Analytical Sciences最新文献

{"title":"Development of methodology for the visual identification of Tributyltin (TBT) in antifouling paint matrices","authors":"Fabricio Araújo Gonçalves Cruz,&nbsp;Cid Pereira,&nbsp;Marcos Antônio dos Santos Fernandez,&nbsp;Aricelso Maia Limaverde Filho,&nbsp;Tiago Lima da Silva","doi":"10.1007/s44211-024-00620-9","DOIUrl":"10.1007/s44211-024-00620-9","url":null,"abstract":"<div><p>Organotin compounds (OTC), mainly tributyltin (TBT), have been used since the 1970s as biocides in the composition of antifouling paints. Due to its physical–chemical characteristics, TBT has high toxicity to the marine environment affecting non-target organisms. The present study aims to develop a method of direct visual identification of TBT in antifouling paints using the cyclopalladate complex, 4- (2-thiazolylazo) resorcinol (TAR-Pd), synthesized in our laboratory. Tests were performed in blank and in the paint matrix with the following OTC: TBT-O; TBT-Cl; TPT-Cl; DBT-Cl (tributyltin oxide, tributyltin chloride, triphenyltin chloride, dibutyltin chloride), in addition to the SnCl₄ and SnCl₂ compounds (tin IV chloride and tin II chloride), all at a concentration of approximately 20 g/ kg of dry paint). The test was performed by applying paint samples to test bodies and scraping a few tens of milligrams of the dry paint film. The scraped paint samples were submitted to the test, showing a different staining reaction for the TBT-Cl and SnCl₄ samples concerning blank and other samples (TBT-O, TPT, DBT-Cl, and SnCl₂). Solution tests were performed to characterize reaction products by spectroscopy in the visible band. The method developed has potential for application in real samples, being selective for TBT-Cl and SnCl₄ in an acid medium, obtaining a limit of detection, in the range of 1–10 mg/kg dry paint.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1843 - 1855"},"PeriodicalIF":1.8,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual dual-mode aptasensor for non-small cell lung cancer exosome detection via HRP self-coupling enhanced oxidized iridium nanoparticle aggregation","authors":"Xin Xu,&nbsp;Ze Zhang,&nbsp;Tong Shen,&nbsp;Hongzhi Pan,&nbsp;Dong Chang","doi":"10.1007/s44211-024-00582-y","DOIUrl":"10.1007/s44211-024-00582-y","url":null,"abstract":"<div><p>The main reason for the high mortality rate of non-small cell lung cancer is that patients are usually diagnosed at an advanced stage of the disease. Exosomes, small membrane vesicles secreted by normal cells or tumor cells, play a significant role in the progression of NSCLC. This study successfully optimized the preparation of artificial nanoenzymes self-coupling with horseradish peroxidase (IrO₂NPs@HRP-AptCD63), without adding any ligand, demonstrating remarkable catalytic activity suitable for detecting the EGFR protein on the surface of NSCLC exosomes. When fused with the CD63 aptamer for identifying NSCLC exosomes, IrO₂NPs@HRP showed enhanced catalytic activity in the 3,3′,5,5′-tetramethylbenzidine-H₂O₂ oxidation–reduction system, thereby enhancing the colorimetric signal. This phenomenon can be distinguished by the naked eye and quantified using a UV–Vis spectrophotometer. Meanwhile, as the redox reaction occurs, the current signal of 3,3′,5,5′-tetramethylbenzidine-H₂O₂, acting as an electrolyte, changes. The developed aptasensor generates dual-mode signal outputs, firstly, to visually assess the samples for their positive or negative status, and subsequently employ more in-depth electrochemical or colorimetric analysis methods for a detailed quantitative analysis of suspected positive samples. The detection limits of electrochemical analysis and colorimetric analysis were 0.9 × 10³particles/mL and 0.14 × 10³particles/mL, respectively. Compared with traditional biomarkers such as CA125, this method exhibits exceptional specificity, capable of simultaneously distinguishing serum exosomes of healthy volunteers, COPD patients, and NSCLC patients, promoting exosome detection in mouse models for tumor monitoring. Additionally, it elucidates the changes in EGFR protein expression on the surface of serum exosomes throughout the developmental trajectory.