Analytical Sciences最新文献

{"title":"Correction: Mesoporous polydopamine microspheres for rapid ppb-level ultra-sensitive formaldehyde detection","authors":"Luyu Wang, Jia Song, Chunyang Yu","doi":"10.1007/s44211-026-00909-x","DOIUrl":"10.1007/s44211-026-00909-x","url":null,"abstract":"","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"42 6","pages":"487 - 488"},"PeriodicalIF":2.0,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of a green ammonia production process by machine learning","authors":"Sho Takaoka,&nbsp;Hiromasa Kaneko","doi":"10.1007/s44211-026-00903-3","DOIUrl":"10.1007/s44211-026-00903-3","url":null,"abstract":"<div><p>Green ammonia is attracting attention as a way of realizing a decarbonized society. In this study, we designed a green ammonia production process under limited power supply. In conventional process optimization, candidates for the design variables are selected based on the experience of the process engineer and calculation results, and optimization is performed by repeated simulations. However, as the number of design variables increases, an enormous number of simulations are required to search for optimal candidates. In this study, we used Bayesian optimization to select candidates for the design variables with a high probability of achieving the target values of the objective variables. Candidate selection and simulation were repeated to maximize green ammonia production with limited power supply. The process was compared with previously reported green ammonia production processes, which showed that the process designed in this study produced the maximum amount of green ammonia at ≤ 10 MW.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"42 7","pages":"557 - 566"},"PeriodicalIF":2.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44211-026-00903-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep autoencoder for low dimensionality for high dimensional data in regression models and direct inverse analysis of models","authors":"Hiromasa Kaneko","doi":"10.1007/s44211-026-00904-2","DOIUrl":"10.1007/s44211-026-00904-2","url":null,"abstract":"<div>\u0000 \u0000 <p>In constructing machine learning models between features X and output variables Y in molecular, material, and process designs, and process control, when the number of X is huge, models are likely to overfit, and it takes time to construct models. Deep autoencoder (DAE) was focused on, and reduction of dimensions in the huge number X with DAE was investigated. Spectral data, profile data, and time-series data were used to virtually generate data whose number of X was 10,000, 100,000, and 1,000,000. For each dataset, DAE model was constructed with training data, and then test data of X was reconstructed by transforming X into latent variables Z and Z into X, and then, it was confirmed that DAE could reconstruct X with high reproducibility regardless of the number of X in all the datasets. In addition, regression models were constructed with Gaussian mixture regression (GMR), which could perform direct inverse analysis of model, between Z and Y, and then, Y could be predicted accurately regardless of the number of X. It was confirmed that DAE could appropriately reduce the dimension even when X was as large as 1 million. Furthermore, by combining DAE with GMR, it became possible to directly predict X values from target Y values by calculating Z from Y with GMR and transforming Z into X with DAE.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"42 7","pages":"567 - 576"},"PeriodicalIF":2.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44211-026-00904-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous detection of SARS-CoV-2 proteins and nucleic acids by coupling PNIPAM with circle-to-circle amplification","authors":"Yu Feng,&nbsp;Jiaxin Liu,&nbsp;Kebing Yi,&nbsp;Ziwen Tang,&nbsp;Feng Gong,&nbsp;Yimiao He,&nbsp;Xiaoyun Shan,&nbsp;Hui Xu,&nbsp;Fuxiang Zhou,&nbsp;Xinghu Ji,&nbsp;Zhike He","doi":"10.1007/s44211-026-00905-1","DOIUrl":"10.1007/s44211-026-00905-1","url":null,"abstract":"<div><p>In the past few years, the global uncontrollable spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has underscored the need for rapid, sensitive, and accurate detection methods. Given the continuous mutation characteristics of viruses, single-target detection carries the risk of false-positive or false-negative results, whereas dual-target detection can effectively mitigate such risks. Therefore, thermosensitive polymer poly(N-isopropylacrylamide) (PNIPAM) was