Aesthetic Surgery Journal最新文献

{"title":"Non-Tobacco Nicotine Dependence Is Associated With Increased Early Postoperative Complications Following Reduction Mammaplasty.","authors":"Matthew Q Dao, Ethan Fung, Bernice Z Yu, Parul Rai, Jasmin Wilson, Arjun Nanda, Rebecca Suydam, Peter W Henderson, Peter J Taub","doi":"10.1093/asj/sjaf151","DOIUrl":"https://doi.org/10.1093/asj/sjaf151","url":null,"abstract":"<p><strong>Background: </strong>Within the past decade, non-tobacco nicotine dependence (NTND) has become more prevalent. However, the impact of non-tobacco nicotine products on breast surgery remains less explored. Despite limited evidence, plastic surgeons routinely advise nicotine cessation regardless of source, which underscores the need to define the specific risks associated with NTND.</p><p><strong>Objectives: </strong>The present study sought to assess the effect of preoperative NTND on postoperative complications and revisions in patients who underwent reduction mammaplasty.</p><p><strong>Methods: </strong>The Research Network on TriNetX, a federated global database, was queried. Patients with a history of breast cancer or tobacco product usage were excluded. Two cohorts were formed: patients diagnosed with preoperative NTND (n=1,432) and those without any documented history of nicotine dependence (n=44,149). A 1:1 propensity score-matching was performed for demographics and comorbidities. Primary outcomes evaluated postoperative complications at 30 days and 90 days. Secondary analysis assessed breast deformity and surgical revision at 2 years.</p><p><strong>Results: </strong>Following 1:1 matching, 1,424 patients remained in both cohorts. At 30 days after surgery, the NTND cohort had significantly elevated risk for surgical site infection, hematoma, acute postoperative pain, and any surgical site complications (p<0.05). Within 90 days post-op, patients with NTND continued to have significantly elevated risks for these complications (p<0.05). However, no significant differences were observed for postoperative breast deformity and revision at 2 years.</p><p><strong>Conclusions: </strong>Although preoperative non-tobacco nicotine use is not linked to increased rates of long-term deformity and revision rates, it is associated with significantly higher risks of early postoperative complications following reduction mammaplasty.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Analysis of Infraorbital Aging Over a 15-Year Period: An MRI-Based Study in Asian Subjects.","authors":"Sehoon Yoon, Hak Chang, Ki Yong Hong","doi":"10.1093/asj/sjaf152","DOIUrl":"https://doi.org/10.1093/asj/sjaf152","url":null,"abstract":"<p><strong>Background: </strong>Palpebral bags are commonly managed with infraorbital fat excision during lower blepharoplasty. This surgical approach is based on the assumption of age-related anterior herniation of infraorbital fat. However, controversy remains regarding the true volumetric changes of infraorbital fat with aging.</p><p><strong>Objectives: </strong>This study aimed to investigate longitudinal anatomical changes in the infraorbital region.</p><p><strong>Methods: </strong>A retrospective longitudinal analysis of serial magnetic resonance images from 50 healthy individuals (20 males and 30 females) aged 20-60 years was conducted; the mean interval between scans was 18.3 years. Six parameters were measured at the mid-pupillary level: the vertical height of orbital aperture (VHOA), infraorbital fat protrusion length (IPL), soft tissue thickness at the orbicularis retaining ligament (TORL), Anterior globe protrusion (GP), nasion-sella-orbital rim angle (NSO), and maxillary angle (MA). Statistical analyses evaluated parameter changes and correlations with the follow-up interval.</p><p><strong>Results: </strong>Significant increases in the VHOA and NSO and decreases in the TORL and MA were observed (p < 0.05), indicating progressive orbital skeletal remodeling and soft tissue thinning. IPL and GP remained unchanged in supine position, suggesting no volumetric change of infraorbital fat or displacement of the globe. Regression analysis confirmed follow-up interval as key predictor of VHOA and NSO changes.