Peng, Lan Han, Xiaoqun Wang

{"title":"Spatial regulation effects of Taohong Siwu decoction on disordered lipids in a rat model of ischemic stroke assessed using mass spectrometry imaging","authors":"Xueting Zhang, Qingqing Xie, Zhuqing Liu, Daiyin Peng, Lan Han, Xiaoqun Wang","doi":"10.1007/s44211-025-00813-w","DOIUrl":"10.1007/s44211-025-00813-w","url":null,"abstract":"<div>Ischemic stroke serves as a disease closely related to cerebral blood vessels, with high mortality, disability, and recurrence rates. Growing studies have confirmed that lipid disturbances have a strong correlation with ischemic stroke damage. Taohong Siwu decoction (THSWD) as a classical remedy in Chinese pharmacopeia medicinal formula could promote blood circulation and eliminate stagnation of blood. THSWD has attracted extensive attention in its research on treating cerebral ischemia–reperfusion injury. However, the spatial effects about THSWD on lipids in ischemic stroke have not been adequately studied. Here, we comprehensively determined the spatial effects of THSWD on lipid dysregulation about the rodent cerebral tissue with middle cerebral artery occlusion–reperfusion (MCAO/R) using desorption electrospray ionization mass spectrometry imaging (DESI-MSI). Our findings suggest that the spatial distributions of 40 lipids were observed in normal rat brain tissue slices and significant dysregulation was observed in 37 lipids after ischemia–reperfusion injury, primarily in the cortex and striatum. DESI-MSI revealed that THSWD improved the abnormal expression of most lipids. DESI-MSI is an effective and intuitive method about studying the changes in lipid levels within spatial brain tissue after ischemic stroke, particularly following treatment with THSWD. This approach provides a unique perspective in exploring the potential mechanism underlying the therapeutic impacts of THSWD on ischemic stroke.<h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 9","pages":"1511 - 1521"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimation of the average molecular weight of microbial polyesters from FTIR spectra using artificial intelligence. 利用人工智能从FTIR光谱估计微生物聚酯的平均分子量。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-08 DOI: 10.1007/s44211-025-00780-2

Peter Polyak, Paweł Chaber, Marta Musioł, Grażyna Adamus, Marek Kowalczuk, Judit E Puskas, Miroslawa El Fray

{"title":"Estimation of the average molecular weight of microbial polyesters from FTIR spectra using artificial intelligence.","authors":"Peter Polyak, Paweł Chaber, Marta Musioł, Grażyna Adamus, Marek Kowalczuk, Judit E Puskas, Miroslawa El Fray","doi":"10.1007/s44211-025-00780-2","DOIUrl":"10.1007/s44211-025-00780-2","url":null,"abstract":"In this paper, we present a method for calculating the average molecular weight of microbial polyesters using Fourier transform infrared spectroscopy (FTIR) data as input. FTIR spectra provide the necessary quantitative information, as the impact of chain ends on the spectra is influenced by the average molecular weight of the polymer. Since FTIR data can be collected rapidly and is available in abundance, it serves as an ideal input for machine learning algorithms, such as artificial neural networks. The robustness and reliability of the model are improved by designing the neural network to use absorbance ratios instead of absolute absorbances as input. We also propose a new feature selection method that facilitates the identification of absorbance ratio regions best suited to serve as input for the neural network. Our approach ensures that variations in sample preparation do not compromise the accuracy of the model. The proposed computational method is demonstrated using a microbial polyester [poly(3-hydroxybutyrate), PHB], which is a biopolymer natively synthesized by multiple bacterial strains. Although the computational method has been tested with PHB, the underlying concept can be extended to other polymers. To facilitate broader application, a step-by-step guide for developing similar models is also provided.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"1015-1027"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-overpotential and highly sensitive detection of NADH with electrochemically pretreated cup-stacked carbon nanofiber electrodes. 电化学预处理杯状叠碳纳米纤维电极低过电位高灵敏度检测NADH。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-02 DOI: 10.1007/s44211-025-00776-y

Sota Goto, Taiyo Iwasaki, Kikuo Komori

{"title":"Low-overpotential and highly sensitive detection of NADH with electrochemically pretreated cup-stacked carbon nanofiber electrodes.","authors":"Sota Goto, Taiyo Iwasaki, Kikuo Komori","doi":"10.1007/s44211-025-00776-y","DOIUrl":"10.1007/s44211-025-00776-y","url":null,"abstract":"Cup-stacked carbon nanofibers (CSCNFs), the surface of which provides highly ordered graphene edges and electroactive oxygen-containing functional groups, were investigated as electrode materials for oxidation of β-Nicotinamide adenine dinucleotide (NADH) at low overpotential. The NADH oxidation was facilitated at the CSCNF-modified glassy carbon (CSCNF/GC) electrode, the surface of which was electrochemically activated at -0.40 V (vs. Ag|AgCl) to generate electrochemically reduced electroactive oxygen-containing functional groups. The anodic peak current of NADH oxidation was observed at about + 0.065 V by cyclic voltammetry measurements. The obtained value was negatively shifted by ~ 0.33 and ~ 0.63 V compared with the CSCNF/GC electrode without the electrochemical reductive pretreatment and the GC electrode, respectively. In addition, NADH-dependent glucose dehydrogenase (GDH) molecule-modified CSCNF/GC electrodes enabled the detection of glucose at the low overpotential effectively in the presence of NAD+, which accepts electrons from GDH and then reduces to NADH, after the electrochemical reductive pretreatment. Thus, the electrochemical reductive pretreatment of CSCNF electrodes would be useful for the development of highly sensitive NADH-dependent enzymatic biosensors.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"989-996"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breath biomarkers for esophageal cancer: identification, quantification, and diagnostic modeling. 食管癌的呼吸生物标志物：鉴定、量化和诊断模型。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-04-15 DOI: 10.1007/s44211-025-00769-x

