Analytical Sciences最新文献_第6页

Bio-electroanalytical Chemistry = Research Footprint and the Future = 生物电分析化学=研究足迹与未来=。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-06-11 DOI: 10.1007/s44211-025-00765-1

Isao Taniguchi

{"title":"Bio-electroanalytical Chemistry = Research Footprint and the Future =","authors":"Isao Taniguchi","doi":"10.1007/s44211-025-00765-1","DOIUrl":"10.1007/s44211-025-00765-1","url":null,"abstract":"<div><p>During the past 40 years, bioelectrochemistry and bio-electroanalytical chemistry have developed. Especially, after the 1970s and 80s, protein electrochemistry has changed dramatically, because direct rapid electron-transfer reactions of metalloproteins were found to be observed on simple solid modified electrodes. The surface structures of such functional modified electrodes have also been studied at the atomic and/or molecular level using STM images on the single crystal surfaces to understand the roles of the surface structures. Since then, various electroanalytical techniques have been used to apply to analyze electrochemical behavior of important metalloproteins (i.e., cytochrome c, myoglobin, and ferredoxin) to understand the fundamental origins of their biological functions. In this short review, some of the achievements at the early stage of recent bioelectrochemistry of biologically important metalloproteins to analyze functions of biomolecules and their promising applications to prepare some biological devices, such as sensors and bio-fuel cells, are introduced based on research activities so far done in our group together with brief prospects.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1115 - 1120"},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and structure elucidation by NMR spectroscopy of an impurity in flame retardants preparation 阻燃剂制备中杂质的核磁共振鉴定和结构解析。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-06-10 DOI: 10.1007/s44211-025-00805-w

Domenico C. M. Albanese, Irene Gado, Francesca Vasile

{"title":"Identification and structure elucidation by NMR spectroscopy of an impurity in flame retardants preparation","authors":"Domenico C. M. Albanese, Irene Gado, Francesca Vasile","doi":"10.1007/s44211-025-00805-w","DOIUrl":"10.1007/s44211-025-00805-w","url":null,"abstract":"<div><p>Polyamidoamines obtained through the polyaddition of natural alpha-aminoacids to <i>N,N′</i>-methylenebisacrylamide were shown to be remarkably active flame retardants for cotton. The presence of a disulfide linkage together with phosphorus atoms was previously chosen as desirable structural requirements and added to the polymer chain for their flame retardants properties. The conjugation of cystamine with diethyl vinyl phosphonate to obtain the desired monomer is accompanied by the formation of a by-product that must be identified and characterized to optimize the reaction. The ability of nuclear magnetic resonance to detect and quantify the components of a mixture in solution has become increasingly important in the analysis of manufacturing processes. Here, we have used NMR spectroscopy to identify and quantify an impurity in the synthesis of the precursor of a flame retardant without removing the main product from solution. 1D and 2D NMR spectra were used to obtain the identification and full characterization of the molecules and the by-product was identified through the analysis of different nuclei, such as <sup>1</sup>H, <sup>13</sup>C, <sup>15</sup>N and <sup>31</sup>P.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1413 - 1418"},"PeriodicalIF":2.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of photoenergy conversion systems and high-sensitivity sensing using metal nanoparticles 利用金属纳米颗粒开发光能转换系统和高灵敏度传感。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-06-10 DOI: 10.1007/s44211-025-00796-8

Yukina Takahashi

引用次数: 0

Development of pine needle reference materials for atmospheric mercury biomonitoring 大气汞生物监测用松针标准物质的研制。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-06-06 DOI: 10.1007/s44211-025-00802-z

