Aesthetic Surgery Journal最新文献

{"title":"Evaluating the Role of Gynecomastia Surgery in Improving Sexual Function and Hormonal Profiles.","authors":"Tansu Akdağ, Abdullah Akdağ, Mustafa Özkan, Osman Enver Aydın","doi":"10.1093/asj/sjaf026","DOIUrl":"10.1093/asj/sjaf026","url":null,"abstract":"<p><strong>Background: </strong>Patients with gynecomastia may experience hormonal imbalances and sexual dysfunctions, such as erectile and ejaculatory disorders.</p><p><strong>Objectives: </strong>This study evaluates the changes in hormonal parameters and sexual function following gynecomastia surgery.</p><p><strong>Methods: </strong>Thirty-two male patients (aged 15-65) without systemic or genetic comorbidities underwent gynecomastia surgery. Preoperative and postoperative hormonal parameters free and total testosterone, estrogen (EST), prolactin (PRL), follicle-stimulating hormone, luteinizing hormone, sex hormone-binding globulin, and sexual function scores (International Index of Erectile Function [IIEF], Premature Ejaculation Diagnostic Tool [PEDT]) were assessed. A urologist blinded to the study evaluated patients andrologically.</p><p><strong>Results: </strong>The mean age of the patients was 25.69 ± 10.37 years. Postoperative PRL and EST levels significantly decreased (P = .03 and P < .001, respectively). All IIEF subscale scores showed significant postoperative improvements (P-values ranging from <.001 to .006). PEDT scores significantly decreased postoperatively (P < .001).</p><p><strong>Conclusions: </strong>Surgical treatment of gynecomastia leads to significant improvements in hormonal parameters and sexual function. These benefits should be considered in surgical planning.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"584-588"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Factors That Impact FACE-Q Aesthetics Outcomes: An Exploratory Cross-sectional Regression Analysis.","authors":"Lucas Gallo, Isabella Churchill, Patrick Kim, Charlene Rae, Sophocles H Voineskos, Achilles Thoma, Andrea L Pusic, Stefan J Cano, Anne F Klassen","doi":"10.1093/asj/sjaf027","DOIUrl":"10.1093/asj/sjaf027","url":null,"abstract":"<p><strong>Background: </strong>The FACE-Q Aesthetics is a validated tool for assessing patient-reported outcomes related to surgical and nonsurgical facial aesthetic treatments. Recognizing patient-specific variables that may influence FACE-Q scores is essential to control for potential confounders in research.</p><p><strong>Objectives: </strong>This study aimed to identify factors that predict FACE-Q Aesthetics scale scores.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among an international cohort of participants recruited through the Prolific platform. Participants aged 20 years or older, who had undergone noninvasive facial aesthetic procedures within the past year, were included. Demographic and clinical information was collected, and univariable and multivariable linear regression analyses were employed to assess predictors of FACE-Q Face Overall, Psychological, and Social scale scores.</p><p><strong>Results: </strong>A total of 1259 participants were analyzed, with an average age of 42.6 years (±11.9). The mean scores were 52.4 (±18.3) for the Face Overall scale, 56.5 (±23.7) for the Psychological scale, and 62.7 (±24.0) for the Social scale. Several factors were significantly associated (P < .05) with higher scores, including lower BMI, African American ethnicity, male gender, Fitzpatrick skin Type V, residence in the United States, financial stability, and residual effects of previous aesthetic treatments. Younger participants were more likely to report higher Face Overall scores (P < .05).</p><p><strong>Conclusions: </strong>This study identified several patient characteristics that predict Face Overall, Psychological, and Social scale scores. These findings offer valuable insights into how patient-specific factors influence outcomes following facial aesthetic procedures and underscore the need to account for these variables in future research using the FACE-Q Aesthetics tool.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"543-551"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterioembolic Characteristics of Differentially Diluted CaHA-CMC Gels Within An Artificial Macrovascular Perfusion Model.","authors":"Danny J Soares, Julia Fedorova, Yu Zhang, Akash Chandawarkar, Alexis Bowhay, Larry Blevins, Thomas J Kean, David K Funt","doi":"10.1093/asj/sjaf028","DOIUrl":"10.1093/asj/sjaf028","url":null,"abstract":"<p><strong>Background: </strong>Despite the recently increased incidence and improved awareness of filler-induced ischemic injuries, the arterioembolic behavior of filler products has not been well described.