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 8","pages":"1459 - 1473"},"PeriodicalIF":1.8,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on cellular uptake of a hydrophobic near-infrared-absorbing diradical-platinum(II) complex solubilized by albumin using hyperspectral imaging, spectrophotometry, and spectrofluorimetry","authors":"Ryota Sawamura,&nbsp;Atsuko Masuya-Suzuki,&nbsp;Nobuhiko Iki","doi":"10.1007/s44211-024-00621-8","DOIUrl":"10.1007/s44211-024-00621-8","url":null,"abstract":"<div><p>Owing to its biopenetrability and minimal invasiveness, near-infrared (NIR) light in the region between 700–1100 nm has attracted attention in cancer diagnosis and therapy. Our group previously reported that the hydrophobic diradical-platinum(II) complex PtL₂ is a promising agent for cancer photothermal therapy (L = 3,5-dibromo-1,2-diiminobenzosemiquinonate radical). Because PtL₂ does not fluoresce, its intercellular uptake of PtL₂ cannot be observed with a fluorescence microscope. In this study, we clarified the uptake and intracellular behavior of PtL₂ solubilized by bovine serum albumin (BSA) using hyperspectral imaging enabling spectrophotometric analysis of the image. The spectral changes in the obtained images indicated that the internalization of PtL₂ was followed by crystallization of the complex during the long incubation period (&gt; 4 h). Additionally, the binding constant <i>K</i>_b = 5.91 × 10⁴ M^–1 could be estimated upon fluorescence quenching analysis of BSA upon binding of PtL₂; <i>K</i>_b is two orders of magnitude smaller than that of albumin–common drugs. Considering the small <i>K</i>_b and low solubility of PtL₂ in water, we ultimately proposed the internalization path and fate of PtL₂ in the cell: release of PtL₂ from BSA near cellular membranes and subsequent cellular uptake via membrane permeation followed by saturation, resulting in crystallization.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1857 - 1865"},"PeriodicalIF":1.8,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of quantitative detection methods for four Alzheimer’s disease specific biomarker panels using electrochemical immunosensors based on enzyme immunoassay","authors":"Il Kyu Park,&nbsp;Young Sun Choi,&nbsp;Seo Yun Jo","doi":"10.1007/s44211-024-00614-7","DOIUrl":"10.1007/s44211-024-00614-7","url":null,"abstract":"<div><p>Accurate and timely diagnosis of Alzheimer's disease (AD) is necessary to maximize the effectiveness of treatment and using biomarkers for diagnosis is attracting attention as a minimally invasive method with few side effects. Electrochemical immunosensor (EI) is a method that is in the spotlight in the medical and bioanalytical fields due to its portability and field usability. Here, we quantified four AD specific biomarkers using EIs based on enzyme immunoassay. We selected and developed quantitative methods for the biomarkers using screen-printed gold electrodes. For three biomarkers, quantification was performed using competition immunoassays in which antigen–antibody premix mixtures were applied to antigen-immobilized electrodes and the limit of detection (LOD) values were secured, 1.20 ng/ml, 1.30 ng/ml, and 1.74 ng/ml, respectively. For the other, a sandwich immunoassay using antibody pair was selected for quantification and LOD was also achieved as 0.077 ng/ml. All four biomarkers in buffer samples were successfully quantified and reliable R² values were obtained, and reliable calibration curves were secured for three biomarkers in spiked human serum samples. The immunosensors developed and will be optimized are expected to be used in various fields, including detection of biomarkers for not only AD but also related diseases.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1809 - 1821"},"PeriodicalIF":1.8,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid spectrophotometric determination and extraction of platinum(IV) from pharmaceuticals assisted by 2-(2-(1-(thiophene-2-yl) ethylidene) hydrazinyl) benzoic acid (TEHBA)","authors":"Amruta Murkute,&nbsp;Haribhau Aher,&nbsp;Somnath Bhumkar,&nbsp;Shashikant Kuchekar","doi":"10.1007/s44211-024-00612-9","DOIUrl":"10.1007/s44211-024-00612-9","url":null,"abstract":"<div><p>It has been suggested that the chelating agent 2-(2-(1-thiophene-2-yl) ethylidene) hydrazinyl) benzoic acid (TEHBA) be utilized to extract, separate and measure platinum(IV) by UV–visible spectrophotometry at the microgram level. Following 5 min of heating the reaction mixture in a water bath, Pt(IV)-TEHBA complex formed. This complex was formed in the presence of potassium iodide solution with a molar absorption coefficient 1.9 × 10³ dm³ mol⁻¹ cm⁻¹. At 420 nm, the substance exhibited the greatest absorption. As Beer’s law described, the Pt(IV)-TEHBA complex for platinum(IV) has a beer’s range of 10–50 μg cm⁻³. It was determined that the proportion ratio of the Pt(IV)-TEHBA complex was 1:1 after its extraction. Despite the investigation of interference from various ions, it was ascertained that the method exhibited selectivity exclusively towards platinum(IV). The trace amounts of platinum(IV) were extracted and quantified from synthetic mixtures representing alloys, binaries and ternary synthetic mixtures. The process of extracting platinum(IV) from pharmaceutical samples involves the implementation of a specific method. Moreover, the procedure exhibits a progressive segregation of palladium(II), platinum(IV) and nickel(II) while also boasting its ease of operation.