Aesthetic Surgery Journal最新文献

{"title":"Introduction to \"Medical and Health Benefits of Aesthetic Plastic Surgery\".","authors":"Paul Wilson, Nora Nugent, Marc Pacifico","doi":"10.1093/asj/sjaf056","DOIUrl":"10.1093/asj/sjaf056","url":null,"abstract":"","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":"45 Supplement_2","pages":"S33-S34"},"PeriodicalIF":3.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prepectoral Breast Reconstruction: Early and Long-term Complications and Outcomes of Total Coverage ADM and Implants vs Polyurethane-Coated Implants Without Use of Acellular Dermal Matrix.","authors":"Marzia Salgarello, Mauro Barbera, Giuseppe Visconti, Lorenzo Scardina, Gianluca Franceschini, Alba Di Leone, Liliana Barone Adesi, Nicolò Lentini, Roberta Pastorino","doi":"10.1093/asj/sjaf158","DOIUrl":"https://doi.org/10.1093/asj/sjaf158","url":null,"abstract":"<p><strong>Background: </strong>Immediate prepectoral breast reconstruction (IPBR) has emerged as a prominent alternative to subpectoral techniques, offering favorable outcomes in selected patients. Among available options, implant coverage with acellular dermal matrix (ADM) and the use of polyurethane (PU)-coated implants without ADM represent two widely adopted strategies.</p><p><strong>Objectives: </strong>The aim of this study was to examine the comparative efficacy and complication profiles of implant coverage with acellular dermal matrix (ADM) and the use of polyurethane (PU)-coated implants without ADM.</p><p><strong>Methods: </strong>This retrospective cohort study included 97 patients (135 breasts) undergoing IPBR following nipple-sparing, skin-sparing, or skin-reducing mastectomy between April 2015 and October 2019. Patients were stratified into two groups: those receiving ADM-covered textured implants and those receiving PU-coated implants. Outcomes assessed included early (<4 weeks), mid-term (>4 weeks), and long-term (≥1 year) complications, as well as aesthetic results evaluated through blinded assessment using a standardized Likert scale.</p><p><strong>Results: </strong>PU-coated implants were associated with significantly lower rates of early postoperative seroma (2.9% vs. 33.8%, p<0.001) and infection (1.4% vs. 6.2%). At five years, the incidence of severe capsular contracture (Baker grade 3-4) was markedly higher in the ADM group (47.7% vs. 24.3%, p<0.001), particularly in patients who had not received postmastectomy radiotherapy. No significant differences were observed in the incidence of rippling or step-off deformities. Aesthetic outcomes were superior in the PU group, with significantly better breast symmetry and global aesthetic evaluation (p=0.021).</p><p><strong>Conclusions: </strong>PU-coated implants offer a safer and more effective approach in IPBR, with reduced complication rates and improved aesthetic outcomes compared to ADM-covered implants. Patient-specific anatomical and oncologic factors should guide implant selection to optimize surgical outcomes.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical Insight Into the Zygomatico-orbital Artery Using 3-Dimensional Computed Tomography Angiography: Providing a Safe Area in the Temporal Region.","authors":"Helin Yücedağ Gündoğdu, Onur Gündoğdu, Bahattin Paslı, Atiye Cenay Karabörk Kılıç, Burcu Erçakmak Güneş","doi":"10.1093/asj/sjaf162","DOIUrl":"https://doi.org/10.1093/asj/sjaf162","url":null,"abstract":"<p><strong>Background: </strong>The zygomatico-orbital artery (ZOA) poses a potential risk during aesthetic and surgical procedures due to its anastomoses with the ophthalmic artery. Accurate knowledge of its anatomical course is crucial to define safe zones and reduce complications in the temporal region.</p><p><strong>Objectives: </strong>The goal of this study is to define the course of the ZOA according to the reference points determined for guiding temporal procedures in a safer manner.</p><p><strong>Methods: </strong>This retrospective cross-sectional study employed the analysis of head and neck computed tomography (CT) angiograms obtained from 197 subjects aged 22 to 83 years. Patients with head trauma or craniotomy affecting the artery were excluded to ensure the accuracy of the results. The parameters were evaluated using three-dimensional volume rendering (3D-VRT), thin-slab axial, and thickness enhanced sagittal maximum intensity projection (MIP) images.</p><p><strong>Results: </strong>The results obtained from the 103 ZOAs that were analyzed demonstrated that 82 (79.61%) of the arteries originated from the superficial temporal artery (STA), displaying an average diameter of 0.91 mm, while 21 (20.39%) originated from the frontal branch, with an average diameter of 0.85 mm. ZOAs originating from the STA were observed to be situated at a deeper level at the starting point in comparison to ZOAs originating from the frontal branch (5.78 and 4.91 mm depth from the skin, respectively, and p=0.008).