</p><p><strong>Objectives: </strong>To evaluate the embolic behavior of varying dilutions of calcium hydroxylapatite-carboxymethylcellulose (CaHA-CMC) gel mixtures within an artificial macrovascular perfusion model of the proximal facial artery with correlation against published instances of ischemic injuries in the literature.</p><p><strong>Methods: </strong>CaHA-CMC gel mixtures were assessed through the Pulsatile Unit for the Laboratory Simulation of Arterioembolic Restrictions (PULSAR) system at different flow rates. The occlusive behavior, embolic particle size distributions, and morphological attributes were evaluated through direct photographic and videographic captures followed by digital image processing. The PubMed database was systematically queried for all published instances of CaHA-CMC-associated ischemic injuries.</p><p><strong>Results: </strong>Undiluted CaHA-CMC demonstrated highly cohesive behavior upon PULSAR inoculation, with a tendency toward proximal occlusion. Gel fragmentation resulted in a polydisperse embolic mixture averaging 0.151 ± 0.61 mm² (interquartile range: 0.006-0.022 mm²) in size. Product dilution had a profound effect on embolic behavior, with a significant reduction in average particle size (0.018 ± 0.03 mm²; interquartile range: 0.005-0.018 mm²; P < .0001) and complete elimination of proximally occlusive capacity for hyperdiluted mixtures compared with undiluted product (P = .002). Confirmed hyperdiluted CaHA-CMC-associated ischemic injuries represented only 3% of published reports, with a predominantly self-limited clinical course.</p><p><strong>Conclusions: </strong>Embolized CaHA-CMC gels produce polydisperse particle mixtures with a preponderance of microparticles. Hyperdilution profoundly reduced the proximally occlusive potential of the product.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"645-653"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological Changes in Rectus Abdominis Muscle Associated With Pregnancy and Abdominoplasty.","authors":"Dong Wei, Xufeng Shi, Jie Ren, Xin Cui","doi":"10.1093/asj/sjaf037","DOIUrl":"10.1093/asj/sjaf037","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy can alter the rectus abdominis, but abdominoplasty can potentially correct these changes.</p><p><strong>Objectives: </strong>The aim of this study was to examine these muscle changes during pregnancy and to evaluate how effectively abdominoplasty with double folds of the rectus abdominis tightens the muscle.</p><p><strong>Methods: </strong>Clinical data were obtained from nulliparous and pregnant patients who had undergone abdominoplasty with double folds of the rectus abdominis. Measurements were made of linea alba width, rectus abdominis width, thickness, and cross-sectional area, and abdominal circumference. Postoperative complications were also recorded. Patient satisfaction with the morphology of the rectus abdominis, both pre- and postsurgery, was assessed on a 5-point Likert scale.</p><p><strong>Results: </strong>The study included 400 women: 171 nulliparous, 106 with 1 pregnancy (Group 1), and 123 with 2 or more pregnancies (Group 2). Complete postoperative data were available for 32 patients (Group 3). Significant widening of the linea alba was found in Groups 1 and 2. The rectus abdominis width increased significantly in Group 1 but not in Group 2. Its thickness remained unchanged in Group 1 but decreased in Group 2, mirroring the pattern of its cross-sectional area. In Group 3, both the linea alba and rectus abdominis width decreased, while thickness and cross-sectional area increased. Satisfaction with muscle morphology improved significantly postsurgery, with no serious complications reported.</p><p><strong>Conclusions: </strong>Pregnancy can cause the rectus abdominis muscle to separate, widening the linea alba and flattening the muscle. Abdominoplasty, which reinforces the muscle with double folds, effectively resolves this, resulting in high patient satisfaction and few complications.