{"title":"Commentary On: Interval to Secondary Facelift: A Match-Cohort Analysis of Interval Time, Technique, and Complications.","authors":"James M Stuzin","doi":"10.1093/asj/sjag237","DOIUrl":"https://doi.org/10.1093/asj/sjag237","url":null,"abstract":"","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Single-Stage Nipple Sparing Mastectomy with Concurrent Mastopexy: A Systematic Review and Meta-Analysis.","authors":"Ella Gibson, Viviana Vega, Ara A Salibian","doi":"10.1093/asj/sjag242","DOIUrl":"https://doi.org/10.1093/asj/sjag242","url":null,"abstract":"<p><p>Patients with macromastia or breast ptosis are typically considered poor candidates for nipple-sparing mastectomy (NSM) due to concerns regarding nipple and mastectomy flap vascularity as well as challenges in maintaining optimal nipple position due to the redundant skin envelope. Several techniques for concurrent NSM and mastopexy have been described with encouraging results; however, data is limited to case series with small sample sizes. PubMed, Scopus, and Cochrane databases were queried to identify all studies analyzing outcomes in patients who underwent nipple-sparing mastectomy and simultaneous mastopexy with implant-based reconstruction. Study characteristics, patient demographics, surgical techniques, and post-operative complications were collected from relevant articles. Random-effects model meta-analysis was performed to assess complication rates. Nineteen studies, with a pooled total of 1,076 breasts were identified for analysis. The average patient was 48.1 ± 5.2 years old with a mean BMI of 27.2 ± 3.0 and a mean mastectomy specimen weight of 701.3 ± 93.8 g. The majority of mastopexies were performed using a Wise-pattern skin resection (70%) however there was a wide variety of dermal pedicles used to supply the nipple-areolar complex (NAC). Meta-analysis demonstrated acceptable complication rates, including partial NAC necrosis (5.9%, CI 3.0-9.5 %), total NAC necrosis (0.9%, CI 0.0-2.4%), and mastectomy flap necrosis (3.1%, CI 0.7-6.6%). The current literature supports the safety of performing single-stage NSM and mastopexy in favorable and highly selective patient populations. Additional studies are needed to refine specific, objective preoperative and intraoperative indications as well as to evaluate aesthetic and patient-reported outcomes.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Mediating Role of Happiness in the Effect of Women's Attitudes Toward Genital Aesthetic Surgery on Psychological Well-being.","authors":"Zeynep Ogul, Eda Yakit Ak","doi":"10.1093/asj/sjag239","DOIUrl":"https://doi.org/10.1093/asj/sjag239","url":null,"abstract":"<p><strong>Background: </strong>Genital self-image may influence women's psychological well-being and attitudes toward genital aesthetic surgery. However, the relationships among genital self-image, happiness, and psychological resilience remain insufficiently understood.</p><p><strong>Objectives: </strong>This study aimed to examine the relationships between women's genital self-image, happiness, and psychological resilience and to determine whether happiness mediates the association between genital self-image and psychological resilience.</p><p><strong>Methods: </strong>This descriptive cross-sectional study included 360 women. Data were collected using the Female Genital Self-Image Scale (FGSIS), Happiness Scale (HS), and Brief Resilience Scale (BRS), together with a demographic information form. Data were analyzed using ANOVA, correlation analysis, logistic regression, and mediation analysis.</p><p><strong>Results: </strong>FGSIS scores differed significantly according to age, education, income, and number of children. Number of children was negatively correlated with FGSIS (r = -0.409, p < .001) and HS (r = -0.344, p < .001). FGSIS was positively correlated with HS (r = 0.252, p < .001) and BRS (r = 0.231, p < .001), while HS was positively correlated with BRS (r = 0.434, p < .001). Mediation analysis demonstrated a significant direct effect of FGSIS on BRS (β = 0.152, p = .006) and an indirect effect through HS (β = 0.119, p < .001), with a significant total effect (β = 0.271, p < .001).</p><p><strong>Conclusions: </strong>Genital self-image was positively associated with happiness and psychological resilience, with happiness mediating this association.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149236574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vicente Antonio Jesús Fernandois Barrera, Kiara Alexandra Maldonado Rodriguez, Alain Chaple-Gil, Javier Basualdo Allende, Eduardo Maximiliano Fernández Godoy
