Aesthetic Surgery Journal最新文献

{"title":"Response to: The Dark Side of 3D Simulation in Breast Augmentation: How to Use Its Advantages and Avoid Its Drawbacks.","authors":"Isil Akgun Demir","doi":"10.1093/asj/sjaf016","DOIUrl":"10.1093/asj/sjaf016","url":null,"abstract":"","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"NP132"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Site Allergic Contact Dermatitis Due to 2-Octyl Cyanoacrylate: A Systematic Review and FDA MAUDE Review.","authors":"James E Fanning, Maria J Escobar-Domingo, Marco Montoya, Jose Foppiani, Daniela Lee, John B Park, Benjamin Rahmani, Amitai S Miller, Sarah J Karinja, Ashley N Boustany, Sally Y Tan, Bernard T Lee","doi":"10.1093/asj/sjae237","DOIUrl":"10.1093/asj/sjae237","url":null,"abstract":"<p><p>Skin adhesives containing 2-octyl cyanoacrylate are a common source of allergic contact dermatitis (ACD), a complication of postoperative wound healing. Few studies have described postoperative cutaneous reactions to skin adhesives and their clinical management. The aim of this study was to review the incidence, descriptions, and clinical management of surgical site ACD caused by 2-ocyl cyanoacrylate. A comprehensive systematic literature search was conducted in September 2023 of the PubMed/MEDLINE (National Library of Medicine, Bethesda, MD), Web of Science (Clarivate Analytics, Philadelphia, PA), and Cochrane databases (Cochrane Library, John Wiley & Sons, Ltd., Hoboken, NJ) for studies reporting ACD after skin closure with liquid adhesives containing 2-octyl cyanoacrylate. Additionally, we queried the FDA Manufacturer and User Facility Device Experience (FDA MAUDE, U.S. Food and Drug Administration, Silver Spring, MD) in September 2023 and retrieved clinician-inputted records of ACD caused by liquid adhesives containing 2-octyl cyanoacrylate from 2014 to2023. Nine articles were included for review, with a median of 102 patients exposed to 2-octyl cyanoacrylate for surgical site skin closure. The reported incidence of cutaneous reactions to 2-octyl cyanoacrylate ranged from 0.5% to 14%. The review also included 609 unique FDA MAUDE records reporting surgical site skin reactions to 2-octyl cyanoacrylate. Orthopedic procedures were the most common type of procedure, representing 47% of FDA MAUDE records. Nineteen clinical descriptors of cutaneous reactions were utilized. Topical corticosteroids and oral antihistamines were the most commonly prescribed treatments to manage postoperative cutaneous reactions. Reported incidences of cutaneous reactions to 2-octyl cyanoacrylate vary widely and guidelines for clinical management remain unclear. The FDA MAUDE provides important insights to cutaneous reactions to 2-octyl cyanoacrylate including surgery-type, cutaneous descriptors, and clinical management. Future research is needed to identify patients at risk of 2-octyl cyanoacrylate skin reactions in the preoperative setting.</p><p><strong>Level of evidence: 3 (therapeutic): </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"NP119-NP125"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Different Hemostatic Net Applications in a Rat Dorsal Skin Flap Model.","authors":"Bilge Kaan İsmail, Kemal Fındıkçıoğlu, Serhat Şibar, Çiğdem Elmas","doi":"10.1093/asj/sjaf010","DOIUrl":"10.1093/asj/sjaf010","url":null,"abstract":"<p><strong>Background: </strong>Although several articles have discussed the use of hemostatic nets to close dead spaces, no in vivo experimental studies have examined simultaneously the histology and tissue perfusion of these techniques.</p><p><strong>Objectives: </strong>The aim of this study was to compare variations of the hemostatic net technique commonly used in current practice.</p><p><strong>Methods: </strong>Two different hemostatic net suturing techniques and 2 suture removal times were tested, with a control group for comparison. In a modified McFarlane flap model, hemostatic net sutures were placed in either a vertical or horizontal pattern. Suture removal times were set at 60 hours and 7 days. Perfusion in the proximal, middle, and distal parts of the flap was assessed by SPY-assisted immunofluorescence angiography (Novadaq, Kalamazoo, MI) at 0 minutes, 60 hours, and 7 days after the first surgery. The rat dorsal flap was photographed in a standardized manner 1 week postsurgery. Flap survival areas were calculated as a percentage using ImageJ software (US National Institute of Health, Bethesda, MD). On day 20, all rats were killed and sent for histological examination.