Yuke Ren, Fei Wang, Ziyi Zhu, Raojun Luo, Guojun Lv, Haibin Cui

{"title":"Breath biomarkers for esophageal cancer: identification, quantification, and diagnostic modeling.","authors":"Yuke Ren, Fei Wang, Ziyi Zhu, Raojun Luo, Guojun Lv, Haibin Cui","doi":"10.1007/s44211-025-00769-x","DOIUrl":"10.1007/s44211-025-00769-x","url":null,"abstract":"Esophageal cancer is a major global health issue with a high mortality rate. Early diagnosis is crucial for improving patient outcomes, but traditional diagnostic methods are often invasive and costly. This study explores the potential of exhaled volatile organic compounds (VOCs) as a non-invasive diagnostic tool for esophageal cancer. Using gas chromatography-mass spectrometry (GC-MS), we analyzed the breath samples of 80 esophageal cancer patients and 60 healthy controls, identifying and quantifying over 100 VOCs. The results revealed significant differences in the concentrations of VOCs such as acetone, ethanol, and isoprene between the two groups. A multi-parameter regression diagnostic model based on a neural network algorithm achieved an accuracy of 90.3% in distinguishing esophageal cancer patients from healthy individuals. Further optimization incorporating physiological factors, including smoking, drinking, and dietary habits, improved the model's accuracy to 92.4%, with a specificity of 93.1%, representing a significant improvement over previous studies. These results suggest that VOCs analysis in exhaled breath holds great promise as a non-invasive, cost-effective, and accurate method for early detection of esophageal cancer.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"965-976"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anion recognition properties of acridine-urea conjugate in bulk and silica nanopore systems. 吖啶-尿素偶联物在体孔和二氧化硅纳米孔体系中的阴离子识别性能。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-05-07 DOI: 10.1007/s44211-025-00784-y

Sho Kimura, Akira Yamaguchi

{"title":"Anion recognition properties of acridine-urea conjugate in bulk and silica nanopore systems.","authors":"Sho Kimura, Akira Yamaguchi","doi":"10.1007/s44211-025-00784-y","DOIUrl":"10.1007/s44211-025-00784-y","url":null,"abstract":"This study investigated the anion recognition properties of acridine-urea conjugate (AcU) in bulk DMSO and silica nanopore. The free AcU in bulk DMSO was in tautomeric equilibrium between fluorescent amino form (a-AcU) and non-fluorescent imino form (i-AcU). Owing to this tautomerization of AcU, the free AcU worked as fluorescence enhancement sensing by hydrogen bonds mediated complexation between urea unit and anion. The estimated dissociation constants were 1.4 ± 0.2 mM for CH3COO- and 3.1 ± 1.0 mM for H2PO4-, whereas those for Cl-, ClO4-, and HSO4-were quite large. The hydrogen bond between urea unit and anion was also available for the anion recognition by AcU immobilized at the pore surface of mesoporous silica when the anion concentration is above 0.2 mM. In addition, we found that fluorescence of protonated a-AcU (a-AcHU+) could also be utilized for the recognition of weak acid anions over strong acid anions when the anion concentration is below 0.1 mM. The AcU@MPS with two recognition system has potential application for the anion recognition.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"1041-1049"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the X-ray-induced damage to sulfur in glass by laboratory X-ray fluorescence and wet chemical analysis. 用实验室x射线荧光和湿化学分析评价x射线对玻璃中硫的损伤。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-07-01 Epub Date: 2025-04-29 DOI: 10.1007/s44211-025-00777-x

Yoshitaka Saijo, Hiroyuki Hijiya

{"title":"Assessment of the X-ray-induced damage to sulfur in glass by laboratory X-ray fluorescence and wet chemical analysis.","authors":"Yoshitaka Saijo, Hiroyuki Hijiya","doi":"10.1007/s44211-025-00777-x","DOIUrl":"10.1007/s44211-025-00777-x","url":null,"abstract":"Accurate valence state analysis of sulfur in glass is crucial because sulfur, a multivalent element, plays a pivotal role in regulating glass properties. X-ray analysis is a key technique for determining the valence state of sulfur; however, high-brightness synchrotron X-ray analysis can induce damage to sulfur in glass, reducing result reliability. Laboratory wavelength-dispersive X-ray fluorescence with a single crystal (single-crystal WD-XRF) is useful for routine analysis of average sulfur valence in glass samples; however, potential damage has not been reported. In this study, the stability of sulfur valence states in glass samples subjected to X-ray irradiation was investigated. WD-XRF measurements were conducted for up to 50 h, allowing in situ observation of sulfur damage. Wet chemical analysis was subsequently performed to verify the average sulfur valence in the irradiated areas. Two types of standard soda-lime silicate glasses, SRM 1831 (clear glass, high sulfur valence) and SGT10 (amber glass, low sulfur valence), were analyzed. Average sulfur valence remained stable in SRM 1831 but was gradually oxidized in SGT10 by X-ray irradiation. Wet chemical analyses confirmed these results, indicating that the sulfur valence change in SGT10 was actual. These analyses suggest that the oxidized layer of SGT10 was limited to the surface layer of the glass. This study highlights the importance of the conditions of WD-XRF analysis for the accurate determination of sulfur valence in glass, and the need for cross-validation with wet chemical analysis.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":"1007-1013"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0