</p><p><strong>Conclusions: </strong>Palpebral bags primarily result from structural changes that contribute to pseudoherniation of infraorbital fat and increased prominence above the tear trough. The volume of infraorbital fat itself remains relatively stable. These findings support a lower blepharoplasty approach that prioritizes correcting structural changes over aggressive fat excision.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neck Lift After Nonsurgical Treatments: Fibrosis, Fat Loss, and Surgical Complexity.","authors":"Thomas Gerald O'Daniel, Sarah Patton","doi":"10.1093/asj/sjaf149","DOIUrl":"https://doi.org/10.1093/asj/sjaf149","url":null,"abstract":"<p><strong>Background: </strong>Noninvasive neck treatments, including lipolysis injectables, cryolipolysis, and energy-based devices, have become popular alternatives to surgery. While marketed as safe and effective, these procedures may induce fibrosis, tissue destruction, and anatomical changes that complicate secondary surgical interventions.</p><p><strong>Objectives: </strong>This study aimed to assess the impact of prior noninvasive neck treatments on surgical complexity, intraoperative findings, and outcomes in secondary neck lift procedures.</p><p><strong>Methods: </strong>A retrospective review of 180 neck lift procedures performed in 2023 by a single surgeon was conducted. Patient demographics, prior treatments, intraoperative findings, and postoperative outcomes were analyzed.</p><p><strong>Results: </strong>Of 180 patients, 123 (68%) had prior neck treatments, including surgical neck lift and/or noninvasive therapies including chemolipolysis (Kybella), cryolipolysis (CoolSculpting), radiofrequency-assisted lipolysis (FaceTite, Morpheus8, SmartLipo, Ultherapy, Profound), and suture suspension (MyEllevate, PDO threads). Intraoperative findings in patients having undergone non-surgical treatments revealed fibrosis, loss of normal tissue planes, platysma and deep fascia rigidity, and unpredictable fat distribution. A deep cervicoplasty with management of subplatysma structures were required in 94% of the cases. While no major complications occurred, nearly all patients exhibited contour irregularities postoperatively from the destruction of the supraplatysma fat and platysma. In all cases there was an increased operative time.</p><p><strong>Conclusions: </strong>Noninvasive neck treatments significantly alter tissue architecture, increasing surgical complexity and impacting aesthetic outcomes. Surgeons should anticipate these challenges, modify techniques accordingly, and emphasize thorough preoperative evaluation and patient counseling to anticipate increased risk and optimize results.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistical Superiority Without Clinical Relevance: A Critical Appraisal of Recent HA Filler Studies.","authors":"Jessica Hicks, Torun Bromée, Bill Andriopoulos","doi":"10.1093/asj/sjaf139","DOIUrl":"https://doi.org/10.1093/asj/sjaf139","url":null,"abstract":"","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Histopathological Investigation of Stromal Vascular Fraction and Nanofat in Vulvar Lichen Sclerosus.","authors":"Patricia Gutierrez-Ontalvilla, Agustina Gomez Rojas, Marisa Iborra Colomino, Serli Canikyan, Yaren Kul, Ceren Duyan, Pilar Codoñer","doi":"10.1093/asj/sjaf148","DOIUrl":"https://doi.org/10.1093/asj/sjaf148","url":null,"abstract":"<p><strong>Background: </strong>Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis that impairs quality of life through symptoms like itching, pain, and atrophy, and has limited response to conventional corticosteroid therapy.</p><p><strong>Objectives: </strong>To evaluate the safety and efficacy of the Lichen-SVF protocol, a regenerative treatment combining nanofat and mechanically isolated stromal vascular fraction (SVF) for moderate to severe VLS.