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"621-628"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aesthetic Efficacy and Safety of Combined Microfocused Ultrasound With Visualization and Calcium Hydroxylapatite Treatment: A Systematic Review of Human Evidence.","authors":"Mojgan Amiri, Renald Meçani, Christa D Niehot, Guido Muharremi, Julieta Spada, Rossana Vasconcelos, Tatjana Pavicic, Sonja Sattler, Melissa K Levin, Siew Tuck Wah, Julia Carroll, Sonya Cook, Taulant Muka","doi":"10.1093/asj/sjae239","DOIUrl":"10.1093/asj/sjae239","url":null,"abstract":"<p><p>Although microfocused ultrasound with visualization (MFU-V) and calcium hydroxylapatite- carboxymethylcellulose (CaHA-CMC) have their individual strengths and have demonstrated effectiveness in aesthetic improvement and improving skin laxity, a combined treatment may sometimes be required to achieve comprehensive aesthetic enhancements that meet patients' needs and preferences. This review systematically summarizes the available evidence on combined MFU-V and CaHA-CMC treatment. A comprehensive search was conducted in Embase, MEDLINE ALL (Ovid), Web of Science Core Collection, and Cochrane Central. We included studies conducted in adults that examined the effectiveness, safety, and/or mechanism of action of combined MFU-V and CaHA-CMC treatment. Out of 4019 references, 11 studies, mainly pre-post studies, were included in this analysis. Overall, regardless of the area treated, improvements in global aesthetic scales, skin quality parameters, and patients' satisfaction following combined treatment, accompanied by mild to moderate adverse effects, were found. In addition, histological studies indicated increased neocollagenesis and elastin synthesis posttreatment. Our review highlights promising outcomes from combined MFU-V and CaHA-CMC treatment. Nevertheless, due to the limited number of studies, further research is essential to gain a deeper understanding of this combined treatment's efficacy, safety, and applicability.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"638-642"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous Lower Pole Release for Double Bubble Prevention in Constricted-Base Breasts: The \"Plus One\" Augmentation Technique.","authors":"Sonia Fertsch, Andreas Wolter, Alberto Rancati, Claudio Angrigiani, Matthias Voigt, Christoph Andree","doi":"10.1093/asj/sjaf014","DOIUrl":"10.1093/asj/sjaf014","url":null,"abstract":"<p><strong>Background: </strong>Breasts with a broad base, constricted inframammary fold (IMF) and a short distance between the nipple and the IMF are predisposed to form a double bubble (DB) deformity. Most publications have focused on the correction of a DB rather than on its prevention and thorough analysis of the IMF.</p><p><strong>Objectives: </strong>The goal of this study was the introduction of a third dissection plane in breast augmentation for preventing or correcting DB deformities.</p><p><strong>Methods: </strong>This study was a retrospective analysis conducted by a single surgeon, involving 46 patients with a well-defined constricted IMF who underwent breast augmentation with the \"plus one\" technique between 2019 and 2021. Patients who required mastopexy were excluded. All procedures were analyzed for lower pole curvature with visual and graphical photographic analysis. The lower pole breast contour was plotted as a graph for better comparison of outcomes. BREAST-Q surveys were conducted before and 3 months after surgery. Follow-ups were done at 2 weeks, 6 months, and 12 months after surgery.</p><p><strong>Results: </strong>The curve of the postoperative lower pole was convex in 96% of the cases. In 4%, the curve tended to straighten out in the lower pole. In 1 case, the curve became concave at 1 point, indicating a DB deformity, making a DB complication rate of 2%. The mean preoperative satisfaction score was 43 ± 2, and the postoperative satisfaction score was 94 ± 3 on the BREAST-Q scale.</p><p><strong>Conclusions: </strong>The plus one method showed stable and satisfying results and was easily reproducible with a low complication rate. This can be performed as either a prophylactic or corrective measure.