</p><p><strong>Results: </strong>There was no statistically significant difference in macroscopic flap survival between the groups (P > .05). Group 5 (control) was statistically different with lower neovascularization scores than the other groups in all 3 segments (P < .01).</p><p><strong>Conclusions: </strong>Hemostatic nets may improve neovascularization at the flap base but do not significantly affect overall flap survival.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"429-433"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The IMAP and MICAP Flaps for Autologous Breast Reconstruction: An Anatomic, Clinical, and Outcome Study.","authors":"Claudio Angrigiani, Alberto Rancati, Esteban Spinelli, Agustín Rancati, Maurice Y Nahabedian","doi":"10.1093/asj/sjae249","DOIUrl":"10.1093/asj/sjae249","url":null,"abstract":"<p><strong>Background: </strong>Local flaps for breast reconstruction are becoming recognized as a viable alternative to remote flaps.</p><p><strong>Objectives: </strong>The purpose of this article was to describe the anatomy and clinical outcomes of internal mammary artery perforators and lateral intercostal artery perforator flaps for breast reconstruction.</p><p><strong>Methods: </strong>Twelve cadaveric specimens were injected with colored latex and dissected to demonstrate the medial perforators of the fifth intercostal space. Twenty-two patients had partial or total breast reconstruction with internal mammary artery perforator flaps, which were combined with lateral intercostal artery perforator flaps in 4 patients. The study was performed at the Hospital de Clinicas Jose de San Martin, which is affiliated with the Universidad de Buenos Aires in Argentina, between March 2018 and December 2023. Outcomes were based on clinical evaluation and statistical analysis. Patient satisfaction was assessed on a 5-point Likert scale based on whether patients were clothed or unclothed.</p><p><strong>Results: </strong>All flaps survived without any evidence of partial flap necrosis. There were no major complications (total flap loss, partial necrosis); however, fat necrosis was demonstrated in 2 patients. Minor complications included a small hematoma and a minor wound dehiscence. Patient satisfaction was rated as very good or excellent in 100% of females when clothed and rated as good to very good in 93.3% of females when unclothed.</p><p><strong>Conclusions: </strong>Submammary perforator flaps can be raised on numerous vascular pedicles. This study has demonstrated that the internal mammary and the lateral intercostal perforators can be successfully utilized for partial or total breast reconstruction in properly selected patients.</p><p><strong>Level of evidence: 4 (therapeutic): </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"NP105-NP112"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NivobotulinumtoxinA in the Treatment of Glabellar Lines With or Without Concurrent Treatment of Lateral Canthal Lines in Two Phase 3 Clinical Trials.","authors":"William Coleman, Vince Bertucci, Shannon Humphrey, Joely Kaufman-Janette, Terrence Keaney, David Pariser, Nowell Solish, David Wirta, Robert A Weiss","doi":"10.1093/asj/sjae233","DOIUrl":"10.1093/asj/sjae233","url":null,"abstract":"<p><strong>Background: </strong>Botulinum neurotoxins in aesthetic medicine require reconstitution before administration, which may be inconvenient and present errors among injectors.</p><p><strong>Objectives: </strong>The aim of this study was to evaluate the efficacy and safety of ready-to-use nivobotulinumtoxinA liquid formulation for the treatment of glabellar lines (GL) with or without treatment of lateral canthal lines (LCL).