integrated with an isothermal amplification method—circle-to-circle amplification (C2CA) in this study, enabling individual and simultaneous detection of the SARS-CoV-2 S1 protein and N gene, respectively. PNIPAM-capture probe conjugates enabled specific target recognition and thermal separation from complex matrices, while C2CA achieved exponential signal amplification by leveraging two cascaded rolling circle amplification (RCA) reactions. During single-target detection, the method exhibited linear ranges of 0.1–1000 pg/mL for S1 protein detection and 0.1–1000 pM for Ng detection, with the limit of detection (LOD) of 55 fg/mL and 11.2 fM, respectively. The spiked recovery experiment demonstrated that this method possesses high specificity and robust anti-interference capability. Furthermore, in order to improve the accuracy and efficiency, simultaneous detection was achieved by integrating S1 protein and Ng detection into a single reaction system and labeling differential fluorophores. The LOD was 68.3 fg/mL for S1 protein and 33.1 fM for Ng, respectively. This method combines the advantages of homogeneous reaction and isothermal amplification, eliminating the need for complex instruments and cumbersome procedures, thereby making it suitable for resource-limited settings.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"42 6","pages":"421 - 430"},"PeriodicalIF":2.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a micro separation and analysis system for uranyl ions composed of microplug extraction and liquid scintillation detection","authors":"Xinyi Qian,&nbsp;Naoki Shitara,&nbsp;Naokazu Idota,&nbsp;Takehiko Tsukahara","doi":"10.1007/s44211-026-00887-0","DOIUrl":"10.1007/s44211-026-00887-0","url":null,"abstract":"<div>\u0000 \u0000 <p>The efficient separation and analysis of alpha-emitting radionuclides, which will reduce environmental and radiation workers’ workloads, is of growing importance in the conducting of safe and long-term nuclear decommissioning and environmental assessments. This study developed a novel analytical system comprising micro-extraction and liquid scintillation counting (LSC), capable of rapidly and simply analyzing alpha nuclides in small amounts of samples. Bulk extractions and micro-extractions of UO₂²⁺ were performed using two types of extractive liquid scintillators containing bis(2-ethylhexyl) phosphate (HDEHP) and <i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-tetra-octyldiglycolamide (TODGA) ligands. The UO₂²⁺ extraction rates were evaluated through inductively coupled plasma-optical emission spectrometry (ICP-OES) and LSC measurements. When measuring LSC spectra of the bulk-extracted organic scintillator phases, peaks assigned those of ²³⁸U and ²³⁴U isotopes were clearly observed. The peak intensities and counting rates increased linearly with increasing UO₂²⁺ concentrations, confirming that the UO₂²⁺ extraction rates determined from LSC measurements agreed well with those from ICP-OES. From the LSC spectra and counting rates of micro-extracted samples, it was confirmed that the HDEHP-type extractive scintillator achieved 100% extraction of UO₂²⁺ within 20 s in the lower HNO₃ concentration ranges, which was more than 90 times faster than bulk extraction (30 min), and that quantitative analysis of uranium using LSC was feasible up to 3 M HNO₃. The results demonstrate that the microfluidic-LSC approach has significant potential as an advanced separation−analysis method. It enables direct measurements of alpha-emitting radionuclides in organic phases without additional operations such as pretreatment and back-extraction.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"42 7","pages":"645 - 652"},"PeriodicalIF":2.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic imprinted surface enhanced Raman scattering biosensor for the detection of bone loss biomarker CTX-I","authors":"Diantao Zheng,&nbsp;Qiuyan Li,&nbsp;Ran Hu,&nbsp;Baoliang Zhang","doi":"10.1007/s44211-026-00901-5","DOIUrl":"10.1007/s44211-026-00901-5","url":null,"abstract":"<div><p>Serum C-terminal telopeptide of type I collagen (CTX-I) is a key bone turnover biomarker in osteoporosis, and its elevated levels are indicative of increased bone resorption. Current techniques for CTX-I measurement suffer from high operational requirements, complex procedures, and high costs. This study focuses on a novel strategy for detecting serum CTX-I concentration to predict the occurrence and severity of osteoporosis. Using silver-capped