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"574-583"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Subcutaneous Injection of Tranexamic Acid on Ecchymosis and Edema After Oculofacial Surgery: A Prospective, Randomized, Split-Face, Double-Blind Study.","authors":"Teresa H Chen, Dylann Fujimoto, Eduardo Damous Feijó, Jose Eduardo Rios, Marisa Novaes de Figueiredo Rassi, Rafael Leão, Jeremiah P Tao, Roberto Murillo Limongi","doi":"10.1093/asj/sjaf036","DOIUrl":"10.1093/asj/sjaf036","url":null,"abstract":"<p><strong>Background: </strong>Tranexamic acid (TXA) is an antifibrinolytic that is regularly used to reduce bleeding in surgical specialties.</p><p><strong>Objectives: </strong>The objective of this study was to assess the effects of subcutaneous TXA in oculofacial plastic surgeries, with the hypothesis that TXA reduced postoperative ecchymosis and edema.</p><p><strong>Methods: </strong>This was a prospective, randomized, double-blind, split-face study. The sides of the face were randomized to local anesthetic (bupivacaine with epinephrine) mixed with TXA or sodium chloride (placebo). Photographs were taken immediately postoperatively and on postoperative day (POD) 7. Photographs were graded by 2 masked investigators with the Surgeon Periorbital Rating of Edema and Ecchymosis criteria. Patients selected the side that they subjectively determined to have less ecchymosis and edema. As a secondary outcome, patients rated pain on each side of their face with the Wong-Baker FACES pain scale.</p><p><strong>Results: </strong>Twenty-four patients undergoing bilateral, symmetric oculofacial surgery were included in the study. There was a statistically significant difference in postoperative periocular ecchymosis on POD7 (with TXA .91 ± 0.73 vs placebo 1.61 ± 1.03; P = .020) and in periocular edema on POD1 (with TXA 1.30 ± 0.76 vs placebo 2.00 ± 0.85; P = .028). All patients selected the side of the face receiving TXA as having less periocular ecchymosis and edema. There was no statistically significant difference in subjective pain level between the side receiving TXA vs placebo. There were no intraoperative or postoperative complications.</p><p><strong>Conclusions: </strong>Subcutaneous TXA was safe and reduced periocular ecchymosis and edema compared to contralateral placebo injections in this series of patients undergoing bilateral oculofacial plastic surgeries.</p><p><strong>Level of evidence: 2: </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"563-567"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Online Patient Forums to Understand Breast Reduction Concerns: A Machine-Learning Analysis of 3,078 Patient Questions Over 15 Years.","authors":"Elaine Lin, Jenny A Foster, Melissa M Tran, Tara Pillai, Raiven Harris, Nicholas C Oleck, Rebecca W Knackstedt","doi":"10.1093/asj/sjaf077","DOIUrl":"https://doi.org/10.1093/asj/sjaf077","url":null,"abstract":"<p><strong>Background: </strong>Patients are increasingly using social media and online forums to learn about plastic surgery, which can influence their expectations. Understanding patient concerns on these platforms will facilitate productive clinic discussion and ensure patients are receiving accurate, evidence-based information.</p><p><strong>Objectives: </strong>We analyzed breast reduction questions posted on RealSelf (Seattle, WA), an online plastic surgery forum.</p><p><strong>Methods: </strong>The website https://www.realself.com/questions/breast-reduction was accessed on June 9, 2023. Posting date and poster self-reported location were extracted. Question header and text were manually reviewed. Questions were categorized by timing (preoperative vs. postoperative) and topic. Regional and temporal trends were assessed. A machine-learning (ML) algorithm was applied to identify the top (most representative) preoperative and postoperative questions.</p><p><strong>Results: </strong>3,078 questions from August 2008 to May 2023 were analyzed. Questions most frequently originated from the Southern United States (34.5%) and were asked preoperatively (58.4%). The most common question topics were Postoperative Care (24.9%), Postoperative Appearance/Sensation (15.7%), and Surgical Logistics (10.2%). The distribution of topics varied significantly between location (p<0.01), with topics like Insurance (p<0.01) more likely to be asked in the South.</p><p><strong>Conclusions: </strong>This is the first study to leverage ML workflows to analyze a large volume of patient questions about breast reduction from an online plastic surgery forum. Analyzing patient questions on social media and online forums like RealSelf with ML techniques can provide valuable insight into common concerns and informational gaps surrounding plastic surgery. Plastic surgeons should consider these results to guide patient conversations, combat misinformation, and facilitate deliverance of efficient care.