</p><p><strong>Methods: </strong>This prospective, open-label study included 18 women with moderate-to-severe VLS and participants ranged from 24 to 81 years old, reflecting the broad clinical spectrum of this condition. Each received a single treatment involving intra- and subdermal injection of autologous nanofat (40 cc) and SVF (2-3 cc) into vulvar and perianal regions. Clinical follow-up occurred at 1, 3, 6, and 12 months. Symptom severity (CSS), itching (5D Itch Scale), quality of life (Skindex-29), and sexual function (FSFI) were assessed using validated scales. Pre- and 12-month biopsies were analyzed histologically and immunohistochemically for markers such as stromal hyalinization, microvascular density, and T-cell infiltration.</p><p><strong>Results: </strong>Statistically significant reductions in CSS Symptoms (from 20.12 to 4.71, p = 0.0025), CSS Signs (from 5.79 to 2.00, p = 0.0014), and Itching 5D (from 6.82 to 2.35, p = 0.0136) were observed at 12 months. Quality of life improved (Skindex-29: from 42.88 to 24.82, p = 0.0313). FSFI scores showed non-significant improvement. Histologically, a marked reduction in stromal hyalinization (p = 0.0036) and CD3+ T-cell infiltration (p = 0.0068), along with increased microvascular density (p = 0.0121), confirmed regenerative effects. No serious adverse events occurred.</p><p><strong>Conclusions: </strong>The Lichen-SVF protocol offers a safe and effective regenerative option for women with VLS who do not respond to standard treatments. As low-dose corticosteroids were maintained throughout follow-up, the protocol should be viewed as a complementary approach that enhances, rather than replaces, conventional therapy.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Time of Maximal Vasoconstrictive Effect of Epinephrine in Facelift Surgery.","authors":"Sami Tarabishy, Abigail Meyers, Marjorie C Kragel, Pierce L Janssen, James E Zins","doi":"10.1093/asj/sjaf141","DOIUrl":"https://doi.org/10.1093/asj/sjaf141","url":null,"abstract":"<p><strong>Background: </strong>It remains unclear how long a plastic surgeon should wait for the optimal vasoconstrictive effect of epinephrine in local anesthetic prior to incision for aesthetic facial surgery.</p><p><strong>Objectives: </strong>This study investigates the optimal timing for epinephrine-induced vasoconstriction in facelift procedures by measuring cheek skin temperature changes using forward-looking infrared thermography (FLIR).</p><p><strong>Methods: </strong>A retrospective chart review was conducted on all patients who underwent facelift surgery by the senior author between July 2023 and June 2024. Skin surface temperature was recorded at baseline and at predetermined time points up to 15 minutes following injection of the standardized epinephrine-containing local anesthetic solution. Additional patient data were obtained from electronic medical record review.</p><p><strong>Results: </strong>Twenty-seven patients were included in the study. The median time for each patient to reach their lowest recorded cheek temperature was 5 minutes post-injection (mean 5.1±2.9 minutes). Injected cheeks exhibited the largest median temperature decrease of 2.3°C at 7 minutes, followed by gradual rewarming to baseline. Uninjected nasal skin warmed steadily throughout the observation period. Of the 27 patients, 15 (55.6%) reached their minimum cheek temperature by 5 minutes, 23 (85.2%) by 7 minutes, and all 27 (100%) by 11 minutes.</p><p><strong>Conclusions: </strong>These findings demonstrate that the maximal vasoconstrictive effect of epinephrine in facelift surgery occurs approximately 5-7 minutes after injection. We recommend that facelift surgeons wait 5-7 minutes before initiating incisions and dissection to balance optimal hemostasis with procedural efficiency.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Contours, Different Risks: A 9-Year Comparison of Trends and Postoperative Complications in Patients Undergoing Aesthetic Surgery With Prior Bariatric Surgery vs Glucagon-Like Peptide 1 Receptor Agonist Use.","authors":"Jeffrey Khong, Rachana Suresh, Kitae E Park, Hooman Soltanian","doi":"10.1093/asj/sjaf131","DOIUrl":"https://doi.org/10.1093/asj/sjaf131","url":null,"abstract":"<p><strong>Background: </strong>The significant weight loss associated with bariatric surgery and glucagon-like peptide 1 receptor agonist (GLP-1 RA) use often prompts patients to seek aesthetic procedures to address changes in skin tightness and body contours.