Akane Yamakawa, Kimiyo Nagano, Kaoru Onishi, Miyuki Ukachi, Kozue Inamasu

{"title":"Development of pine needle reference materials for atmospheric mercury biomonitoring","authors":"Akane Yamakawa, Kimiyo Nagano, Kaoru Onishi, Miyuki Ukachi, Kozue Inamasu","doi":"10.1007/s44211-025-00802-z","DOIUrl":"10.1007/s44211-025-00802-z","url":null,"abstract":"<div><p>Two reference materials (RMs) were developed at the National Institute for Environmental Studies (NIES) for biomonitoring atmospheric mercury (Hg). First-year pine needles (<i>Pinus thunbergii</i>), reflecting atmospheric conditions over approximately one year were collected from Nara and Ibaraki prefectures and designated as NIES RM No. 1001 Pine Needle I (PN I) and NIES RM No. 1002 Pine Needle II (PN II), respectively. After removing surface dust, the needles were oven-dried at 70 ℃, ground, homogenized, bottled, and sterilized using <sup>60</sup>Co irradiation. Homogeneity and long-term stability tests were conducted for total Hg (THg) using cold-vapor atomic absorption spectrometry, confirming the material's suitability as RMs. The THg concentrations of PN I and PN II were 5.4 ± 0.4 ng/g and 22 ± 2 ng/g, respectively, lower than the NIST SRM 1575a Pine Needles (39.9 ± 0.7 ng/g). Given decreasing background levels of atmospheric Hg, precise measurement of low-concentration samples is increasingly important. Hg isotopic analysis was performed using a two-stage furnace or microwave-assisted digestion. Isotopic values for PN I were δ<sup>202</sup>Hg = –2.63 ± 0.24‰, Δ<sup>199</sup>Hg = –0.22 ± 0.17‰, Δ<sup>200</sup>Hg = –0.01 ± 0.10‰, and Δ<sup>201</sup>Hg = –0.19 ± 0.17‰ (2SD, n = 8), while those for PN II were δ<sup>202</sup>Hg = –1.64 ± 0.23‰, Δ<sup>199</sup>Hg = –0.51 ± 0.10‰, Δ<sup>200</sup>Hg = 0.00 ± 0.06‰, and Δ<sup>201</sup>Hg = –0.52 ± 0.13‰ (2SD, n = 12). Various trace element concentrations (Al, Ba, Ca, Cd, Cu, Fe, K, P, Rb, and Zn) were also measured. These candidate RMs are suitable for quality control in heavy metal and Hg isotope studies of foliage and similar matrices.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1373 - 1382"},"PeriodicalIF":2.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular orientation analysis of perfluoroalkyl groups in the solid surface by backscattering Raman spectrometry 固体表面全氟烷基分子取向的后向散射拉曼光谱分析。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-06-05 DOI: 10.1007/s44211-025-00797-7

Takafumi Shimoaka, Masashi Ootsuki, Yuta Yamaguchi, Nobutaka Shioya, Takeshi Hasegawa

{"title":"Molecular orientation analysis of perfluoroalkyl groups in the solid surface by backscattering Raman spectrometry","authors":"Takafumi Shimoaka, Masashi Ootsuki, Yuta Yamaguchi, Nobutaka Shioya, Takeshi Hasegawa","doi":"10.1007/s44211-025-00797-7","DOIUrl":"10.1007/s44211-025-00797-7","url":null,"abstract":"<div><p>Recently, unique surface properties of poly- and perfluoroalkyl substances (PFAS) have been revealed to be derived from a two-dimensional (2D) packing of perfluoroalkyl (R<sub>f</sub>) groups with perpendicularly standing orientation, i.e., the end-on orientation, which is revealed by the stratified dipole arrays (SDA) model. This indicates that analysis of the 2D aggregation of R<sub>f</sub> groups is crucial for understanding the PFAS-specific properties, and analysis of the primary structure alone is insufficient. In the present study, we employ an analytical method of backscattering Raman spectrometry to explore the 2D aggregation of R<sub>f</sub> groups in terms of molecular orientation. Measurements of solid particles of perfluoro-<i>n</i>-alkane with theoretical consideration of the Raman activity on backscattering optical arrangement make us find useful marker bands derived from the R<sub>f</sub> groups. Analysis of the band enables us to determine the end-on orientation of the R<sub>f</sub> chain about the surface of bulk PFAS: when the R<sub>f</sub> chains are end-on oriented, the bands assigned to a specific symmetry species selectively disappear, whereas the other Raman-active bands remain. In short, the disappearance of the marker bands makes us determine the end-on orientation very easily. In addition, we demonstrate that the marker band can be used to visualize in-plane distribution of the end-on orientation by utilizing mapping measurements.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1355 - 1364"},"PeriodicalIF":2.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection scheme of arginine as aptamer target based on particle dissociation in coupled acoustic-gravitational field 基于声重场耦合粒子解离的精氨酸适体靶检测方案。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-06-04 DOI: 10.1007/s44211-025-00798-6