Fe₃O₄ (Fe₃O₄@Ag) as the substrate material, an artificial antibody for CTX-I was prepared via magnetic core-shell molecularly imprinted polymers (MIPs), and surface-enhanced Raman scattering (SERS) was used as a signal output device. With crystal violet (CV) at 10⁻⁴ M as the reporter molecule, the proposed biosensor exhibited a good linear response over the range of 10 pg/mL to 2 ng/mL (R² = 0.986, LOQ = 4.79 pg/mL), covering the normal reference range required for identifying bone turnover. Moreover, the biosensing platform demonstrated resistance to matrix interference in real serum and urine samples. After six reuse cycles, the SERS intensity of CV decreased by only 10.5%, and after 15 days of storage at 4 °C, it decreased by 15.7%. The Fe₃O₄@Ag-MIPs were used to detect CTX-I with excellent uniformity (RSD = 4.1%) and repeatability (RSD = 2.7%), and the overall analysis time was 30 min. The proposed biosensing platform was applied to analyze known real serum samples obtained from human. The proposed biosensor was validated using enzyme-linked immunosorbent assay (ELISA), and the developed biosensor showed good correlation with ELISA. The experimental results indicate that the proposed novel biosensing platform is a fast, low-cost, and reliable tool for the rapid detection of the bone biomarker CTX-I in serum or urine.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"42 6","pages":"399 - 409"},"PeriodicalIF":2.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resonance-enhanced multiphoton ionization time-of-flight mass spectrometry for the real-time analysis of a retronasal aroma compound from a cumin sandwich","authors":"Hazuki Uno,&nbsp;Masaaki Ukita,&nbsp;Tomohiro Uchimura","doi":"10.1007/s44211-026-00907-z","DOIUrl":"10.1007/s44211-026-00907-z","url":null,"abstract":"<div><p>This study was focused on developing a process to objectively determine the release behavior of retronasal aromas in food in real time, which could contribute to the development of foods better suited to consumer preferences. In food, organic compounds with low molecular weight easily vaporize to elicit a retronasal aroma, and such compounds are referred to as volatile. In this study, the release of aroma during the eating of small sandwiches was measured and verified in real-time via resonance-enhanced multiphoton ionization time-of-flight mass spectrometry (REMPI-TOFMS). Cumin and small slices of bread were used as food samples that would easily vaporize and could be detected in the breath of a person eating them. Laser pulses emitting at 266 nm during REMPI selectively detected the naturally occurring organic compound <i>p</i>-cymene in cumin. While it was being chewed, the time profile for <i>p</i>-cymene as a retronasal aroma compound showed the increases and decreases in the detection of this food in breaths released in a 6 s cycle (3 s intake, 3 s exhalation). Overall, the retronasal aroma increased and then decreased. The total ion signals of <i>p</i>-cymene obtained during chewing (integrated area under the time profiles) were slightly smaller when eating 1 g of bread than when eating 3 or 7 g. The bread samples were mixed with saliva during chewing, and the oral cavity became relatively saliva-rich. In other words, the bread was easily converted to a liquid food, and the vaporization of the <i>p</i>-cymene in cumin seemed to be suppressed with smaller slices of bread. Moreover, a fit function for the obtained time profile was proposed in the present study. The profile was constructed by combining the subtracted values of the two logistic functions and a trigonometric function. As a fit result, the start and end times of the overall transient time profile were both earlier when eating 1 g of bread than when eating 3 or 7 g; the start time was numerically ca. 3 s earlier, and on average, <i>p</i>-cymene was found to be emitted from the nose half a breath earlier under the present eating conditions.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"42 6","pages":"411 - 419"},"PeriodicalIF":2.