</p><p><strong>Methods: </strong>Two multicenter, phase 3, double-blind, randomized trials enrolled participants with moderate-to-severe GL (Study 001) or moderate-to-severe GL + LCL (Study 005). Participants received double-blind nivobotulinumtoxinA (20 U) or placebo (Period 1) then ≤2 open-label nivobotulinumtoxinA GL treatments (Period 2) in Study 001 or double-blind nivobotulinumtoxinA 20 U (GL), nivobotulinumtoxinA 44 U (GL + LCL), or placebo (Period 1) then ≤2 double-blind injections of the same treatment (Period 2) in Study 005. The composite primary endpoint was the proportion of participants achieving a ≥2-grade improvement on a facial wrinkle scale at maximum frown on investigator and participant assessment; coprimary endpoints were investigator- and participant-assessed FWS \"none or mild\" ratings.</p><p><strong>Results: </strong>At Day 30, significantly higher responder rates were observed for the composite primary endpoint with GL treatment alone (Study 001, 46.1%; Study 005, 45.1%) and GL + LCL (Study 005, 41.3%) vs placebo (0%; all P < .001). Responder rates of \"none or mild\" by investigator and participant assessment, respectively, were significantly higher for GL treatment alone (Study 001, 77.2% and 65.0%; Study 005, 74.3% and 68.8%) and GL + LCL (Study 005, 74.0% and 61.2%) vs placebo (all P < .001). Adverse events were similar between treatment groups and placebo.</p><p><strong>Conclusions: </strong>Liquid nivobotulinumtoxinA was effective and well tolerated for treating moderate-to-severe GL alone or with LCL.</p><p><strong>Level of evidence: 1 (therapeutic): </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"404-413"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Stepwise Approach to Surgical Decision-making for Lower Eyelid Ectropion: Insights from a Retrospective Study.","authors":"Yinmin Wang, Jun Yang, Shun Yu, Rui Jin, Chuan Gu, Lin Lu","doi":"10.1093/asj/sjae250","DOIUrl":"10.1093/asj/sjae250","url":null,"abstract":"<p><strong>Background: </strong>Cicatricial lower eyelid ectropion is a serious complication resulting from undesired lower lid blepharoplasty or impaired wound healing. Surgical treatment for ectropion is challenging for oculoplastic surgeons due to the unpredictability of surgical outcome and the difficulty of surgical design.</p><p><strong>Objectives: </strong>The authors aimed to fully describe the surgical decision-making strategy for cicatricial ectropion, and to potentially enhance treatment outcomes.</p><p><strong>Methods: </strong>In this study, we conducted a retrospective review of the treatment of 26 patients (30 eyelids) with cicatricial ectropion between 2017 and 2021. We summarized the corresponding decision-making processes before and during surgery. Treatment involved scar tissue release combined with lateral canthal procedures and repair of the skin defect.</p><p><strong>Results: </strong>During the early postoperative stage, no flap necrosis was observed, and complete surgical healing was achieved within 2 weeks. The ectropion grading scale showed a significant decrease after surgical treatment based on our approach, and most patient symptoms were alleviated. Additionally, the majority of the patients expressed high satisfaction with the aesthetic outcome of the procedure.</p><p><strong>Conclusions: </strong>This treatment approach significantly enhanced both the appearance and function of the lower lid, which holds considerable promise as an ideal surgical design for cicatricial ectropion.</p><p><strong>Level of evidence: 3 (therapeutic): </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"341-346"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D Technology for Autologous Breast Reconstruction: Increased Aesthetic Outcomes and Quality of Life Utilizing Patient-Specific Templates.","authors":"Maximilian Zaussinger, Karl Schwaiger, Jürgen Schwarzbauer, Bernhard Schwartz, Matthias Holzbauer, Kathrin Bachleitner, Gudrun Ehebruster, Manfred Schmidt","doi":"10.1093/asj/sjaf005","DOIUrl":"10.1093/asj/sjaf005","url":null,"abstract":"<p><strong>Background: </strong>In autologous breast reconstruction accomplishing aesthetically pleasing outcomes represents an integral challenge. Three-dimensional (3D) technology may aid in accurate flap shaping and subsequent breast appearance.</p><p><strong>Objectives: </strong>The aim of this study was to evaluate the applicability of 3-dimensional technology for surgical planning and its influence on outcomes for breast reconstruction.