Microfluidic paper-based analytical devices: proven applications and future prospects in therapeutic drug monitoring, homeland security, and chemical education.
{"title":"Microfluidic paper-based analytical devices: proven applications and future prospects in therapeutic drug monitoring, homeland security, and chemical education.","authors":"Manabu Tokeshi","doi":"10.1007/s44211-025-00758-0","DOIUrl":null,"url":null,"abstract":"<p><p>Since the report by Whitesides et al. in 2007 on paper-based microfluidic analytical devices (μPADs), numerous studies have been published. The characteristics of μPADs, such as low cost, simplicity, and suitability for resource-limited settings, make them promising for a wide range of applications, including medical diagnostics, environmental analysis, and food testing. While these applications have been well-documented, this review focuses on the less common applications in therapeutic drug monitoring, homeland security, and chemical education. Specifically, the μPADs discussed in this review were developed for the determination of lithium ions in blood for therapeutic drug monitoring, the determination of the nerve agent VX for homeland security, and the measurement of ascorbic acid and pH for chemical education.</p>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Sciences","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s44211-025-00758-0","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Since the report by Whitesides et al. in 2007 on paper-based microfluidic analytical devices (μPADs), numerous studies have been published. The characteristics of μPADs, such as low cost, simplicity, and suitability for resource-limited settings, make them promising for a wide range of applications, including medical diagnostics, environmental analysis, and food testing. While these applications have been well-documented, this review focuses on the less common applications in therapeutic drug monitoring, homeland security, and chemical education. Specifically, the μPADs discussed in this review were developed for the determination of lithium ions in blood for therapeutic drug monitoring, the determination of the nerve agent VX for homeland security, and the measurement of ascorbic acid and pH for chemical education.
期刊介绍:
Analytical Sciences is an international journal published monthly by The Japan Society for Analytical Chemistry. The journal publishes papers on all aspects of the theory and practice of analytical sciences, including fundamental and applied, inorganic and organic, wet chemical and instrumental methods.
This publication is supported in part by the Grant-in-Aid for Publication of Scientific Research Result of the Japanese Ministry of Education, Culture, Sports, Science and Technology.