</p><p><strong>Conclusions: </strong>The findings of this study emphasize the necessity of a comprehensive understanding of the anatomical variations, the course and location of the ZOA to ensure safe clinical interventions.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonmuscle-Mediated Effects of Botulinum Toxin A on Fat Graft Survival in Nude Mice: Timing-Dependent Graft Outcomes.","authors":"Fangzhou Xie, Rao Fu, Botao Zheng, Wei Ding, Yibo Zhao, Hao Liu, Ying Wang, Xintao Wang, Yun Xie","doi":"10.1093/asj/sjaf160","DOIUrl":"https://doi.org/10.1093/asj/sjaf160","url":null,"abstract":"<p><strong>Background: </strong>Enhancing fat graft survival is a key goal in adipose regenerative medicine. Although botulinum toxin type A (BoNTA) has shown potential benefits, its effects beyond muscle paralysis remain incompletely understood.</p><p><strong>Objectives: </strong>The authors of this study aim to investigate the nonmuscle-mediated effects of BoNTA on fat graft survival and quality.</p><p><strong>Methods: </strong>BALB/c-nu nude mice, with the subcutaneous skull area selected for fat transplantation because of its minimal muscular activity, were assigned to 3 groups (n = 5/group/time point): a control group receiving only fat graft and saline, and 2 experimental groups receiving BoNTA either simultaneously (BoNTA group) or 1 week (Pre-BoNTA group) before grafting. Graft volume was measured through liquid overflow at 1, 4, 8, and 12 weeks. Histological analysis and immunostaining were performed to assess adipose integrity, vascularization, inflammation, fibrosis, apoptosis, and proliferation.</p><p><strong>Results: </strong>At Week 12, fat retention rates reached 33.67% in the Pre-BoNTA group and 35.16% in the BoNTA group, both significantly higher than the control (20.79%, P < .01). Histological analyses demonstrated superior outcomes in these treatment groups, characterized by improved vascularization, preserved adipocyte morphology, reduced inflammation and fibrosis, and favorable apoptotic and proliferative profiles. Notably, the BoNTA group showed greater preservation of adipocyte architecture, lower inflammatory cell presence, and stronger antiapoptotic effects than the Pre-BoNTA group, despite comparable volume retention.</p><p><strong>Conclusions: </strong>BoNTA improves the survival rate and quality of fat grafts through nonmuscle-mediated effects. Additionally, the timing of BoNTA administration exerts a significant influence on graft outcomes.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of a Proposed Hyaluronic Acid (Lunaphil Ultra) Compared to the Reference Product (Juvéderm Ultra 4) for the Management of Moderate or Severe Nasolabial Folds: A Randomized, Double-Masked, Within-Subject, Equivalency-Controlled Trial.","authors":"Kamran Jazayeri, Omid Zargari, Hoshyar Gholami, Araz Sabzvari, Hamidreza Kafi, Kamran Balighi","doi":"10.1093/asj/sjaf156","DOIUrl":"https://doi.org/10.1093/asj/sjaf156","url":null,"abstract":"<p><strong>Background: </strong>Nasolabial folds (NLFs) are a natural alteration that become more noticeable with aging and dramatically affect facial skin beauty. Hyaluronic acid (HA) dermal fillers are frequently utilized to correct these visible signs of aging.</p><p><strong>Objective: </strong>The objective of this study was to evaluate and compare the effectiveness and safety of Lunaphil Ultra vs Juvéderm Ultra 4 in the treatment of NLFs.</p><p><strong>Methods: </strong>Each participant received Lunaphil Ultra and Juvéderm Ultra 4 in 1 of their NLFs. For each participant the products were injected at the first visit, and if needed an additional injection (touch-up) was done at the second visit. The duration of the study was 24 weeks for each participant. The primary outcome of this study was to assess the mean level of NLF severity score improvement compared to baseline with the Wrinkle Severity Rating Scale (WSRS) at Week 24.</p><p><strong>Results: </strong>The mean ± SD level of improvement by WSRS was -0.80 ± 0.66 for Lunaphil Ultra and -0.81 ± 0.67 for the Juvéderm Ultra 4 group (P value > .99). The difference between the 2 groups was within the predefined equivalency margin of ± 0.17. Of the treated NLFs, 71.15% in the Lunaphil Ultra group and 66.35% in the Juvéderm Ultra 4 group received a touch-up injection (P value = .33).</p><p><strong>Conclusions: </strong>As indicated by the study results, Lunaphil Ultra had an acceptable efficacy and safety profile in the Iranian population and was equivalent to Juvéderm Ultra 4 in WSRS improvement.