</p><p><strong>Methods: </strong>Outcomes of 50 female patients who underwent deep epigastric artery perforator flap breast reconstruction were analyzed. The patient population was divided into 2 study groups (with 3D technology vs without), including 25 patients each. Based on individual 3D scans and simulations, patient-specific templates were utilized intraoperatively in the 3D group. Quality of life assessment and aesthetic evaluations of breast appearance were statistically evaluated and compared.</p><p><strong>Results: </strong>Various scales of the BREAST-Q showed statistically significantly better values in the 3D group (P < .05). Concerning breast appearance, patients with 3D technology rated their breast shape and projection statistically significantly higher compared to the control group (P < .05). In addition, blinded ratings of external plastic surgeons were statistically significantly higher related to shape, symmetry, and projection of breasts with 3D technology (P < .05). All patients treated with 3D technology-assisted breast reconstruction strongly recommended this approach.</p><p><strong>Conclusions: </strong>Patient-specific templates represent a practical method for facilitating personalized flap planning and shaping. Results demonstrated that 3D technology significantly enhances breast reconstruction outcomes concerning aesthetics and postoperative quality of life.</p><p><strong>Level of evidence: 3 (therapeutic): </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"373-380"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forehead Lift With Cross-frontal Scalp Anchorage.","authors":"Mehmet Gencer, Yunus Sağlam, Burak Ergün Tatar, Metin Kerem","doi":"10.1093/asj/sjae253","DOIUrl":"10.1093/asj/sjae253","url":null,"abstract":"<p><strong>Background: </strong>Over the past decade, facial aesthetics has gained popularity, with a notable increase in upper facelift procedures. Despite the popularity of brows and forehead lifts, the optimal fixation technique remains controversial. Common methods involve suturing of the temporal fascia or using monocortical miniscrews anchored to the frontal bone. Other options include the use of microscrews, percutaneous fixation posts, Kirschner wires, Mitek anchors, Endotine devices, bone tunnels, miniplates, and fibrin glue.</p><p><strong>Objectives: </strong>The aim of this study was to present a method in which pulling force is transmitted directly to the brow/forehead skin through subperiosteal dissection, utilizing the scalp as a suspension point.</p><p><strong>Methods: </strong>This retrospective study included 129 patients who underwent surgery between May 2022 and June 2023. Patients with less than 12 months of follow-up, irregular follow-up, or a history of botulinum toxin or brow contouring were excluded. Preoperative and 12-month postoperative photographs were evaluated with the Brow Positioning Grading Scale.</p><p><strong>Results: </strong>No persistent dimples were observed; on average, dimples resolved within 4 weeks. Postoperative edema, erythema, and bruising resolved within 6 days. Complications, including chemosis, stitch-site infections, muscle weakness, paresthesia, and asymmetry, were all resolved. Significant improvements in eyebrow height and Brow Positioning Grading Scale scores were noted at the 12-month follow-up visit.</p><p><strong>Conclusions: </strong>This technique offers a natural upper face rejuvenation option that is particularly suitable for patients with lower brow positions or of advanced age.</p><p><strong>Level of evidence: 4 (therapeutic): </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"333-340"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Synchronized Radiofrequency and High-intensity Facial Electrical Stimulation on Facial Muscles and the Superficial Fascial System in the Midface.","authors":"Konstantin Frank, Kai O Kaye, Gabriela Casabona, Emily Glaue, Rui Zeng, Ting Song Lim, Vanessa Brebant, Lukas Prantl, Nicholas Moellhoff, Sebastian Cotofana","doi":"10.1093/asj/sjae252","DOIUrl":"10.1093/asj/sjae252","url":null,"abstract":"<p><strong>Background: </strong>Midfacial aging involves skeletal changes, muscle weakening, and fat redistribution, resulting in volume loss, skin sagging, and deepened nasolabial folds. High-intensity facial electrical stimulation (HIFES) combined with radiofrequency (RF) is a novel noninvasive method for addressing these changes by enhancing muscle mass and remodeling subcutaneous tissue.