{"title":"Patient-Reported Aesthetic Outcomes of Botulinum Toxin Type A: A Systematic Review and Meta-Analysis of Placebo-Controlled Randomized Trials.","authors":"Vicente Antonio Jesús Fernandois Barrera, Kiara Alexandra Maldonado Rodriguez, Alain Chaple-Gil, Javier Basualdo Allende, Eduardo Maximiliano Fernández Godoy","doi":"10.1093/asj/sjag236","DOIUrl":"https://doi.org/10.1093/asj/sjag236","url":null,"abstract":"<p><p>Botulinum toxin type A (BoNT-A) is widely used for facial rejuvenation, but patient-perceived benefit is best evaluated against an inert control. This systematic review assessed whether BoNT-A, compared with placebo, vehicle, or saline placebo, improves aesthetic self-perception and related patient-reported outcomes. PubMed/MEDLINE, Embase, Scopus, Web of Science, and CENTRAL were searched from inception through September 25, 2026 using a sensitivity-oriented strategy. Randomized controlled trials in adults were eligible when they contained an extractable BoNT-A-versus-placebo contrast and a patient-reported aesthetic outcome. Seventy-five reports were retained: 70 contributed direct comparative evidence from 65 unique placebo-containing RCTs enrolling 18,581 participants across all randomized arms, and five linked reports were retained only for contextual mapping. Four clinically homogeneous responder subsets were quantitatively pooled; all favored BoNT-A, with pooled risk ratios ranging from 5.53 to 14.74 and I2=0% in each analysis. BoNT-A consistently improved treatment or appearance satisfaction, patient-rated facial-line severity or bother, perceived age/youthfulness, and selected appearance-related psychosocial outcomes. Overall RoB 2 was Low in 39/65 RCTs (60.0%) and Some concerns in 26/65 (40.0%). GRADE certainty was moderate for satisfaction/global aesthetic improvement, patient-reported facial-line severity/appearance appraisal, and perceived age/naturalness; low for appearance-related psychological well-being; and very low for general quality-of-life/self-esteem constructs. Placebo-controlled evidence supports a consistent patient-perceived aesthetic benefit of BoNT-A, while broader psychological and quality-of-life claims remain less certain.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexis K Gursky, Hailey P Wyatt, Anandhini D Narayanan, Sergio A Segrera, Carter J Boyd, Nolan S Karp
{"title":"Does NAD+ Have a Role in Aesthetic Plastic Surgery? An Evidence-Based Review.","authors":"Alexis K Gursky, Hailey P Wyatt, Anandhini D Narayanan, Sergio A Segrera, Carter J Boyd, Nolan S Karp","doi":"10.1093/asj/sjag232","DOIUrl":"https://doi.org/10.1093/asj/sjag232","url":null,"abstract":"<p><p>Nicotinamide adenine dinucleotide (NAD+) is an essential metabolic coenzyme that has gained substantial attention in recent years, driven by claims of anti-aging, metabolic, and neurocognitive benefits. Its use has expanded beyond medical spas and wellness clinics, and NAD+ is now being incorporated into some aesthetic plastic surgery practices, where it is marketed for \"improved postoperative healing\" and \"enhanced recovery\". However, support for these claims in surgical and aesthetic contexts remains largely anecdotal, drawn primarily from preclinical, non-surgical data, and patient testimonials rather than clinical studies. Nevertheless, NAD+ therapy continues to rise in popularity, making an objective evaluation of its relevance to plastic surgery timely and necessary. This narrative review provides plastic surgeons with an evidence-based overview of NAD+, including its mechanism of action, claimed benefits, available clinical evidence, safety and regulatory issues, and ethical considerations to clarify its current role within aesthetic plastic surgery.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M J Rowland-Warmann, Patricia Barrera, Mike Clague, Brittony Croasdell, Stella Desyatnikova, Greg J Goodman, Maria Hawkins, David A Hill, Gillian Murray