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 9","pages":"1765 - 1777"},"PeriodicalIF":1.8,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residue and dissipation kinetics of novel nematicide fluopyram in rice assessed by QuEChERS–liquid chromatography–tandem mass spectrometry","authors":"C. Selvi,&nbsp;K. Bhuvaneswari,&nbsp;A. Suganthi,&nbsp;P. Karthik,&nbsp;V. Muralitharan,&nbsp;P. Thangachamy","doi":"10.1007/s44211-024-00616-5","DOIUrl":"10.1007/s44211-024-00616-5","url":null,"abstract":"<div><p>Supervised field trial was conducted to study the dissipation pattern of fluopyram in rice plant after application of fluopyram 400 g/L SC(Velum Prime) as soil drenching at the time of sowing in nursery bed at X (500 g a.i. ha⁻¹) and 1.25X (625.2 g a.i. ha⁻¹) doses. Samples of rice plant were collected on 0, 1, 3, 7, 10, 15, and 20 days after transplanting. QuEChERS-based extraction method was validated and adopted to determine the residues of fluopyram in rice seedlings, whole rice grains (with husk), polished rice grain, husk, straw, and soil using LC–MS/MS (liquid chromatography–tandem mass spectrometry).The initial deposit of fluopyram in rice plant recorded were 0.27 and 0.41 mg kg⁻¹in X and 1.25X doses, respectively. Fluopyram residues dissipated following first-order kinetics with half-life of 2.53 and 2.57 days at X and 1.25X doses, respectively. Residues were detected in seedlings up to 15 days after transplanting and were at below LOQ in whole rice grains (with husk), polished rice grain, husk, straw, and soil collected at harvest. Monitoring study revealed that application of novel nematicide fluopyram for the management of nematodes in rice does not pose any risks to consumers.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1823 - 1832"},"PeriodicalIF":1.8,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular symmetry change of perfluoro-n-alkanes in ‘Phase I’ monitored by infrared spectroscopy","authors":"Taisuke Araki,&nbsp;Takayuki Oka,&nbsp;Nobutaka Shioya,&nbsp;Takeshi Hasegawa","doi":"10.1007/s44211-024-00611-w","DOIUrl":"10.1007/s44211-024-00611-w","url":null,"abstract":"<div><p>Phase diagram of polytetrafluoroethylene (PTFE) comprises four regions. Phases II and IV are characterized by twisted perfluoroalkyl (R_f) chains having different twisting rate of 13/6 and 15/7, respectively, while Phase III is characterized by a planer trans-zigzag molecular skeleton like a normal alkyl chain. These are confirmed by X-ray and electron diffraction and have already been established. Unlike these, Phase I is left an unresolved matter. This phase is complicated indeed and is not symbolized by a single molecular structure. At an ambient pressure, Phase I is the temperature region above 30 ºC (303 K), and the helical molecular structure is supposed to be gradually untwisted with an elevating temperature. This untwisting image is roughly suggested by the diffraction, neutron scattering, and thermal expansion techniques, but the conventional approaches have all experimental limitations because the untwisting accompanies disorder (or defect) in the twist along the chain. To explore the transition between two different helical structures of the R_f chain having disordered structures, vibrational spectroscopic techniques are expected to be an alternative approach. For infrared spectroscopy, for example, the twisting rate of the molecule is simply recognized as a degree of molecular symmetry. Here, we show that the band progression peaks of the CF₂ symmetric stretching vibration mode are quite sensitive and useful for pursuing the molecular symmetry change in Phase I for both peak intensity and position using perfluoro-n-alkanes having different chain length covering both even and odd number of the CF₂ groups.