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiplex Lateral Flow Assay Combining CD30 and IL-10 for the Detection of BIA-ALCL.","authors":"Peng Xu, Kristen Brosamer, Katerina Kourentzi, Richard Willson, Honghua Hu, Anand Deva, William P Adams, Caroline Glicksman, Patricia McGuire, Marshall Kadin","doi":"10.1093/asj/sjaf078","DOIUrl":"https://doi.org/10.1093/asj/sjaf078","url":null,"abstract":"<p><strong>Background: </strong>Breast Implant associated anaplastic large cell lymphoma (BIA-ALCL) has affected more than 1700 women. Treatment morbidity is reduced and survival improved by early detection and removal of implant and capsule.</p><p><strong>Objective: </strong>To address the need for early detection, we developed a multiplex lateral flow assay (LFA) for soluble IL-10 and CD30 in seromas surrounding implants.</p><p><strong>Methods: </strong>The range of detection was determined with recombinant CD30 or IL-10 added to a benign seroma to simulate clinical conditions. Then clinical samples from 23 women with BIA-ALCL and 17 benign seromas were analyzed with a multiplex LFA detecting soluble IL-10 and CD30.</p><p><strong>Results: </strong>When recombinant proteins were added to benign seromas, CD30 was detected down to a concentration of 0.5 ng/mL, while IL-10 could be detected to down to 5 ng/mL. Significant differences were found between CD30 and IL-10 test line/control line ratios (TL/CL) of 23 BIA-ALCL and 17 benign seromas. Visual inspection of LFAs resulted in 65% sensitivity improved to 87% using image analysis.</p><p><strong>Conclusions: </strong>We conclude the multiplex IL-10/CD30 can detect BIA-ALCL with 100% specificity and 65% sensitivity in this group of 40 clinical seromas based on visual assessment of LFA strips. Sensitivity was improved to 87% with image analysis which can provide a screening test for BIA-ALCL. The multiplex LFA demonstrated a perfect positive predictive value (100%), indicating that all positive results correctly identified BIA-ALCL cases. The negative predictive value of 99% can exclude BIA-ALCL.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Tranexamic Acid and Systemic Dexamethasone for Post-rhinoplasty Edema and Ecchymosis: First Direct Comparison.","authors":"Omer Vural, Alper Koycu","doi":"10.1093/asj/sjaf073","DOIUrl":"https://doi.org/10.1093/asj/sjaf073","url":null,"abstract":"<p><strong>Background: </strong>Postoperative edema and ecchymosis are common concerns following rhinoplasty, often prolonging recovery and affecting patient satisfaction. Systemic dexamethasone is widely used to reduce these complications, while topical tranexamic acid has recently gained attention. However, no study has directly compared their efficacy or evaluated their combined effect.</p><p><strong>Objectives: </strong>This study aimed to compare the effectiveness of topical tranexamic acid, systemic dexamethasone, and their combination in reducing postoperative edema and ecchymosis after rhinoplasty.</p><p><strong>Methods: </strong>A prospective, randomized, triple-blinded controlled trial was conducted on 60 patients, who were randomly assigned into four groups: topical tranexamic acid (n=15), systemic dexamethasone (n=15), combination therapy (n=15), and control (n=15). Standardized clinical scoring was used to assess periorbital edema and ecchymosis on postoperative days 1, 3, and 7. Intergroup and intragroup comparisons were performed using appropriate statistical tests, with a significance threshold of p ≤ 0.05.</p><p><strong>Results: </strong>Both topical tranexamic acid and systemic dexamethasone significantly reduced postoperative edema and ecchymosis compared to the control group (p < 0.05), with no significant difference between them. The combination therapy provided no additional benefit over monotherapy.</p><p><strong>Conclusions: </strong>Topical tranexamic acid is as effective as systemic dexamethasone in reducing postoperative edema and ecchymosis, making it a viable alternative, especially for patients with contraindications to corticosteroids. The combination of both agents did not yield additional benefits.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}