{"title":"Consensus Recommendations on the Diagnosis and Management of Noninflammatory and Inflammatory Nodules Secondary to Poly-L-Lactic Acid Injections.","authors":"M J Rowland-Warmann, Patricia Barrera, Mike Clague, Brittony Croasdell, Stella Desyatnikova, Greg J Goodman, Maria Hawkins, David A Hill, Gillian Murray","doi":"10.1093/asj/sjag189","DOIUrl":"https://doi.org/10.1093/asj/sjag189","url":null,"abstract":"<p><strong>Background: </strong>Poly-L-lactic acid (PLLA) is a widely used biostimulatory injectable for face and body rejuvenation. Although uncommon, nodule formation secondary to PLLA injection remains one of the most challenging complications of PLLA treatment. Inconsistent terminology and variable management approaches have resulted in uncertainty regarding diagnosis and treatment, leading to unpredictable outcomes.</p><p><strong>Objectives: </strong>The aim of this study was to develop international expert consensus recommendations for the clinical classification, prevention, and management of PLLA-associated nodules.</p><p><strong>Methods: </strong>An international multidisciplinary panel of experienced aesthetic clinicians with expertise in PLLA treatment and complication management was convened to develop consensus recommendations for the classification, prevention, and management of PLLA-associated nodules based on the available literature and collective clinical experience.</p><p><strong>Results: </strong>The panel developed a practical clinical classification distinguishing noninflammatory and inflammatory nodules, together with recommendations for prevention, diagnosis, and management. A practical treatment algorithm was produced to support clinical decision making.</p><p><strong>Conclusions: </strong>These international expert consensus recommendations provide clinicians with a pragmatic, simple-to-follow, evidence-informed framework for the diagnosis, prevention, and management of PLLA-associated nodules in routine aesthetic practice.</p><p><strong>Level of evidence: 5 (risk): </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patricia McGuire, Caroline Glicksman, Allen Gabriel, Marisa Lawrence, Melinda Haws, Holly Wall, Simeon Wall, Steven Bresnick
{"title":"Breast Implant Flipping: Prevalence, Clinical Correlation, and Independent Risk Factors in a Consecutive Ultrasound Cohort.","authors":"Patricia McGuire, Caroline Glicksman, Allen Gabriel, Marisa Lawrence, Melinda Haws, Holly Wall, Simeon Wall, Steven Bresnick","doi":"10.1093/asj/sjag235","DOIUrl":"https://doi.org/10.1093/asj/sjag235","url":null,"abstract":"<p><strong>Background: </strong>Silicone breast implants are designed with an anterior domed surface, and relatively flat posterior surface that contains the cured silicone patch. With implant flipping (an anterior-posterior malposition), the posterior patch rotates to an anterior position.</p><p><strong>Objectives: </strong>There are currently no prospective published studies reporting the prevalence of implant flipping and its associated symptoms in aesthetic patients. This prospective study used in-office high-resolution ultrasound (HRUS) to evaluate the prevalence of breast implant flipping, assess associated changes in breast shape, appearance, and symptoms, and identify potential risk factors.</p><p><strong>Methods: </strong>Consecutive patients with silicone breast implants presenting for routine follow-up underwent HRUS at 7 study sites in the United States over a 4-month period between April 1st and August 1st, 2026. Demographic data included age and BMI. Implant data included time since surgery, whether a primary of revision procedure, number of revisions, manufacturer, size, style, surface, use of ADM or scaffold, pocket location, capsule grade, flipped or not, and rupture.