</p><p><strong>Objectives: </strong>We sought to examine trends in aesthetic surgery utilization and postoperative complication rates between these two patient populations.</p><p><strong>Methods: </strong>Using the TriNetX database, we identified patients undergoing aesthetic procedures between 2016-2024 and stratified cohorts based on prior bariatric surgery or GLP-1 RA use. Mean annual growth rates between groups were compared using least-squares means with post-hoc Tukey tests. Postoperative 90-day complication rates including hematoma, seroma, infection, wound dehiscence, DVT/PE, emergency department utilization, readmissions, and mortality were evaluated using risk ratios after propensity score matching.</p><p><strong>Results: </strong>Between 2016-2021, the mean annual growth rate aesthetic procedures among GLP-1 RA users was 36.1% per year, compared to 27.1% among post-bariatric patients (p=0.0026). After 2021, the mean annual growth rate aesthetic procedures increased to 53.8% (+17.7%, 95% CI: [10.4%, 25.4%]) for GLP-1 RA users and declined to -4% (-31.1%, 95% CI: [-37.7%, -25.5%]) for post-bariatric surgery patients. After matching, bariatric surgery patients had higher risk of hematoma (RR: 1.99; CI: [1.10, 3.62], p<0.05), infections (RR: 1.37; CI: [1.01, 1.88], p<0.05), and emergency department use (RR: 1.54; CI: [1.05, 2.26], p<0.05).</p><p><strong>Conclusions: </strong>Aesthetic surgery utilization is sharply increasing among patients with prior GLP-1 RA use compared to post-bariatric surgery patients. Postsurgical hematoma, infection, and emergency department utilization were greater in post-bariatric patients. Future studies are needed to investigate underlying factors.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended Antibiotic Prophylaxis in Implant-based Breast Reconstruction: A Systematic Review and Meta-analysis.","authors":"Chandler Hinson, Matthew Sink, Douglas Sammer, Andrew Y Zhang, Andrei Odobescu","doi":"10.1093/asj/sjaf144","DOIUrl":"https://doi.org/10.1093/asj/sjaf144","url":null,"abstract":"<p><p>Extended prophylactic antibiotic (EPA) regimens are commonly used following implant- or tissue expander (TE)-based breast reconstruction, though their efficacy in preventing infection-related complications remains unclear. This systematic review and meta-analysis evaluated whether EPA use (>48 hours postoperatively) reduces surgical site infections (SSIs), explantation, or reoperation events compared to short-course antibiotic regimens (≤48 hours). A comprehensive search of four databases was conducted through May 2025, following PRISMA guidelines. Sixteen studies were included, comprising 8,173 patients in the EPA group and 2,676 in the non-EPA group. Outcomes assessed included overall, minor, and major infections, as well as explantation and reoperation rates. Risk ratios (RR) with 95% confidence intervals (CI) were calculated, and study quality was evaluated using the Downs and Black checklist. No statistically significant differences were found between groups for overall infection (RR 0.90, 95% CI: 0.75-1.06), minor infection (RR 0.62, 95% CI: 0.28-1.33), major infection (RR 0.83, 95% CI: 0.50-1.38), explantation (RR 0.77, 95% CI: 0.46-1.30), or reoperation (RR 1.17, 95% CI: 0.78-1.78). These findings suggest that EPA does not confer additional clinical benefit in reducing postoperative complications following implant-based breast reconstruction. In light of the known risks associated with prolonged antibiotic use-including gastrointestinal disturbances, Clostridium difficile infection, and antibiotic resistance-these results support more judicious, evidence-based prescribing practices. This study provides updated evidence to inform antibiotic stewardship efforts and standardize care in breast reconstruction.