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44211-026-00907-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescence spectroelectrochemistry for the study of electrochemiluminescence of the CdTe quantum dots/tripropylamine coreactant system","authors":"Masayuki Nakayama,&nbsp;Musashi Nakajima,&nbsp;Atom Hamasaki,&nbsp;Fumiki Takahashi,&nbsp;Hirosuke Tatsumi,&nbsp;Jiye Jin","doi":"10.1007/s44211-026-00906-0","DOIUrl":"10.1007/s44211-026-00906-0","url":null,"abstract":"<div><p>This study investigates the electrochemiluminescence (ECL) behavior of water-soluble cadmium telluride quantum dots (CdTe QDs) synthesized via a microwave-assisted hydrothermal method. The ECL response was examined in the presence of tri-n-propylamine (TPrA) as a coreactant, revealing two anodic ECL emissions, denoted as ECL₁ and ECL₂, at potentials of + 0.85 V and + 1.2 V, corresponding to TPrA oxidation and CdTe QD oxidation, respectively. These emission intensities showed strong dependence on pH, suggesting multiple mechanistic pathways. In situ fluorescence microscopy was employed to observe interactions between electrogenerated TPrA intermediates and CdTe QDs at the electrode surface, providing insights into the reaction mechanisms. It is proposed that ECL₁ arises from reactions involving the TPrA^•+ intermediate under mildly basic conditions (pH 8–9), where both TPrA^•+ and TPrA^• radicals facilitate electron transfer with CdTe QDs, resulting in low-potential ECL emission. The findings demonstrate that TPrA^•+ acts as both a fluorescence quencher and a reactive intermediate, advancing understanding of the pH-dependent anodic ECL mechanism of semiconductor QDs.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"42 6","pages":"431 - 439"},"PeriodicalIF":2.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44211-026-00906-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical analysis of bacterial metabolic activity and spore germination via formazan formation","authors":"Hikaru Ikeda,&nbsp;Miya Kawanaka,&nbsp;Koki Takenaga,&nbsp;Akira Tokonami,&nbsp;Kanta Sako,&nbsp;Satohiro Itagaki,&nbsp;Shigeki Nishii,&nbsp;Hiroshi Shiigi","doi":"10.1007/s44211-026-00891-4","DOIUrl":"10.1007/s44211-026-00891-4","url":null,"abstract":"<div><p>Despite improved sanitation protocols, foodborne illnesses caused by spore-forming bacteria remain a persistent concern. In this study, we developed a method to visualize bacterial metabolic activity via dark-field microscopy by exploiting the optical properties of formazan particles generated from the reduction of the tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) by intracellular cofactors. <i>Escherichia coli</i> was used as a model organism to track formazan formation, which became pronounced following cell division, showing a strong correlation with metabolic activity. The method was further applied to various bacterial species with diverse respiratory and fermentation characteristics to evaluate the influence of metabolic profiles on formazan formation. Moreover, <i>Bacillus subtilis</i> spores were employed to investigate metabolic changes during germination and outgrowth. Time-lapse imaging revealed stage-specific formazan production, demonstrating the potential of this technique to monitor the metabolic reactivation process non-destructively. These findings suggest that MTT-based optical monitoring can serve as a valuable tool for assessing bacterial viability and spore germination dynamics, with potential applications in food safety and microbial risk control.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"42 5","pages":"329 - 340"},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc oxide nanorods modified thin film gold electrode designed by nanoimprint lithography technique for simultaneous electrochemical determination of two heavy metal ions","authors":"Nongmaithem Herojit Singh,&nbsp;Rakesh Singh Moirangthem,&nbsp;N. Mohondas Singh","doi":"10.1007/s44211-026-00899-w","DOIUrl":"10.1007/s44211-026-00899-w","url":null,"abstract":"<div><p>The concurrent detection of heavy metal ions in environmental and industrial samples is essential for effective monitoring and pollution control. This study presents a zinc oxide nanorods (ZnONRs)-modified gold thin film electrode, fabricated via nanoimprint lithography (NIL), for electrochemical detection of cadmium (Cd²⁺) and copper (Cu²⁺) ions. The NIL technique enables the creation of different nanostructures in different patterns with enhanced surface area-to-volume ratio, improving electrochemical performance. ZnONRs modification increases active sensing sites and promotes efficient electron transfer. The developed electrode demonstrates detection limits of 2.45 µM for Cd²⁺ and 1.5 µM for Cu²⁺ using cyclic voltammetry, along with good reproducibility and stable sensing behavior.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"42 6","pages":"389 - 398"},"PeriodicalIF":2.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}