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 9","pages":"1723 - 1731"},"PeriodicalIF":1.8,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11358247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing ethanol content determination in hydrogels: non-destructive and operational methods for health and criminal inspections","authors":"Diego M. de Souza,&nbsp;Lívia de B. Salum,&nbsp;Robiedson R. Damasceno,&nbsp;Pedro J. de Moura Messias,&nbsp;Camila M. Silva,&nbsp;João V. de S. Cardoso,&nbsp;Pedro A. de O. Morais","doi":"10.1007/s44211-024-00617-4","DOIUrl":"10.1007/s44211-024-00617-4","url":null,"abstract":"<div><p>The significance of accurate determination of ethanol content in hydrogel formulations was accentuated during COVID-19 pandemic coinciding with the heightened demand for sanitizing agents. The present article proposes three robust methodologies for this purpose: Fourier Transform Infrared Spectroscopy (FTIR), Raman spectroscopy, and Densitometry with matrix effect correction by Near-Infrared Spectroscopy (NIR). All three methods demonstrated outstanding linearity (<i>R</i>² ≥ 0.99) and minimal errors (&lt; 1.7%), offering simplicity and operational efficiency. FTIR and Raman, being non-destructive and requiring minimal preparation, enable practical on-site analysis capabilities, underscoring the potential of the spectroscopic methods to expedite health investigations and inspections, empowering on-site ethanol determination, and relieving the burden on official laboratories. Additionally, the densitometry with NIR-based approach showcased superior accuracy and precision compared to spectroscopic methods, meeting validation criteria while offering operational advantages over the costly official distillation-based method. Therefore, it stands as a reliable and reproducible technique for comprehensive health and criminal compliance assessments, making it a compelling alternative for both industry and official laboratories.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1833 - 1841"},"PeriodicalIF":1.8,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tritium concentration in the modern commercial D2O reagents","authors":"Tomoko Ohta,&nbsp;Satoshi Fukutani,&nbsp;Takumi Kubota,&nbsp;Yasunori Mahara","doi":"10.1007/s44211-024-00615-6","DOIUrl":"10.1007/s44211-024-00615-6","url":null,"abstract":"<div><p>We investigated the tritium concentration in commercial modern D₂O reagents frequently used in nuclear magnetic resonance analysis for analytical chemistry and in environmental tracer testing. The concentration of tritium in 11 D₂O and 1 H₂¹⁸O reagents ranged from 61 Bq/L (5 × 10² TU) to 2.5 × 10³ Bq/L (2 × 10⁴ TU) in order of magnitude. The tritium concentration in the D₂O reagents have increased with the increasing purity of D₂O. The tritium concentration in all reagents was an order of magnitude greater than that in the surface waters at the Fukushima off-site of the Fukushima Daiichi Nuclear Power Plant after the accident in 2011 and in precipitation during the nuclear test era. However, the concentration of the tritium was lower than the regulatory limit for the concentration of tritium in drinking water accepted by the World Health Organization guidelines. The internal exposure effects from drinking the tritium water, which is contaminated by the tritium condensed in the reagent production processes, were negligible, even if the reagent was used in the environmental tracer test.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><img></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 10","pages":"1927 - 1930"},"PeriodicalIF":1.8,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selection of structure-induced aptamer targeting small molecule based on capillary sieving electrophoresis","authors":"Masahide Wada,&nbsp;Tatsuro Endo,&nbsp;Hideaki Hisamoto,&nbsp;Kenji Sueyoshi","doi":"10.1007/s44211-024-00588-6","DOIUrl":"10.1007/s44211-024-00588-6","url":null,"abstract":"<div><p>In this study, a structure-induced aptamer targeting small molecules was selected using capillary sieving electrophoresis (CSE). CSE was conducted using a capillary filled with a background solution containing hydroxypropyl cellulose as a sieving matrix to separate the aptamer candidates by changing their structures via complexation. Before aptamer selection, the original random-sequence DNA library was used to create structure-not-preorganized DNA sub-library containing straight-chain-like structures using CSE. Next, a structure-induced aptamer targeting <span>l</span>-tyrosinamide was selected from the prepared sub-library. Six aptamer candidates were selected, one of which showed a binding ability comparable to that of the reported <span>l</span>-tyrosinamide aptamer and selectivity toward the analogs. These results indicated that the proposed method can be applied to select structure-induced aptamers that target small molecules.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7802,"journal":{"name":"Analytical Sciences","volume":"40 8","pages":"1499 - 1508"},"PeriodicalIF":1.8,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141299840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}