Analytical Sciences最新文献_第8页

Characterization of ene reaction products of Cookson-type fluorescent reagents and their application for recognizing amyloid β aggregation. cookson型荧光试剂烯反应产物的表征及其在β淀粉样蛋白聚集识别中的应用。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-05-23 DOI: 10.1007/s44211-025-00795-9

Kotone Nojiri, Yusuke Hatakawa, Seon Hwa Lee, Tomoyuki Oe

{"title":"Characterization of ene reaction products of Cookson-type fluorescent reagents and their application for recognizing amyloid β aggregation.","authors":"Kotone Nojiri, Yusuke Hatakawa, Seon Hwa Lee, Tomoyuki Oe","doi":"10.1007/s44211-025-00795-9","DOIUrl":"https://doi.org/10.1007/s44211-025-00795-9","url":null,"abstract":"The Cookson reagent (4-phenyl-1,2,4-triazoline-3,5-dione, PTAD) is a powerful dienophile for the Diels-Alder reaction and is used as a protecting group for conjugated dienes in organic chemistry. PTAD also undergoes a selective ene reaction with tyrosine (Tyr) residues in aqueous solvents. In this study, we investigated the ene reaction products with Tyr using two Cookson-type fluorescent reagents, 4-(1-naphthyl)-1,2,4-triazoline-3,5-dione (NTAD) and 4-[2-(6,7-dimethoxy-4-methyl-3-oxo-3,4-dihydroquinoxalyl)ethyl]-1,2,4-triazoline-3,5-dione (DMEQTAD). The fluorescence properties were examined to develop peptide probes using Tyr itself, angiotensin II, and amyloid β40 (Aβ40) as models. NTAD-Tyr showed major changes in fluorescence spectra based on the conditions of the surrounding environment, such as pH, solvent hydrophobicity, and human serum albumin concentration. The increase in the fluorescence intensity of NTAD-Tyr was greater than that of DMEQTAD-Tyr, especially for pH and human serum albumin. Furthermore, a wavelength shift (blue shift) was observed for NTAD-Tyr but not for DMEQTAD-Tyr. Therefore, NTAD was used for the following peptide experiments. NTAD-Aβ40 showed an unexpected red shift in a hydrophobic solvent, which was the opposite shift to NTAD-Tyr and NTAD-Ang II. In the aggregation study of Aβ40 co-incubated with NTAD-Aβ40, the fluorescence of NTAD-Aβ40 increased and reached a plateau earlier than the common thioflavin T method for recognizing β-sheet formation.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperature-modulated separation of therapeutic cells, viral vectors, and exosomes using functional polymers. 使用功能聚合物对治疗细胞、病毒载体和外泌体进行温度调节分离。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-05-23 DOI: 10.1007/s44211-025-00785-x

Kenichi Nagase, Hideko Kanazawa

引用次数: 0

Progress and prospect in analytical science and technology 分析科学技术的进展与展望

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-05-09 DOI: 10.1007/s44211-025-00770-4

Noritada Kaji

引用次数: 0

Microfluidic devices integrated with track-etched porous membranes for cell-based bioanalysis. 微流控装置集成的轨迹蚀刻多孔膜的细胞为基础的生物分析。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-05-09 DOI: 10.1007/s44211-025-00789-7

Naoki Sasaki

引用次数: 0

Unusual lanthanide ion exchange selectivity modulated via crystalline morphology change of a mixed-metal coordination polymer. 不同寻常的镧系离子交换选择性通过混合金属配位聚合物的晶体形态变化调制。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-05-02 DOI: 10.1007/s44211-025-00775-z

Yuiko Tasaki-Handa

{"title":"Unusual lanthanide ion exchange selectivity modulated via crystalline morphology change of a mixed-metal coordination polymer.","authors":"Yuiko Tasaki-Handa","doi":"10.1007/s44211-025-00775-z","DOIUrl":"https://doi.org/10.1007/s44211-025-00775-z","url":null,"abstract":"The separation of lanthanides is critical for ensuring supply security of lanthanide elements, and modulating separation selectivity is a significant approach to control this process. The author's research has explored modulating lanthanide ion (Ln3+) exchange selectivity through crystallographic transitions in phosphate ligand-based crystalline coordination polymers (CCPs). This review reports Ln3+ ion exchange in two systems: LnL1, a CCP formed by bis(2-ethylhexyl) phosphate (L1) with Ce3+, Nd3+, and Sm3+, and LnL2, a CCP formed by bis(4-nitrophenyl) phosphoric acid (L2) with Ce3+. In these systems, Ln3+ selectivity deviated from the conventional pattern corresponding to the atomic number in the lanthanide series. This phenomenon can be attributed to spatial constraints of ion exchange sites within the CCP framework: the ion exchange reaction is influenced by both electrostatic interactions and steric effect. When Ln3+ is incorporated into the CCP surface, structural distortion due to the coexistence of two Ln3+ types induces a change in crystal morphology. This change acts as a gate-opening mechanism, facilitating subsequent ion exchange reactions toward the inside of CCP. The combination of two Ln3+ species likely determines the occurrence of a structural transition, finally influencing Ln3+ ion exchange selectivity. While it is challenging to directly apply the systems in this study to a practical separation system, this CCP-specific mechanism involving distortion and transition of the crystal's higher-order structure is expected to contribute to developing a new Ln separation method in the future.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Control of Pt···Pt interactions in Pt(II) complex crystals as luminescence sensors for the detection of external stimuli: recent achievements and perspectives. 控制Pt（II）复合体晶体中Pt···Pt相互作用作为检测外部刺激的发光传感器：最近的成就和观点。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-04-30 DOI: 10.1007/s44211-025-00778-w