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Associated Collagen Remodeling in Vaginal Tissue: A Histomorphometric Analysis.","authors":"Zhenyang Xiao, Lei Zhou, Jianying Wu, Songhua Yang, Yali Wu, Pu Zhang, Ang Li, Aiqiong Tang, Na Sang, Jing Yang","doi":"10.1093/asj/sjaf157","DOIUrl":"https://doi.org/10.1093/asj/sjaf157","url":null,"abstract":"<p><strong>Background: </strong>The female reproductive system undergoes progressive degeneration with age, among which the imbalance of collagen metabolism in vaginal wall tissue is a key pathological feature.</p><p><strong>Objectives: </strong>This study aims to deeply investigate the dynamic trend of collagen within the vaginal wall of women of different ages and the interrelationship of its subtype proportions, to determine whether there are age-related changes in collagen.</p><p><strong>Methods: </strong>A total of 40 healthy women were included and divided into four groups according to age: Group A (20-30 years), Group B (30-40 years), Group C (40-50 years), and Group D (>50 years). The morphological characteristics of the mucosa were assessed through colposcopy, and histological changes in the vaginal wall were analyzed using HE, Masson, and Sirius Red staining.</p><p><strong>Results: </strong>With increasing age, the color of the vaginal mucosa gradually changed from pink (Group A) to pale or dark red (Group D), the density of the rugae decreased, and the surface moisture decreased. Histological staining showed that epithelial thickness significantly decreased with age, and the collagen content in the lamina propria was greatly reduced. The collagen in the muscularis remained relatively stable but still showed a significant decrease after the age of 40. Sirius Red polarized light staining showed that the ratio of Type I/III collagen significantly increased with age.</p><p><strong>Conclusions: </strong>This study systematically revealed for the first time the dynamic characteristics of vaginal wall collagen with aging, confirming that collagen in the lamina propria shows more significant loss compared to the muscularis. We found that the Type I/III collagen ratio increases in an age-dependent manner, and this imbalance in collagen subtype ratio may lead to vaginal functional decline. These findings not only provide evidence for the aging of the female reproductive system but also open up new research directions for developing precise interventions targeting collagen metabolism.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicenter, Randomized Split-Face Trial of a Crosslinked Hyaluronic Acid Filler With Lidocaine for Nasolabial Fold Correction.","authors":"Konstantin Frank, Jeanine Downie, Michael Gold, John Joseph, Jeremy Green, Sabrina Fabi, David Bank, Joel L Cohen, Ava Shamban, Robert Weiss, Alice Krames-Juerss, Gary Monheit","doi":"10.1093/asj/sjaf137","DOIUrl":"https://doi.org/10.1093/asj/sjaf137","url":null,"abstract":"<p><strong>Background: </strong>Nasolabial folds (NLFs) are common age-related facial lines, often treated with dermal fillers. Princess® FILLER Lidocaine (PFL; now saypha® filler Lidocaine) and Juvéderm® Ultra XC (JUXC) are both hyaluronic acid-based fillers used for this purpose.</p><p><strong>Objectives: </strong>To evaluate the effectiveness and safety of PFL in reducing NLF severity compared to JUXC using a split-face study design.</p><p><strong>Methods: </strong>In this randomized, subject- and investigator-blinded multicenter study, subjects with moderate to severe NLFs received PFL on one side of the face and JUXC on the other. Baseline NLF severity was assessed using the 5-point Nasolabial Fold Severity Rating Scale (NLF-SRS). Follow-up assessments occurred at weeks 12, 24, 36, and/or 48. The primary endpoint was the proportion of NLF-SRS responders at week 24. Secondary endpoints included assessments by photographic reviewers and treating investigators, along with Global Aesthetic Improvement Scale (GAIS) ratings. Safety was monitored via adverse event reporting and subject diaries. FACE-Q questionnaires evaluated subject satisfaction. Repeat treatment was permitted at week 36 or 48 if needed.</p><p><strong>Results: </strong>At week 24, PFL demonstrated non-inferiority to JUXC (82.2% vs. 81.9% responders; difference 0.37%, p < 0.0001). Secondary assessments confirmed this finding. Adverse events occurred in 24.4% of subjects post-PFL, with most being mild to moderate. Serious TEAEs were rare (1.1%).</p><p><strong>Conclusions: </strong>PFL is a non-inferior alternative to JUXC for treating moderate to severe NLFs, with comparable efficacy, safety, and patient satisfaction.