</p><p><strong>Objectives: </strong>The goal of this study was to assess the efficacy of HIFES and synchronized RF in improving midfacial aesthetics, specifically muscle thickness, skin displacement, and facial volume.</p><p><strong>Methods: </strong>This prospective, nonrandomized study included 37 participants who underwent 4 HIFES and RF treatments over 24 weeks. Assessments at baseline, 4, 16, and 24 weeks were performed with ultrasound imaging, electromyography (EMG), 3-dimensional surface imaging, and the Modified Fitzpatrick Wrinkle Scale. A related porcine study evaluated the treatment's histological effects.</p><p><strong>Results: </strong>Zygomaticus major muscle thickness increased from 2.06 mm to 2.80 mm, with a 39.3% rise in EMG signal strength, indicating improved muscle function. Skin displacement analysis revealed horizontal (0.90 mm) and vertical (1.01 mm) shifts, particularly laterally. Midface volume increased by 1.43 cm³ at 24 weeks. The porcine study confirmed increased muscle fiber size, myonucleus count, and mass density, aligning with human results.</p><p><strong>Conclusions: </strong>HIFES and synchronized RF treatments significantly improved muscle thickness, skin displacement, and facial volume, effectively rejuvenating the midface. These clinical findings, supported by histological evidence, suggest a promising noninvasive approach for facial rejuvenation. Further randomized studies are needed to confirm these results and assess long-term effects.</p><p><strong>Level of evidence: 4 (therapeutic): </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"422-428"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide and Postoperative Outcomes in Nondiabetic Patients Following Body Contouring Surgery.","authors":"Joshua E Lewis, Mbinui Ghogomu, Stanley J Hickman, Adedamola Ashade, Raven J Hollis, Jimmie E Lewis, Wei-Chen Lee","doi":"10.1093/asj/sjae241","DOIUrl":"10.1093/asj/sjae241","url":null,"abstract":"<p><strong>Background: </strong>Semaglutide is a medication for weight loss in obese patients. Recently, many plastic surgeons have recommended semaglutide following bariatric surgery to increase weight loss. However, postoperative complications such as wound dehiscence, delayed healing, and infection pose significant risks.</p><p><strong>Objectives: </strong>In this study we aimed to examine the relationship between preoperative semaglutide and postoperative complications in nondiabetic obese patients undergoing body contouring surgery. We hypothesized that semaglutide would increase the risk of postoperative complications.</p><p><strong>Methods: </strong>In this retrospective cohort study we utilized the TriNetX Research database. Nondiabetic patients who underwent body contouring surgery between 2021 and 2024 after bariatric procedures were included. Patients were divided into 2 cohorts: Cohort A (4215 patients), which received semaglutide for ≥6 months before surgery, and Cohort B (104,927 patients), without semaglutide. Propensity score matching was employed to create comparable cohorts based on age, gender, race, and BMI. The primary outcomes included postoperative complications within 30 days of surgery.</p><p><strong>Results: </strong>Significant differences were found between the cohorts. Semaglutide patients had higher rates of wound dehiscence (5.19% vs 2.78%, P < .0001); delayed wound healing (2.58% vs 1.21%, P < .0001); surgical site infections (5.37% vs 2.87%, P < .0001); nausea, vomiting, and diarrhea (11.27% vs 5.34%, P < .0001); hypertrophic scar formation (5.53% vs 3.86%, P = .0011); and surgical site pain (6.05% vs 3.29%, P < .0001).</p><p><strong>Conclusions: </strong>Preoperative semaglutide in nondiabetic patients undergoing body contouring surgery following bariatric procedures is associated with higher rates of adverse postoperative outcomes. These findings highlight the need for enhanced preoperative counseling and surgical planning to minimize risks and improve patient outcomes.</p><p><strong>Level of evidence: 3 (therapeutic): </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"381-386"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}