</p><p><strong>Results: </strong>Five hundred and ninety consecutive patients were enrolled over 4 months. Mean age 43 years with range 22-82, mean BMI 23 with range of 16-34.5. Primary augmentations accounted for 64.6% of procedures, while revision augmentations accounted for 35.4%. Device manufacturer distribution, 63.9% Allergan, 12.4% Mentor, 15.9% Motiva, and 7.1% Sientra. Implant flipping was identified in 75 patients (12.7%).</p><p><strong>Conclusions: </strong>Implant flipping was identified by HRUS in one in eight patients. Larger implant volume, prepectoral placement, and lack of soft tissue support were independently associated with flipping. HRUS improves detection, patient counseling, and surgical planning.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad R Goodarzi, Nora F Nugent, Marc D Pacifico, Michael Tyler, James E T Wokes
{"title":"Beauty Abroad, Burden at Home: Complications and National Health Service Impact of Cosmetic Tourism-Insights From the British Association of Aesthetic Plastic Surgeons National Database.","authors":"Mohammad R Goodarzi, Nora F Nugent, Marc D Pacifico, Michael Tyler, James E T Wokes","doi":"10.1093/asj/sjag056","DOIUrl":"10.1093/asj/sjag056","url":null,"abstract":"<p><strong>Background: </strong>Cosmetic surgery tourism has increased rapidly, with growing numbers of UK patients returning with complications requiring National Health Service (NHS) care. Limited regulation and inconsistent perioperative standards contribute to preventable harm.</p><p><strong>Objectives: </strong>The aim of this study was to characterize the nature, severity, and causes of complications from overseas cosmetic surgery and estimate the resulting burden on the NHS.</p><p><strong>Methods: </strong>A national retrospective study analyzed all 198 cases reported to the British Association of Aesthetic Plastic Surgeons (BAAPS) Cosmetic Tourism Complications Database between September 2022 and September 2024. Demographic, procedural, and clinical data were examined, and complications were graded using the BAAPS 5-stage classification.</p><p><strong>Results: </strong>Patients were predominantly female (93%) with a mean age of 39 years; 76% had surgery in Turkey. Abdominoplasty (45%) was the most common procedure, followed by breast and liposuction surgeries. Frequent complications included wound dehiscence (37%), infection (28%), seroma (24%), and tissue necrosis (20%). Nearly half (48%) required operative management under general anesthesia, 28% minor procedures, and 4% intensive care; 1 death occurred from pulmonary embolism. Thematic analysis identified inadequate aftercare (21%), poor preoperative optimization (12%), and premature air travel (5%) as recurrent contributory factors. Estimated NHS treatment costs (£5883-£9328 per patient) equated to £1.2 to £1.8 million over 2 years.</p><p><strong>Conclusions: </strong>Cosmetic surgery tourism poses a substantial clinical and financial challenge for the NHS. A multilevel harm-reduction strategy-encompassing patient education, complication insurance, international accreditation, and data surveillance-is essential to improve safety and reduce preventable harm.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"1177-1183"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessandro Bianchi, Giuseppe Visconti, Liliana Barone Adesi, Lorenzo Scardina, Martin Alejandro Sanchez, Alba Di Leone, Gianluca Franceschini, Marzia Salgarello
{"title":"Oncoplastic Breast Reconstruction With J-Scar Mammaplasty: Outcomes and Versatility of an Innovative Technique.","authors":"Alessandro Bianchi, Giuseppe Visconti, Liliana Barone Adesi, Lorenzo Scardina, Martin Alejandro Sanchez, Alba Di Leone, Gianluca Franceschini, Marzia Salgarello","doi":"10.1093/asj/sjag148","DOIUrl":"10.1093/asj/sjag148","url":null,"abstract":"<p><strong>Background: </strong>Oncoplastic breast surgery represents a philosophy that prioritizes both oncologic and aesthetic outcomes, introduced to overcome the limitations of conventional breast-conserving surgery. Over the years, it has demonstrated oncological safety along with numerous advantages, particularly related to patients' satisfaction and quality of life, which make acceptable complication rates as high as 16%.