Masaki Yoshida, Masako Kato

{"title":"Control of Pt···Pt interactions in Pt(II) complex crystals as luminescence sensors for the detection of external stimuli: recent achievements and perspectives.","authors":"Masaki Yoshida, Masako Kato","doi":"10.1007/s44211-025-00778-w","DOIUrl":"10.1007/s44211-025-00778-w","url":null,"abstract":"This review summarizes recent advances in the control of the luminescent chromic behavior of Pt(II) complex crystals, focusing on the design strategies of their molecular and packing structures. Square-planar Pt(II) complexes exhibit unique chromic luminescence owing to flexible Pt···Pt interactions, enabling their use as highly sensitive optical sensors to visualize external stimuli and environmental changes. However, the energy of the Pt···Pt interaction is relatively weak, making it difficult to precisely design and control the chromic luminescence based on the Pt···Pt interactions. This review discusses the challenging control of Pt···Pt interactions based on molecular assembly and presents design strategies using hydrogen bonding, halogen interactions, π-π stacking, and ion-pairing and counterion effects, with specific examples for each approach. Future research will focus on expanding analytical approaches, integrating these materials into sensing devices, and exploring synergies between chromic luminescence and other physical properties such as magnetism and conductivity. These advancements are expected to lead to innovative sensing technologies and significant breakthroughs in analytical chemistry and materials science.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of ultra-thin glass sheets and their application to MEMS devices. 超薄玻璃片的制备及其在MEMS器件中的应用。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-04-26 DOI: 10.1007/s44211-025-00774-0

Yo Tanaka

引用次数: 0

Emergent mutual separation strategy for rare-earth elements based on crystallization of coordination compounds. 基于配位化合物结晶的稀土元素紧急互分离策略。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-04-23 DOI: 10.1007/s44211-025-00768-y

Atsuko Masuya-Suzuki

{"title":"Emergent mutual separation strategy for rare-earth elements based on crystallization of coordination compounds.","authors":"Atsuko Masuya-Suzuki","doi":"10.1007/s44211-025-00768-y","DOIUrl":"10.1007/s44211-025-00768-y","url":null,"abstract":"Over the past several decades, rare-earth (RE) elements have been widely used in industrial products due to their exceptional physical, chemical, and mechanical properties. The discovery and industrial applications of RE elements have largely been driven by advances in their mutual separation, as RE ions exhibit highly similar chemical properties. In recent years, the growing production of RE-based products has highlighted concerns over supply risks. Recovering RE ions from end-of-life industrial products, often referred to as \"urban mines,\" offers a sustainable solution and supports a circular RE economy. To promote RE recycling, there is a pressing need to develop separation methods with higher selectivity and lower environmental impact. This mini-review focuses on a novel strategy for RE separation based on the crystallization of coordination compounds, as reported over the past decade. First, separation systems utilizing the crystallization of coordination polymers constructed with RE ions and organic bridging ligands are summarized. Then, separation through the crystallization of discrete RE complexes with organic ligands is described, with particular emphasis on ligand structure, separation factors, and crystallization conditions.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface plasmon resonance (SPR) sensing utilizing far- and deep-ultraviolet light. 利用远紫外光和深紫外光的表面等离子体共振（SPR）传感。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-04-22 DOI: 10.1007/s44211-025-00772-2

Ichiro Tanabe

引用次数: 0

Microfluidic technologies for protein crystallography: advances and applications. 蛋白质晶体学的微流控技术：进展与应用。

IF 1.8 4区化学

Analytical Sciences Pub Date : 2025-04-21 DOI: 10.1007/s44211-025-00767-z

Masatoshi Maeki, Akihiko Ishida, Manabu Tokeshi

{"title":"Microfluidic technologies for protein crystallography: advances and applications.","authors":"Masatoshi Maeki, Akihiko Ishida, Manabu Tokeshi","doi":"10.1007/s44211-025-00767-z","DOIUrl":"10.1007/s44211-025-00767-z","url":null,"abstract":"Three-dimensional protein structure determination by X-ray crystallography is essential for understanding biological function and accelerating drug discovery. However, obtaining high-quality protein crystals remains a significant bottleneck. The conventional crystallization methods are often labor-intensive, require large sample volumes, and offer limited control over the crystallization environment. This review summarizes the application of microfluidic technologies to protein crystallography with a focus on their advantages over the conventional crystallization methods. Microfluidic devices enable nanoliter-scale sample handling, precise control over crystallization conditions, and high-throughput screening, addressing major limitations of the conventional approaches. This review introduces various microfluidic platforms, including droplet-based and microwell-based systems, for protein crystallization, crystal growth control, and on-chip X-ray diffraction analysis. The review also covers the use of microfluidics for creating diffusion-controlled crystal growth environments, real-time crystal growth measurement, on-chip X-ray diffraction measurement, and room-temperature X-ray crystallography with automated data processing.","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0