Akihisa Miyagawa, Koki Nakano, Kengo Oshiyama, Shigenori Nagatomo, Kiyoharu Nakatani, Shoji Ishizaka

{"title":"Detection scheme of arginine as aptamer target based on particle dissociation in coupled acoustic-gravitational field","authors":"Akihisa Miyagawa, Koki Nakano, Kengo Oshiyama, Shigenori Nagatomo, Kiyoharu Nakatani, Shoji Ishizaka","doi":"10.1007/s44211-025-00798-6","DOIUrl":"10.1007/s44211-025-00798-6","url":null,"abstract":"<div><p>In this study, we proposed a novel detection concept using aptamer DNA based on particle dissociation in a coupled acoustic-gravitational (CAG) field. When the CAG field was formed in the channel, the PS particles on the glass plate exerted the acoustic radiation force (<i>F</i><sub>ac</sub>), sedimentation force (<i>F</i><sub>sed</sub>), and binding force between the PS particle and glass plate (<i>F</i><sub>bind</sub>). The applied voltage to the transducer (<i>V</i>) required for particle dissociation from the glass plate depends on the <i>F</i><sub>bind</sub>. When the arginine is introduced to the system, in which the PS particles are immobilized onto the glass plate through the DNA hybridization using aptamer for arginine, the change in <i>F</i><sub>bind</sub> can be induced, allowing us to detect the arginine concentration as the change in <i>V</i>. Thus, we demonstrated a detection concept for arginine that enables rough concentration estimation despite the limited precision.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1407 - 1412"},"PeriodicalIF":2.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma separation from whole blood on paper-based fluidic devices 用纸基流体装置分离全血血浆。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-06-04 DOI: 10.1007/s44211-025-00752-6

Tomoki Yabutani

引用次数: 0

Therapeutic applications of nanobots and nanocarriers in cancer treatment 纳米机器人和纳米载体在癌症治疗中的应用。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-06-04 DOI: 10.1007/s44211-025-00799-5

Zaitoon Khan, Nimra Khan, Mithra Geetha, Reyhanath Pilakka Veettil, Deepak Mahadev Kasote, Anwarul Hasan, Kishor Kumar Sadasivuni

{"title":"Therapeutic applications of nanobots and nanocarriers in cancer treatment","authors":"Zaitoon Khan, Nimra Khan, Mithra Geetha, Reyhanath Pilakka Veettil, Deepak Mahadev Kasote, Anwarul Hasan, Kishor Kumar Sadasivuni","doi":"10.1007/s44211-025-00799-5","DOIUrl":"10.1007/s44211-025-00799-5","url":null,"abstract":"<div><p>Cancer remains a pressing global health concern, burdening individuals, families, and healthcare systems worldwide, mainly because of the limited availability of therapeutic options. These days, nanotechnology is revolutionizing cancer research by offering promising drug delivery systems. Among these, nanobots and nanocarriers are key nanotechnology components, offering groundbreaking strategies in cancer therapy by delivering drugs, enhancing diagnostics, and preventing diseases at molecular levels. Nanobots and nanocarriers, engineered at sizes ranging from 1 to 100 nm, demonstrate biocompatibility with cellular systems, offer precise drug delivery, and reduce side effects compared to conventional therapies such as chemotherapy and surgery. Research efforts now focus on transitioning nanobots and nanocarriers from laboratories to clinics, aiming for precision medicine, targeted drug delivery, enhanced therapy efficacy, and minimal side effects. This review aims to highlight the potential of nanobots and nanocarriers in cancer treatment and provide insights into their role in paving the way for clinical applications and improving outcomes in cancer therapy.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1305 - 1324"},"PeriodicalIF":2.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A simple and cost-effective distance-based paper analytical device for phosphate ion determination 一种简单、高性价比的远距离纸张分析装置，用于测定磷酸盐离子。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-06-02 DOI: 10.1007/s44211-025-00800-1