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Beyond Accuracy: Interpreting AI Performance in Surgical Decision-Making.","authors":"Alpay Duran, Anıl Demiröz, Oguz Çörtük, Bora Ok, Mustafa Özten, Sinem Eroğlu","doi":"10.1093/asj/sjaf153","DOIUrl":"https://doi.org/10.1093/asj/sjaf153","url":null,"abstract":"","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nationwide Analysis of Complications and Risks Associated With Types of Liposuction in 69,424 Patients.","authors":"Mariam Saad, Sara C Chaker, Andrew J James, Ya-Ching Hung, Lisandro Montorfano, Galen Perdikis, James C Grotting, Kent Higdon, Susan Orra","doi":"10.1093/asj/sjaf147","DOIUrl":"https://doi.org/10.1093/asj/sjaf147","url":null,"abstract":"<p><strong>Background: </strong>Liposuction is the most common plastic surgery procedure performed in the United States. Continued advancements have led to the development of five common approaches to liposuction.</p><p><strong>Objectives: </strong>This study aims to compare complications and associated risk factors between liposuction modalities.</p><p><strong>Methods: </strong>Patients undergoing liposuction from March 2015 to December 2022 were identified using the CosmetAssure database (Birmingham, AL, USA). Demographics and major complications were reported. Findings were compared between five types of liposuction: conventional, infusion-assisted, laser-assisted, power-assisted, and ultrasound-assisted. Risk factors and complications associated with each type were identified. A subgroup analysis of patients who received liposuction alone was also completed.</p><p><strong>Results: </strong>A total of 69,424 patients underwent liposuction, with an average age of 43 and a female predominance of 93.2%. Conventional liposuction (56.5%) was the most prevalent method, followed by power-assisted (32%), laser-assisted (8%), ultrasound-assisted (4%), and infusion-assisted (0.4%). Complication rates varied, with infusion-assisted liposuction showing a 6.7 times higher risk, while laser-assisted liposuction had a 50% lower risk compared to conventional liposuction. The overall complication rate among patients receiving liposuction alone was 1.16% with infusion-assisted liposuction having the highest risk. Patients who underwent infusion-assisted liposuction had a higher rate of infection (0.54%, p<0.05).</p><p><strong>Conclusions: </strong>Liposuction is associated with low complication rates, with hematoma and infection being the most prevalent. While power-assisted liposuction had the highest rate of major complications, regression analysis controlling for confounders showed that infusion-assisted liposuction had the highest risk of serious complications. Factors like diabetes and being underweight correlate with higher complication risk.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rates of Positive Aspiration Prior to Facial Hyaluronic Acid Filler Injections: Outcomes of a Multicenter, Cross-Sectional Study.","authors":"Andreas Nikolis, Andrei Metelitsa, Luiz Avelar, Philippe Berros, Priyanka Chadha, Sebastian Cotofana, Carlo Di Gregorio, Sabrina Fabi, Firas Hamdan, Lisa Kellett, Stephanie Lam, Fabiano Magacho, Kuldeep Minocha, Quynh Nguyen, Ishaan Ramkisson, Kaitlyn M Enright, Tyler Safran","doi":"10.1093/asj/sjaf150","DOIUrl":"https://doi.org/10.1093/asj/sjaf150","url":null,"abstract":"<p><strong>Background: </strong>Before administering hyaluronic acid (HA) fillers, aspiration can be performed as a safety measure to verify whether the needle tip is possibly located within a vascular structure. However, the efficacy and utility of aspiration have been questioned. A real-world evaluation would contribute to the literature and understanding of how this technique is used globally.</p><p><strong>Objectives: </strong>Determine the incidence (%) of positive pre-treatment aspiration in a real-world setting.</p><p><strong>Methods: </strong>An observational study with a cross-sectional design was conducted to evaluate the incidence of positive aspiration before facial HA injections. Investigators from fourteen aesthetic/dermatologic practices in nine different countries participated in the study. The active data collection period was twelve weeks. Data of all patients presenting to the participating clinics during the active data collection phase, and who underwent HA injections to any region of the face were included. The aspiration technique included slowly pulling back on the plunger of the syringe and holding it back for a minimum of five seconds, to allow proper time for flashback.</p><p><strong>Results: </strong>Data from 5,106 aspirations performed in 1007 individual patients was collected. In total, there were 35 cases (0.69%) of positive aspiration. However, there were significant differences in the incidence reported by investigators (range: 0 to 6.72%).</p><p><strong>Conclusions: </strong>The results of this study may be used in an assessment of the utility of pre-treatment aspiration as a safety measure before performing HA filler injections, and they contribute to the understanding of the effect of various factors on positive pre-injection aspiration under clinical conditions.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}