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biostimulants in Aesthetic Medicine: A Systematic Review and Meta-analysis of Efficacy, Safety, and Patient Satisfaction.","authors":"Lee Smith, Masoud Rahmati, Damiano Pizzol, Guillermo Felipe López-Sánchez, Laurent Boyer, Guillaume Fond, Bach Xuan Tran, Julia Gawronska, Dong Keon Yon, Roshan Ravindran","doi":"10.1093/asj/sjaf142","DOIUrl":"https://doi.org/10.1093/asj/sjaf142","url":null,"abstract":"<p><p>Biostimulants, including calcium hydroxyapatite (CaHA), poly-L-lactic acid (PLLA), and polycaprolactone (PCL), have become popular in aesthetic medicine as they lead to long-term tissue rejuvenation. However, their efficacy (e.g. dermal, volume, and anatomic outcomes), satisfaction and safety remain unclear. This systematic review and meta-analysis collates and appraises the available data on biostimulants, examining their efficacy, adverse events and patient satisfaction. A comprehensive search was conducted in PubMed/Medline (National Library of Medicine, Bethesda, MD), Scopus (Elsevier, Amsterdam, the Netherlands), Embase (Elsevier), and Web of Science (Clarivate, Philadelpha, PA, USA), up to January 14th, 2025. Studies were included that assessed the effects of biostimulants on efficacy, adverse events and patient satisfaction in observational studies. Meta-analyses using random-effects models were performed on individual proportions and applied to seven outcomes (satisfaction, bruising, ecchymosis, edema, erythema, nodules development, pain). A total of 197 articles were screened, and 25 studies were included in the systematic review. The results of meta-analyses indicate that the pooled satisfaction rate of biostimulants was estimated at 91% (95% CI: 67-98, I2= 87.3%); bruising 27% (95% CI: 12-50, I2= 96%), ecchymosis 22%; (95% CI: 11-40, I2= 95.5%), edema 5%; (95% CI: 1-18, I2= 93.6%), erythema 16% (95% CI: 4-47, I2= 94.3%), nodules development 5% (95% CI: 2-10, I2= 85.5%), pain 92% (95% CI: 63-99, I2= 87.7%,). Among studies not included in the meta-analysis all parameters studied showed significant improvements in terms of dermal, volume, anatomic and satisfaction outcomes. Biostimulants demonstrate clinical promise and a favourable tolerability profile in aesthetic medicine, despite the common occurrence of minor adverse events, most notably pain.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Suture Materials on the Development of Capsular Contracture in Silicone Implants.","authors":"Emrah Işıktekin, Burçin Acuner, Merve Torun Karadere, Banu Doğan Gün, Ahmet Eksal Kargı","doi":"10.1093/asj/sjaf140","DOIUrl":"https://doi.org/10.1093/asj/sjaf140","url":null,"abstract":"<p><strong>Background: </strong>Capsular contracture leads to undesirable outcomes when using breast prostheses. While implant characteristics and surgical techniques have been studied extensively, the impact of suture materials on capsule formation remains unclear.</p><p><strong>Objectives: </strong>To evaluate the effects of different suture materials on capsular contracture development in a rat model with silicone implants.</p><p><strong>Methods: </strong>The rats were divided into five groups. Silicone measuring 1.0x1.0x0.5 cm was implanted in the thoracodorsal region. The incisions were closed using poly(glycolide-co-lactide), polypropylene, polydioxanone, glycomer 631, and polyglycolide-co-caprolactone in Groups 1 to 5, respectively. The capsule surrounding the implant was examined in histopathological specimens collected during the 12th week after implantation.</p><p><strong>Results: </strong>Capsule thickness varied significantly among groups, with Group 1 exhibiting the highest mean thickness and Group 4 the lowest. Inflammation levels also differed, with Group 3 showing the highest proportion of moderate to severe inflammation, whereas Group 4 primarily exhibited mild inflammation. The type of inflammation varied, with Groups 3, 4, and 5 predominantly showing mixed-type inflammation. The presence of foreign body giant cells was highest in Groups 1 and 2, while Group 4 had the lowest. No significant differences were observed in hemosiderin presence, collagen organization, or myofibroblast density.</p><p><strong>Conclusions: </strong>In terms of the type and degree of inflammation, presence of foreign body giant cells, and average capsule thickness, Group 4 (glycomer 631) suture had the best overall performance, and Group 1 (poly(glycolide-co-lactide) performed the worst. Glycomer 631 sutures may reduce capsular contracture in silicone implant surgeries compared to other suture materials.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}