Sasitorn Ngamprasertsuk, Paweenar Duenchay, Wijitar Dungchai

{"title":"A simple and cost-effective distance-based paper analytical device for phosphate ion determination","authors":"Sasitorn Ngamprasertsuk, Paweenar Duenchay, Wijitar Dungchai","doi":"10.1007/s44211-025-00800-1","DOIUrl":"10.1007/s44211-025-00800-1","url":null,"abstract":"<div><p>Phosphate ion (PO<sub>4</sub><sup>3–</sup>) monitoring in water sources is crucial due to its significant role in living systems and environmental impact, particularly in eutrophication. Conventional phosphate detection methods require sophisticated instruments and trained personnel. We report the development of a simple and cost-effective distance-based paper analytical device for phosphate ion detection. The device utilizes a complex of ferric ion (Fe<sup>3+</sup>), salicylic acid (SA), and polyethyleneimine (PEI) as the colorimetric indicator. Upon reaction with phosphate ions, Fe<sup>3+</sup> forms a complex with phosphate, replacing the Fe<sup>3+</sup>–SA complex, leading to a visible color change from orange to colorless. The phosphate concentration is quantified by the distance of color change, which can be observed with the naked eye. Under the optimal conditions, the linearity was found in the range 5 to 75 mg/L (R<sup>2</sup> = 0.9954), and the naked-eye detection limit was found at 2 mg/L. Furthermore, by applying a preconcentration method, the detection limit can be improved tenfold, achieving an LOD of 0.2 mg/L. Our proposed device for water sample application was also validated with the standard molybdenum blue method. A paired t-test was performed to compare the results obtained from both methods, and the statistical analysis indicated no significant difference between the two methods (p > 0.05). The method validation studies also showed acceptable performance, with spiked sample recoveries ranging from 85.05% to 117.97%, within the internationally recognized acceptable criteria of 80–120%. This method offers an alternative approach for accurate, rapid, on-site phosphate monitoring.</p><h3>Graphical abstract</h3><p>Schematic 1. Illustration of the fabrication process of a distance-based paper analytical device for the detection of phosphate ions.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 8","pages":"1365 - 1372"},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent applications of near infrared to pharmaceutical process monitoring and quality control 近红外技术在制药过程监测和质量控制中的最新应用。

IF 2 4区化学

Analytical Sciences Pub Date : 2025-05-25 DOI: 10.1007/s44211-025-00794-w

Chao Zhang, Yuanyuan Liu, Zhiqiang Tang, Xuejun Chen, Hui Zhang, Nan Liu, Changhong Huo, Zengming Wang, Aiping Zheng

{"title":"Recent applications of near infrared to pharmaceutical process monitoring and quality control","authors":"Chao Zhang, Yuanyuan Liu, Zhiqiang Tang, Xuejun Chen, Hui Zhang, Nan Liu, Changhong Huo, Zengming Wang, Aiping Zheng","doi":"10.1007/s44211-025-00794-w","DOIUrl":"10.1007/s44211-025-00794-w","url":null,"abstract":"<p>NIR is a rapid, non-destructive analytical technique that leverages the absorption properties of molecules in the near-infrared region. This technology has become indispensable in the pharmaceutical industry due to its efficiency in analyzing solids, liquids, and various pharmaceutical preparations across numerous applications, including drug discovery, process monitoring, and quality control. With the advent of portable NIR instruments, the technology has gained a pivotal role in PAT, optimizing manufacturing processes and ensuring consistent product quality for real-time product release. This review reports on the remarkable versatility of NIR spectroscopy in the pharmaceutical field, covering a wide range of qualitative determinations, such as sample identification, crystal morphology, and eutectic analysis. It also addresses the quantitative analysis of samples and in-line applications in continuous manufacturing processes, including granulation, drying, tableting, and coating. The fundamentals of NIR spectroscopy, as well as its applications in botanical and biological products, are discussed. Additionally, the review examines the prospects and challenges associated with using NIR spectroscopic techniques. NIR spectroscopy served as an effective and powerful tool for both qualitative and quantitative analysis of pharmaceuticals and for monitoring continuous production. </p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"41 7","pages":"923 - 944"},"PeriodicalIF":2.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0