</p><p><strong>Objectives: </strong>The J-mammaplasty is rarely cited in the oncoplastic approach, however it represents the standard of choice at our institution. The aim of this study is to report our large experience of J-mammaplasty in level 2 oncoplastic breast surgery.</p><p><strong>Methods: </strong>This study enrolled 157 patients who underwent quadrantectomies and J-scar oncoplasties over a period of 3 years. Patients' demographics and morphological breast features were collected preoperatively, with photographs, and procedure specific variables were recorded intraoperatively. Complications were identified during follow-up visits. After a minimum of 12 months, surgeon and patients' reported outcomes were recorded.</p><p><strong>Results: </strong>J-type oncoplastic reduction mammaplasty was optimally applied to patients with a wide range of characteristics, including large breasts and third-degree ptosis, as well as different tumor features, such as location, with lateral quadrants being the most common. The overall complication rate was 7%.</p><p><strong>Conclusions: </strong>The J-mammoplasty has been applied to oncoplastic breast surgery and refined for reconstructive purposes for over 20 years at our institution. It represents a highly versatile, safe technique with high patient satisfaction.</p><p><strong>Level of evidence: 4 (therapeutic): </strong>For image description, please refer to the figure legend and surrounding text.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"1228-1235"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Do Glucagon-Like Peptide-1 Receptor Agonists Sabotage Fat Grafts?: A Scoping Review of Glucagon-Like Peptide-1 Receptor Agonist Effects on Adipocyte Biology and Implications for Autologous Fat Transfer.","authors":"Xavier Chalhoub, Zhi Yang Ng","doi":"10.1093/asj/sjag108","DOIUrl":"10.1093/asj/sjag108","url":null,"abstract":"<p><p>The rapid adoption of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for weight management has created an unprecedented overlap with aesthetic surgery. Millions of patients experiencing GLP-1-mediated weight loss now present with facial volume depletion, soft tissue deflation, and contour irregularities; conditions for which autologous fat grafting remains the gold-standard solution. However, the fundamental biology of GLP-1 receptor agonism may be inherently antagonistic to the mechanisms upon which fat graft survival depends. This scoping review, conducted in accordance with the PRISMA extension for Scoping Reviews (PRISMA-ScR), synthesizes current preclinical and clinical evidence on the effects of semaglutide, liraglutide, tirzepatide, and the emerging triple agonist retatrutide on adipocyte metabolism, adipose-derived stem cell (ASC) function, and tissue revascularization, and maps these effects onto established models of fat graft take. We identify multiple potential interference points, including GLP-1-mediated adipocyte browning and thermogenic activation with upregulation of uncoupling protein 1 (UCP1) and mitochondrial uncoupling, enhanced lipolysis through adipose triglyceride lipase and hormone-sensitive lipase (HSL) upregulation, suppression of white adipogenic differentiation in ASCs with preferential commitment toward thermogenic beige lineages, and modulation of inflammatory and angiogenic signaling during the critical revascularization window. The growing off-label use of retatrutide in bodybuilding communities introduces additional concerns through glucagon receptor-mediated lipolysis and thermogenesis. Despite the strong mechanistic rationale, no clinical or preclinical studies have directly examined fat graft outcomes in patients receiving incretin-based therapies. We propose a framework for future investigation and offer preliminary, mechanism-based clinical considerations regarding perioperative GLP-1 RA management in fat transfer patients. These recommendations should be understood as hypothesis-generating rather than evidence-based guidelines. Level of Evidence: 1 (Therapeutic) For image description, please refer to the figure legend and surrounding text.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"1214-1220"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}